ライフサイエンスコーパス: imperfect

1 omography and computed tomography scans, are imperfect.

2 iated diagnostic and treatment paradigms are imperfect.

3 monitoring strategy, even when compliance is imperfect.

4 nitive identification remain both scarce and imperfect.

5 alic acid production and disease severity is imperfect.

6 ssessment of individual risks remains highly imperfect.

7 nd models for predicting target activity are imperfect.

8 e-directed mutagenesis method is popular but imperfect.

9 ality to detected variants is imperative but imperfect.

10 vior, but knowledge of their interactions is imperfect.

11 , and PTLD tumor light chain restriction was imperfect.

12 ting and cardiac magnetic resonance, remains imperfect.

13 s (MS), and existing diagnostic criteria are imperfect.

14 nted cleavage have been devised, but all are imperfect.

15 xpression of the PrD of Gts1p, containing an imperfect 28 residue glutamine-alanine repeat, was suffi

16 iously characterized and consist entirely of imperfect 69-bp terminal inverted repeats characteristic

17 Our imperfect ability to detect and report disease hinders a

18 ppa = 0.55-0.62, P < 0.01) and had a strong, imperfect ability to discriminate between persons retain

19 o be causal are not always so, mainly due to imperfect ability to predict the pathogenicity of varian

20 hysical activity estimates corrected with an imperfect accelerometer measurement might over- or under

21 tion versus kinetic limitations arising from imperfect accommodation of organic species into the part

22 th 2 common devices, retinal specialists had imperfect accuracy and low sensitivity in detecting reti

23 on of ribonucleotides in the nucleus and the imperfect accuracy of replicative DNA polymerases in cho

24 he main limitations of the scores were their imperfect accuracy, the need for access to urine LAM tes

25 stem (CNS) (odds ratio [OR], 3.7; P < .001), imperfect adherence to antiretroviral therapy (ART) (OR,

26 ic infections of the central nervous system, imperfect adherence to antiretroviral therapy, and depre

27 tral nervous system (CNS) (OR=3.7, p<0.001), imperfect adherence to antiretroviral treatment (ART) (O

28 Past opportunistic infections of the CNS, imperfect adherence to ART as well as depression were as

29 Past opportunistic infections of the CNS, imperfect adherence to ART, and depression were associat

30 Our model estimates that the impact of imperfect adherence was worst in children, highlighting

31 blind individuals showed substantial albeit imperfect agreement, suggesting that linguistic communic

32 e CT and PET parts of a PET/CT scan leads to imperfect alignment of anatomic features seen by the 2 m

33 Because of its imperfect amphipathicity, protegrin binds weakly, at mos

34 t 11,600 years ago(8), but that period is an imperfect analogue for present-day emissions owing to th

35 their transient (time-dependent) response is imperfect and a small amount of heat is scattered.

36 However, this modularity is imperfect and also restricted to short peptide stretches

37 mation on female pregnancy and lactation and imperfect and biased recapture rates.

38 aptation and substitutes, however, are often imperfect and come at some cost.

39 e same time, cluster analysis is known to be imperfect and depends on the choice of algorithms, param

40 Second, surveillance methods are imperfect and fail to detect some individuals.

41 sence of the target species and accounts for imperfect and incomplete detection of the species presen

42 Acknowledging the imperfect and incomplete relationship between Ag-stimula

43 Management strategies are imperfect and involve burdensome long-term dietary exclu

44 ies are long lasting and full of detail, yet imperfect and malleable.

45 Although our therapies are imperfect and many patients remain symptomatic, appropri

46 accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome,

47 patch-leaving decisions do not consider the imperfect and noisy sampling process through which an an

48 or identifying in vivo targets of an RBP are imperfect and not amenable to examining small numbers of

49 gesting that the discrimination mechanism is imperfect and occasionally leads to autoimmunity due to

50 l in wild populations are estimated based on imperfect and potentially biased observation processes,

51 These models are imperfect and refinement would allow more accurate progn

52 rget duplex structures that include perfect, imperfect and seedless duplexes.

53 They are thus imperfect and should be interpreted as the best availabl

54 y, yet diagnostic agreement among experts is imperfect and the precise factors involved in clinical d

55 maller have a longer G1, the compensation is imperfect and they still bud at smaller cell sizes.

56 eripheral clinical specimens, which may have imperfect and uncertain sensitivity and specificity, so

57 induced by oral poliovirus vaccine (OPV) is imperfect and wanes with time, permitting transmission o

58 can be challenging when diagnostic tests are imperfect and when some individuals go for long periods

59 However, negative selection is imperfect, and autoreactive T cells exist in healthy ind

60 itial assembly reaction can be predominently imperfect, and completion involves the slow correction o

61 tomated annotation of prokaryotic genomes is imperfect, and errors due to fragmented assemblies, cont

62 the steady-state assumption is biologically imperfect, and several key stoichiometric coefficients a

63 However, imaging modalities are imperfect, and some will ultimately have no HCC on expla

64 ssay sensitivity and specificity were indeed imperfect, and we were able to draw several conclusions

65 Although imperfect AREs make up 99.9% of the motifs, the degree o

66 advances are adaptive for some species, but imperfect as evidenced by the observed consistent select

67 hile effective, current immunosuppression is imperfect as it lacks specificity and imposes unintended

68 new environment in order to strike an often imperfect balance between the host and the infectious pa

69 es in two dimensions can be stopped, even by imperfect barriers perforated by a series of gaps.

70 Targets are determined by imperfect base pairing of the microRNA to the 3'-UTR of

71 changes in stability induced by mutations of imperfect base pairs, as in naturally occurring polymorp

72 However, predictive germination was imperfect, calling for some degree of bet hedging.

73 even when detection of symptomatic plants is imperfect, can lead to very effective control.

74 Imperfect capture success, diagnostic sensitivity, and v

75 lenticulo-sutural dysplasia and osteogenesis imperfect, caused by mutations in the COPII coatomer com

76 support the concept of partially blocked or imperfect circulation between the upper and lower mantle

77 rdelino flexibly integrates information from imperfect clonal trees inferred based on bulk exome-seq

78 e found that Bmp9 knockout in mice led to an imperfect closure of the DA.

79 metallic electrode, allowed by the intrinsic imperfect compactness of the functionalization layers, w

80 While this is an imperfect comparison, the data suggest that the separati

81 however, vasa mRNA escapes silencing due to imperfect complementarity to AT-chX piRNAs.

82 rently repress multiple mRNA targets through imperfect complementarity.

83 CACE estimates in stepped wedge trials with imperfect compliance could enhance reporting and interpr

84 ma and how any benefits might be affected by imperfect compliance or increased variability in the hom

85 olved rDNA sequence variation resulting from imperfect concerted evolution of the ribosomal DNA regio

86 between the system and the environment, and imperfect control of the system parameters.

87 adening in ensemble measurements, as well as imperfect control over size, shape, faceting, surface re

88 More broadly, across taxa, imperfect coordination of collective behaviors might be

89 nding to cognate oriP DNA, which comprise 20 imperfect copies of a 30-bp dyad symmetry enhancer and a

90 Imperfect copies of these U1 snRNA genes, also located o

91 Notably, we found strong but imperfect correlations between low translational status

92 pMDA, implemented during one year with imperfect coverage in low transmission areas with sub-op

93 of functional MRI and, on the other hand, by imperfect cross-species homologies in animal model syste

94 nanostructures and functional materials with imperfect crystalline structures-such as those with defe

95 ctures within starch granules, suggestive of imperfect crystallite development.

96 a method that exploits commonly encountered imperfect crystals and enables model-free phasing.

97 Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals ca

98 P = .33), on-treatment drug use (P >.99), or imperfect daily adherence (P = .35) but was significantl

99 However, our study findings are limited by imperfect data and assumptions that could be improved up

100 strate a method that improves the utility of imperfect data by accounting for measurement error.

101 ions, limitations of diagnostic testing, and imperfect data capture remain major limitations to accur

102 ng because of the massive volume of data and imperfect data quality.

103 cal challenge of reinforcement learning from imperfect data, which has proved to be a major obstacle

104 show that chromosome mis-segregation due to imperfect DDR signaling in response to dysfunctional tel

105 We account for Kepler's imperfect detectability of such planets by injecting syn

106 The imperfect detection in both, DNA and RNA, was identified

107 be metacommunity structure that accounts for imperfect detection in survey data-detection error-corre

108 Occurrence models that account for imperfect detection of species are increasingly used for

109 the landscape, low prevalence at a site, and imperfect detection of the diagnostic tests.

110 streets while controlling for cofactors and imperfect detection of vectors.

111 BS surveys were low, and models that ignored imperfect detection severely underestimated the proporti

112 tistate occupancy approach that accounts for imperfect detection to assess whether sex and breeding s

113 After correcting for imperfect detection, we found that local land-use determ

114 es that corrected for unsurveyed patches and imperfect detection.

115 s applicable to other diagnostic assays with imperfect detection.

116 d we compute data analytics that correct for imperfect detection.

117 7-species bat community while accounting for imperfect detection.

118 tial scale to correct for biased testing and imperfect diagnostic accuracy to provide a more realisti

119 alysis to account for incomplete testing and imperfect diagnostic accuracy.

120 Challenges in standardized surveillance and imperfect diagnostic tools have resulted in patchy local

121 us epimutations' appear to be a byproduct of imperfect DNA methylation maintenance and epigenome rein

122 aining repeats adjacent to other variants or imperfect DNA repeats such as polyalanine repeats.

123 al heterogeneity is a natural consequence of imperfect DNA replication.

124 ight from the RNA world to the contemporary 'imperfect' DNA world.

125 It contains one long, imperfect double helix (domain I), one branched domain (

126 The imperfect effectiveness emphasizes the need for better i

127 d the one licensed vaccine has a complex and imperfect efficacy profile.

128 r data suggest that miltefosine has good but imperfect efficacy to a wide variety of Leishmania speci

129 ed to balance the limitations of dwelling in imperfect environmental conditions and the risks associa

130 However, "imperfect" floral iridescence does not lead to mistaken

131 After processing from imperfect fold-back structures, miRNAs are incorporated

132 he inclusion and exclusion errors related to imperfect food targeting.

133 years ago) is real and not an artefact of an imperfect fossil record: rapid diversification of animal

134 tion, however, can be jeopardized because of imperfect functional annotation of genes, and ambiguity

135 rily by slow Ribo-T assembly rather than its imperfect functionality.

136 Even with imperfect funding and resource-need data, the proposed c

137 intrinsic to exome sequencing is inherently imperfect, generating large amounts of unintended off-ta

138 ver, presymptomatic diagnosis is hampered by imperfect genotype-GALC activity-phenotype correlations.

139 t uncovered a compensation mechanism, albeit imperfect, given the phenotype of affected individuals,

140 ycosyltransferases may in vitro complete the imperfect glycosylation pattern of proteins, recombinant

141 of overweight or obese children by using the imperfect gold standard methodology.

142 steatosis index (HSI) was analyzed using the imperfect gold standard methodology.

143 The top part of this imperfect hairpin aptamer was modified in such a way tha

144 Many phenotypes have imperfect heritability, so that a measurement of the phe

145 of the proposed system and its robustness to imperfect homing, incomplete penetrance of toxins and tr

146 ification, and they revealed significant but imperfect homology to segments of commensal Acinetobacte

147 an recover from infection, (ii) vaccines are imperfect, (iii) individuals are ex ante heterogeneous,

148 a (HCC) is a devastating malignancy in which imperfect imaging plays a primary role in diagnosis.

149 and echocardiography remains diagnostically imperfect in cases of prosthetic valve IE or cardiac imp

150 ity and sensitivity of detection methods are imperfect in complex samples, including in excreta.

151 wever, the predicted body weight approach is imperfect in patients with ARDS because the amount of ae

152 However, imperfect in silico models--even at the secondary struct

153 ty, and we observed that the correlation was imperfect, indicating that the fitness effects of mutati

154 umber of shortcomings, including reliance on imperfect indicators of fecal contamination instead of a

155 the profits under two scenarios (perfect and imperfect information about future electricity prices),

156 To overcome the limits of incomplete and imperfect information linking genes to disease, we pool

157 y cannot be easily found, reflecting current imperfect information of the target organism.

158 alytical inaccuracies or the implications of imperfect information, structuring and communicating cau

159 itive challenge of making decisions based on imperfect information.

160 hmark and long-standing challenge problem in imperfect-information game solving.

161 due to a nonuniform speed prior rather than imperfect integration.

162 icacy in delivery of human Abs might reflect imperfect interaction between the human membrane IgH cha

163 e substrate and thus presents an elastically imperfect interface.

164 Yet, it is imperfect; internal noise introduces errors into memory

165 was there evidence for a significant role of imperfect intestinal immunity in the transmission of pol

166 region-of-interest signal and corrected for imperfect inversion pulse efficiency.

167 ical cruciform extrusion at both perfect and imperfect inverted repeat (IR) sequences.

168 is called BirA has been reported to bind an imperfect inverted repeat located upstream of the biotin

169 e-offs might be found in the many naturally "imperfect" iridescence-producing structures found in ani

170 nd that the loss in detection ability due to imperfect knowledge of the leakage probability can be qu

171 Imperfect knowledge of the times at which 'snapshots' of

172 s and Thr residues, located primarily in the imperfect KTKEGV repeats of the alphaS N-terminus, are i

173 In practice, imperfect labeling biases the distribution of oligomeric

174 idated using computer-simulated data and the imperfect labeling was quantified in cells with ion chan

175 ic valve classification, models trained with imperfect labels substantially outperform a supervised m

176 ytic exchange current density-to account for imperfect light absorption, charge transport and catalys

177 processes, including monument building, with imperfect, limited, presence-only data.

178 roscience research suggests that there is an imperfect link between structural connectivity and funct

179 Calcineurin inhibitors are imperfect long-term maintenance immunosuppressive agents

180 infection (LTBI) are challenging because of imperfect LTBI diagnostic tests.Objectives: To assess th

181 or decreases at specific loci) that reflects imperfect maintenance of epigenetic marks.

182 ering that is present in most samples due to imperfect manufacturing procedures.

183 icrobiome composition in several animals and imperfect marker specificity and sensitivity.

184 ive GATA and ETS (FGF) binding sites contain imperfect matches to consensus motifs.

185 thological effects that are brought about by imperfect matching of spacers to the integrated phage se

186 ew adaptation hypothesis, using a cascade of imperfect mathematical integrators, that reproduces the

187 However, distance is an imperfect measure of exposure because it does not quanti

188 Body mass index is an imperfect measure of surgical risk in this population, p

189 ates of the sensitivity and specificity of 2 imperfect measures of substance use derived from a previ

190 e-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen

191 ay not be a major driver of the evolution of imperfect mimicry and that other factors, such as ecolog

192 her provide evidence that this tolerance for imperfect mimicry is attributable to collaboration betwe

193 earning in mimicry evolution, and shows that imperfect mimicry is expected to be the norm.

194 Although the forces behind the evolution of imperfect mimicry remain poorly studied, recent hypothes

195 story undoubtedly affects the development of imperfect mimicry, ecological community context has larg

196 especially those regarding the evolution of imperfect mimicry.

197 be considered when studying the evolution of imperfect mimicry.

198 lection on small-bodied individuals leads to imperfect mimicry.

199 en ignored and may be an important driver of imperfect mimicry.

200 sms by which animals learn might explain how imperfect mimics survive.

201 stinct target sites that generate distorted, imperfect miRNA-target duplexes.

202 raphic pump, with the worst of these mixers, imperfect mixing accounted for 99.6% of the observed noi

203 at currently utilized laboratory strains are imperfect models for studying L. monocytogenes pathogene

204 However, since mice are imperfect models of human macrophage biology, for exampl

205 tes that the MC3T3-E1 derived cell lines are imperfect models of osteoblast biology, and reinforce th

206 Even where there are accepted, albeit imperfect models, the leap from promising preclinical dr

207 These reports of imperfect niche tracking imply shifts in species' realiz

208 nkeypox also clarifies the various ways that imperfect observation can impact inference of transmissi

209 . growth, selection, population dynamics) or imperfect observation of biological systems.

210 rica (197 region-years) while accounting for imperfect observations and grounding our findings in spe

211 ti-event capture-recapture approach to model imperfect observations of true epidemiological states.

212 ptimal model parameters may be inferred from imperfect observations provided the conditions of observ

213 However, these estimates all use the same imperfect ocean dataset and share additional uncertainty

214 predictions of "death before discharge" were imperfect-only 104 of 187 of patients with a prediction

215 ingly reflects an ability not just to detect imperfect or inaccurate claims but also to assess what i

216 instrumental or optical limitations such as imperfect overlap of detection volumes or detector cross

217 dentifying realistic conditions that lead to imperfect parameter recovery in all four pRF implementat

218 atic cancer patients remains fractured, with imperfect patient selection and ongoing bias in referral

219 he original albostrians allele conferring an imperfect penetrance of the variegated phenotype even at

220 ial treatment regimes, individual drugs have imperfect penetration throughout the body, so there may

221 Together with imperfect performance and application of existing diagno

222 s requiring additional parameter selection), imperfect performance, and lack of confidence in existin

223 t autocorrelation modeling in AFNI, although imperfect, performed much better than the autocorrelatio

224 Inadequate knowledge and imperfect phlebotomy procedures were noted.

225 t viewpoint of a fly photoreceptor being an 'imperfect' photon counting machine, we explain how these

226 We show that even the use of imperfect POC diagnostics can significantly reduce total

227 lations show that the PRD generally forms an imperfect polyproline (polyP) II helical conformation.

228 ally buried into an insulating layer and the imperfect positioning of the tip with respect to the NP

229 sed Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing only partial or unproven efficacie

230 Aortic diameter is an imperfect predictor of aortic complications in connectiv

231 However, composition was an imperfect predictor of inclusion formation in Drosophila

232 However, this data is imperfect, preventing input into computational algorithm

233 tcomes, but their studies measure impacts on imperfect proxies for ecosystem services (e.g., avoidanc

234 iagnosed cases are available and serve as an imperfect proxy of incidence.

235 unt for inter-assay variability arising from imperfect QMMs and generates estimates of pathogen densi

236 sions, these approaches have been limited by imperfect quantum state selectivity.

237 late, yet these correlations are often quite imperfect, raising questions as the origins of such mism

238 ally depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines.

239 ion, but also ribosomal frameshifting and/or imperfect repeat DNA replication, expansion, and repair,

240 It contains three imperfect repeats, and stepwise removal of these repeats

241 RPT) and short (sRPT) isoforms with 10 and 7 imperfect repeats, respectively.

242 pregnant women have enjoyed better-although imperfect-representation in research; and (4) recommenda

243 Nevertheless, TMB is an imperfect response biomarker.

244 The main study limitations were imperfect response rates and the use of self-reported ca

245 A common shortcoming of ICDs is imperfect rhythm discrimination, resulting in the delive

246 In addition, ligand-jump experiments reveal imperfect riboswitching of single mRNA molecules.

247 ition to the local requirement for a central imperfect RNA duplex containing the modified adenosines,

248 at endogenous circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of double-s

249 cape evolution and network selection through imperfect searches for dynamically accessible states.

250 nstead was correlated with their adoption of imperfect secondary structures.

251 However, non-canonical binding modes from imperfect/seedless duplexes are not well predicted by co

252 In any setting, their power is limited by imperfect selectivity (binding of undesired targets) and

253 challenging to therapeutically target due to imperfect selectivity that leads to either off-target to

254 influence of psychosocial factors, good but imperfect self-care adherence, and health system failure

255 Organisms can be thought of as imperfect self-replicators which produce closely-related

256 Imperfect sensitivity of diagnostic tests and lack of sp

257 of tuberculosis (TB) but still suffers from imperfect sensitivity.

258 e RT-PCR; however, this benchmark itself had imperfect sensitivity.

259 h high specificity and predictive value, but imperfect sensitivity.

260 ctors that limited novel gene discovery: (1) imperfect sequencing coverage across the exome hid poten

261 lacing missing protein ion transporters with imperfect small molecule mimics.

262 on their careers, they perceived STMs as an imperfect solution to unmet surgical needs.

263 drawbacks, including a relatively big size, imperfect specificity and restriction to DNA targets fla

264 ns is challenged by the high sensitivity and imperfect specificity of MRI.

265 linear and geometric nonlinear behaviour of imperfect spider web structure.

266 ics in the large-amplitude free vibration of imperfect spider web structures using finite element ana

267 er web, radial imperfect spider web, central imperfect spider web, and circular rings imperfect spide

268 ral imperfect spider web, and circular rings imperfect spider web, are considered.

269 der web: spiral imperfect spider web, radial imperfect spider web, central imperfect spider web, and

270 ferent types of imperfect spider web: spiral imperfect spider web, radial imperfect spider web, centr

271 Four different types of imperfect spider web: spiral imperfect spider web, radia

272 For the hPhe analog, an imperfect stereochemical complementarity could be overco

273 pic ones, and demonstrate how facets such as imperfect substitutability can arise in a more straightf

274 ortunately, current screening modalities are imperfect, suffering from limited sensitivity and high f

275 for which contrast enhancement serves as an imperfect surrogate for tumor volume and is influenced b

276 , and is also susceptible to missing factor, imperfect surrogate, and disease heterogeneity confoundi

277 and may not fully capture uncertainty due to imperfect surveillance data and uncertainty about the tr

278 This imperfect synchronization, observed in the beta frequenc

279 or heterogeneous mixtures that resulted from imperfect synthesis conditions, aggregation from product

280 Considering the imperfect tagging of imputation and potential overestima

281 Using bioinformatics, we show that this imperfect targeting is likely to occur frequently in nat

282 plete testing, while 14% (0.3-36%) is due to imperfect test accuracy.

283 have now demonstrated that niche tracking is imperfect, that species' climate niches may vary with po

284 largely reduces its power efficiency, due to imperfect topology and transistors.

285 ts to programmatically generate large-scale, imperfect training labels.

286 To investigate whether this imperfect transparency acts as camouflage, we used in si

287 transposases, Mos1 and Mboumar-9, for their imperfect transposon IRs in each step of transposition:

288 ance and low-power electronic circuits using imperfect two-dimensional topological insulators.

289 cal splice signals as pathogenic, but due to imperfect understanding of RNA splice signals other vari

290 nt of new treatments has been hampered by an imperfect understanding of the biological processes that

291 However, an imperfect understanding of the precise biologic mechanis

292 Trial limitations included imperfect uptake of targeted intervention behaviors, lim

293 e some protection may seem better than none, imperfect vaccination can present epidemiological, ecolo

294 iovirus circulation in most of the world and imperfect vaccination coverage are resulting in immunity

295 Owing to imperfect vertical transmission, many heritable microbes

296 Furthermore, imperfect, waning intestinal immunity among older childr

297 While the projection is imperfect, we argue that because of the strong nonlinear

298 itions of luminal A and B breast cancers are imperfect when compared with multigene expression-based

299 Yet mimicry is often imperfect: why does selection not improve mimicry?

300 lammatory response, the outcome is generally imperfect, with some degree of fibrosis, which is define