ライフサイエンスコーパス: improper

1 Improper access to the genome leads to translocations an

2 lity to bind and bundle actin in vitro cause improper actin organization in vivo and reduce total tra

3 ernal chromosome sequences by preventing the improper activation of DNA-damage-response pathways but

4 This Fbn2(-/-) phenotype is accounted for by improper activation of latent TGF-beta that selectively

5 Collectively, these findings indicate that improper activation of p38 MAPK is a precursor of consti

6 psid assembly, favoring correct folding over improper aggregation.

7 ts exhibit several meiotic defects including improper alignment of bivalents at metaphase I, unequal

8 resolution, and mapping approaches, in which improper alignment of reads to a reference genome that i

9 Disruption of this feedforward loop leads to improper AMPK activation and multiple metabolic defects.

10 identification of OG:A is crucial to prevent improper and detrimental MutY-mediatedadenine excision f

11 There was inconsistent evidence for improper assignment of ASA and FHS.

12 nnel activity, an effect that was not due to improper association with Gbeta.

13 dynamically modifies kinetochores to correct improper attachments and ensure faithful chromosome segr

14 The Ipl1/Aurora B kinase corrects improper attachments by phosphorylating kinetochore comp

15 es (PEFs), highest near poles, can stabilize improper attachments by pushing mal-oriented chromosome

16 Improper attachments typically lack tension between kine

17 on specific mechanisms to avoid and resolve improper attachments.

18 one or both badges, reversal of badges, and improper badge placement are a major hindrance to this g

19 efficient B-cell regulation may influence an improper balance between an effector inflammatory respon

20 ing domains are implicated in cancer through improper binding of chromatin.

21 ion for proper binding and selection against improper binding.

22 gnal-dependent activation and/or resulted in improper biological outputs.

23 cruitment to the spindles, thus resulting in improper bipolar spindle formation that ultimately leads

24 Disruption of the PBD function results in improper bipolar spindle formation, chromosome missegreg

25 Podocyte depletion may result from improper calcium handling due to abnormal activation of

26 due to spatial heterogeneity of the nucleus, improper calibration of the FCS focal volume, or the int

27 n trabecular bone occur independently of the improper cartilage ECM degradation caused by Mmp13 defic

28 rosine kinase cSrc are infertile and exhibit improper cauda epididymis development.

29 ase activity is indispensable for preventing improper cell cycle re-entry and endoreduplication.

30 ng showed an elongated phenotype, indicating improper cell division.

31 estes and initiate spermatogenesis; however, improper cellular associations and abnormal sperm format

32 Improper cellular expression of the W4.64A was observed

33 nd-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of

34 arget area and branch aberrantly, leading to improper cellular positioning.

35 t cells defective in Cep63 binding exhibited improper Cep63 and Cep152 localization and impaired Sas6

36 e they reduce the curdling of milk and cause improper cheese ripening, which consequently lead to an

37 The improper choice of negative examples, in particular, can

38 patched was disrupted in mutants, reflecting improper chondrocyte/perichondrium signaling.

39 s with aberrant kinetochore-MT interactions, improper chromosome alignment and abbreviated mitosis.

40 tions in the Drosophila gene greatwall cause improper chromosome condensation and delay cell cycle pr

41 These attachments can result in improper chromosome segregation and are a significant so

42 rstanding genetic disorders that result from improper chromosome segregation.

43 about the severity of AK and consequences of improper CL hygiene.

44 In infarcted heart, improper clearance of dying cells by activated neighbori

45 Improper clearing of acetylcholine and prolonged excitat

46 Ipl1 released these improper connections, whereas Mps1 triggered the formati

47 Improper contact lens care and contact with nonsterile w

48 outputs, they suffer from signal loss due to improper contact of a rigid sensor with the skin.

49 mation but short enough to limit roaming and improper contacts with heads of neighboring tetramers.

50 ering-permissive conformation while avoiding improper contacts with heads of neighboring tetramers.

51 variability in metabolic data and the use of improper control groups.

52 remodeling of coronary vessels, resulting in improper coronary artery formation.

53 multiple pathways, raising the potential for improper cross talk.

54 A new study reveals both the consequences of improper crossover patterning in Drosophila and the role

55 ion along MAdCAM-1 substrates resulting from improper de-adhesion of the lymphocyte trailing edge.

56 ficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain the

57 uced FA use in heart failure may result from improper delivery, potentially via decreased perilipin 5

58 genes contributes to tumor progression, the improper dependency of H3K27me3 by mC in immortalized ce

59 s leads to compromised myocardial integrity, improper deposition of basement membrane, and a resultan

60 erized by the presence of myofibroblasts and improper deposition of extracellular matrix (ECM) compon

61 ed with abnormalities in the exoskeleton and improper development of the epidermis.

62 l retardation, as the TH decrease results in improper development of the nervous system.

63 The improper development of these structures in nhr-6(lg6001

64 Hereditary deafness is often mediated by the improper development or degeneration of cochlear hair ce

65 rowth and function of the vertebrate eye and improper development results in congenital defects, such

66 Unfortunately lack of expertise can lead to improper diagnosis of wound etiology and inaccurate woun

67 he disease is probably underestimated due to improper diagnostic pathway.

68 Congenital heart defects often result from improper differentiation of cardiac progenitor cells.

69 s a childhood tumor thought to arise through improper differentiation of neural crest cells.

70 Improper differentiation of the central cell led to defe

71 Deletion of COUP-TFII at E7.5 results in improper differentiation of the metanephric mesenchyme a

72 eiotic defects in late prophase I, including improper disassembly of the SC and aberrant chromosome c

73 of proper rod outer segment development and improper disc formation.

74 nal therapeutics due to metabolic excretion, improper disposal, and industrial waste has been well-re

75 MANF bound to a model ER protein exhibiting improper disulfide bond formation during reductive ER st

76 Improper DNA double-strand break (DSB) repair results in

77 Common error types were improper dose/quantity (46%) and prescribing (25%).

78 ins can cause severe disease associated with improper drug or ion flux.

79 pression of epidermal HDAC activity leads to improper ectodermal organ morphogenesis and disrupted ha

80 f Arhgap29(K326X/+) mice ( n = 37) exhibited improper epithelial contact between developing oral stru

81 sult in poor performance on examinations and improper evaluation of techniques and materials.

82 otect the nascent transmembrane domains from improper exposure in the cytosol, but also need to accur

83 Improper extension of sequence tags can obscure or misle

84 Improper extracellular localization of the latent comple

85 found to be mysteriously abundant in hybrid improper ferroelectric (Ca,Sr)3Ti2O7 crystals.

86 t] ferroelectric) domain walls in the hybrid improper ferroelectric Ca[Formula: see text]Ti[Formula:

87 Results of switching behavior of the improper ferroelectric LuFeO(3) are presented.

88 Here, a novel improper ferroelectric, CsNbW(2) O(9) , with the hexagon

89 nt of charged conducting domain walls in the improper-ferroelectric Cu3B7O13Cl.

90 Improper ferroelectricity (trimerization) in the hexagon

91 of two types of octahedron rotation, hybrid improper ferroelectricity has been theoretically predict

92 Hexagonal YMnO(3) shows a unique improper ferroelectricity induced by structural trimeriz

93 he possibility of having magnetically driven improper ferroelectricity, as in the much studied famili

94 In CuO, a multiferroic with improper ferroelectricity, the anisotropic THz absorptio

95 trate the unexpectedly rich nature of hybrid improper ferroelectricity.

96 has a stronger frequency dispersion for the improper ferroelectrics compared to a proper ferroelectr

97 tion in (001) films of layered A3B2O7 hybrid-improper ferroelectrics with experimentally accessible b

98 This particularly applies to improper ferroelectrics, where the polarization is induc

99 eter controls the switching dynamics of such improper ferroelectrics.

100 caused by the absence of flagella instead of improper flagellar assembly.

101 te-directed mutagenesis of LF2p reveals that improper flagellar length and defective flagellar assemb

102 oss of 4CL activity, probably as a result of improper folding as indicated by molecular modeling.

103 per lipid substrate or MTP may result in the improper folding of apoB and, consequently, its degradat

104 e, presumably due to inefficient assembly or improper folding of the fragments.

105 or deletion of the DFGWG motif alone led to improper folding of the transiently expressed GFP fusion

106 suggest that the cataracts resulted from an improper folding status of lens proteins caused by Sep15

107 ence compared with wild-type Rem, suggesting improper folding.

108 are rapidly degraded, most likely because of improper folding.

109 TCN seems to be improper for this purpose.

110 ecretion of exosome proteins, in part due to improper formation of MVBs.

111 of some of them appears to be linked to the improper formation of protein bodies (PBs) where zein st

112 These defects were accompanied by improper formation of the boundary between dorsal and ve

113 rovides the substrate for cognition, whereas improper formation or function of these synapses leads t

114 enzymes and that under certain circumstances improper FtsZ function can destroy the structural integr

115 athways in PS-deficient P. patens implicated improper function of the cytoskeletal network.

116 Improper function of voltage-gated sodium channels (NaVs

117 cellular environment plays a key role in the improper functioning of CMs in MFS.

118 Improper functioning of this process contributes to the

119 into neuropsychiatric diseases that involve improper generalization between different contexts.

120 During lactation, an improper glucose supply often threatens mammary gland (M

121 Improper glucose-stimulated insulin secretion from pancr

122 ha-glucosidase I and II enzymes resulting in improper glycosylation and misfolding of viral glycoprot

123 epletion results in misaligned lamellipodia, improper Golgi positioning, and reduced invasion.

124 own to reduce malaria cases by 50%; however, improper handling and human behavior can diminish their

125 the original paper to the use of DMSO and to improper handling.

126 Improper homeostasis of Th1 and Th2 cell differentiation

127 ts a mechanistic link between TOE1 mutation, improper hTR processing and telomere dysfunction in dise

128 rove public health, poor education level and improper human practices can strongly influence on water

129 The sepsis syndrome represents an improper immune response to infection and is associated

130 n these conditions are essentially caused by improper immune response.

131 l improperly predisposing it to be a site of improper implantation of the gestational sac.

132 sponses to chemokines, abnormal trafficking, improper in situ positioning, and loss of polarity compo

133 We suggest three steps to identify improper inferences from migration data and to enhance u

134 d procedures to minimize the risk of bias or improper influence during development of the guidelines.

135 (PTSD) is thought to develop, in part, from improper inhibition of fear.

136 GFP-IBD may trigger premature or improper integrase oligomerization.

137 the incomplete list of siRNAs features, (ii) improper integration of the heterogeneous cross-platform

138 rant trafficking of the altered proteins and improper interaction with components of the cytoskeleton

139 nvironments, underscores the need to prevent improper interactions during folding and refolding of me

140 Consequently, scoring function terms for improper interactions received little weight in paramete

141 r periphery, FSHD likely arises instead from improper interactions with transcription factors or chro

142 y and recovery thereof that may even lead to improper interpretation of results.

143 operly into the clear fiber state and to the improper involution of cells from the anterior epitheliu

144 cal and experimental evidence indicates that improper involution plays a role in the development of t

145 urely to kinetochores and spindle, cementing improper k-MT attachments and leading to high rates of l

146 C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer formation in

147 Improper kinetochore attachments activate the spindle as

148 his tension contributes to the correction of improper kinetochore attachments and is opposed by the c

149 MCAKs act at kinetochores to correct improper kinetochore-microtubule (k-MT) attachments, and

150 phorylates kinetochore substrates to correct improper kinetochore-microtubule (KT-MT) attachments, wh

151 Aurora B functions to correct improper kinetochore-microtubule attachments and alert t

152 hosphorylation of prometaphase kinetochores, improper kinetochore-microtubule attachments and weakene

153 mechanism causing CIN is the persistence of improper kinetochore-microtubule attachments called mero

154 osome misalignment and missegregation due to improper kinetochore-microtubule attachments.

155 er chromosome congression, and correction of improper kinetochore-microtubule attachments.

156 Phosphorylation by Aurora B, which corrects improper kinetochore-microtubule connections in vivo, re

157 ured osteoblasts from Fbn1(-/-) mice exhibit improper latent TGF-beta activation as well, but mature

158 Improper lengths of actin-thin filaments are associated

159 in SLOS is defective Ret signaling owing to improper lipid raft composition or function.

160 me splitting, which we attribute in part, to improper localisation of the nuclear envelope protein TP

161 These data suggest that, in MFS, improper localization of latent TGFbeta complexes compos

162 Moreover, improper localization of these regulators hinders expans

163 that lack tumor-suppressor activity present improper localization.

164 ipi* states are shown to be artifacts of the improper long-range behavior of standard density-functio

165 Improper lubricin modification and degradation has been

166 defective lymphovenous valve morphogenesis, improper lymphatic drainage, defective lymphatic valve m

167 Monoculture and improper management may reduce soil fertility and deteri

168 se presentations of CSC is critical to avoid improper management.

169 Improper mass calibration, inadequate instrument optimiz

170 ults suggest that the neonatal lesion causes improper maturation, but not loss, of PFC interneurons d

171 Improper mechanical ventilation settings can exacerbate

172 rs aquatic environments through patient use, improper medicine disposal, and production.

173 Improper meiotic chromosome segregation causes condition

174 xcessive values reported due to selection of improper method of determination of Se in mushrooms rela

175 Improper methodology and reporting of RCTs can lead to e

176 rgence-time estimates were generated through improper methodology on the basis of a single calibratio

177 iated kinesin (MCAK) are required to release improper microtubule attachments.

178 We show that improper microtubule-chromosome attachment (merotely) is

179 l1/Aurora B protein kinase that destabilizes improper microtubule-kinetochore attachments.

180 any motor neurons from affected animals show improper mitochondrial distribution, characterized by ti

181 umulation at G(2)/M, massive DNA damage, and improper mitotic chromosome condensation.

182 -Set7 expression upon loss of HCF-1 leads to improper mitotic H4-K20 methylation and cytokinesis defe

183 Improper modeling of those relationships often results i

184 f the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to

185 roscopy that intersublattice exchange in the improper multiferroic cupric oxide (CuO) creates electro

186 rger mass of oligosaccharides, indicative of improper N-linked glycosylation addition and/or trimming

187 l errors in E- embryos were characterized by improper nervous system patterning of the usually carefu

188 , aberrant IL-6 transcription is mediated by improper NF-kappaB p65 phosphorylation and nuclear local

189 Improper nuclear localization of 4qter is discussed as a

190 We conclude that improper nuclear positioning contributes to muscle dysfu

191 These results link improper nuclear positioning specifically to the death o

192 eterogeneities, cell cycle asynchronies, and improper nuclear reprogramming.

193 sity to lack flagella or produce flagella in improper numbers or at nonpolar locations, indicating th

194 resolution limit makes partition density an improper objective function for global optimization.

195 These results suggest that the improper oligomeric assembly of DISC1-S704C may underlie

196 We show that specific improper operating conditions may even for advanced tech

197 electrode materials has been regarded as an improper option for rechargeable aluminium-ion batteries

198 or more phases of this process, thus causing improper or impaired wound healing.

199 Improper or inadequate actions taken after blood and bod

200 Improper or poor oxygen supply to cells within the tissu

201 ticularly in the spermatozoa midpiece due to improper oxidation and polymerization of sperm capsular

202 This is exemplified by improper pairing and synapsis of homologous chromosomes

203 orate correct nucleotides as well as to form improper pairings.

204 ormation and yield of particles and corrects improper particle morphology.

205 Improper pathway activation causes defects in axonal gui

206 Loss of Sema3d leads to improper patterning of the coronary veins, a phenotype r

207 These defects ultimately result in improper patterning of the embryonic central nervous sys

208 ked with cardiac dysfunction, allows for the improper physiological response in maintaining glucose a

209 Improper placement of nasogastric tube used for feeding

210 riphosphate (CTP) at position 76 arises from improper placement of the alpha phosphate of the incomin

211 s with preserved transport activity but with improper plasma membrane localization for rescue by the

212 chanism, failure in this process resulted in improper Plk1 recruitment to kinetochores, mitotic arres

213 quality control mechanisms that exclude the improper polymerase from a particular strand.

214 iminished replication, likely as a result of improper positioning of templates at the catalytic site.

215 rs plana vitrectomy (PPV) can occur owing to improper positioning of the infusion cannula in the supr

216 Improper post-exposure practices were identified, 9.8% d

217 Deleterious mutations caused improper posttranslational processing, incorrect disulfi

218 including developmental disorders, in which improper primary ciliogenesis and Hh signaling play a ma

219 ts in vitro, and the deletion of Mmp9 caused improper processing of DSP in natural teeth.

220 proteolytic capacity as a consequence of the improper processing of lysosomal hydrolases, which is de

221 In vitro cleavage demonstrated improper processing of pre-miRNA by DGCR8-E518K.

222 of paramount importance to all organisms, as improper progression through the cycle could result in d

223 rthermore, 12j administration suppressed the improper proliferation of Muller cells and promoted the

224 letion of Arp3 in primary melanocytes causes improper proliferation, spreading, migration and adhesio

225 L/+) mice an Ins2-Akita mutation that causes improper protein folding and islet apoptosis to lower pl

226 Our hypothesis is that improper protein maturation and incompletely folded stat

227 Vis-a-vis virion morphogenesis, an improper protein-protein interaction within an early ass

228 quiescent or differentiated cells results in improper re-entry into the cell cycle, again in an appar

229 Improper regeneration of the alveolar epithelium is ofte

230 afforded only a non-natural analogue through improper regiocontrol.

231 is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency disea

232 The data indicates that patients with improper regulation in the concentration of specific acu

233 stem has evolved to annul pathogens, but its improper regulation is linked with diseases.

234 Pmk1 activation in the absence of Mst11 and improper regulation of appressorium formation, the direc

235 DSBs are necessary for CSR, but improper regulation of DSBs can lead to chromosomal tran

236 ss of E6AP catalytic activity and likely the improper regulation of E6AP substrate(s) are important i

237 We found that improper regulation of IL-1beta production resulted in s

238 ution simulation of spc98/+ mutants revealed improper regulation of interpolar (iMT) and kinetochore

239 Several disease states are associated with improper regulation of nitric oxide production, making N

240 However, improper regulation of PCD by NF-kappaB can have severe

241 and age-related diseases that are linked to improper regulation of S6K1.

242 Aberrant formation or improper regulation of these interactions can easily lea

243 text of Hh signaling, or the consequences of improper regulation.

244 ntered using the graft's delivery system and improper reporting to the Food and Drug Administration.

245 Improper representation of surface conditions in CNTL ru

246 Taken together, these results suggest that improper repression of MeCP2, secondary to trisomic over

247 Improper sample preparation leads to detrimental cascade

248 loss of Mef2c in skeletal muscle results in improper sarcomere organization.

249 We examine factors such as improper scaling and biases in species representation as

250 nt repair of double-stranded DNA breaks, and improper segregation of sister chromosomes.

251 can cause genomic instability resulting from improper segregation of the broken fragments into daught

252 ects in heart development, consisting of the improper septation of the cardiac outflow tract (OFT) an

253 Improper setup can result in equipment malfunction or ma

254 The neural defects are associated with improper Shh expression in the underlying rostral axial

255 Improper signaling of the IL-36 receptor (IL-36R), a mem

256 ulin-A(SP24)D is inefficiently cleaved at an improper site, producing two subpopulations of molecules

257 98hc deletion in murine epidermis results in improper skin homeostasis and epidermal wound healing.

258 We showed that improper Smad2/3 signaling in Fbn1-null VSMC is in part

259 relationship from a pattern evaluated at the improper spatial scale.

260 Improper spatiotemporal expression of RA during developm

261 We show that improper specification and proliferation of second heart

262 esult from its intrinsic nature and not from improper specimen collection.

263 positioned spindle rather than inhibited by improper spindle position.

264 Huntington disease muscle was compromised by improper splicing and a corresponding reduction in total

265 ificant underestimates of concentrations and improper statistical model validation that, in turn, can

266 biogenic amine found in food products due to improper storage and poor hygiene.

267 the embryonic trachea that might result from improper stratification of the embryonic tracheal epithe

268 letion of a single allele of Gli1 results in improper stromal remodeling and perdurance of the inflam

269 veral limitations still exist; most notably, improper structural organization of neural cells and a l

270 2 and KPNA2, which is likely responsible for improper subcellular localization of DeltaValBRCA1.

271 pling may be falsely detected when employing improper surrogate methods.

272 In this model, an incomplete or improper switch would kinetically trap intermediates.

273 iscriminated, irrespective of their average (improper) symmetry.

274 Improper synapse formation in Spag6KO mice was associate

275 d GATA3 in the nascent TE lineage results in improper TE development, leading to failure in embryo im

276 tributed to Rankl up-regulation secondary to improper TGFbeta activation and signaling.

277 processing in stathmin(-/-) females leads to improper threat assessment, which in turn affects innate

278 Because improper timing or location of cell wall degradation wou

279 However, whether these defects contribute to improper tissue building in vivo requires further clarif

280 hampered by sub-optimal expression levels or improper tissue-specificity of particular promoters, or

281 A widely used assay to identify mutants with improper TPEV employs the URA3 gene at the telomere of c

282 and symmetry mode analysis indicate that the improper transition (T(C) = 1100 K) involves unit cell t

283 ide components, thereby clearing the cell of improper translation products and defective components o

284 amino acid substitution in Npt2a can lead to improper translocation of the protein to the cell membra

285 Furthermore, improper treatment contributes to increased antibiotic r

286 n circulation may result in misdiagnosis and improper treatments.

287 P1 mutant mice also had improper ureteral bladder insertion sites and shortened

288 ally normal, E15.5 Fgfr2(ST-/-) mice exhibit improper ureteral insertion sites into the bladder, cons

289 omes through incorrect diagnosis of disease, improper use of a given therapy, and irreproducible rese

290 s from these studies were also rated for the improper use of causal language and biased interpretatio

291 misleadingly citing others' results, and 4) improper use of causal language in citing others' work.

292 ased interpretation of one's own results, 2) improper use of causal language in describing one's own

293 ination of Se in mushrooms relate largely to improper use of flame atomic absorption spectroscopy (AA

294 ain contributors to poor health outcomes and improper use of health care among immigrants.

295 ures, as well as to identify adulteration by improper use of the rye-wheat flour ratios in bread maki

296 ansmission is limited due to inconsistent or improper use, as well as physical decay in effectiveness

297 per balloon use and 56.0% involved no use or improper use.

298 the morbidity and mortality associated with improper VAD self-care.

299 through questionable experimental design or improper validation methods.

300 an absence of labyrinth formation causing an improper vascularization of the placenta.