ライフサイエンスコーパス: importance

1 s of electrochemical reactions is of crucial importance.

2 governing ligand dynamics is of fundamental importance.

3 for the treatment of sepsis is of the utmost importance.

4 d in proteobacteria, highlighting its global importance.

5 Such processes may have been of prebiotic importance.

6 h more granular interpretation of wavelength importance.

7 test for canine bartonelloses is of clinical importance.

8 c infections and to inform pandemic planning.IMPORTANCE A recently emerged lineage of human-like H3N2

9 Despite its economic and cultural importance, a high-quality reference genome is currently

10 Despite their importance, ADAR RNA substrates have not been mapped ext

11 ure selection based on measuring permutation importance against a null distribution.

12 This underlines the importance and potential of sustained intervention regar

13 However, the importance and regulation of TRIM21 during bacterial inf

14 entify those residues of critical functional importance and revealed a unique sequence signature that

15 a dominance across 13 dimensions of risk and importance and through composite indexes.

16 port distances to the cytoplasm were of less importance, and these fibers exhibit a pattern not stati

17 HF worsening were common, were of prognostic importance, and were reduced by dapagliflozin.

18 ents of H129-based anterograde viral tracers.IMPORTANCE Anterograde transneuronal tracers derived fro

19 mechanism of action and their physiological importance are still elusive for most of them including

20 ith low asparagine concentration is of great importance as a measure to mitigate acrylamide concentra

21 mass spectrometry (LC/ESI/HRMS) are gaining importance as they enable identification of hundreds or

22 fe-cycle, and global commercial and cultural importance, as a taxa, anguillid eels can act as indicat

23 it is now a real possibility, and of central importance at this time, to assess the potential impact

24 tes apoptosis in noninfected bystander cells.IMPORTANCE B cell lymphoma 2 (Bcl-2) family proteins pla

25 rstanding innate antiviral defenses in birds.IMPORTANCE Birds are important hosts of viruses that hav

26 ic targeting for promoting neuronal recovery.IMPORTANCE Brain injury induced by acute simian (or huma

27 s, reduction of transmission is of paramount importance, but social distancing is challenged by high

28 e responses in affording protection from HIV.IMPORTANCE CD40-CD40 ligand (CD40L) interaction is cruci

29 fails to restore T cell repertoire diversity.IMPORTANCE Checkpoint inhibitors are effective immunothe

30 overlooked in vaccine design and evaluation.IMPORTANCE Differences in HIV pathogenesis between males

31 ion systems in S. aureus and establish their importance during pathogenesis.

32 ddition to Ebola vaccine development efforts.IMPORTANCE Ebola outbreaks result in significant morbidi

33 nimizes disruption of intestinal homeostasis.IMPORTANCE Enteric viral infections are a major cause of

34 different thermal environments is of crucial importance, especially in the face of global climate cha

35 ts for autophagy during flavivirus infection.IMPORTANCE Flaviviruses and other arthropod-transmitted

36 Second, it is of great importance for archaeological sciences, since a predomin

37 F, that impedes HIV infection in macrophages.IMPORTANCE For at least 30 years, it has been known that

38 onic integrated circuits that are of immense importance for broad applications in data communication,

39 This information is of particular importance for future efforts toward establishing prophy

40 lthough this receptor is considered to be of importance for hemostasis, the rate-limiting steps of CL

41 Kv1 channels and, consistent with ZDHHC14's importance for Kv1 channel clustering, loss of ZDHHC14 d

42 of ATG16L1 in full light and emphasizes its importance for maintaining host cell homeostasis.

43 Despite their importance for neural circuit function, only a little is

44 r some time that these organelles are of key importance for normal cellular functions, a growing numb

45 m a civilian or military source, is of major importance for society and future improvements in nuclea

46 tive auditory nerve fibers, which will be of importance for the development of treatments for age-rel

47 estriction of HIV replication in macrophages.IMPORTANCE HIV continues to be a major public health pro

48 tural immune mechanism limiting viral spread.IMPORTANCE HIV infection modulates the surface expressio

49 role in driving early HIV-1 viral evolution.IMPORTANCE HIV-1 has exceptionally high sequence diversi

50 media which mimic nature are of significant importance; however, they are often restrained by the so

51 al mRNA processing and viral DNA replication.IMPORTANCE Human bocavirus 1 (HBoV1) is one of the signi

52 ich may aid viral evasion of innate immunity.IMPORTANCE Human leukocyte antigens (HLAs) are cell surf

53 ue visual system as well as their commercial importance in Asian and European countries.

54 cidence and recurrence rates, is of integral importance in cancer immunotherapy to inform management

55 os, a protandric hermaphrodite of commercial importance in North America, is the primary target speci

56 These innovations are of paramount importance in order to facilitate efficient isolation, c

57 or normal motor control, as evidenced by its importance in Parkinson Disease and related disorders.

58 Their importance in proliferation, apoptosis, and cell death u

59 nformation over long distances is of central importance in quantum science and engineering(1).

60 Discovery of their importance in regulation of excitability opens new avenu

61 l and subtropical regions) were also of high importance in specific global contexts (e.g. for individ

62 ive synthesis (chiral induction) is of great importance in stereochemistry, molecular biology and pha

63 nign laboratory finding with little clinical importance in the absence of gout or kidney stones.

64 This finding may be of even greater importance in the era of the COVID19 epidemic, when slee

65 The use of omics is gaining importance in the field of nanoecotoxicology; an increas

66 These observations highlight the importance in the further characterization of the neurop

67 ransformation of chemical contaminants is of importance in various natural and engineered systems.

68 culature, suggesting constitutive functional importance in vivo.

69 origin and swine-origin A(H1N1)pdm09 viruses.IMPORTANCE Influenza virus infects a wide range of hosts

70 This importance is highlighted by the pathological consequenc

71 loop investigation is limited and functional importance is poorly understood.

72 s by preventing their premature accumulation.IMPORTANCE Kaposi's sarcoma-associated herpesvirus (KSHV

73 he host cell that enhance antiviral defenses.IMPORTANCE Kaposi's sarcoma-associated herpesvirus (KSHV

74 flamed tissues are associated with severe LF.IMPORTANCE Lassa fever may cause severe disease in human

75 Despite their epidemiological importance, little is known about their infection phenot

76 nomodulatory complexes within infected cells.IMPORTANCE Many viruses replicate almost entirely in the

77 efficiency of reovirus host cell attachment.IMPORTANCE Nonenveloped virus entry is an incompletely u

78 We highlight the importance of a coordinated and consistent data collecti

79 Here, we reveal the importance of a mutation's collateral fitness effects, w

80 The images demonstrated the importance of accurate head positioning, because a sligh

81 This case highlights the importance of accurate identification and treatment of a

82 re, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimension

83 We investigated the frequency and clinical importance of acquired asymptomatic brain magnetic reson

84 The importance of affect processing to human behavior has lo

85 Assessing the relative importance of age structure and increases in human capit

86 Despite the importance of AKT overactivation in tumor progression, r

87 This paper thus demonstrates the importance of an intact alcove in forming and stabilizin

88 ic repertoires in human autoimmunity and the importance of antigen discovery for improved understandi

89 ework presented in this study reinforces the importance of assessing dog ownership well-being outcome

90 Taken together, these results underlie the importance of balanced vaccine-induced activating versus

91 A signal transduction, and the physiological importance of basal ABA signaling in stomatal regulation

92 These data underscore the importance of beta-lactams for SaB, including considerat

93 s on healthcare reform while recognizing the importance of biomedical research, providers, and health

94 Our findings highlight the importance of both Calpha and Cbeta subunits of PKA duri

95 /m(3)) to PM(2.5) in Delhi, highlighting the importance of both external transport and local emission

96 This formal genetic evidence for the importance of Btnl heteromers also applied to the steady

97 We demonstrate the importance of chromosome-scale phased assemblies for the

98 es lie under circadian control; however, the importance of circadian mechanisms in the underlying fib

99 However, given the importance of climatic water balance on SIC accumulation

100 This case highlights the importance of close coordination between clinicians and

101 The importance of complex traits in biology and medicine has

102 ability as a reality check and considers the importance of computation in data collection/storage and

103 e for ICU interprofessional team rounds; the importance of conducting rounds at patients' bedside; es

104 These results highlight the importance of considering 3D cultures to model host-path

105 Our results suggest the importance of considering both natural and human factors

106 Our findings highlight the importance of considering lineage-specific TEs in studyi

107 These findings highlight the importance of considering multiple maternal features whe

108 AD has increased over time, highlighting the importance of considering SCAD among patients with acute

109 Our findings highlight the importance of considering these structures, as regions o

110 The importance of core fucosylation can be seen in the compl

111 These results illustrate the importance of coupling controlled reaction environments

112 endent Cav-1 phosphorylation, indicating the importance of CSD in the interaction.

113 This study underlines the importance of DC-mediated priming in identifying novel r

114 ur and life history, while demonstrating the importance of demographic-dependent selection in shaping

115 The importance of dietary acid load (DAL) in the pathogenesi

116 Recent studies have explored the importance of different forms of extracellular PDL1, suc

117 Relative importance of different groups varied differently across

118 heoretical models of addiction emphasize the importance of different memory systems for understanding

119 in Parkinson disease (PD) pathology and the importance of dopaminergic cells in this tissue, we aime

120 The importance of dried blood spots (DBSs) has increased in

121 United States, and recognition of the health importance of drinking water in lieu of sugar-sweetened

122 to sections based on the target analyte, the importance of each analyte and then the reported IDA sys

123 l culture cluster networks by estimating the importance of each network node and their information fl

124 e (PIS) was further provided to quantify the importance of each pathway.

125 model of maternal obesity to investigate the importance of early life ER stress in the nutritional pr

126 criptional profiles of PBMC, reinforcing the importance of early TI.

127 ideration for applied phage biology, and the importance of ecology in evolution of phage resistance.

128 This work underscores the importance of employing true null mutants in genetic com

129 To characterize the relative importance of environmental conditions, photoreactivity,

130 nvironments and HMP patterns may reflect the importance of environmental filtering in shaping competi

131 ere confirmed with this assay, including the importance of enzyme and substrate concentrations, covar

132 We also discuss the importance of eradicating NPM1-mutated clones to achieve

133 This work highlights the importance of examining NPs in their post-use phases in

134 es in the land carbon sink and highlight the importance of fire management in climate mitigation.

135 Our findings highlight the importance of formulations that conform to the ocular su

136 his context, this review discusses about the importance of four fruits species representative of Myrt

137 Together, our studies illustrate the importance of functionally interrogating diverse tumour

138 re have been many recent reviews on: (i) the importance of g(m) for accurately modelling net rates of

139 Our data emphasize the importance of gene expression regulation through the dyn

140 subtype in the literature and highlight the importance of genetic testing in the relevant clinical c

141 Considering the importance of genomics in the development of any crop, t

142 This underlies the importance of glia-matrix communication for structural a

143 other air pollutant emissions highlights the importance of ground-level NH(3) emissions from composti

144 e RAS+B system, potentially highlighting the importance of heterotrophy.

145 These results show the importance of high ATP in DnaA oligomerization and its d

146 sampling/survey data to explore the relative importance of holobiont adaptation (i.e., a symbiont com

147 reover, increasing island area increased the importance of homogeneous selection, but reduced the imp

148 small to admit either guest, signalling the importance of host dynamics for guest entrance to and tr

149 t directions for future research, noting the importance of identifying the operative dimensions of po

150 Given the importance of inappropriate NOTCH1 signalling in T-cell

151 r land use change studies and highlights the importance of including land-atmosphere coupling, which

152 aquatic vertebrate fauna and highlights the importance of including multiple water types in conserva

153 into the development of NKTCL by showing the importance of inflammation and immune regulation through

154 ation, and oxidative stress, underlining the importance of inflammatory mediators in the pathology of

155 This model shows the importance of initial asymmetry and its reinforcement by

156 Our study underscores the importance of integrating evolutionary responses in real

157 ly in tumour subtyping-have demonstrated the importance of integrative clustering techniques for comb

158 Despite the importance of interfacial proteins, comparatively little

159 Here, we discuss the importance of interpretable ML, different strategies for

160 s in microbiome science have highlighted the importance of intestinal microbes in human physiology an

161 bstrate K(+) and Cl(-) ions, demonstrate the importance of key coordinating residues for transporter

162 These results underscore the importance of ligand-independent TNFR1 dimerization in N

163 onclusion, our study clearly illustrates the importance of local community assembly processes in shap

164 c sclerosis in Han Chinese and suggested the importance of LRP2BP in systemic sclerosis pathogenesis.

165 This highlights the importance of maintaining effective surveillance systems

166 Long-standing evidence supports the importance of maintaining healthy populations of microbi

167 Our results highlight the importance of managing the increasing homogenization of

168 f MEN components, we determined the relative importance of MEN signaling from the SPB that is deliver

169 This points to the potential importance of microbial dormancy and resting stages in t

170 experimental evidence for the developmental importance of miRNAs in a non-bilaterian animal.

171 This study highlights the importance of mitochondrial aconitase activity in the de

172 is presumably maintained by coevolution, the importance of mitonuclear coevolution in key biological

173 The functional importance of mRNA localization to centrosomes is unclea

174 For the first time, we discovered the importance of multivalency in the PML II-ICP0 interactio

175 In this study, we investigated the importance of Musashi proteins in the development and fu

176 hus, we adopt a long-term perspective on the importance of nearby neighbors during a period when high

177 demonstrate the importance of neutrophil extracellular traps in helminth

178 id and extensive dark oxidation elevates the importance of nocturnal chemistry and biomass burning as

179 ms, giving a few examples to demonstrate the importance of nonequilibrium thermodynamics for understa

180 the first comprehensive investigation of the importance of NTR nucleotides in the context of the enti

181 Our findings emphasize the importance of NUCB1 as an essential component of MMP tra

182 Although our findings do not exclude the importance of other signaling differences between BBzeta

183 Collectively, these results highlight the importance of PARP family members and ADPRylation in gen

184 e receptive period, emphasizing the possible importance of paternity confusion.

185 It highlights the importance of pathologist/machine interactions for the c

186 To assess the importance of pathways for aromatic compound oxidation t

187 Together, these results highlight the importance of PD-1 agonistic treatment in allergic asthm

188 ology of complex diseases and highlights the importance of performing GWAS in non-European population

189 early childhood asthma and demonstrates the importance of phenotype-specificity for discovery of ast

190 These studies demonstrate the importance of phospholemman phosphorylation in the regul

191 Despite the clinical importance of polymyxins and the emergence of multidrug

192 Despite long-standing recognition of the importance of precipitation amount and variability for m

193 encapsulation strategies by highlighting the importance of preconditioning or priming the capacity of

194 uced PIP2 clustering in MACA, indicating the importance of protein multimerization.

195 ollective invasion to study the behavior and importance of protrusion-enriched RNAs.

196 s' experience of arthritis pain, realize the importance of providers' support on patients' adaptation

197 Our study highlights the importance of pyrimidine salvage during the earliest sta

198 Error-prone PCR mutagenesis reinforced the importance of R225 substitutions, found in 100% of selec

199 The Summit attendees identified the importance of raising awareness among critical care clin

200 of redundancy and focus on the evolutionary importance of redundancy in terms of the number of genot

201 'avoiding overthinking' in referring to the importance of relying less on high-level explicit strate

202 These findings highlight the potential importance of reward circuitry in ketamine's mechanism o

203 dvance and solidify our comprehension of the importance of root exudates in ecosystem response to dro

204 of reports in the literature documenting the importance of S-acylation in human physiology and diseas

205 Given the physiological importance of S-acylation, it is unsurprising that pertu

206 us inspection of food contact materials, the importance of sample preparation for nontarget screening

207 In this Review, we highlight the importance of single-particle spectroscopy in revealing

208 Building upon data suggesting the importance of sleep in learning and memory, we tested a

209 However, extremely little is known about the importance of social relationships between neighbouring

210 , cellular sites of cytokinin perception and importance of spatially heterogeneous cytokinin distribu

211 While the importance of staff-resident (dyadic) interactions durin

212 We have investigated the importance of stereochemistry, the effect of N-terminal

213 , and men who have sex with men, include the importance of strategies for maintaining persistent adhe

214 ute to these associations and underscore the importance of studying such factors, particularly in the

215 and open ocean mean values and highlight the importance of subglacial aluminosilicate mineral weather

216 ly lower incidences of ESLD, underlining the importance of successful HCV treatment for reducing ESLD

217 This work highlights the importance of sulfonamide precursors in contributing to

218 st performance, these findings emphasize the importance of symbiont community diversity and stochasti

219 In this review article, we highlight the importance of tailoring nano-DDS to address bacteriocin

220 Despite the importance of TBR for swallowing performance, the mechan

221 soluble quinone analogues, demonstrating the importance of testing compounds under physiologically re

222 Our study demonstrates the importance of the adaptability that is enabled by statis

223 Researchers now recognize the importance of the coral microbiome, but they often overl

224 esearch is needed to understand the clinical importance of the findings.

225 analysis highlights the overall evolutionary importance of the geophytic habit (i.e. belowground bud

226 t the receptor distal N-termini, despite the importance of the latter in signaling, regulation, and b

227 n DIAAS (from 117% to 97%), highlighting the importance of the matrix effect on nutritional protein q

228 tion catalysts and overstate the novelty and importance of the Mo-doped Ni/MgO catalysts for the dry

229 ient than TBP and ExBox(+4) , confirming the importance of the newly formed excited-state manifold in

230 ing of attention in aging and underscore the importance of the noradrenergic system in late-life cogn

231 esearch is needed to understand the clinical importance of the observed differences.

232 Understanding the importance of the oceanic background state, local and re

233 The results highlight the importance of the RadD protein for general chromosome ma

234 survival was similar regardless of degree of importance of the second ITA target-77% at 15 years (p =

235 dary degeneration of cones, highlighting the importance of the spatial and temporal location of key m

236 ctivated lung mesenchyme and establishes the importance of the WNT signaling pathway in the mTORC1-dr

237 aken together, these findings underscore the importance of their function as an evolutionary advantag

238 st lineage cells in order to investigate the importance of these cells as a source for loading-induce

239 max (soybean) canopy to review the relative importance of these delays on net cumulative assimilatio

240 nding and tetramerization domains cement the importance of these domains in tumor suppression.

241 The importance of these in-silico findings is validated expe

242 we discuss recent evidence highlighting the importance of these specialized plasma membrane domains

243 In comparison, much less is known about the importance of these two arms of the defence for the ecol

244 fic transketolase genes (tktAB) suggests the importance of this enzyme for xylose metabolism.

245 in a semantic judgment task, indicating the importance of this higher-order topological feature for

246 pregnancy(15-20), highlighting the clinical importance of this infection.

247 despite the biological and biotechnological importance of this macromolecule, its tertiary structure

248 bending by APE1, providing evidence for the importance of this mechanism.

249 e hematite-Fe(2+) redox couple to assess the importance of this process for the attenuation and remed

250 drial degradation (mitophagy) reaffirmed the importance of this process in PD aetiology.

251 ronal TRPV4-associated Ca(2+) responses, the importance of tightly regulated Ca(2+) dynamics for mito

252 ed earlier than recommended, emphasizing the importance of timely application.

253 The importance of tissue damage in the pathophysiology of GV

254 revious assumptions but also reinforcing the importance of tissue Na(+) excess, are both mechanistic

255 These results highlight the importance of training residents in performing MIGS proc

256 Together, this study demonstrates the importance of UDP-GalNAcA in the pathobiology of A. baum

257 ofiles of pigmented corns, and emphasise the importance of using acidified solutions for the extracti

258 ce of homogeneous selection, but reduced the importance of variable selection, for soil bacterial com

259 quitin ligase complex have shed light on the importance of WNK's cellular degradation on renal ion tr

260 on of PE in these major biological processes.IMPORTANCE Phosphatidylserine (PS) and phosphatidylethan

261 The feature importance recorded by the RF classifier indicates that

262 we develop an approximate algorithm based on importance sampling, using simpler probabilistic models

263 The pathway importance score (PIS) was further provided to quantify

264 idovudine and valganciclovir in this disease.IMPORTANCE Spliced X-box binding protein 1 (XBP-1s), par

265 matic constraints are often assigned greater importance than biotic interactions such as competition.

266 referred to as a 'passive conduit' of lesser importance than its left-sided counterpart.

267 It is of utmost importance that manufacturers update continuously values

268 t with human skin, it is now of even greater importance that the effects of air pollutant exposure on

269 l-pathway models-can be distinguished by the importance that they place on four key affordance dimens

270 cultures to model host-pathogen interaction.IMPORTANCE The "pathogen" hypothesis of Alzheimer's dise

271 uent antiretroviral therapy still is unclear.IMPORTANCE The antiretroviral drug rilpivirine was devel

272 o loss of protective antiviral host immunity.IMPORTANCE The current trend in CNS disease biology is t

273 ient EBV-induced lymphomagenesis in CBH mice.IMPORTANCE The EBV protein EBNA3A is expressed in latent

274 The obtained results highlight the importance the pitomba fruit as a promising source of na

275 tes autophagy to facilitate ZIKV replication.IMPORTANCE The re-emergence of Zika virus (ZIKV) and its

276 at might spillover into humans in the future.IMPORTANCE The severe acute respiratory syndrome coronav

277 However, despite their functional importance, the mechanisms controlling digit morphology

278 Despite its importance, the molecular mechanisms regulating DG neura

279 Despite their increasing importance, there is currently little guidance on how to

280 Despite its importance to all manifestations of GBS disease, studies

281 live-attenuated vaccines or vaccine vectors.IMPORTANCE To date, no Food and Drug Administration (FDA

282 erse sp(3) -rich skeletal ring systems is of importance to drug discovery programmes and natural prod

283 mechanism is unknown but likely of critical importance to explain the geochemical behavior of U.

284 ake fisheries is still limited despite their importance to food security and livelihoods.

285 uld be considered independently, giving more importance to high-quality and longer-term studies.

286 9)Zr-Df-IAB22M2C for PET imaging is of prime importance to identify patients responding early to canc

287 BACKGROUNDSerological assays are of critical importance to investigate correlates of response and pro

288 Our findings are of importance to raise awareness of this complication among

289 cal function of the produced compounds is of importance to reveal functional interactions in microbio

290 hanges that occur during infection and their importance to virus spread.

291 ction with tRNA fragments advocate paramount importance toward understanding BEX family involvement i

292 We assessed feature importance using a random forests classifier and perform

293 x VSV recombinants carrying large transgenes.IMPORTANCE Vesicular stomatitis virus (VSV)-based oncoly

294 t from other factors that modulate CoV entry.IMPORTANCE Virus entry into host cells is one of the key

295 against ocular herpes infection and disease.IMPORTANCE We report that naturally protected HSV-1-sero

296 ses to candidate EEHV vaccines in the future.IMPORTANCE Whether clinical illness and deaths associate

297 Despite this importance, whether NAD(+) capping dynamically responds

298 viral control after ATI in SIV-infected RMs.IMPORTANCE While effective, antiretroviral therapy is no

299 litating efficient reactivation from latency.IMPORTANCE While HSV antivirals reduce the severity and

300 in addition to local targeted interventions.IMPORTANCE While traditional epidemiological studies are