ライフサイエンスコーパス: import

1 pherin/importin) complex and disrupt nuclear import.

2 , and increased impairment of INPP5E ciliary import.

3 arboxylation, proline synthesis, and cystine import.

4 esting IPO11 facilitates betacatenin nuclear import.

5 ing that deubiquitination promotes efficient import.

6 type, and utilization of the nutrients they import.

7 or normal growth, is not involved in protein import.

8 response to Cu starvation by controlling Cu import.

9 tically by RNA, as well differential nuclear import.

10 on or at the nuclear envelope during nuclear import.

11 with TIM23 and inhibit mitochondrial protein import.

12 P), a gene that negatively regulates glucose import.

13 en co-opted for independent roles in ciliary import.

14 ntify >100 genes involved in LDL-cholesterol import.

15 the lack of glucose, but rather by l-cystine import.

16 in the cytoplasm and promotes its nuclear re-import.

17 tilized, MntABC functioned in manganese (Mn) import.

18 the lack of deficit in mitochondrial protein import.

19 osynthesis inhibitors by increased polyamine import.

20 that assists mainly in mitochondrial protein import.

21 eping operation and the history of honey bee imports.

22 ion and income growth greatly depend on meat imports.

23 ntially exports 3Na(+) out of the cell, then imports 2K(+) into the cell at an approximate rate of 20

24 Imported across the plasma membrane by SLC1A5, glutamine

25 sible, hook-like assembly that constrains an import activating peptide epitope between two subunits o

26 signals, and that this limits KPNA7 nuclear import activity.

27 The AdcR regulon includes genes encoding Zn import (adcABC), Zn sparing (rpsN.2), and Zn scavenging

28 nosoma brucei lacks tRNA genes and therefore imports all of its tRNAs from the cytosol.

29 es are loaded on HIV-1 DNA after its nuclear import and before its integration in the host genome.

30 himurium obtains fumarate by DcuABC-mediated import and conversion of L-malate and L-aspartate.

31 M23 complex assembly required for preprotein import and coupling of respiratory pathways.

32 ade to monitor the kinetics of HIV-1 nuclear import and define the biochemical staging of these steps

33 e second enzyme of the bacterial sialic acid import and degradation pathway and adds phosphate to N-a

34 Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich regions of

35 of upd3 is triggered by impaired peroxisomal import and elevated JNK signaling in aged oenocytes.

36 is disagreement over the mechanism of indole import and export and no clearly defined target through

37 e, cell-shape maintenance, and regulation of import and export of materials.

38 Analysis of protein import and function of complex I revealed that while fun

39 del that unifies Vpr manipulation of nuclear import and inhibition of innate immune activation to pro

40 HIV-1 infection, specifically during nuclear import and integration targeting.

41 f NOCT is necessary and sufficient to confer import and processing in the mitochondria.

42 hts into the pathways for tRNAPhe retrograde import and re-export and is a tool that can be used on a

43 y proteins mediating tRNA retrograde nuclear import and re-export using the unique wybutosine modific

44 However, how these species import and regulate heme levels is not fully defined yet

45 sue-specific regulation of organelle protein import and suggest that it operates by selective evoluti

46 ommon, easy-to-use format that can be easily imported and analysed using multiple software packages.

47 t perform self-checks on the authenticity of imported and purchased goods.

48 es in HIV-1 capsid stabilization, nucleotide import, and reverse transcription.

49 as uncoating, reverse transcription, nuclear import, and transport to integration sites are incomplet

50 Therefore, optimizing the protein import apparatus of plastids, designated as the transloc

51 ember 2014 to October 2017, 254 kidneys were imported based on our assessment of a VXM.

52 erved process called tRNA retrograde nuclear import, before relocalization back to the cytoplasm via

53 ane space and inhibits mitochondrial protein import by interacting with TIM23, a major component of m

54 we show dynamic regulation of mitochondrial import by the ubiquitin system.

55 We show that TG2 increases glucose import by up-regulating the transcription of the glucose

56 Middle East relies heavily on virtual water imports by the end of the century.

57 ng the expression of iron import genes; iron import can reflect iron transport into the cytosol or mi

58 Applying that logic to data on imported cases and local deaths in the United States thr

59 te risk that might be ill-prepared to detect imported cases and to limit onward transmission.

60 ingly, we prove that incorrectly identifying imported cases as local will deceptively decrease this p

61 With the majority of imported cases going undetected (6 out of 10), countries

62 re able to control onwards transmission from imported cases of COVID-19.

63 t can occur during the first few weeks after imported cases start appearing.

64 ns and quantify the proportion of undetected imported cases.

65 However, we estimated 36% of detection of imported cases.

66 Seventeen (57%) participants imported cases.

67 f local cases was 8 years older than that of imported cases.

68 have use genetics to separate HIV-1 nuclear import cofactor dependence from MxB sensitivity.

69 slaughtered, via the 204 exporting and 3,383 importing companies handling that trade, and finally to

70 from liquid FG-Nup droplets, but functional import complexes underwent facilitated import into dropl

71 oduct inhibition of the importer, so cystine import continues into cells that are already sated with

72 nies handling that trade, and finally to 152 importing countries.

73 re enhanced in response to Singapore's first imported COVID-19 case on 23 January 2020.

74 n oxic habitats have acquired the ability to import cystine as a sulfur source.

75 To minimize this problem, the imported cystine is rapidly reduced.

76 Actively importing cystine is potentially toxic due to its low so

77 OmniPath App, a Cytoscape plugin to flexibly import data from OmniPath via a simple and intuitive int

78 DCD DDKT and regional/national imports declined nationwide but most steeply in states w

79 inates mitochondrial proteins whose eventual import depends on USP30.

80 Our software provides advanced functions for importing DNA variants, computing mutation types, and ex

81 circulatory death (aIRR 5.38, P = 0.001) or imported donor organ (regional share aIRR 1.69, P = 0.03

82 asis and are required for high-affinity iron import during active proliferation of mammalian cells.

83 n sequences (NLSs) and the effect of size on import efficiency.

84 anding of the requirements for their nuclear import, especially the role of multivalent binding to tr

85 ng protein, suggesting that balanced nuclear import/export and dendritic spine localization are essen

86 east, although it is not clear whether these import factors are independent or additive.

87 a deeper appreciation for whether different import factors play distinct roles in retrovirus replica

88 try is facilitated using three distinct host import factors that interact with nuclear localization s

89 rvey included questions about anaphylaxis to imported fire ants (IFAs).

90 ameter biophysical model that correlates the import flux with the energetics of large cargo transport

91 slocation routes before mitochondrial matrix import for cPMP biosynthesis involving both proteins.

92 It was able to import four substrates, including rhodamine 123 (Rh123)

93 of the prediction error theory of dopamine, imported from artificial intelligence, represents the fu

94 atched norovirus found in frozen raspberries imported from China that were used to make the implicate

95 vo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epith

96 vast majority of Aedes-borne infections are imported from endemic regions by travelers, who can beco

97 Most genomes currently in LINbase were imported from GenBank, but users can upload their own ge

98 rties can be defined a priori or dynamically imported from models and simulations.

99 still required, because the number of cases imported from other countries has increased.

100 f the physical carbon in 16 global cities is imported from outside their urban boundaries, and this o

101 In total, 22 new geriatric variables were imported from the ACS NSQIP geriatric pilot study.

102 Vitamin B12 is normally imported from the bacterial diet via lysosomal degradati

103 ransit peptide, and then posttranslationally imported from the cytosol.

104 mber countries in 2018 of which a third were imported from the US.

105 ound that both NLS1 and NLS2 possess nuclear import function, with NLS1 responsible for nuclear local

106 d of IrtAB is seemingly contradictory to its import function.

107 iron by up-regulating the expression of iron import genes; iron import can reflect iron transport int

108 differences between the quality of local and imported honey with total acid, sucrose and ash as the p

109 of cellular Imp-alpha/beta1-mediated nuclear import.IMPORTANCE Human adenoviruses (HAdVs) represent a

110 al key molecular determinants of large cargo import in cells.

111 TT interacts with TIM23 and inhibits protein import in intact mitochondria.

112 tant role of hepatocyte-specific peroxisomal import in mediating non-autonomous regulation of cardiac

113 racteristics, limited testing availability, "imported" infections, asymptomatic disease transmission,

114 These programs remove arrested import intermediates from mitochondrial protein transloc

115 Together these data highlight how protein import into a subcellular compartment can be regulated b

116 the transporters/translocators mediating Pi import into chloroplasts.

117 ional import complexes underwent facilitated import into droplets.

118 These WPGD1 and WPGD2 fusion proteins import into isolated chloroplasts, demonstrating a funct

119 We quantified protein import into isolated pea (Pisum sativum) leaf chloroplas

120 Evidence for tissue-specific regulation of import into plastids, and subsequent modulation of plast

121 motifs that specifically enhance preprotein import into root leucoplasts.

122 on of transit-peptide motifs, which enhances import into specific plastid types.

123 eless, the molecular mechanism of nucleotide import into the capsid remains unknown.

124 to the leaf phloem and, at the sink end, its import into the growing embryo.

125 PEX14-PEX5 complex is essential for protein import into the parasites' glycosomes.

126 proteins which facilitate glycosaminoglycan import into the periplasm; distinct kinetic and genetic

127 across domains and that this activity can be imported into a heterologous gene locus.

128 We show that cystine imported into Escherichia coli can transfer disulfide bo

129 notransmitter exported by diseased cells and imported into host cells to activate the innate immune S

130 years; 46.6% female; 13.0% black race) were imported into ImageJ to measure densitometry differences

131 frican cheetah, one modern and one historic, imported into India at different times.

132 nthesized as a polyprotein precursor that is imported into mitochondria and subsequently separated in

133 It is imported into mitochondria by the mitochondrial disulfid

134 After they are imported into mitochondria, these targeting signals are

135 ausing some poly(GR) to be cotranslationally imported into mitochondria.

136 isoform of yeast CAE, even though it was not imported into mitochondria.

137 NA, translated on cytoplasmic ribosomes, and imported into mitochondria.

138 Despite its remoteness, the viruses imported into New Zealand represented nearly all of the

139 These di- and tricarboxylates are imported into the cell by the divalent anion sodium symp

140 The periplasmic P(i) can be gradually imported into the cytoplasm by ATP-powered transport, ho

141 vealed that iron-loaded carboxymycobactin is imported into the cytoplasm by the ATP binding cassette

142 genes, synthesized on cytoplasmic ribosomes, imported into the mitochondrial matrix, and assembled in

143 that CPSF6 interacts with NP1 to escort NP1 imported into the nucleus for its function in the modula

144 Therefore, the vRNPs must be imported into the nucleus for viral transcription and re

145 ved-hundreds of millions of live animals are imported into the U.S.A. alone every year.

146 It is, therefore, hypothesized that nickel import is critical for P. mirabilis urease activity and

147 We show that the import is dominated by weak interactions of OmpF pores w

148 Mitochondrial iron import is essential for iron-sulfur cluster formation an

149 itions and decreased when mitochondrial iron import is increased through overexpression of the high-a

150 rt depends entirely on Crm1/Xpo1, whereas re-import is mediated by Kap122 plus redundant, kinetically

151 considerably up-regulated when mitochondrial import is perturbed.

152 gated the mechanism by which plastid protein import is regulated by light during photomorphogenesis i

153 alth, are heme auxotrophs, meaning they must import it from their mammalian hosts or insect vectors.

154 A total of 42% of the recipients of imported kidneys had a 100% calculated panel reactive an

155 A total of 93% of the imported kidneys were transplanted into intended recipie

156 Here, we assayed nuclear import kinetics of 30 large cargo models based on four c

157 The mechanisms that import Kyn into the nervous system are poorly understood

158 tholog of the human LAT1 transporter, AAT-1, imports Kyn into sites of KynA production.

159 rmore, countries with high food availability import large quantities of meat products to satisfy thei

160 American lobsters (Homarus americanus) imported live into Europe as a seafood commodity have oc

161 The import machinery coordinates with mitochondrial protease

162 at evolved as highly specialized siderophore-import machinery in mycobacteria.

163 r or stabilizer of the mitochondrial protein import machinery that is specifically up-regulated upon

164 siderophore-mediated activation of the iron import machinery through a sigma regulator are unclear.

165 , a major component of mitochondrial protein import machinery, but evidence for functional ramificati

166 onal NLS that interacts with canonic nuclear import machinery.

167 e compared with quinine for the treatment of imported malaria cases in nonendemic countries with a hi

168 We analyzed the cohort of all severe imported malaria patients reported to the French Nationa

169 Our findings uncover a novel nuclear import mechanism for betacatenin in cells with high Wnt

170 This has suggested that nuclear import mechanism may determine MxB sensitivity.

171 ted engagement of porins is intrinsic to the import mechanism of group A colicins.

172 important support for the model that nuclear import mechanisms have been co-opted for independent rol

173 Nuclear import, mediated in part by karyopherin-alpha (KPNA)/imp

174 rrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and bioge

175 embrane-reconstituted IrtAB is sufficient to import mycobactins, which are then reduced by the sidero

176 C25A51 as a mammalian transporter capable of importing NAD(+) into mitochondria.

177 Mitochondria import nearly their entire proteome from the cytoplasm b

178 ese are the only binding proteins capable of importing nickel for incorporation into the urease enzym

179 coupled oscillators that account for nuclear import, nuclear positioning determines the pacemaker loc

180 unique strategies evolved by mycobacteria to import nutrients and other products through this highly

181 Surprisingly, we observe that nuclear import occurs with relatively rapid kinetics (<5 h) and

182 eurons results in the generation and nuclear import of a 30 kDa fragment comprising most of L1's C-te

183 upon light exposure is a prerequisite to the import of abundant nuclear-encoded photosynthesis-associ

184 of the TOC-TIC apparatus to accommodate the import of abundant photosynthesis-associated proteins du

185 Notably, in many cells, Slc7a5 import of amino acids is required to maintain mTOR activ

186 phosphotransferase system (PTS) couples the import of carbohydrates with their phosphorylation prior

187 resentation of Louisiana clones and minimize import of clones from Miami.

188 laboratory part of multicentre studies (e.g. import of drawing schemes and sample processing steps),

189 e to a constructive debate over the role and import of empathy in nursing practice.

190 veloped allowing the creation of new and the import of existing DNA nanostructures.

191 nctions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell m

192 assembly protein-10), indicating endothelial import of functional miR-210.

193 w that the MA region is required for nuclear import of Gag through the TNPO3 pathway.

194 Blocking the nuclear import of GAPDH by suppressing Src signaling or through

195 The biogenesis of mitochondria requires the import of hundreds of precursor proteins.

196 veal the molecular mechanisms of the nuclear import of IAV vRNP but also provide potential anti-influ

197 srupt its cargo loading, and inhibit nuclear import of importin beta, importin alpha/beta, and transp

198 interacts with karyopherins to disturb their import of IRF3 and NF-kappaB to promote replication in m

199 Following glucose deprivation, the import of l-cystine and its subsequent reduction to l-cy

200 a-1, -2 and -3 are necessary for the nuclear import of LHP1.

201 Smut), however, we revealed that the nuclear import of M is ubiquitous, because MNESmut was retained

202 y-coupling factor (ECF) transporters mediate import of micronutrients in prokaryotes.

203 TbPam27 is specifically required for the import of mitochondrial presequence-containing but not f

204 ncovered that under conditions of stress the import of MNRR1 into the mitochondria was blocked, allow

205 n-beta-like protein required for the nuclear import of MYB4, a transcriptional repressor of phenylpro

206 hondrial Na(+)/Ca(2+) exchanger promotes the import of Na(+) into the matrix.

207 dies revealed that eEF1D impeded the nuclear import of NP and PA-PB1 heterodimer of IAV, thereby supp

208 tly interacts with NP1, mediates the nuclear import of NP1, and plays a role in the maturation of cap

209 evealed a novel role of CPSF6 in the nuclear import of NP1, in addition to the critical role of CPSF6

210 In this work, we show that the import of oxidized cysteine (cystine) via system x(C) (-

211 idoreductases and also peroxins that mediate import of peroxisomal membrane proteins from the ER, hin

212 Mix23 is critical for the efficient import of proteins into the mitochondrial matrix, partic

213 ated motor (PAM) complex, is crucial for the import of proteins to the mitochondrial matrix.

214 Nuclear import of proteins was decreased in affected individuals

215 envelope proteins that are necessary for the import of PyoG and its killing activity.

216 of enhanced efficacy was a Trojan horse-like import of RBT, but not rifampin, through fhuE, only in n

217 IAV replication by inhibition of the nuclear import of RNP subunits, which not only uncovers a novel

218 , like a sensory structure for the affective import of stimuli and conveys this information to the me

219 ich dephosphorylates and induces the nuclear import of the osteogenic transcription regulator nuclear

220 gnal (NLS) sequence,MRKTKLAPT, important for import of the protein to host nucleus.

221 stitution reduced binding and KPNA7-mediated import of these cargoes.

222 Chloroplast biogenesis requires the import of thousands of nuclear-encoded preproteins by es

223 ciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in or

224 automatically on behalf of users during the import of transcript quantification files.

225 infected cells, thus perturbing the nuclear import of transcription factors of the innate immune sig

226 at the karyopherin Mtr10 mediates retrograde import of tRNAPhe, constitutively and in response to ami

227 Mitochondrial import of USP30 substrates is impaired in USP30 knockout

228 SIV failed to promote the efficient nuclear import of viral genome and suggests that MAPK/ERK-2-medi

229 2/SIV is known to be involved in the nuclear import of viral genome in nondividing cells, but the mec

230 new insights into the mechanisms of nuclear import of vRNP proteins.IMPORTANCE Influenza A virus is

231 en PB1 and RanBP5, which impeded the nuclear import of vRNP.

232 Water stressed regions rely heavily on the import of water-intensive goods to offset insufficient f

233 ted ECs and, strikingly, blocked the nuclear import of YAP induced by Ab-induced HLA I activation in

234 The nuclear import of YAP was associated with a rapid decrease in YA

235 Import of yeast peroxisomal matrix proteins is initiated

236 ta reveal increased recycling, some isolated imports of Islamic plant ash glasses from Mesopotamia, a

237 ve resulted in a significant increase in U.S imports of unconventional oil since 2018.

238 amily of ATP-hydrolyzing transporters, which import or export substrates across membranes, and have m

239 TD) of the endonuclease bacteriocin ColE9 is imported passively across the Escherichia coli OM throug

240 show that depleting CPSF6 to change nuclear import pathway does not impact MxB sensitivity, but muta

241 is inhibiting the classical protein nuclear import pathway mediated by importin-alpha (Imp-alpha) an

242 s suggest that RSV hijacks this host nuclear import pathway using a unique mechanism, potentially all

243 ntioxidant pathways and the intertwined iron import pathway.

244 Our results highlight antioxidant and iron import pathways as determinants of HIV-1 latency and sup

245 strating that HIV-1 can use distinct nuclear import pathways during infection.

246 id protein(1) to engage the cellular nuclear import pathways of the target cell and mediate their nuc

247 2 plus redundant, kinetically less efficient import pathways.

248 (Pex) proteins that are required for protein import, peroxisomal growth, and division.

249 proteome, regulation of division and protein import, pexophagy, matrix protein degradation, solute tr

250 ed chloroplasts, the membrane integration of imported Plsp1 correlated with its dissociation from Cpn

251 ed the extraction of precursors blocking the import pore in the outer membrane.

252 structural support for the formation of the import pore.

253 ar-encoded mitochondrial proteins need to be imported, processed, folded, and assembled into their fu

254 zing the importance of mitochondrial protein import processes for development, reproduction, and agei

255 ry and providing resilience to mitochondrial import processes in plants, especially under stress cond

256 ities and impart robustness to mitochondrial import processes in plants.

257 IPO11 (Importin-11) is a nuclear import protein that shuttles cargo from the cytoplasm to

258 After importing quantitative data files, there are various dat

259 bes depended on molecular weight and nuclear import rate, as well as on myotube width.

260 KairosMS imports raw data from common file types, processes it, a

261 ightly controlled proteostasis of the TOC159 import receptor during proplastid to chloroplast transit

262 Strikingly, the nuclear import receptor Karyopherin-beta2 reverses the mutant de

263 of nuclear-encoded preproteins by essential import receptor TOC159.

264 overexpression of Pex5, the key peroxisomal import receptor, blocks age-related upd3 induction and a

265 import2 (ppi2) mutant lacking Toc159 protein import receptors have active photoreceptors, even though

266 mber of the Importin-alpha family of nuclear import receptors.

267 he IAV-host interactions involved in nuclear import remain poorly understood.

268 this factor(s) was mapped to reduced nuclear import, replication, and translation, as well as deficie

269 tness in clonal plants because parasites can import resources from connected, unparasitized ramets, p

270 estabilizing compound PF74 following nuclear import, revealing that uncoating is completed in the nuc

271 and Lon protease, and mitochondrial protein import significantly aggravates alpha-synuclein seeding.

272 ion, whereas the Hsp70 protein Ssa2 mediates import specifically in the latter.

273 equently occurs: many communities export and import strains.

274 rhabditis elegans Msp1 homologue triggers an import stress response in the worm, which indicates a co

275 Basally, ubiquitylated translocon import substrates accumulate, suggesting a quality contr

276 ing the substrate-binding proteins from each import system (nikA and yntA), we show that Ynt is the p

277 parum-infected erythrocytes as a cholesterol import system, likely between the PVM and the erythrocyt

278 Escherichia coli YecSC-FliY cysteine/cystine import system.

279 Three distinct bacterial ABC import systems of sulfur-containing compounds have been

280 is strain HI4320 encodes two putative nickel import systems, designated Nik and Ynt.

281 Imported text entries made up the majority of text in ne

282 EHR documentation consists largely of imported text, is often authored by support staff, and i

283 t substituted products are more likely to be imported than the product listed on the label.

284 Once imported, the level of CRWN4 within the nucleus is modul

285 Scientists can import their own or publicly available HTS data into Lab

286 at the C9orf72-HRE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerbating pr

287 ly, we demonstrated that significant lactate import through MCT1 occurs even when glucose is not limi

288 The inhibition of Na(+) import through the Na(+)/Ca(2+) exchanger is sufficient

289 diomic datasets in their entirety, from data import to feature processing and visualization, and impl

290 outputs from both GOMCL and GOMCL-sub can be imported to Cytoscape for additional visualization effec

291 performed a retrospective review of kidneys imported to our center to assess the reasons driving lat

292 ation events including mechanisms of nuclear import, uncoating, reverse transcription, integration, a

293 e within minutes after controlled TF nuclear import using time-series chromatin immunoprecipitation (

294 munity reflected by immediate termination of imported viruses.

295 se that, rather than promoting HIV-1 nuclear import, Vpr interacts with karyopherins to disturb their

296 eriments displayed that mitochondrial matrix import was facilitated via an internal motif overriding

297 BbSre1 transcriptional activity and nuclear import were repressed in DeltaBbOhmm cells and affected

298 reased processing of the Yfh1 precursor upon import, which likely contributes to the iron homeostasis

299 nositol hexakisphosphate (IP6) enhances dNTP import, while binding of synthesized molecules like benz

300 Targeting cystine import with an xCT transporter-lowering MEK inhibitor, i