1 (T2D) is a complex and polygenic disease yet
in need of a complete picture of its development mechani
2 New faculty are
in need of a formal program endorsed by their administra
3 matched donors is feasible for most patients
in need of a HCT, and could lower GVHD and increase avai
4 of homophily is that the people who are most
in need of a health innovation may be among the least li
5 ion coverage--the proportion of a population
in need of a health intervention that actually receives
6 over 4 million volunteer donors for patients
in need of a hematopoietic stem cell transplant.
7 The majority of patients
in need of a hematopoietic-cell transplant do not have a
8 pital care, he developed mediastinitis, were
in need of a laparascopy and intensive care.
9 D allocation policy, patients that are least
in need of a liver transplant now receive the highest-ri
10 Psychiatry is
in need of a major overhaul.
11 The field is greatly
in need of a more unified approach to its definition and
12 n of patients with severe TBI and severe TBI
in need of a neurosurgical intervention were similar in
13 d not help identify patients with severe TBI
in need of a neurosurgical intervention.
14 77 patients (1%) with a GCS score of 15 were
in need of a neurosurgical operation, and fewer than 51
15 pharmacology, has left integrin therapeutics
in need of a new strategy.
16 Seventeen patients (20 total sites),
in need of a non-molar extraction and delayed implant pl
17 al dominant polycystic kidney disease (APKD)
in need of a renal transplant.
18 nical decisions; policy makers are similarly
in need of a rigorous patient-centered, comparative effe
19 be defined as the proportion of a population
in need of a service that resulted in a positive health
20 a-cells after expansion is still a challenge
in need of a solution.
21 e origin and maintenance of SSB is a problem
in need of a solution.
22 family, with the first person in that group
in need of a transplant being prioritized to receive a k
23 they were preliminary matches with patients
in need of a transplant.(1) The study found that people
24 The field is
in need of a user-friendly tool to examine spatiotempora
25 y before their recipient is matched, or even
in need of,
a kidney transplant, and deceased donor init
26 ) > or =5 mm and bleeding upon probing (BOP)
in need of access flap surgery (AFS).
27 nal EBF variability and identify populations
in need of additional breastfeeding support.
28 al circuitry that remain opaque and that are
in need of additional experimentation to enrich our unde
29 and we identify future challenges and areas
in need of additional research.
30 viduals with occult opportunistic infections
in need of additional screening.
31 ent population of which many are elderly and
in need of additional therapies.
32 However, the most important areas
in need of advancement, outcome studies and new therapeu
33 hich patients develop severe disease and are
in need of aggressive treatment.
34 vent ART interruptions for patients with HIV
in need of alloBMT.
35 h has collected HLA typing from CLL patients
in need of allogeneic hematopoietic stem cell transplant
36 The majority of patients are not
in need of an acute intervention beyond decongestion, an
37 Many infectious diseases are still
in need of an effective vaccine including HIV, malaria,
38 hese 2 techniques in female patients who are
in need of an elective cholecystectomy.
39 infections, and better targeting of children
in need of antibiotic prescription.
40 children with severe infections and children
in need of antibiotic treatment.
41 iliar that they rarely strike us as standing
in need of any explanation in the first place.
42 % (92.2-92.9) of individuals would have been
in need of ART with immediate initiation, initiation at
43 ound a substantial population to be viremic,
in need of ART, and at risk for transmission.
44 survival time, the proportion of individuals
in need of ART, and the proportion of individuals with H
45 However, the quantity of chemicals
in need of assessment and the challenges of species extr
46 d (ca 4000 species) of all freshwater fishes
in need of assessment by 2020.
47 se at the highest risk for asthma burden and
in need of assistance.
48 Questions currently
in need of attention include how to identify and treat p
49 p investigators to focus on key aspects most
in need of attention when reporting PROs in future trial
50 Among adolescents
in need of behavioral health services, co-occurring diso
51 The lipidomics community is
in need of benchmark reference values to assess the vali
52 es are devastating conditions that are still
in need of better understanding, and both oligodendrocyt
53 , and discussion of the report with patients
in need of cardiac surgery.
54 sis has been recognised as an abnormal state
in need of care throughout history and by diverse cultur
55 also experienced by individuals who are not
in need of care.
56 e to expand prison populations with patients
in need of care.
57 odulated by precursor binding is complex and
in need of careful dissection.
58 nguishing non-cancerous specimens from those
in need of careful examination and could help save time
59 nical practices in oxygen administration are
in need of change based on the increasing understanding
60 tributions and resources available to people
in need of chronic illness management and support.
61 ment of biomarkers of IBD activity and areas
in need of clarification from regulatory agencies and so
62 s are promising, particularly for candidates
in need of CLDLITx.
63 , therefore, target NEC infants who are most
in need of close monitoring and those who may benefit fr
64 be important for identification of patients
in need of closer cardiovascular monitoring.
65 r clinical diagnosis as it may flag patients
in need of closer monitoring.
66 are needs constitute a vulnerable population
in need of comprehensive and accessible care.
67 t could be used to routinely screen patients
in need of comprehensive follow-up.
68 retical calculations so far, which have been
in need of confirmation from real catalysis.
69 Waterlogged archaeological wood is often
in need of consolidation prior to drying to prevent shri
70 al or a pool of deleterious alleles that are
in need of constant suppression.
71 We also identify areas
in need of continuing research, to answer the fundamenta
72 work structure, whose relative importance is
in need of continuing study.
73 sfied was defined as the proportion of women
in need of contraception who were using a contraceptive
74 lowing surgery for signs of ongoing bleeding
in need of control.
75 dical diagnosis of asthma, identifying those
in need of corticosteroid therapy.
76 Early identification of nontrauma patients
in need of critical care services in the emergency setti
77 ortunities, challenges, solutions, and areas
in need of development.
78 We first quantified the population
in need of diabetes diagnosis and care by estimating the
79 Those
in need of dietary change at baseline (n = 210) were exa
80 ative assessment might help screen for those
in need of earlier intervention.
81 y to undergo spontaneous clearance and those
in need of early antiviral therapy.
82 and mortality make cancer a health challenge
in need of effective and better tolerated therapeutic ap
83 oorly understood at the genetic level and is
in need of effective therapeutic approaches.
84 vanced form of cerebral small vessel disease
in need of efficacious therapeutic strategies.
85 produced in biology research, scientists are
in need of efficient data analysis methods.
86 d of identifying DRI nutrients that are most
in need of either a new or an updated systematic review.
87 lity, and identify children < 5 years of age
in need of emergency chelation therapy for lead poisonin
88 ly evaluate, prepare, and transport patients
in need of emergent surgery.
89 Decision makers worldwide are
in need of empirical data to inform and implement emerge
90 environment which are largely unexamined and
in need of empirical data.
91 decision-making are particularly complex and
in need of enhancements.
92 t a bare-minimum estimate of rectal bleeding
in need of evaluation and treatment.
93 24 604 individuals with rectal bleeding are
in need of evaluation in Sierra Leone.
94 this review, we put forward the main issues
in need of evidence and propose a different approach to
95 stion whether depletion is a real phenomenon
in need of explanation.
96 el1p targets telomerase to the DNA ends most
in need of extension.
97 Patients
in need of extraction of a single posterior tooth (premo
98 Twenty-four consecutive subjects
in need of extraction of maxillary premolars were recrui
99 Given the extent of western forests
in need of fire restoration, efficiently allocating trea
100 independent cohorts of symptomatic patients
in need of first-line immunochemotherapy (151 patients f
101 bsence of eLAP are at high risk of death and
in need of focused attention.
102 l subgroups, however fewer than 50% of women
in need of FP use modern contraception in Senegal.
103 mong the top 10 proteins of unknown function
in need of functional characterization, while YeaZ and Y
104 ication of many novel mitochondrial proteins
in need of further characterization.
105 Career development issues are broad and
in need of further development by the Society of Critica
106 for analyzing network-level observations is
in need of further development.
107 eria leading to predictable regeneration are
in need of further exploration.
108 fidence intervals for accuracy estimates are
in need of further improvement.
109 to which age modifies these associations is
in need of further investigation in large, community-bas
110 Limitations and issues
in need of further investigation include the following:
111 Areas
in need of further investigation include the mechanism(s
112 avin-mediated taxis, and highlight key areas
in need of further investigation.
113 natural host-microorganism communication is
in need of further investigation.
114 these data into practice, highlighting areas
in need of further investigation.
115 nd its association with clinical outcomes is
in need of further investigation.
116 and therapies and highlight important areas
in need of further investigation.
117 e been accumulating in RNA databases and are
in need of further molecular characterization.
118 reliable method to identify cancer survivors
in need of further neurocognitive follow-up.
119 expected outcomes, while highlighting areas
in need of further research and technological advancemen
120 Finally, we will outline areas
in need of further research because understanding the re
121 using an evidence-based approach, and areas
in need of further research were identified.
122 e in patients with PEW, and highlights areas
in need of further research.
123 ghted as an area of clinical concern and one
in need of further research.
124 ective in stable cirrhotic patients, but are
in need of further study in patients with more advanced
125 Areas
in need of further study were identified.
126 ological mechanisms driving this outcome are
in need of further study, trematode infections appear to
127 ion of category, rather than a criterion set
in need of further study, will provide greater legitimac
128 ns when possible, and suggest areas that are
in need of further study.
129 ltifunctional nonparenchymal cell population
in need of further study.
130 oReview will help to pinpoint the areas most
in need of further study.
131 th gaps in knowledge are identified as areas
in need of further study.
132 nd highlight important outstanding questions
in need of further study.
133 ith hoarding symptoms represent a population
in need of further treatment research.
134 film formation must be approached as a model
in need of further validation, rather than utilized as a
135 s, their treatment, and areas of uncertainty
in need of future investigation.
136 ific goals of identifying areas particularly
in need of future research and of articulating an initia
137 e treatment options; and (3) highlight areas
in need of future research.
138 may serve to direct glucose into the muscles
in need of glycogen replenishment.
139 a BL from an alternative class for patients
in need of gram-negative antibiotic coverage.
140 impaired adolescents is a salient challenge
in need of greater attention and further research.
141 ts with chronic illness is a serious problem
in need of greater recognition and intervention and furt
142 sthospital care options are ill-prepared and
in need of guidance.
143 dly growing age group globally, and are most
in need of health care and assistance.
144 d health outcomes in remote populations most
in need of health services.
145 s a rationale for service provision to those
in need of help who could not previously access it and t
146 , of those adolescents who were likely to be
in need of help, only about 9% received treatment.
147 e than 300 000 people in Nepal are currently
in need of herniorrhaphy.
148 assessment of dietary acrylamide exposure is
in need of high quality methods for evaluating dietary e
149 These patients are
in need of high surveillance.
150 ments will be of great value to applications
in need of high-throughput yet sensitive flow cytometry
151 reatment option in selected and fit patients
in need of highly active first-line therapy.
152 associated with a substantial burden of RTIs
in need of hospitalization.
153 All patients with acute ischemic stroke are
in need of hyperacute secondary prevention because the r
154 Answering pages from nurses about patients
in need of immediate attention is one of the most diffic
155 hostile attributions may help identify those
in need of immediate practitioner input and/or referral
156 rs that allow the identification of patients
in need of impending mechanical ventilation.
157 (HFpEF) is a heterogeneous clinical syndrome
in need of improved phenotypic classification.
158 Hypertension is a heterogeneous syndrome
in need of improved subtyping using phenotypic and genet
159 ted with high morbidity and mortality and is
in need of improved therapeutic interventions.
160 riod), is a significant public health burden
in need of improved treatment.
161 in guiding investigators towards areas most
in need of improved treatment.
162 ld, the body of work also exposes some areas
in need of improvement in study design, selection of out
163 Some areas
in need of improvement were identified, such as hydrophi
164 tion to skill retention, and other areas are
in need of improvement.
165 mathematical formulations are appropriate or
in need of improvement.
166 verview of the field and identify areas most
in need of improvement.
167 new or stricter protections and 514 species
in need of improvements to fisheries management.
168 rapidly proliferating cancer cells that are
in need of increased protein synthesis.
169 ort, enables early identification of infants
in need of increased surveillance for TR-ROP.
170 rk to date has further highlighted the areas
in need of innovation as we continue to strive to improv
171 set of patients with carotid atherosclerosis
in need of intensified medical therapy or carotid artery
172 the neutropenic and nonneutropenic patients
in need of intensive care unit care, mortality, or attri
173 tant system for identifying complex patients
in need of intensive care.
174 entifying those with Barrett's esophagus and
in need of intensive surveillance, to an increasing numb
175 It remains a neglected tropical disease
in need of international recognition.
176 n health and identify population groups most
in need of intervention programs.
177 provide a framework for identifying families
in need of intervention.
178 epends on early identification of those most
in need of intervention.
179 ging larger associated environmental impacts
in need of investigation.
180 health behavior, especially among those most
in need of it.
181 Proper care of young children
in need of kidney transplant (KT) requires many skilled
182 rows, residents of the United States who are
in need of kidney transplantation occasionally contract
183 justice and reduces the potential for people
in need of kidneys in low-income and medium-income count
184 els are well-suited to identify ICU patients
in need of life-saving interventions prior to the occurr
185 technologies and training, and many patients
in need of local therapy, SBRT has found a place in the
186 sons displaced by war are a vulnerable group
in need of long-term health surveillance for psychiatric
187 bstruction (11.7%), and anastomotic stenosis
in need of mechanical dilatation (10.7%).
188 Furthermore, nearly 60% of youth
in need of mental health services do not receive the car
189 hile we recognize RECIST is far from perfect-
in need of modification as a measure of efficacy for som
190 d for early stratification of acute patients
in need of more aggressive treatment.
191 ent that species recognition in the group is
in need of more attention, and that many basic assumptio
192 d standardization of therapeutic approach is
in need of more careful study.
193 The world is
in need of more effective approaches to controlling tube
194 nt, which often includes a taxane, are still
in need of more effective combination therapies.
195 arcoma has a high mortality rate and remains
in need of more effective therapeutic approaches.
196 is a common soft-tissue sarcoma of childhood
in need of more effective therapeutic options.
197 fection constitutes a serious health problem
in need of more effective therapies.
198 ion constitutes a significant health problem
in need of more effective therapies.
199 may constitute an additional high-risk group
in need of more frequent skin cancer screening.
200 till an infant field, and we highlight areas
in need of more research, both theoretical and empirical
201 cline and depression, helping identify those
in need of more specialist neurological assessment and t
202 the preferred strategy in patients with T1D
in need of multivessel revascularization.
203 nefit in patients with type 1 diabetes (T1D)
in need of multivessel revascularization.
204 was found between the proportion of patients
in need of neurosurgery with GCS scores of 3 to 8 and th
205 nts with severe traumatic brain injury (TBI)
in need of neurosurgical intervention is complicated in
206 nd Measures: Proportion of patients with TBI
in need of neurosurgical intervention per GCS score or S
207 iagnostic screening of intracranial injuries
in need of neurosurgical intervention, but may also prov
208 tion would identify patients with severe TBI
in need of neurosurgical intervention.
209 espect to their ability to identify patients
in need of neurosurgical interventions, no difference wa
210 nonimmunocompetent individuals that remains
in need of new therapeutic options.
211 ependence is a major public health challenge
in need of new treatments.
212 ocytic leukemia (CLL) is a B-cell malignancy
in need of new, effective, and safe therapies.
213 y difficult-to-treat cancer and patients are
in need of novel therapies.
214 me and young-adult households in the LMD are
in need of nutrition interventions with an emphasis on i
215 hose individuals who are either not actually
in need of,
or unlikely to respond to, a drug.
216 Eighteen patients
in need of oral prosthetic rehabilitation that included
217 at involve data sharing to identify patients
in need of palliative care, identification of better car
218 requiring expert perceptual skills or those
in need of perceptual rehabilitation (such as individual
219 ,100-70,500]) will remain the countries most
in need of policies for the prevention and management of
220 le to ecosystem services, yet are those most
in need of preservation, tradeoffs may exist for these c
221 dent CKD and may aid in identifying subjects
in need of primary preventive regimens.
222 oportion of these lesions remains active and
in need of proper management.
223 oteomics measurements discover a host factor
in need of protection to improve resource redistribution
224 ith proliferative diabetic retinopathy (PDR)
in need of PRP were randomly assigned to 1 of 4 groups:
225 ory of self-harm or depression, which may be
in need of psychiatric support after GBP.
226 iders to identify childhood cancer survivors
in need of psychosocial services and provide them with a
227 ventilator protocol which targeted variables
in need of quality improvement, as identified by prior w
228 Tissue biopsy evaluation in the clinic is
in need of quantitative disease markers for diagnosis an
229 archers to reshape science-to identify areas
in need of reexamination, reweight former certainties, a
230 anxiety disorder (GAD) is a chronic disorder
in need of reliable data to guide long-term treatment.
231 derly patients are the fastest-growing group
in need of renal transplantation.
232 ssed to ICDAS >/= 5 associated with sealants
in need of repair and none to halfway or more through th
233 udy (isolated orbital fracture thought to be
in need of repair, with diplopia within 30 degrees of pr
234 Although
in need of replication and further study, results sugges
235 However, many of these findings are
in need of replication, and few have taken into account
236 While tentative and
in need of replication, these results, consistent with t
237 While
in need of replication, these results, validated by pred
238 te diverticulitis and identifies other areas
in need of research.
239 y areas of mast cell activation syndrome are
in need of research.
240 All patients
in need of revascularization were identified with corona
241 n 1997 that this nutrient is likely the most
in need of revised requirements.
242 ntly accepted picture of proton diffusion is
in need of revision.
243 twork as the major load-bearing structure is
in need of revision.
244 The AJCC staging system for RPS is
in need of revision.
245 sensitivity to climate may be misleading and
in need of revision.
246 /Ph-promoted radical conjugate additions, is
in need of revision.
247 by chemical correlation with 1 and 2 are not
in need of revision.
248 eplacement of all indigenous populations, is
in need of revision.
249 remains unproven, and as such, a hypothesis
in need of rigorous testing.
250 nfected and HIV/HCV co-infected patients are
in need of safe, effective, all-oral HCV regimens.
251 he wealthier households, who nonetheless are
in need of similar interventions.
252 A total of 25 patients
in need of sinus augmentation were recruited for the stu
253 lish-acculturated Hispanics are particularly
in need of skin cancer prevention interventions.
254 dual differences in how primates behave when
in need of social support.
255 the previously predicted binding motifs are
in need of some revision.
256 th numerous local endemic species, which are
in need of special conservation efforts.
257 Former child soldiers are considered
in need of special mental health interventions.
258 cline and depression, helping identify those
in need of specialist neurological assessment and suppor
259 tation and clearly defines a high-risk group
in need of specific intervention.
260 emiological data to quantify the populations
in need of specific interventions, baseline coverage ind
261 uidelines differ in how they identify adults
in need of statin therapy; furthermore, it is unclear ho
262 predicted CVD risk category and, therefore,
in need of statin treatment under Adult Treatment Panel
263 Examples of areas
in need of study are highlighted, and I end by advocatin
264 ation, the transfer of undocumented patients
in need of subacute care to their country of origin.
265 ere revised for patients with cardiac stents
in need of subsequent surgery to recommend delaying elec
266 g management of patients with cardiac stents
in need of subsequent surgery.
267 the current picture of elephant evolution is
in need of substantial revision.
268 ly the perception of stigma among those most
in need of such care.
269 Wetland ecosystems are particularly
in need of such monitoring due to their sensitivity to r
270 We are
in need of suitable data compression algorithms that can
271 rs to take into account in identifying women
in need of support.
272 dentify patients with cirrhosis who are most
in need of surveillance.
273 decisions, a challenging and complex problem
in need of systematic analysis.
274 de in untreated follicular lymphoma patients
in need of systemic therapy.
275 hree prognostic groups and predicts patients
in need of targeted therapies.
276 e, such as patients with sickle cell anemia,
in need of the procedure.
277 ced MRCP might also better identify patients
in need of therapeutic ERCP.
278 nd without effective ART for an adult cohort
in need of therapy (2007) and for adults who became elig
279 NASA was
in need of these gas mixtures to ensure the safety of th
280 However, more than 65% of patients
in need of this procedure lack a human leukocyte antigen
281 These predictors may help identify infants
in need of timely eye examinations.
282 tiviral T cell response to identify patients
in need of treatment and to guide future development of
283 sions involve determining which patients are
in need of treatment and which are most likely to benefi
284 ution of medicines at no cost to individuals
in need of treatment does not guarantee that those indiv
285 ls for identifying those who are at risk and
in need of treatment in low-resource settings.
286 (ALL), it is essential to identify patients
in need of treatment intensification.
287 tients are increasingly asymptomatic and not
in need of treatment when attending for their routine de
288 avenues for CO delivery to diseased tissues
in need of treatment, without concomitant formation of e
289 accessed treatment, out of an estimated 334
in need of treatment.
290 ted people who had significant liver disease
in need of treatment.
291 try, may be the only option for 70% of those
in need of unrelated hematopoietic stem cell transplanta
292 o determine whether the recommendations were
in need of updating.
293 competitive alternative for children with AL
in need of urgent allograft.
294 ven further limited for symptomatic patients
in need of urgent treatment.
295 tions and metabolites is a current challenge
in need of user-friendly tools.
296 cal trials and immunocompromised individuals
in need of vaccination would profit from viral strains w
297 ch theorists may distribute or revise models
in need of validation and experimentalists may search fo
298 Although
in need of validation in less-selected populations, low
299 ctin and heparan sulfate in tissues that are
in need of vascularization so that it can aid in directi
300 re on children and young adults, however, is
in need of well-powered randomized controlled trials.