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1 rker analysis from the single-arm safety run-in (part 1; n = 9) and biomarker (part 2; n = 27) cohort
5 four dengue serotypes (DENV) up to Month 36 in part 1, and symptomatic dengue and serious adverse ev
10 e sexually dimorphic behaviour of the PAR is in part a result of kinetic differences between the sexe
11 imal to the EBV gL glycosylation site, which in part accounts for differences in EphA2 binding affini
12 udy include potential missing data, which is in part addressed by the use of cross-matched laboratory
16 ma immune activation marker heterogeneity is in part attributable to age, sex, cirrhosis, body mass i
18 ic/Latino heritage and this disparity may be in part attributed to differences in sociodemographic ch
26 gesting that their effect on tumour risk may in part be accounted for by their influence on cell comp
28 tcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral su
29 s of SCFAs in allergic disease can, at least in part, be explained by epigenetic suppression of human
30 ised that this lack of clinical success can, in part, be explained by the insufficiently stringent cl
31 asons for delays are multifactorial and may, in part, be related to poorer long-term monitoring of ri
32 ssors can trigger reactivation from latency, in part because activation of the glucocorticoid recepto
33 recognition of fullerenes is unprecedented, in part because archetypal PDIs are also electron defici
34 alent animal diseases are poorly understood, in part because cell models of spontaneously forming pri
35 and synthesis; this promotes complete repair in part because earlier rounds of synthesis generate mic
36 f ecologically important species is limited, in part because extreme events are rare and difficult to
37 lity, directly testing this idea is hindered in part because it is not known which genes control cork
39 and antibiotic lethality is not understood, in part because mycobacteria encode four MutT enzymes an
40 ossil hominins is not always clear, at least in part because of a poor understanding of how different
41 versus secondary sources, has been uncertain in part because of limited knowledge of the precursor em
42 y any role in rejection is unknown, however, in part because of limited techniques for distinguishing
43 -induced metabolic transcriptional programs, in part because of suppression of key transcriptional re
44 ted drugs are presently in clinical testing, in part because of the difficulty in identifying molecul
45 scapes are rarely managed to suppress pests, in part because researchers seldom measure key variables
46 however, relatively rare in coding sequence, in part because RIP preferentially attacks GC-poor long
47 clinical care for pediatric cardiac arrest, in part because signal noise causes high index time-vari
48 sign space has been explored experimentally, in part because that space has not yet been described in
49 vaccines have historically performed poorly, in part because the antigens utilized were mainly monome
50 heir efficacy relative to placebo is modest, in part because the clinical diagnosis of major depressi
51 ecies such as P. falciparum and P. knowlesi, in part because the extent to which pooled transfections
53 garettes (e-cigarettes) have become popular, in part because they are perceived as a safer alternativ
54 on algorithms have limited predictive power, in part because they were not trained on high-quality ep
55 a found in higher plants has proved elusive, in part because until recently higher-plant Rubiscos cou
56 l cognitive decline and is thought to arise, in part, because of a chronic pro-inflammatory state in
57 ence of human-unique factors and may emerge, in part, because persisting can resolve uncertainty.
58 er, these results suggest that we use rules, in part, because they reduce the costs of decision-makin
59 nza A virus PA-X is a fusion protein encoded in part by a +1 frameshifted open reading frame (X-ORF)
60 e to DNA damage and oxidant stress regulated in part by a BMPR2 dependent transcription factor comple
61 ient, and sometimes water, additions, driven in part by accelerated nitrification on the initially mo
63 its during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and
66 letion causes centriole duplication defects, in part by causing a rapid decline in the level of TUBGC
68 CARM1 orchestrates this coactivator activity in part by depositing the H3R17me2a histone mark in the
69 promoting sympathetic innervation, at least in part by driving the expression of TGFbeta1 in parench
70 PV GPe and STN neuron activity is generated in part by elevated striatopallidal transmission, while
71 e pathophysiology of MDD, potentially driven in part by excessive hippocampal gluatmatergic efferents
72 ing can result in T cell exhaustion mediated in part by expression of programmed cell death-1 (PD-1)
74 redox compounds, is lost on charging, driven in part by formation of molecular O(2) inside the solid.
76 GFbeta promotes protein translation at least in part by increasing the mitochondrial oxidation of glu
77 thesis or JH action arrested vitellogenesis, in part by inhibiting the expression of doublesex (Dsx),
79 onment, local immune dysregulation is driven in part by macrophages and dendritic cells that are pola
81 ot mutations acquired in a chronology driven in part by oncogenic fitness, and arise in an allelic co
82 tastasis of breast cancer by recruiting MDSC in part by pyroptosis-induced IL-1beta generation and do
83 facilitates the replication of telomeric DNA in part by recruiting the BLM helicase, which can resolv
84 receptor agonist, suppress colon cancer risk in part by reducing the number of Lgr5(+) stem cells in
87 eating behavior is hypothesized to be driven in part by reward deficits likely due to neuroadaptation
88 lipoprotein (HDL) metabolism is facilitated in part by scavenger receptor class B, type 1 (SR-B1) th
91 lar effects of hydrogen sulfide are mediated in part by sulfane sulfur species, including persulfides
94 e afforded this luxuriously slow development in part by the extended period of caregiving provided by
95 use of gene therapy technologies is limited in part by the lack of small genetic switches with wide
98 d helix-helix interaction, which are removed in part by variants at these positions, including the AL
99 ic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in
102 that syndecan exerts its influence, at least in part, by coordinating integrin activity in bcCML.
103 es in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VG
104 infection parameters are governed, at least in part, by different environmental factors operating du
105 ive the stem-like phenotype in glioblastoma, in part, by differentially regulating subsets of miRNAs.
106 /2 functionally regulated cell invasiveness, in part, by disrupting polarized cell motility under con
108 ents in precision medicine will be achieved, in part, by employing novel methodological tools that re
109 uppresses NPY/AgRP neuron activity, at least in part, by enhancing miniature inhibitory postsynaptic
110 of a core kinase cassette that is regulated, in part, by interactions involving Hippo, Salvador, and
114 al features of MVR events and is controlled, in part, by non-uniform calcium elevation across the AZ.
116 ring islet morphogenesis is guided, at least in part, by repelling Slit2/3 signals from the pancreati
117 in the absence of co-stimulation and do so, in part, by repressing the expression of BATF and, conse
118 ng sepsis, and this phenomenon is explained, in part, by the activity of CETP, a major determinant of
119 nt for human well-being that is constrained, in part, by the allocation of healthcare resources relat
120 ime is technically challenging, and limited, in part, by the invasive nature of recording tools.
121 l-to-mesenchymal transition (EMT), mediated, in part, by the p38 mitogen-activated protein kinase (MA
122 with PD-L1 negative tumors may be explained, in part, by the presence of intra-tumoral platelets.
128 ary uranyl complexes within the aquifer are, in part, created by infiltration through the vadose zone
133 licit their effector function, was, at least in part, dependent on formation of the microbiome, and c
134 l studies suggest that these differences are in part driven by aberrant glucocorticoid secretion duri
136 proton delivery are incompletely understood, in part due to an absence of information on exact proton
137 s organism in cancer progression is limited, in part due to challenges in maintaining F. nucleatum vi
138 function by reversibly binding to proteins, in part due to concerns about off-target reactivity.
139 mutations improved VSV replication, at least in part due to improved virus attachment to SUIT-2 cells
140 mutations improved VSV replication, at least in part due to improved virus attachment to SUIT-2 cells
142 es by which these traits evolve are complex, in part due to interacting ecological and evolutionary f
145 ural changes of the materials are not clear, in part due to the difficulty in identification during e
146 ology has largely remained unclear, at least in part due to the intrinsic challenges of connecting re
147 underlying mechanisms have remained elusive, in part due to the lack of relevant data and difficulty
148 ir efficacy in many solid tumors is limited, in part due to the low frequency of tumor-specific T cel
150 g this visual receptor have been identified, in part due to the unique characteristics of its light-s
151 re key drivers in many biological processes, in part due to their specificity towards their substrate
152 The initial reluctance to accept UKD was in part due to uncertainty about donor motivations and w
153 ociated alpha-synuclein (alpha-syn) fibrils, in part, due to lack of information of the structural pr
154 ese findings are noteworthy because they may in part explain how obesity drives colon cancer progress
155 ne-1-carboxylate oxidase 4 (ACO4), which may in part explain increased ethylene production and signal
156 croRNA expression, specifically miR-326, may in part explain regional differences in inflammatory cel
157 e underlying normative neural circuitry may, in part, explain the propensity of particular lesions to
158 y many to be expensive and prone to failure, in part explaining its low rates of implementation compa
159 arasites appropriated polyspecific I domains in part for their ability to engage with multiple ligand
160 ecedent glucoprivation may account, at least in part, for impairment of specific CRRs critical for re
161 erbated uveitis in CD19-STAT3KO mice derived in part from enhanced expression of costimulatory molecu
163 egation of proteins to neuronal axons arises in part from local translation of mRNAs that are first t
164 its in auditory and visual processing emerge in part from microstructural alterations to specific sen
166 tyrosine oxidation is proposed to originate in part from the requirement for stronger oxidants, lead
168 l hypersensitivity and pain result, at least in part, from increased excitability of primary afferent
172 e hypothesis that the primate amygdala acts, in part, like a sensory structure for the affective impo
173 or experience substantial cell death that is in part mediated by IFN-independent activities of STING.
174 ose-dependent transcriptional repression was in part mediated by O-GlcNAcylation of the transcription
175 what of a mystery but has been thought to be in part mediated by the release of myokines, skeletal mu
176 owth inhibition in PRDM10-deficient mESCs is in part mediated through EIF3B-dependent effects on glob
177 s indicate that the AhR-FoxM1 axis, at least in part, mediates colonic stem/progenitor cell behavior.
182 looded animals and a major pest of livestock in parts of South America and the Caribbean where it rem
183 y 2018 but gender disparities remained acute in parts of sub-Saharan Africa, and North Africa and the
184 strategies to optimize health care delivery in parts of the world who have not yet confronted this e
185 mulation conditions, palmitate can, at least in part, offset left ventricle (LV) dysfunction in heart
187 apsed aggressive B-cell non-Hodgkin lymphoma in part on the basis of durable remission rates of appro
188 lasticity is one such mechanism, and depends in part on the downregulation of calcium-dependent SK-ty
189 on caused by GEM, with SI traceability based in part on the known spontaneous emission lifetime of th
190 y of Ex-4 to reduce cocaine seeking depends, in part, on activation of LDTg-to-VTA GABAergic projecti
192 e recruitment into a recall response relies, in part, on cues imparted by chemokines that coordinate
193 dent on its DNA binding domain and, at least in part, on poly-ADP ribose polymerase (PARP) activity.
194 inction learning, and these deficits depend, in part, on stress-induced norepinephrine (NE) release i
195 effectiveness of preregistration may depend, in part, on whether the process facilitates sufficiently
196 proved by the SRAs at the time of the study) in part one of the study, and 50 mg film-coated tablets
197 spectra reveals that these spectral features in part originate from hydrogen vibrations confined by n
198 associated with neurofibrillary degeneration in part owing to reduced tau disaggregation, raising the
199 s with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a ce
201 rm rate of visual field change in an eye is, in part, predicted by the rate in the fellow eye, partic
202 defined by tissue and nerve type, are seeded in part prenatally, and self-maintain via proliferation.
203 nding site of EphA2 on EBV gH/gL is at least in part proximal to the EBV gL glycosylation site, which
204 ties of PMNs in different tumor settings may in part reflect the effects of hypoxia on direct PMN-tum
205 etter to warmer-drier measurement intervals, in part reflecting increasing mortality with decreasing
206 photoreceptor survival and retinal health is in part reliant on melatonin orchestration of circadian
207 ention, our findings indicate that they may, in part, restore ecological functions reflective of the
209 , and using mouse models, have characterized in part the mechanisms of action of adjuvants on pre-exi
210 y among IDU-associated cases likely reflects in part the younger demographic; however, Candida endoca
218 stress is neutralized in resilient animals, in part through an adaptive reorganization of prefrontal
221 le and 3D genome folding signature, mediated in part through cohesin redistribution on chromatin.
223 in crypts and induces budding in organoids, in part through elevated and sustained activation of mit
225 responsive kinase that promotes renal injury in part through phosphorylation-dependent suppression of
227 nvolution where Sox10 seems to work at least in part through regulation of the miR-424(322)/503 clust
228 the UK National Institute of Health Research in part through the Biomedical Research Centre at Univer
231 ts indicate that bacterial infection, acting in part through the NPC, alters core clock gene expressi
232 ome can alter systemic alloimmunity in mice, in part through the production of short-chain fatty acid
233 lasticity and/or exerting neurotoxic effects in part through their effects on NMDA receptor signaling
234 c actions of TGF-beta are mediated, at least in part, through a metabolic maladaptation in glutamine
235 late cell growth and proliferation, at least in part, through alterations in metabolic gene expressio
236 d, and this trajectory is mediated, at least in part, through altered DNA methylation patterns in upp
238 astoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis
243 ls are believed to orchestrate MS pathology, in part, through the production of two proinflammatory c
244 ion and mobilization by insulin is achieved, in part, through utilizing a region of the TGN devoted t
246 The effect on fecundity was probably due in part to a corresponding decrease in glycogen and lipi
247 has been made in glioblastoma therapy, owing in part to a lack of adequate preclinical in vivo models
248 xygenation remains high, and this may be due in part to a lack of standardized mechanical ventilation
249 slower-paced or stopover movements, perhaps in part to access carrion produced by vehicle collisions
250 ling, it has leveled off in recent years due in part to advances in medical technology, health care o
252 resulted in increased adherence of NTHI, due in part to augmented expression of CEACAM1 and ICAM1, ho
254 t' in neuroscience can be controversial, due in part to continuously evolving notions regarding the s
255 ation of precision medicine are complex, due in part to differences in clinical care and a lack of en
256 etings have become visibly more diverse, due in part to ethnic minority travel awards and apparently
258 ced fetal growth restriction (P < 0.01), due in part to increased uterine artery blood flow (P < 0.00
259 i is an incredibly successful parasite owing in part to its ability to persist within cells for the l
260 from ZIKV infection during pregnancy are due in part to pregnancy-induced alteration of innate immune
262 gy remain largely unknown but are likely due in part to previously unappreciated host, microbiota, an
263 tself is insufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS acti
264 ncluding fetal growth restriction (FGR), due in part to reductions in nitric oxide (NO) bioavailabili
265 ity of sensory neuron pathophysiology is due in part to subtype-dependent sensitization of TRPV1 and
266 2, has become an ongoing global pandemic due in part to the challenge of identifying symptomatic, asy
267 behind these processes are still elusive due in part to the difficulty of imaging trace metals togeth
270 d links feeding to odr-10 only in males, due in part to the male-specific expression of daf-7 in ASJ.
271 ce of HER2(+) tumors in Latinas could be due in part to the presence of population-specific genetic v
272 long-term toxicities of such complexes, due in part to the speciation to vanadate ions in the circul
273 reas, guanidines, and cyanoguanidines, owing in part to their similar capacity toward hydrogen bondin
276 der gap in physician pay is often attributed in part to women working fewer hours than men, but evide
278 f systemic EP2 antagonism can be attributed, in part, to blocking brain recruitment of blood-borne mo
279 speed during treadmill running in rats due, in part, to impaired convective and diffusive O(2) deliv
280 ge in inflammatory bowel disease (IBD), due, in part, to insufficient understanding of disease-site,
281 dentified substrates remains incomplete due, in part, to limitations in mass spectrometry-based quant
282 in an mTOR-independent manner due, at least in part, to proteasomal degradation of mTOR by the E3 ub
283 neuron-derived E2 appear to be due, at least in part, to suppression of neuronal FGF2 signaling, whic
284 nflammation, which is attributable at least, in part, to the conversion of the pro-inflammatory angio
285 ed phosphorylation of BfmR was due, at least in part, to the cross-phosphorylation of BfmR by GtrS, a
288 enhancers located within HCDs work at least in part via a distinct mechanism involving the modulatio
290 hyaloid vascular systems, develops at least in part via hemovasculogenesis, a process in which vascu
293 ies and drove CNS axon regeneration in vivo, in part via secretion of a cocktail of growth factors.
294 tulating the symptoms of gastric distension) in part via signalling to the paraventricular hypothalam
299 d other AD risk genes, and explain, at least in part, why every HSV1-infected person is not equally l