ライフサイエンスコーパス: important

1 al toxic effects on people and ecosystems is important.

2 nes with functional information is even more important.

3 ms and precise instrumentation together with important advances in genetics, cell biology and spectro

4 and tissue penetrance, and thus often offer important advantages over biologics.

5 Actuation by light has important advantages: Objects can be actuated from a dis

6 desiense bloodstream forms, which is another important aetiological kinetoplastid parasite.

7 r than 90% "critical" and less than 15% "not important" and were included in the final PICU core outc

8 r monogenic atypical forms of diabetes is an important approach to gaining insight and suggest that a

9 f these pathological NOTCH3 fragments are an important area for future investigation.

10 The inferior frontal lobe is an important area of the brain involved in the stress respo

11 This is important, as pneumococcal vaccination coverage in PLWH

12 These estimates are an important aspect of (68)Ga-PSMA-HBED-CC as a quantitativ

13 d evidence (RWE) is becoming an increasingly important asset in developing novel therapies for cancer

14 presents the first empirical evidence and an important baseline for ingestion of microplastics and ot

15 genetics influence mammographic features is important because the mechanisms through which they are

16 These analyses are important because they provide a starting point for rati

17 supplementation does not provide clinically important benefits for BMD in lactating women.

18 chieved with the generation of synthetically important beta-aryl ketone intermediates in a chemoselec

19 ant compounds within the body, represents an important bioanalytical parameter.

20 By mathematically fitting the data, important biological parameters can then be estimated, i

21 od to in vivo data, potentially providing an important biomarker for cancer diagnosis and treatment.

22 nancies, including gastric cancer, and is an important biomarker in drug discovery.

23 2,3-Dihydro-4-pyridone skeleton is an important building block in organic synthesis because it

24 rphisms in natural populations; and provided important case studies of how assortative mating can evo

25 the lack of efficient early diagnosis is an important cause of its high mortality.

26 phic cardiomyopathy (HCM) is an uncommon but important cause of sudden cardiac death.

27 her with a high index of suspicion for other important causes of ACS.

28 te distributions and to identify dynamically important cell states, such as fate decision states in d

29 lls, we show Hopper's even representation of important cell types in small sketches, in contrast with

30 tic insights, and highlight clobetasol as an important chemical tool for target validation.

31 This suggests autoreception may be an important circuit mechanism by which octopamine modulate

32 Polyketide natural products are an important class of biologically active compounds.

33 ave contributed to our understanding of this important class of microalgae in the context of evolutio

34 Strigolactones are an important class of plant signalling molecule with both e

35 differences are potentially associated with important clinical outcomes.

36 his structure confers to the Ruminococcin C1 important clinical properties including stability to dig

37 2 evolution, and therefore, ISMs can play an important complementary role to phylogenetic tree-based

38 that ecological niche differentiation is an important component of polyploid speciation and that nic

39 tes substantial remittance flows, but raises important concerns for migrant well-being.

40 in trace elemental cycles, with potentially important consequences for global carbon cycling.

41 nd that choice of chain perdeuteration is an important consideration from a technical point of view.

42 Transformation products ought to be an important consideration in chemical alternatives assessm

43 This study suggests that SNVs may become an important consideration in SARS-CoV-2 classification and

44 s entry and efferocytosis and underscore the important contribution of PE in these major biological p

45 s (IFs) in the C. elegans intestine indicate important contributions to intestinal function and organ

46 The loss of uninfected erythrocytes is an important contributor to malarial anemia; however, the m

47 results show that the DPR is a functionally important core promoter element that is widely used in h

48 Cassava is perhaps the most important crop in Africa for smallholder farmers.

49 measure distances of 2-10 nm is particularly important: deformations arising from protein binding com

50 anastomotic leakage (CAL) is the single most important denominator of postoperative outcome after col

51 e epigenetic state of the viral genome is an important determinant of reactivation that varies in a s

52 phingolipid composition of renal cells is an important determinant of renal function.

53 at functionality and tissue localization are important determinants of CD8+ T cell-mediated efficacy

54 thy (CIDP) and diabetes is uncertain despite important diagnostic and management implications.

55 wered to find a statistically and clinically important difference in the primary outcome.

56 individual differences in behaviour explain important differences in survival but not in the directi

57 ped a variant of a GO/NOGO task that reveals important differences in these two types of stimuli.

58 Stem rust is an important disease of wheat that can be controlled using

59 uctural prediction show that CTM provides an important domain for interaction of HOXA1 proteins with

60 without forest clearing but are increasingly important drivers of biomass loss.

61 nvestigate the historical biogeography of an important ecological engineer: the dusky-footed woodrat,

62 Northern boreal peatlands are important ecosystems in modulating global biogeochemical

63 ntinued fat alterations in PLWH will have an important effect on lifespan, healthspan and quality of

64 er renewable electricity sources become more important, electricity production from biomass would off

65 One of the most important emerging aspects of precision medicine in canc

66 The polycomb group protein CBX2 is an important epigenetic reader involved in cell proliferati

67 Here, we show an important extension of this chemistry for the activation

68 We further found that additional important factors are involved in setting this threshold

69 ection rates and treatment switches were not important factors in determining visual acuity outcomes.

70 to as non-consumptive effects (NCEs), are an important feature of predator-prey ecology, but their si

71 The findings of this study represent an important first step in repurposing class I PI3K inhibit

72 are produced during food processing and are important flavor compounds.

73 and in developing erythroid cells and is an important focal point in systemic iron regulation.

74 Perception of visual motion is important for a range of ethological behaviors in mammal

75 137, TNFRSF9) mediates costimulatory signals important for activation and persistence of cytotoxic T

76 at controls the differentiation of Th2 cells important for AD pathogenesis.

77 l dendritic cell type 1 (cDC1) subpopulation important for antigen cross-presentation, that CD40L-ove

78 key role in heme biology in T. gondii and is important for both mitochondrial and general parasite me

79 This may be especially important for calcified marine herbivores, such as the p

80 plets that are increasingly understood to be important for cellular function.

81 Nuclear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmi

82 Average pO2 is important for determining if a transplant site and capsu

83 GCs in AT, whereas other factors may be more important for endogenous MGC formation in vivo.

84 ense mutation in the TYMP gene would be very important for genetic counseling and subsequent early di

85 omote or inhibit origin activation, which is important for genome maintenance.

86 und that the KSHV gH (ELEFN(50-54)) motif is important for higher KSHV fusion and that EBV gH/gL does

87 osal-associated invariant T (MAIT) cells are important for immune responses against microbial infecti

88 The control of gene expression noise is important for improving drug treatment and the performan

89 IFICANCE STATEMENT The dentate gyrus (DG) is important for learning, memory, pattern separation, and

90 release, we hypothesized that I(h) would be important for LNvs communication.

91 Root-associated microbial communities are important for maintaining agricultural productivity.

92 e model of sepsis, P2X7 receptor activity is important for maintaining elevated levels of CD14 in bio

93 the CNS; as professional phagocytes they are important for maintenance of the brain's physiology.

94 regulation of integrin-mediated adhesion is important for many developmental migration events.

95 n hippocampus and mPFC, two regions that are important for memory-guided behaviors, in two tasks: one

96 Our study suggests that primary cilia are important for neuronal maturation and function in cells

97 HSP78), a putative caseinolytic protease, as important for parasite infection of host macrophages and

98 ine) elicit an immune response, which may be important for patient's responses to DNMTi.

99 these data show that CeA-LH projections are important for persistent avoidance of stress-related sti

100 data support the model that TFIIB release is important for Pol II to successfully escape the promoter

101 ative to the active site also appeared to be important for polymer elongation.

102 sector in multisectoral approaches (MSAs) is important for prevention and control of chikungunya and

103 ctional protein that stabilizes ECs, and are important for proper neuronal function.

104 The induction of anti-CSP antibodies is important for protection, however, it is unclear how the

105 ations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesi

106 the facial and vocal tract regions that are important for reconstruction are those that are used to

107 Regulatory networks important for regeneration are constructed through integ

108 arious read assembly programs in practice is important for researchers to choose which programs to us

109 n, which has previously been predicted to be important for Rheb-signalling suppression.

110 esidues, Arg-277 appeared to be particularly important for signal propagation from the allosteric sit

111 90 is a highly conserved molecular chaperone important for the activity of many client proteins.

112 The NF-kappaB family of proteins is important for the cell to mediate this response.

113 Our findings are important for the improvement of CAR-T cell-based immuno

114 llosteric ligands and receptor binding sites important for these allosteric activities.

115 2 activation, and O-fucosylation on EGF9 was important for trafficking of both NOTCH1 and NOTCH2.

116 smission and heterogeneous infectiousness is important for understanding NoV transmission dynamics.

117 r present advances in animal models that are important for understanding the pathogenesis of SARS-CoV

118 predictions of their effects are, therefore, important for understanding these patterns.

119 t another key virulence regulator, ToxR, was important for V. cholerae resistance to hydrogen peroxid

120 pressed during animal infection, implying an important function of this protein in bacterial infectio

121 reported that bacterial DNA methylation has important functions beyond the roles in restriction-modi

122 multiple members of the CslF/H family fulfil important functions during grain development but, with t

123 nal (3D) shape perception is one of the most important functions of vision.

124 This biocatalyst closes an important gap in allowing the conversion of chitin into

125 Knowledge about HWE test fills an important gap in population genetic studies of tetraploi

126 This is an ecologically and economically important global insect species that is continuously exp

127 In order to achieve this clinically important goal, the approach necessarily breaks a protec

128 enomic segments in mammalian cells represent important goals of biomedical research.

129 associated healthcare burden may account for important health-related adverse effects.

130 them into various intestinal BAs(2) that are important hormones that regulate host cholesterol metabo

131 viral defenses in birds.IMPORTANCE Birds are important hosts of viruses that have the potential to ca

132 approaches are likely to identify clinically important HTE, methodological aspects of risk-modeling m

133 Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage

134 es a key set of results showing "when" it is important (i.e., at behavior initiation).

135 1 expression and that PD-L1 expression is an important immune evasion strategy used by KSHV for its s

136 e additional evidence that RNA virus IBs are important immunomodulatory complexes within infected cel

137 nt cannabis may not have excluded clinically important impairment, and the doses tested may not repre

138 Our results have important implications for cancer biology because oxidiz

139 al urban population in China, which may have important implications for improving mental wellness amo

140 ion of amines to hydroperoxy amides may have important implications for nucleation and growth of atmo

141 cell type in somatosensory cortex, which has important implications for our understanding of informat

142 This has important implications for our understanding of the evol

143 This outcome has important implications for risk assessment and the migra

144 lar molecules such as amino acids, which has important implications for SIMS imaging of metabolites a

145 s relevant to the Earth's upper mantle, with important implications for the transport of carbon in aq

146 olcanic degassing of planetary interiors has important implications for their corresponding atmospher

147 understanding B cell biology, but also have important implications for understanding tetraspanin fun

148 Their findings have important implications to vaccine design.

149 llenging for beta-barrel proteins, which are important in cellular transport.

150 ctive nicotine delivery from e-cigarettes is important in consumer acceptance.

151 nserved sequence motifs that are known to be important in helix packing.

152 Mean arterial pressure is critically important in patients with cirrhosis in the ICU, however

153 riptional programs and epigenomic events are important in providing the necessary metabolic network a

154 es, especially of the abundant 3d metals, is important in the design of electrocatalysts and organome

155 Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and

156 sition in the diseased liver and as such are important in the progression of liver fibrosis.

157 raction of avian BST-2 with avian viruses is important in understanding innate antiviral defenses in

158 ventitious root (AR) formation is critically important in vegetative propagation through cuttings in

159 at they evolve rapidly in birds, which is an important indication of their relevance for antiviral de

160 etween the surfactant molecules; this has an important influence on the reaction intermediates' stabi

161 Enemy-risk effects can have important influences on different stages of biological c

162 de that cardiac electrical activity provides important information about the likelihood of future PD

163 Moreover, our work provides important information about the origins and accumulation

164 several novel causal associations providing important insights about the cause of these diseases, wh

165 ristics of this molecule, which will provide important insights into its function as well.

166 y characterizing these algorithms has led to important insights, including the discovery of guidance

167 Studies of within-host evolution provide an important link between experimental studies of virus evo

168 ites in the blood of infected subjects is an important measure of efficacy of drugs and vaccines.

169 lational regulation, our study highlights an important mechanism conferring tamoxifen resistance via

170 Multisite phosphorylation is an important mechanism of post-translational control of pro

171 current (I(KACh)), called I(KH); this is an important mechanism underlying not only the genesis, but

172 in innate immunity and infection, could have important medical and technological applications.

173 in-hospital cardiac arrest has emerged as an important metric to benchmark and incentivize hospital r

174 ized for the zinc and iron content, the most important micronutrients.

175 ity and abundance of 14 species of medically important mites based on total RNA sequencing data sets

176 Temporary labor migration is an increasingly important mode of migration that generates substantial r

177 o convert acetyl-CoA to several commercially important monoterpenes and achieve up to 125-fold increa

178 responding decrease in circulating CXCL1, an important neutrophil recruiter and activator.

179 that the work-loop technique can provide an important novel method with which to assess detailed mec

180 One of the most important objects for a primate is a face.

181 central component of human societies and an important, often adverse, influence on ecosystems.

182 ing archaea of the phylum Thaumarchaeota are important organisms in the nitrogen cycle, but the mecha

183 derstanding of the responses of ecologically important organisms to changing environmental conditions

184 -line antibiotics for many infections, is an important part of efforts to address antimicrobial resis

185 An ophthalmologic examination is an important part of the evaluation of FASD in childhood as

186 Pharmaceutical drugs are an important part of the global healthcare system, with som

187 Important patient clinical determinants of self-care inc

188 better physical framework to understand this important phenomenon.

189 RK1/2 activation, suggesting that TrkA is an important player in the signaling pathway activated by e

190 gands in connection with their receptors are important players in cell-to-cell communications in plan

191 B lymphocytes are important players of the adaptive immune system.

192 es virus transmission involving economically important pollinators, including honey bees (Apis mellif

193 Polyacrylates are important polymers widely used in pharmaceutical industr

194 d that NAT1 undergoes lysine acetylation, an important post-translational modification that can regul

195 lements of the codon theory continue to make important predictions for cerebellar mechanism, and we s

196 ormalities of the corpus callosum (CC) as an important predictor of neurodevelopmental outcomes.

197 R0 is the most important predictor of survival in patients with LRRC.

198 iting most areas of the genome, is producing important preliminary therapeutic results that could pro

199 hic complementarity, which is potentially an important prerequisite for the provisioning of ecosystem

200 This study addresses an important problem in neurology, distinguishing tremor an

201 Our data provide an important proof-of-concept and model system for the pote

202 We identified important protein interaction sites, in addition to site

203 An important question in early neural development is the or

204 de in porous electrocatalysts for these five important reactions are reviewed.

205 ledge from these studies has enabled several important recent breakthroughs.

206 ervation areas in Southeast Asia, a globally important region for biodiversity.

207 ic membrane blebbing is now recognized as an important regulator of cell migration, cancer cell invas

208 entified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor i

209 the small, monomeric GTPases Rac and Rho are important regulators of actin.

210 Histone deacetylases (HDACs) are important regulators of gene expression that are aberran

211 dicate that dynamic RNA methylation plays an important regulatory role in oligodendrocyte development

212 re beginning to be understood and will be an important research focus in the coming years.

213 as completed over a decade ago, providing an important resource for both the research and the clinica

214 Africa, where hepatitis B virus (HBV) is an important risk factor.

215 ndabout guidance receptor 2 (ROBO2) plays an important role during early kidney development.

216 This study supports an important role for B cells in indirect T cell priming an

217 The data support an important role for the dimethylbenzimidazole tail in mov

218 and physiological differences could play an important role governing their distribution patterns.

219 Nurses can play an important role in assisting the delivery of oropharyngea

220 Inflammation plays an important role in cardiovascular disease (CVD) developme

221 ween oxidative stress and autophagy plays an important role in cellular responses to a wide variety o

222 Primary mechanosensory neurons play an important role in converting mechanical forces into the

223 in the 5' untranslated region (UTR) play an important role in Gag:RNA interactions leading to genome

224 lex/cyclosome (APC/C) is reported to play an important role in metaphase-to-anaphase transition.

225 Ube2v1 plays an important role in protein aggregate formation, partially

226 Scientific conferences and meetings have an important role in research, but they also suffer from a

227 n with the DNA replication cycle and have an important role in segregating genetic material.

228 microbiological, imaging techniques play an important role in supporting the diagnosis, grading the

229 This astroglial mechanism plays an important role in the autonomic control of heart rate.

230 ich encodes the netrin-1 receptor and has an important role in the development of the nervous system

231 While magnetic fluctuations play an important role in the materials' unusual electronic stat

232 ation methods are reviewed, as these play an important role in the wide range of applications towards

233 ukaryotes, including humans, and may play an important role in transcription-coupled homologous recom

234 We conclude that MEGF11 plays an important role in tumour survival and that overexpressio

235 However, despite the important role of IL-1beta in controlling local and syst

236 that near-surface humidity plays an equally important role.

237 tion, respectively, in-silico models play an important role.

238 based ligands are versatile donors that play important roles in a wide array of subdisciplines of ino

239 They play important roles in acidification of intracellular vesicl

240 Thus, AHLs have potentially important roles in agriculture and aquaculture.

241 nterleukin (IL)-13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue

242 de range of extracellular proteins that play important roles in bacterial viability and in interactio

243 and their associated microbial biofilms play important roles in determining the settlement location o

244 RNAs (sRNAs) regulate gene expression, play important roles in epigenetic pathways, and are hypothes

245 Epigenetic modifications on chromatin play important roles in regulating gene expression.

246 tion complex (Csm3/Tof1 and Mrc1), which has important roles including aiding normal replication rate

247 Due to PTMs' extremely important roles, many major PTMs have been studied, whil

248 Systematic collation of certain important safety outcomes was rare.

249 ld increase in the antioxidant values and an important SCFAs production were obtained, revealing the

250 enzyme converts guanosine triphosphate to an important second messenger cGMP.

251 Inflammasomes are important sentinels of innate immune defence that are ac

252 ant clinical differences but also identified important similarities between the 2 groups.

253 Reassortment is an important source of genetic diversity in segmented virus

254 Clinically important Staphylococcus aureus obtains iron by extracti

255 n in eukaryotic phototrophs and represent an important step toward a comprehensive assessment of gree

256 a structural model as input, representing an important step toward comprehensive modeling of the MHC

257 s to a real-world problem, thus providing an important step toward understanding human sequential dec

258 Our work marks an important step towards enabling application-specific ana

259 The work also constitutes an important step towards large-scale quantum dot simulator

260 ses in bacterial pathogens is emerging as an important strategy to better understand host-pathogen in

261 An important structural aspect of [Fe(IV)poat(O)](-) is the

262 study establishes the extracellular loops as important structural motifs for ion selectivity and chan

263 ath or to characterise effects in clinically important subgroups.

264 ecies, a too little studied but biologically important substance class.

265 In addition, as an important supplement of the database, several flexible t

266 he prediction of optimal binding energies of important surface intermediates and to estimate the exte

267 of inappropriate antimicrobial therapy is an important target for stewardship intervention.

268 Hybrid genome assembly has emerged as an important technique in bacterial genomics, but cost and

269 ction on the deep nitrogen cycle may be less important than has been suggested by previous investigat

270 issues of anthers, suggesting that OsNLA1 is important throughout the development of rice.

271 uminate the combinations of ingredients most important to align and segregate chromosomes and simulta

272 evidence from many different sources, it is important to consider the role of data uncertainty.

273 t cross-reactivity to additional microbes is important to consider, especially in HIV infection where

274 Thus, it is important to define the patient population that would no

275 In addition, implementation strategies are important to develop to facilitate decision aid integrat

276 To this end, it is important to exploit multiple data streams that are beco

277 Therefore, it is important to gain a better understanding of the relative

278 iome, presents itself in a complex ecosystem important to health and disease.

279 To get a cure for HIV, it is important to identify and characterize the cellular fact

280 It is important to identify individuals having these disorders

281 process first passing through a boundary is important to many diverse applications.

282 6 in other types of leukaemia, this study is important to our understanding of T-ALL.

283 ) of the net land carbon balance (S(net)) is important to predict future climate-carbon cycle feedbac

284 to influence posttranslational modifications important to tumorigenesis and cancer cell growth, here

285 are often subjected to control, thus, it is important to understand how the reduction of this scaven

286 Therefore, it is important to understand salinity distributions and compa

287 Consequently, it is important to understand whether SMC continues to provide

288 he policy applications of this result, it is important to update the scientific record regarding the

289 icrocystis involved ED_co-occurrences are in important topological positions in the network, suggesti

290 ould be manipulated in order to control this important trait and further allow the development of mol

291 ound combined with data on six agronomically important traits and from genotyping-by-sequencing.

292 Both human TSC1 and TSC2 are important tumour suppressors, and mutations in them unde

293 An important unanswered question in chromatin biology is th

294 s into hERG-specific function and articulate important unanswered questions.

295 in determining carpel number variation in an important vegetable crop - cucumber.

296 erent plans and the delivery of four locally important water-related ecosystem services modeled with

297 egates that resemble amyloid fibrils in some important ways but are a distinct species.

298 rong prognostic value, which is increasingly important with the arrival of new immunotherapy modaliti

299 Proteins are perhaps the most important yet frustratingly complicated and difficult cl

300 te the discovery of antiviral drugs for this important zoonotic pathogen.