ライフサイエンスコーパス: impulsivity

1 eural director of reward-driven behavior and impulsivity.

2 psychopathology, cognitive dysfunction, and impulsivity.

3 anding of dopaminergic mechanisms underlying impulsivity.

4 I task, which associates with reward-related impulsivity.

5 faculties whose deficiency can contribute to impulsivity.

6 te that the CLA-PFC pathway is essential for impulsivity.

7 nts also completed self-reported measures of impulsivity.

8 c contributions to individual differences in impulsivity.

9 discounting, decision-making, and reflection impulsivity.

10 ted to differences in pre- and postoperative impulsivity.

11 ationship to inter-individual differences in impulsivity.

12 ions of ADHD - inattention and hyperactivity/impulsivity.

13 in lateral and medial prefrontal regions for impulsivity.

14 at the claustrum-prefrontal cortex regulates impulsivity.

15 re available for meta-analysis of reflection impulsivity.

16 ainty was related to increased postoperative impulsivity.

17 ing this system in either direction elevates impulsivity.

18 (p value < 0.0001) in specific hyperactivity/impulsivity.

19 ssociated with this self-reported measure of impulsivity.

20 derived from a combination of depression and impulsivity.

21 rected context and individual differences in impulsivity.

22 llidum had a positive correlation with total impulsivity.

23 ts in reducing psychostimulant-induced motor impulsivity.

24 ive-limbic subthalamic nucleus in decisional impulsivity.

25 ssion were included as a model of disordered impulsivity.

26 ssion and sex were significant covariates of impulsivity.

27 ms by which OXR blockade may influence motor impulsivity.

28 nd delay discounting are forms of decisional impulsivity.

29 ric disorders, which present with disordered impulsivity.

30 ntagonists to attenuate acute cocaine-evoked impulsivity.

31 ventral SN network was associated with motor impulsivity.

32 ociated with better neurocognition and lower impulsivity.

33 exhibited poorer decision making and greater impulsivity.

34 lability as well as SI variability, but not impulsivity.

35 ling for the effect of higher aggression and impulsivity.

36 sorder is mainly associated with attentional impulsivity.

37 d to psychopathology than are other forms of impulsivity.

38 and empirically distinct from other forms of impulsivity.

39 ogenesis of anxiety or reckless behavior and impulsivity.

40 t sensory detection, sustained attention and impulsivity.

41 rse neuropsychiatric side-effects, including impulsivity.

42 tion to treat conditions featuring excessive impulsivity.

43 Within the three broad domains of impulsivity, 4 parameters (delay discounting of rewards

44 re was evidence of moderate heritability for impulsivity (A(2) = 0.33), modest additive genetic or co

45 Impulsivity, a multifaceted behavioral hallmark of atten

46 Impulsivity, a predisposition toward rapid unplanned rea

47 Impulsivity, a risk factor across the addictions, has al

48 This meta-analysis indicates heightened impulsivity across a range of cognitive domains in Gambl

49 accommodates the commonalities of apathy and impulsivity across disorders and reveals their cognitive

50 ) has been associated with high impulsivity, impulsivity across multiple domains has not been thoroug

51 of CLA-PFC pathway in selectively regulating impulsivity, activation of the claustrum disrupted atten

52 uding (i) the assessment of either apathy or impulsivity alone, despite their frequent co-existence;

53 a fast life-history strategy, one marked by impulsivity and a focus on short-term goals.

54 Here, we sought to examine how trait impulsivity and acute stress exposure affect participant

55 s support a developmental imbalance model of impulsivity and are consistent with the idea that negati

56 Thus, inherent motor impulsivity and binge-like eating are linked and the vmP

57 To explore the relationship between motor impulsivity and binge-like eating in rodents, we identif

58 NAcSh pathway significantly suppressed motor impulsivity and binge-like intake for high-fat food.

59 We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI,

60 Consideration of differential baseline impulsivity and body weight may resolve previous seeming

61 Impulsivity and compulsivity are traits relevant to a ra

62 Here, we reconceptualised impulsivity and compulsivity as partially overlapping ph

63 measuring psychological processes related to impulsivity and compulsivity.

64 Positive associations were found between impulsivity and consumption of alcoholic beverages and a

65 oup displayed elevated levels of self-report impulsivity and delay discounting, and increased risk-ta

66 bility to diseases associated with excessive impulsivity and demonstrates the added explanatory power

67 Individual differences in impulsivity and early adversity are known to be strong p

68 ere used to analyze the associations between impulsivity and energy intake, food-group consumption, d

69 into the pathophysiological underpinnings of impulsivity and especially medication and DBS-associated

70 of impulsivity (response impulsivity, choice impulsivity and impulsive tendency) varied between GD pa

71 pathophysiology of disorders associated with impulsivity and may inform the development of circuit-ba

72 sion; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of mode

73 eal a specific neural circuit that regulates impulsivity and provide evidence of a novel function for

74 Due to increased impulsivity and risk for mania, however, depressed indiv

75 Increased impulsivity and risk-taking in GD are present in biologi

76 establish an objective behavioral marker of impulsivity and show that DBS affects impulsivity by amp

77 and a battery assessing emotion, motivation, impulsivity and social cognition (EMOTICOM).

78 Impulsivity and social-networks-use-disorder symptoms we

79 novel, largely interactive effects of trait impulsivity and stress exposure and suggest that stress

80 Impulsivity and stress exposure are two factors that are

81 lity to measure the components of apathy and impulsivity and their associated neural correlates acros

82 However, the neurobiological bases of impulsivity and their relation to antisocial behavior an

83 ural and functional underpinnings of waiting impulsivity and tics using multi-modal neuroimaging prot

84 cterize correlations between the measures of impulsivity and to identify covariates.

85 ility to withhold prepotent responses (motor impulsivity) and binge intake of high-fat food (HFF) see

86 ay of predisposing personality traits (e.g., impulsivity), and reductions in cognitive functions (e.g

87 positive emotion enhancement and behavioral impulsivity, and another associated with negative emotio

88 ith higher baseline EDVR self-reported lower impulsivity, and discounted rewards as a function of del

89 sed reactivity to imminent handling, waiting impulsivity, and enhanced motivation for reward.

90 y age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adultho

91 re deficits in motor and inhibitory control, impulsivity, and inattention associated with attention-d

92 ding family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would

93 effect of vmPFC-frontoparietal connectivity, impulsivity, and reinforcement on choice quality (p < 0.

94 characteristics of patients, such as gender, impulsivity, and severity of cannabis use, when selectin

95 transient symptoms of hypomania, agitation, impulsivity, and sleeping disorders.

96 ration provides new insights into apathy and impulsivity, and the need for a joint therapeutic strate

97 p of striatal dopaminergic activity to trait impulsivity, and the view that there is a non-linear, po

98 sivity, as proposed by theoretical models of impulsivity, and their associations with GD severity.

99 escents may be causal, whereas hyperactivity-impulsivity appears to act indirectly, through shared pr

100 Apathy and impulsivity are common and disabling consequences of fro

101 that psychiatric traits of compulsivity and impulsivity are linked to regionally specific reductions

102 ur findings confirm that multiple domains of impulsivity are relevant in GD.

103 mphasize roles for positive emotionality and impulsivity as well.

104 Motor impulsivity, as measured by premature responses in the 5

105 e relationships between these three types of impulsivity, as proposed by theoretical models of impuls

106 , this shift was dependent on rats' inherent impulsivity because high impulsive rats demonstrated a g

107 ets were found in both groups, with response impulsivity being the only domain associated with GD sev

108 We describe differences in impulsivity between and within two dog breeds with worki

109 r breeders may reduce average differences in impulsivity between breeds in show lines.

110 selection might have lessened differences in impulsivity between breeds.

111 show lines selected for different levels of impulsivity: Border Collies (herding work) and Labrador

112 accumbens (NAc) controls multiple facets of impulsivity but is a heterogeneous brain region with div

113 as associated with symptoms of hyperactivity-impulsivity but not inattention.

114 owever, LTMs self-reported lower attentional impulsivity, but higher motor and non-planning impulsivi

115 everity did not account directly for waiting impulsivity, but this effect was mediated by connectivit

116 in 1B receptors (5-HT1BRs) in aggression and impulsivity, but this has never been evaluated in humans

117 to impaired value-based decision-making and impulsivity, but whether these risk factors share neural

118 ker of impulsivity and show that DBS affects impulsivity by amplifying automated responding.

119 claustrum to the prefrontal cortex regulates impulsivity by using the designer drugs (DREADDs)-based

120 This study provides evidence that impulsivity can be genetically separated into distinct c

121 etworks that underlie dissociable aspects of impulsivity (cf. choosing and stopping).

122 etween three facets of impulsivity (response impulsivity, choice impulsivity and impulsive tendency)

123 -off encompasses elements of risk-taking and impulsivity-common behaviors in psychiatric disorders-an

124 dicated TD patients showed increased waiting impulsivity compared to controls, which was independent

125 onto-parietal control mechanisms and greater impulsivity/compulsivity scores.

126 ajectories, functional network activity, and impulsivity/compulsivity-related features may lend furth

127 The waiting type of motor impulsivity, defined as the difficulty to withhold a spe

128 s) on a Go/NoGo task and measured decisional impulsivity (delay discounting) using the Monetary Choic

129 ty to predict adaptive outcomes may activate impulsivity, delay discounting, and reward seeking.

130 tivity was higher for behavioural indices of impulsivity, derived from clinician-administered tasks a

131 Impulsivity describes the tendency to act prematurely wi

132 is not in general considered as a product of impulsivity, despite a frequent association with attenti

133 w studies have explored the relation between impulsivity, dietary intake, and eating disorders (EDs)

134 with alcoholism demonstrate increased motor impulsivity during abstinence; however, the neuronal mec

135 ontoparietal connectivity, and the impact of impulsivity during decision-making in depressed individu

136 ortex (vmPFC) contributes to increased motor impulsivity during protracted abstinence from long-term

137 the available evidence, suggesting increased impulsivity during withdrawal.

138 e also found similar levels of hyperactivity/impulsivity, emotional lability, and impairment in males

139 verity is associated with higher attentional impulsivity, especially if there are additionally reduct

140 Associations between impulsivity facets were found in both groups, with respo

141 Research indicates that impulsivity features of ADHD account for a degree of thi

142 hemical mechanisms contributing to increased impulsivity following long-term alcohol exposure and hig

143 tentially responsible for dysregulated motor impulsivity following long-term alcohol exposure.

144 f neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives.

145 Measures of apathy and impulsivity frequently loaded onto the same components r

146 Waiting impulsivity has a preclinical basis as a predictor for t

147 Impulsivity has been suggested as a neurocognitive endop

148 Although a number of genes for impulsivity have been identified, no study to date has c

149 d ratio: 1.74, 95% CI=1.03-2.93), and higher impulsivity (hazard ratio: 1.17, 95% CI=1.00 to 1.37) we

150 ter variant at rs12765063 is associated with impulsivity, hyperactivity and addiction-related phenoty

151 al manganese (Mn) exposure with inattention, impulsivity, hyperactivity, and oppositional behaviors,

152 nor produce changes in neural correlates of impulsivity (i.e. frontostriatal gray matter, functional

153 Troubled mood, higher impulsivity (i.e., positive and negative urgency) and cu

154 It is unclear which type of impulsivity, if any, is intrinsically related to TD and

155 ments aimed at targeting specific aspects of impulsivity improve outcomes.

156 disorder (GD) has been associated with high impulsivity, impulsivity across multiple domains has not

157 ructural correlates of sensation seeking and impulsivity in a large cohort of healthy young adults.

158 HT2 receptor induced head twitch response or impulsivity in a serial reaction time task (SRTT), where

159 in mice, we collected behavioral measures of impulsivity in a single cohort of mice using well-valida

160 ction time task, 4CSRTT) to assess 'waiting' impulsivity in a youth sample (N = 99, aged 16-26 years)

161 Greater impulsivity in all three domains was found in men with G

162 Males displayed increased impulsivity in both dimensions, whereas 5-HT1BR expressi

163 behavioral level, training overload enhanced impulsivity in economic choice, which was captured by a

164 to identify genetic markers associated with impulsivity in experimental animals.

165 the neurocognitive components of apathy and impulsivity in frontotemporal lobar degeneration syndrom

166 ctions from the CLA to the PFC in regulating impulsivity in male rats.

167 a functional link that may help explain high impulsivity in methamphetamine-dependent individuals.

168 Impulsivity in Parkinson's disease may be mediated by fa

169 We aimed to assess the hypothesis that impulsivity in PD is associated with Pavlovian bias, and

170 Our findings suggest that impulsivity in PD patients may be influenced by subjecti

171 and especially medication and DBS-associated impulsivity in PD.

172 top-signal reaction time, indicating greater impulsivity in proportion to the loss of each neurotrans

173 selective 5-HT2CR agonist WAY163909 reduced impulsivity in PWSICdel mice but had no effect on WT beh

174 Here we assess decisional impulsivity in subjects with obsessive compulsive disord

175 Overall, the results suggest that waiting impulsivity in TD was related to tic severity, to functi

176 anatomy predicts sensation seeking and motor impulsivity in the healthy populations, potentially incr

177 y, behavioural apathy was reported alongside impulsivity in the majority of patients with impulse con

178 Waiting impulsivity in unmedicated patients with TD also correla

179 Heightened impulsivity in youth was significantly and specifically

180 rrent anxiety, depression, hyperactivity and impulsivity, inattention, and conduct problems.

181 luded anxiety, depression, hyperactivity and impulsivity, inattention, conduct problems, and psychoti

182 motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms,

183 nts were used to assess latent constructs of impulsivity, including trait impulsiveness and compulsiv

184 Behavioral data showed that choice impulsivity increased in a group of participants who per

185 cies toward increased reward sensitivity and impulsivity, increasing the likelihood of engaging in ri

186 icotine and alcohol use variables as well as impulsivity inhibitory control variables but explain onl

187 telencephalon neural pathway for regulating impulsivity involving communication from melanin-concent

188 Impulsivity is a common symptom in Parkinson's disease (

189 Impulsivity is a multidimensional construct.

190 Impulsivity is a psychological trait linked to health is

191 ated with substance use and ADHD, suggesting impulsivity is an endophenotype contributing to these ps

192 Impulsivity is an endophenotype found in many psychiatri

193 Impulsivity is an endophenotype of vulnerability for com

194 We found that increased motor impulsivity is associated with reduced recruitment of gl

195 Behavioral impulsivity is common in various psychiatric and metabol

196 hibitory function but its role in decisional impulsivity is less well-understood.

197 airs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse co

198 ty for response inhibition, and this form of impulsivity is significantly associated with heightened

199 evelopmental traits, namely compulsivity and impulsivity, is tied to a reduced growth of these MT tra

200 important adverse impact on behaviour, with impulsivity its most widely reported manifestation.

201 Stress and impulsivity levels interacted to drive faster choices ov

202 al change, with more frequent disinhibition, impulsivity, loss of empathy and repetitive behaviours.

203 Decision-making impulsivity may extend to problem (at-risk) gambling, bu

204 We report that heightened waiting impulsivity, measured as premature responding on the 4CS

205 f adult rats phenotyped for one dimension of impulsivity, namely premature responding on the five-cho

206 d some overlapping effects; namely, elevated impulsivity (negative urgency) and increased risk-taking

207 use model, saccharin exposure produced motor impulsivity not only in the saccharin-exposed males but

208 h premature responding, the index of waiting impulsivity on the 4CSRTT.

209 pulsivity, but higher motor and non-planning impulsivity on the BIS-11 than MNPs.

210 week mindfulness intervention did not reduce impulsivity on the go/no-go task or Barratt Impulsivenes

211 ivity: R1 was not associated with decisional impulsivity on the MCQ or inhibitory control on the Go/N

212 We did not observe impaired motor impulsivity on the stop-signal task.

213 Moderating effects of impulsivity on vmPFC-frontoparietal connectivity were as

214 symptoms, both inattention and hyperactivity-impulsivity, on the development of smoking in male and f

215 es were related to a psychometric measure of impulsivity or impulsive behaviors in general.

216 Given the absence of TLPH relationships to impulsivity or neurobiological metrics, differences betw

217 hours (TLPH) did not significantly relate to impulsivity or neurobiological metrics.

218 , several regions were found correlated with impulsivity or risky behaviors in AD and RD values, alth

219 in ASPD, as well as their relationship with impulsivity or risky behaviors.

220 igated their correlations with the scores of impulsivity or risky behaviors.

221 ed with the maximum post-operative change in impulsivity over a six month follow up period.

222 tal connectivity was negatively moderated by impulsivity (p(FWE corrected) < 0.05).

223 s are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the rel

224 ll but statistically significant decrease in impulsivity postoperatively, as quantified by the Barrat

225 vitro - and decision-making characterized by impulsivity, present focus, and an inability to delay gr

226 t, among other functions, compute reward and impulsivity processes.

227 ng for cognitive performance, comorbidities, impulsivity, psychotropic exposure, and possible brain d

228 n the stop-signal reaction time task test of impulsivity, PWSICdel mice showed increased impulsivity

229 ion with myelination was specific to waiting impulsivity: R1 was not associated with decisional impul

230 TN-DBS was not associated with postoperative impulsivity; rather, these relationships were only obser

231 ighlight that ventral striatal CREM mediates impulsivity related to substance abuse and suggest that

232 We investigated the association between impulsivity related traits and BMI at the observational

233 icidal ideation combined with depression and impulsivity, related to reduced motivational control.

234 ormed a Go/No-Go task during fMRI, completed impulsivity-related assessments, and provided monthly re

235 y may be a novel target for the treatment of impulsivity-related brain disorders.

236 ity with broader translational relevance for impulsivity-related disorders in humans.

237 al role of this neural pathway in regulating impulsivity-related disorders such as drug addiction.

238 study may shed light on the understanding of impulsivity-related disorders such as drug addiction.SIG

239 impulsivity, PWSICdel mice showed increased impulsivity relative to wild-type (WT) littermates.

240 sponse element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability.

241 , an association with specific hyperactivity/impulsivity remained significant.

242 whether associations between three facets of impulsivity (response impulsivity, choice impulsivity an

243 een involved in various behaviors, including impulsivity, response to antidepressants, and response t

244 ncoding of the sensory stimulus, acted as an impulsivity signal, overriding sensory evidence to dicta

245 t is influenced by individual differences in impulsivity.SIGNIFICANCE STATEMENT In delay discounting,

246 estimates were significantly associated with impulsivity; specifically, increased uncertainty was rel

247 thway also regulates methamphetamine-induced impulsivity, suggesting a critical role of this neural p

248 The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019)

249 BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025)

250 ticipants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were asso

251 rs reported on inattention and hyperactivity/impulsivity symptoms in questionnaires at 8 years.

252 Hyperactivity/impulsivity symptoms were not related to maternal fever.

253 sychiatric symptoms, including psychotic and impulsivity symptoms, may be beneficial among people at

254 to a specific association with hyperactivity/impulsivity symptoms.

255 e improvement, particularly of hyperactivity-impulsivity, symptoms of inattention are more persistent

256 More symptoms of hyperactivity/impulsivity (t = -2.63; P = .008) and inattention (t = -

257 ildren, second edition [KABC-II]), attention/impulsivity (Tests of Variables of Attention [TOVA]), mo

258 iculties with overactivity, inattention, and impulsivity that are just under the threshold to meet fu

259 idual differences in decision-making tied to impulsivity that are not readily apparent in the absence

260 a potential therapeutic target for increased impulsivity that may contribute to relapse risk.SIGNIFIC

261 to physiological anxiety, compulsivity, and impulsivity; the other linking enhanced threat learning

262 ructure and that stimulation acts to mediate impulsivity through differential recruitment of frontost

263 et the neurobiological underpinnings linking impulsivity to disease remain poorly understood.

264 Despite the centrality of impulsivity to neurobiological models of Gambling Disord

265 genes associated with the expression of the impulsivity trait.

266 healthy controls, we assessed waiting motor impulsivity using a behavioral task, as well as structur

267 We derived dimensions of apathy and impulsivity using principal component analysis and emplo

268 We measured 14 impulsivity variables using three broad categories: impu

269 Of the 14 impulsivity variables, rs3751812 T was associated with m

270 Impulsivity was also positively associated with snacking

271 cross-sectional study was to assess whether impulsivity was associated with energy intake, food-grou

272 Impulsivity was associated with food intakes, snacking,

273 Change in hyperactivity-impulsivity was associated with heritable change in whit

274 Impulsivity was associated with higher action-reward bia

275 Impulsivity was estimated with a temporal discounting ta

276 Impulsivity was evaluated using two approaches: (i) neur

277 Impulsivity was not associated with grey matter volume.

278 2, an interaction of the group with RSFC on impulsivity was observed.

279 Impulsivity was positively associated with energy intake

280 the day confirmed that enhancement of choice impulsivity was related to a specific decrease in the ac

281 Stronger impulsivity was reliably found across three independent

282 Greater temporal discounting (more impulsivity) was associated with 1) lower volume in fron

283 Such interaction effects between stress and impulsivity were also found on decision speed.

284 alyses revealed that different components of impulsivity were associated with distinct variations in

285 frequency and characteristics of apathy and impulsivity were determined by neuropsychological and be

286 Dopamine levels and resultant variation in impulsivity were likely under differential selection in

287 Apathy and impulsivity were present across diagnostic groups, despi

288 ogies induce fast strategy behaviors such as impulsivity, whereas resource-sufficient and predictable

289 cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors

290 to be more specific to decisional than motor impulsivity, which might reflect differences in ventral

291 Hyperactivity-impulsivity, while also more strongly related to smoking

292 value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN networ

293 liefs and was dissociated from participants' impulsivity, willingness to take risks, and mood.

294 s and putative neurobiological mechanisms of impulsivity with broader translational relevance for imp

295 for studying the pathogenesis of anxiety and impulsivity with inclusion of sex as a biological variab

296 causally implicated in increasing decisional impulsivity with less accumulation of evidence during pr

297 c neural activity depended on rats' inherent impulsivity, with impulsive rats exhibiting a stronger n

298 FC pathway prevented methamphetamine-induced impulsivity, without affecting methamphetamine-induced h

299 sed attention), and finally to hyperactivity-impulsivity (working memory beta = -0.014 (CI: -0.038 to

300 We predicted that baseline impulsivity would moderate L-DOPA effects.