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1 ng of common spiral microcoils, for example, impossible).
2 flammasome components and enzymatic activity impossible.
3 biotechnology has proven challenging but not impossible.
4 ly high risk or render common femoral access impossible.
5 tive detection of target molecules virtually impossible.
6 dition is not met, a reliable measurement is impossible.
7 f these complexes by thermal ligand exchange impossible.
8  the level of biochemical systems was almost impossible.
9 e the nucleus making a fine-grained analysis impossible.
10  swim in the bulk, where surface adhesion is impossible.
11 axonomy that is useful for ecologists nearly impossible.
12 preventative clinical management essentially impossible.
13 ender the analysis of low-abundance proteins impossible.
14  viscosity and odor of the IMD, blinding was impossible.
15 o the PTC thus making peptide bond formation impossible.
16 k signals make many bio-imaging applications impossible.
17 s often render an unambiguous identification impossible.
18 amming begins becomes very difficult or even impossible.
19 implants for applications so far technically impossible.
20 t of electromagnetic radiation is completely impossible.
21 he very broad definition of UPFDs makes this impossible.
22 render cAMP compartmentalization essentially impossible.
23 s enormous, and testing all of them would be impossible.
24 nventional configurations that are otherwise impossible.
25 bodies for which viral escape is unlikely or impossible.
26 io bursts are not required, but are also not impossible.
27 agnosis as the clinical diagnosis is usually impossible.
28 hole-genome using these approaches is nearly impossible.
29 value, beyond which natural delivery becomes impossible.
30 lyses of multiple disease states as hitherto impossible.
31 n as single-photon interferences were deemed impossible.
32 ion of IP cleanup to precious samples nearly impossible.
33 entification of such sensors would be nearly impossible.
34 kes any long-range prediction of the path(s) impossible.
35 e out-of-the-box sharing of that data nearly impossible.
36 overy of novel vaccines that were previously impossible.
37 l system, making clinical translation nearly impossible.
38 characterization at macroscales has remained impossible.
39 he prediction of its release at steady state impossible.
40 has rendered systematic testing of this view impossible.
41 s (national or continental scale) is next to impossible.
42 nk" measurement in the absence of analyte is impossible.
43 or their derivatives would be impractical or impossible.
44  signaling by electrophysiology is basically impossible.
45 , also far-field manipulation are considered impossible.
46 suming, and, in some cell types, essentially impossible.
47 cross-sectioning even of minute fragments is impossible.
48 ffer exchange to screen refolding conditions impossible.
49 rential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the
50                         Therefore, while not impossible, a biological catalyst would have to surmount
51 for over a year, such that photosynthesis is impossible and continents and oceans cool by as much as
52 o an era in which HIV testing of infants was impossible and mothers had poor access to antiretroviral
53 mpossible, the acquisition of DNA is usually impossible and phenotype-genotype maps are rarely obviou
54 limitations make plain model-based valuation impossible and require metareasoning strategies to appor
55 the comparison between instruments is nearly impossible and the set of measurements from the various
56 to treating immoral and irrational events as impossible, and provide a case study of high-level cogni
57  where accurate benchmarking is difficult or impossible, and to the importance of nonequilibrium geom
58 ave become popular as they enable previously impossible approaches of environmental observations.
59 d diverse IMS/MS arrangements and modalities impossible at ambient buffer gas pressure were enabled a
60 es of the pathogenicity of VA1 are currently impossible because there are no reported cell culture sy
61 toreceptors are active, but colour vision is impossible because they all use the same visual pigment.
62 ) primary review outcomes, meta-analysis was impossible, because trial outcomes were absent or unclea
63 port during metamorphism has been previously impossible both in nature and in experiment.
64 ant to be exhaustive, as such an endeavor is impossible, but rather aims to balance breadth and depth
65                   This perspective tries the impossible by discussing some recent advances in the con
66 on with 100 % atom economy, but it is almost impossible by thermal catalysis owing to the significant
67 l biological samples that would otherwise be impossible by using regular flat-screen visualization pr
68 st in this formalism by allowing classically impossible calculations to be performed.
69 junction with each other, enabling otherwise-impossible chemical transformations within primordial ce
70 3D metal oxides that could enable previously impossible devices and smart materials.
71 t protein expression is either unfeasible or impossible, driving structural biologists to explore new
72 ethal Ebola virus (EBOV) in humans is almost impossible due to obvious ethical reasons and the sporad
73 , while the excitation of some Fano modes is impossible due to symmetry reasons.
74  and persists in immune-privileged sites was impossible due to the absence of a suitable animal model
75 es identification of worked objects is often impossible due to the loss of identifying characteristic
76  low-temperature phases is thermodynamically impossible during a second-order phase transition in a b
77 es as Cu (111)(5,8) is widely believed to be impossible, even in theory.
78 ble researchers to carry out new, previously impossible experiments.
79 the Goldschmidt tolerance factor rule, it is impossible for (xAMPY)M(2)I(6) to form proper perovskite
80 ons was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respe
81 P. ramorum is now not possible, and has been impossible for a number of years.
82 examination, some changes to staging make it impossible for a stage to be assigned until surgical res
83 f-healable, recyclable, and stable, which is impossible for any traditional thermosets and is therefo
84 e and interpret sinograms that are virtually impossible for human experts.
85 huge volumes of ChIP-seq data make it almost impossible for human researchers to manually uncover all
86 y, high dimensional biomedical data is often impossible for humans and challenging for machines.
87  of sequence analysis is impractical or even impossible for large-scale sequencing centers that simul
88  partial success, communication has remained impossible for persons suffering from complete motor par
89  aquaculture ponds have made it difficult or impossible for previous video cameras to provide clear i
90  growth of the biomedical literature make it impossible for scientists to read all studies related to
91 protocols are time consuming at best or even impossible for some regions in NMR spectra.
92 olloids in water, however, has made PB to be impossible for the open-field radioactive cesium deconta
93  other tasks, such as nest repair, it may be impossible for workers not directly at the work site to
94 d organs is often technically challenging or impossible, for example in heart or brain tissue.
95                         It is difficult, nay impossible, for researchers to check the accuracy of sof
96 ity of performing tasks that are classically impossible has made quantum entanglement a powerful reso
97  with linear communication cost, but this is impossible if [Formula: see text] A key step is to disti
98                         We show that this is impossible if their memory is too low.
99  a support to hold up objects looked more at impossible images with string hanging from below (unsupp
100 l phenotype in vitro that would otherwise be impossible in a patient, opening avenues for future mech
101 xtremely challenging experimentally and even impossible in clinical applications.
102 al circuits in vivo, that would otherwise be impossible in completely freely moving animals.
103  of FGF23 regulation that would otherwise be impossible in humans.
104 of the novel effects which are fundamentally impossible in smooth films.
105 gnetization, something that is fundamentally impossible in smooth magnetic films.
106 l state or the channel in some situations is impossible in the absence of noise in the initial state
107 connectivity pattern, which is thought to be impossible in the brain.
108    Said differently, completely ab initio is impossible in the vast majority of splice sites in annot
109 ich is well known in other hymenopterans, is impossible in this polyembryonic wasp.
110 ation of an arene that was previously deemed impossible in traditional Kolbe-Schmitt reactions.
111 the complete elimination of uncertainties is impossible, LCA results should be complemented by an unc
112 und that this differentiation is practically impossible, moving the question to why it is not possibl
113 f miRNA evolution therefore are difficult or impossible on this basis.
114 at low cost for resources that are otherwise impossible or more difficult to access [5, 6].
115 rapeutic guidance when tissue acquisition is impossible or when the specimen is inadequate.
116 cation to these changes is difficult, if not impossible, owing to the confounding effects of other en
117 eneous flow near lower temperatures which is impossible previously.
118 particle samples, avoiding tedious and often impossible purification and fractionation of nanoparticl
119 nd systematic testing of all combinations is impossible, so robust methods to predict the effects of
120  to produce all drones prior to swarming, an impossible solution on a population scale because queens
121 from infected individuals enables previously impossible studies on HIV persistence.
122 ever, do successfully perform this seemingly impossible task [5], raising the question-what underlyin
123                    Therefore, it would be an impossible task for us to project a coherent "big pictur
124 itating condition no longer appears to be an impossible task.
125 sp(3))-H bonds is often a nontrivial, if not impossible task.
126 to run, and drug development would be a near impossible task.
127 tandard process tomography becomes an almost impossible task.
128 introduction of nontoxic ammunition has made impossible the characterization of GSR particles by the
129 it is a global, aggregated value, that makes impossible the individual analysis of the contribution o
130 ord is difficult because genetic crosses are impossible, the acquisition of DNA is usually impossible
131                         In particular, it is impossible to a priori balance the trade-off between the
132 cyclooctatetraenyl radicals, which have been impossible to access through classical synthetic methods
133 oss multiple years of sampling, it is nearly impossible to accurately detect any directional shift in
134 icro- and macroscopic architectures that are impossible to achieve through traditional manufacturing
135  enabling access to sample sections that are impossible to achieve with conventional sample preparati
136 ir repair in vivo-something otherwise nearly impossible to achieve.
137 important new insights that are difficult or impossible to acquire with conventional approaches.
138 e labels for cell types are costly and often impossible to acquire.
139  can address questions that are difficult or impossible to answer by other means, yet the complexity
140 e to soft tissues are generally difficult or impossible to apply to the skeleton.
141 er larger number of stationary phases, it is impossible to arrive at a single successful approach.
142 ft similar material cultural remains, it was impossible to attribute any open-air site to either spec
143 erfere with Raman detection and is virtually impossible to avoid.
144 In practice, however, it can be difficult or impossible to blind study participants and unblinded tri
145 scales and environments, we found that it is impossible to calibrate a model on both sediment transpo
146 mation about processes in the cell that were impossible to characterize with existing techniques in s
147                  Established infection seems impossible to clear.
148                                 Whilst it is impossible to clinically separate observed behavior of c
149  changes when root growth stops, it has been impossible to compare cellular dynamics as stem cells tr
150 h because visual-only speech is difficult or impossible to comprehend, unlike auditory-only and audio
151 breast cancer make them impractical and even impossible to conduct.
152                                        It is impossible to consider how neural tissue processes these
153            Leibovich et al. argue that it is impossible to control for all continuous magnitudes in a
154          This degree of instability makes it impossible to correlate the structure of AuNPs determine
155                    Space constraints make it impossible to cover all relevant articles in the field,
156 s slow, and many pathogens are fastidious or impossible to cultivate.
157 treat infections that today are difficult or impossible to cure.
158 osquitoes, and orthologous groups are nearly impossible to define.
159 an levels: at low (or high) intensity, it is impossible to demonstrate high variability.
160 fer FAPA conditions, which were difficult or impossible to detect with proton-transfer FAPA or direct
161                               As it is still impossible to determine histamine concentrations in vivo
162 of individual neurons are unknown, making it impossible to determine how mechanisms underlying such a
163 for comparing alternative scenarios makes it impossible to determine if observed faunal differences v
164 irical fitness landscapes of tumor cells are impossible to determine in vivo.
165 ration regime were not documented, making it impossible to determine measurement reliability.
166 results suggest that, when it is impractical/impossible to determine whether tests were conducted for
167 ed separately in populations of cells, it is impossible to determine, with certainty, where the featu
168 ferent experimental conditions, rendering it impossible to directly compare their activity.
169 de (NO2) in the presence of ozone, making it impossible to directly measure (15)N in NO.
170 Cs in human biology and disease, it has been impossible to directly monitor the real-time activation
171 tractants remain unclear, as it is currently impossible to directly observe and accurately measure th
172                        Nowadays, it is still impossible to directly show the difference between exter
173                                This makes it impossible to discern if visual attention has an effect
174 atterns in later development are essentially impossible to discover by chance mutation alone, even fo
175  so many interesting papers presented, it is impossible to discuss everything, but some key areas are
176  and/or consequent stimuli, making it nearly impossible to disentangle the effects of cue learning, t
177 election and immortalization, which makes it impossible to distinguish between alterations directly i
178 ed for selection and immortalization made it impossible to distinguish between alterations induced by
179 ks present a major obstacle that can make it impossible to distinguish one compound from another.
180                                        It is impossible to do justice in one review article to a rese
181 trial, where methodological problems make it impossible to draw any conclusion about efficacy.
182                                  While it is impossible to eliminate a mutation bias of unknown cause
183                           Although it may be impossible to eliminate all ethical dilemmas and conflic
184 read parameters are estimated exactly, it is impossible to estimate the probability of a major outbre
185 emical and structural data that was hitherto impossible to evaluate.
186  the earlier extinction is identified, it is impossible to exclude the possibility that this pattern
187 sociated with human brain function, which is impossible to explain through long-term plasticity.
188 ed in islet xenotransplantation, it has been impossible to explore the mechanism of late islet graft
189 tor and its signaling are deleted, making it impossible to explore the possible signaling-independent
190 te the impact of space weather because it is impossible to forecast the solar eruptions that can caus
191 These results suggest that in general, it is impossible to form flat two-dimensional nanocrystalline
192                      But so far, it has been impossible to fully characterize the sequence of the vir
193             Glioblastoma multiforme (GBM) is impossible to fully remove surgically and almost always
194 ty of protein structures, it is often almost impossible to identify independent subunits, flexible re
195 yletic within the species complex, making it impossible to identify them on the basis of conserved ge
196 any identical accessions that can be hard or impossible to identify without passport information and
197 plex life strategies that would be otherwise impossible to infer from the study of body parts alone.
198 notypic data sets that are very difficult or impossible to integrate at scale because of variable for
199 , in animals and seed plants it is virtually impossible to investigate the effects of specific gamete
200 Terminal uranium nitrides have so far proven impossible to isolate by photolysis of azides.
201    Leibovich et al. argue that because it is impossible to isolate numerosity in a stimulus set, atte
202                  Until recently, it has been impossible to isolate trophoblast cells from the human p
203 ver, is inherently problematic because it is impossible to knock them out.
204 ling, but adds a caution: It is difficult or impossible to know under what conditions transcriptional
205            Without a comparison group, it is impossible to know whether any improvement observed afte
206                                        It is impossible to know whether violence would have occurred
207 g, but with currently available tools, it is impossible to know which infants with bronchiolitis will
208 xpansion, regardless of subset origin, it is impossible to know which subsets contribute to the final
209 uting environment, which may be difficult or impossible to match using written instructions.
210 taclusters in solution that are difficult or impossible to observe by traditional solution techniques
211 e shell of dust and molecules(10), making it impossible to observe their final state (for example, as
212 time scales that often are very difficult or impossible to obtain from experiments alone.
213 ary taxonomic information, however, is often impossible to obtain from objects that are small, heavil
214 collection efficiencies of 100% are probably impossible to obtain with this system geometry.
215 verage COI is high, they can be difficult or impossible to obtain.
216 inical management is less precise, and it is impossible to offer predictive testing of family members
217 owever, studies on cell/matrix interplay are impossible to perform due to disruptions in cell viabili
218 omena that would be otherwise challenging or impossible to perform in a traditional light-sheet micro
219                               Although it is impossible to phenocopy every symptom of human depressio
220 ther find that high-order epistasis makes it impossible to predict evolutionary trajectories from the
221 tween and within the families, that would be impossible to predict from the amino acid sequence alone
222                         To date, it has been impossible to predict or even infer local tissue dosing
223 ng extracellular matrix in culture is almost impossible to predict or experimentally control.
224 o devastating pandemics, but currently it is impossible to predict the pandemic potential of circulat
225                             Currently, it is impossible to predict therapeutic response.
226                            It is essentially impossible to predict whether an LO project might ultima
227 nmental and patient factors, it is currently impossible to predict whether drug exposure will result
228              At the time of diagnosis, it is impossible to predict which patients develop severe dise
229 h eyes following bilateral NAION it is still impossible to predict with certainty the visual outcome
230 ically, and their locations are difficult or impossible to predict.
231                    As human RAD51 has proved impossible to produce in a form that is compatible with
232                                     Although impossible to prove causality with any single approach,
233                     However, it is currently impossible to rationally design nanoparticles that selec
234 C-C functionalizations that are difficult or impossible to realize with transition metals.
235 s, there exist gene tree topologies that are impossible to reconcile with any species tree.
236  dimensions of less than ~200 mum and nearly impossible to remove from designs that contain turns or
237 annotation metadata, it becomes difficult or impossible to reproduce bioinformatic analyses from raw
238 iffraction limit of visible light, making it impossible to resolve their values using live-cell imagi
239 of common problems that make it difficult or impossible to run outside the original institution or ev
240 for these decoders are such that it has been impossible to scale them to naturalistic settings.
241                                  However, if impossible to scale up existing interventions to the ext
242 microscopic visualization, and are currently impossible to screen with pooled methods.
243  the intermediate and deep layers, a feature impossible to see with only iron concentration data larg
244                                  It is often impossible to separate the intrinsic imperfection of omi
245 the effects of these climatic variables were impossible to separate; however, they may play key roles
246 cture and general inertness, it is currently impossible to sinter hBN powder to a dense bulk (with a
247  that the task was either easy, difficult or impossible to solve, infants varied in whether, when and
248                      Yet, some problems seem impossible to solve.
249 out detailed structural information it seems impossible to state, whether a network is robust or if i
250 tate tackling biological problems previously impossible to study and/or quantify.
251 y to investigate aspects of disease that are impossible to study in patients or animal models.
252 st mechanism for testing hypotheses that are impossible to study in the wild.
253 ecisions in early human development that are impossible to study in vivo.
254 transcribed in polycistrones, yet it remains impossible to study nascent mtDNA transcripts quantitati
255 es and continuous magnitudes makes it nearly impossible to study non-symbolic numerosity processing i
256 , and spontaneous onset have made it nigh on impossible to study somnambulism behaviorally during wak
257 ically masks the subsequent steps, making it impossible to study the kinetics of radical chemistry.
258  insight into problems that are difficult or impossible to study with classical computers.
259 iles from FFPE single cells, which have been impossible to study with previous RNA-seq protocols, and
260  their respective functional roles have been impossible to tease apart.
261 n complex turbulent dynamical systems, it is impossible to track and control the large dimension of i
262  bloodstream infections that are effectively impossible to treat in this resource-limited setting.
263 rimental drug, using a randomization process impossible to understand by very sick patients.
264                               However, it is impossible to understand individual information processi
265 om species present in solution could make it impossible to use other detection techniques.
266 range of biological effects, but practically impossible to visualize in single cells.
267 olyelectrolytes, which were hitherto deemed "impossible" to process, since they are infusible and bri
268 and many diseases that are difficult, if not impossible, to achieve in other animal models, notably H
269 s many attributes that are difficult, if not impossible, to achieve with conventional robots composed
270 time being recognized as challenging, if not impossible, to define.
271 erimental protocols, it is difficult, if not impossible, to make meaningful comparisons between diffe
272 f sampling bias, making it difficult, if not impossible, to provide reliable inferences.
273 to be significantly more challenging, if not impossible, to separate by conventional drift tube techn
274 onary infections are difficult, or sometimes impossible, to treat and result in accelerated lung func
275 -noise ratios that make it difficult, if not impossible, to uncover the desired signatures of pathoge
276  microscopy, it is often challenging, if not impossible, to visualize submitochondrial structures or
277 rials that would have been difficult-or even impossible-to obtain using traditional hydrothermal tech
278  structural plasticity allow them to perform impossible tricks and be engaged in biological activitie
279 ask, violation of a Bell inequality, that is impossible under local classical temporal order; it mean
280  very different factors, hence a modeling is impossible unless more precise knowledge regarding the i
281 es of many diverse organisms was practically impossible until recently.
282 e mitochondrial diseases but was long deemed impossible - until now.
283 dividual muscle fibers, which was previously impossible using any laboratory-based imaging technique.
284 s, or even record molecular movie, which are impossible using present electron-beam technologies.
285 , as a consequence of instability, it can be impossible-using traditional methods-to concentrate cert
286 sured looking time responses to possible and impossible video and image stimuli.
287        Result interpretation is difficult or impossible when autoantibodies, alloantibodies, or thera
288  peptides on the basis of methylation-a feat impossible with a comparable commercial cation-exchange
289 tor, enables time-course mechanistic studies impossible with current wounding methods.
290 mission control that would be challenging or impossible with heated nanoscale-patterned metals or sem
291             We prove that strong-coupling is impossible with monolayers due to the large exciton cohe
292 avepackets, and manipulated in ways that are impossible with purely electromagnetic signals, due to t
293 to develop light-based technologies that are impossible with traditional optics.
294                Curing HIV infection has been impossible, with the exception of the "Berlin Patient."
295 tration indicate that an accurate readout is impossible within the experimental times.
296 dy of the link between brain and behavior is impossible without a guiding vision.
297 onjugated polymerization has previously been impossible without chain isolation.
298            Importantly, this would have been impossible without interfacial stratification of plasma
299                     The process of vision is impossible without the photoreceptor cells, which have a
300 t that many CT diagnostic decisions would be impossible without the use of iodine, this study suggest

 
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