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2 ation, alanine substitutions were engineered in place of 28 charged residues residing in the N- and C
10 c suppressor mutant log1-1, with an arginine in place of a conserved glycine, failed to interact in t
13 ng/disease regulation included a blue stripe in place of a red stripe at the right-hand end of the sc
14 with an Ancestral Recombination Graph (ARG) in place of a simple tree, which presents significant co
16 ed by two DRPs, MFN1 and MFN2, that function in place of a single outer membrane DRP, Fzo1 in yeast.
20 richia coli (LacY) with a single-Cys residue in place of A122 (helix IV) transports galactopyranoside
21 values spanning the observed range) are used in place of actual tree-ring delta(13)C measurements.
23 ansformation is also compatible with allenes in place of alkynes to furnish tetrasubstituted alkenyl
24 ls can be substituted by using wood products in place of alternative materials and energy, but wood h
25 ffects than amphotericin, and is widely used in place of amphotericin; however, clinical trials compa
27 stepwise introduction of a reactivity handle in place of an aromatic C-H bond (that is, a nitro group
29 gene and a variety of Dbeta or Jbeta genes, in place of an intact TCRbeta-chain and in association w
31 using a targeting probe for cell procurement in place of an operator-based, cell-by-cell selection pr
32 moxifen 20 mg per day (with matching placebo in place of anastrozole) or oral anastrozole 1 mg per da
33 y curves are recalculated with methyl groups in place of anilino protons, the barrier to isomerizatio
36 d by incorporation of an amphiphilic peptide in place of apolipoprotein A-I as the lipid emulsifier a
38 ponsible, NxxcB, accepts several amino acids in place of Asn and introduces unnatural beta-thioether
39 apy approach combining low-dose rivaroxaban (in place of aspirin) with a P2Y12 inhibitor has not been
42 cipients (n = 5) were treated with alefacept in place of basiliximab, and more intense LFA-1 blockade
47 evelop core isosteres by inserting B-N units in place of C horizontal lineC bonds within aromatic sca
51 ellia sinensis) that accumulate anthocyanins in place of catechins are currently attracting global in
52 oligosaccharide fragment of PNAG, 9GlcNH(2), in place of chemically partially deacetylated PNAG, thre
54 ther billing claims accurately identify CVEs in place of clinical event adjudication in structural he
57 ased use of natural gas in the power sector, in place of coal-fired power generation, drove reduction
60 ative control strategies to use alongside or in place of conventional antibiotics, one approach is th
61 many reports in literature in using aptamers in place of conventional antibodies as capture biomolecu
62 ther network-based strategies should be used in place of conventional field approaches to target indi
63 ion of artificially structured metamaterials in place of conventional materials for improving optical
65 eric complex does not form if Zn(II) is used in place of Cu(I) and transplatin instead of cisplatin.
74 d into standard frontline chemoimmunotherapy in place of Dox, it improved overall survival by control
76 cipants received 50 mg of daily dolutegravir in place of efavirenz for 8 weeks, then began once-weekl
77 Here we show that substituting polyamines in place of elemental counterions significantly enhanced
78 le would facilitate individualized treatment in place of empirical treatment, improve treatment outco
80 HCV RNAs encoding GBV-B structural proteins in place of equivalent HCV sequences designed to allow e
83 d that a vaccinia virus expressing MC021L-HA in place of F13L-HA exhibits a small-plaque phenotype bu
84 oclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and no
85 e use of form II in indoor residual spraying in place of form I would significantly suppress malaria
87 le evidence strongly supports the use of CMA in place of G-banded karyotyping as the first-tier cytog
89 t one optically flat surface and can be used in place of glass microscope slides as sample substrates
90 nerated a GS mutant that catalyzes azido-Ala in place of Gly with high catalytic efficiency and selec
91 he sequence context of plant EPSPSs, alanine in place of glycine at the equivalent position interfere
93 astline, requiring use of lower sulfur fuels in place of heavy fuel oil in main engines of ships.
95 ckground, the presence of a cysteine residue in place of highly conserved tryptophan 1570 alters the
96 e firefly luciferase (Luc) gene was inserted in place of HSP70 as a control for the double insertion.
101 of the P450 enzyme CYP119 containing iridium in place of iron catalyze insertions of carbenes into C-
102 und that manganese can activate Rpe in vitro in place of iron, converting the enzyme to a form that i
106 a similar recombinant virus expressing CD80 in place of LAT had higher latency reactivation than a L
107 sults in the accumulation of Kdo-lipid IV(A) in place of lipid IV(A) without suppression of its growt
108 n to use Plasmodium falciparum parasite rate in place of malaria index in the modelling of malaria de
109 l using modification with gold nanoparticles in place of matrix in this application showing its poten
110 sed for peroxidase activity with water bound in place of Met80, which serves as the axial heme ligand
112 dily incorporated into the Shaker Kv channel in place of methionine residues and modified with azide-
114 n MHV68 virus that encodes KSHV LANA (kLANA) in place of MHV68 LANA (mLANA) and evaluated the virus's
117 ive nitrogenases, which use vanadium or iron in place of molybdenum at their active site, might play
118 enated dioxins and furans that could be used in place of more traditional gas chromatography coupled
123 (GLP-1) containing beta-amino acid residues in place of native alpha residues at selected sites and
127 hosphatidylcholine (PC) has been widely used in place of naturally occurring phosphatidylethanolamine
130 propylphenyl)imidazolidin-2-ylidene) is used in place of Ni(COD)2/SIPr.HBF4/KO(t)Bu (COD = 1,5-cycloo
133 TNF)-alpha antagonists are increasingly used in place of nonbiologic comparator medications, their sa
134 ant viruses expressing these mutant proteins in place of normal A33 had a small-plaque phenotype.
136 d RNA (dsRNA)-dependent protein kinase (PKR) in place of NSs, were protected from wild-type (wt) RVFV
137 titution of aliovalent N(3-) and F(-) anions in place of O(2-) in ZnO brings about major changes in t
138 , recombinant viruses expressing O3 homologs in place of O3 replicated and formed plaques as well or
140 splatin derivative containing phenanthridine in place of one of the chloride ligands, forms highly po
146 e overcome by introducing exchangeable links in place of permanent network crosslinks, a concept prev
148 The derivative 1 containing hbeta(3) Phe in place of Phe showed good mu- and delta-receptor affin
149 e to accept templates with triazole linkages in place of phosphodiesters, we have designed a strategy
151 ehydrobutyrine (Dhb) or dehydroalanine (Dha) in place of phosphothreonine or phosphoserine residues,
153 calcified CaM N lobe interacts with helix B in place of PIP2 to limit excessive IKS current inhibiti
154 ation, making it feasible to use minicircles in place of plasmids in mammalian transgene expression s
155 d here uses silicon photomultipliers (SiPMs) in place of PMTs because SiPMs are much more compact and
156 ssentially we use 3' UTR sequence similarity in place of population cryptic relatedness in the GWAS p
158 fied a novel glycosylation site with alanine in place of proline, suggesting a revised, broader conse
164 etion strains containing unique DNA barcodes in place of regulator genes were mixed with the parental
170 sing a phospho-mimetic aspartic acid residue in place of serine at position 193 (S193D) of C/EBPalpha
171 djusted for urinary albumin:creatinine ratio in place of serum creatinine (P=0.005 for sTNF-R1 and P=
172 s with two yeast I-SceI endonuclease targets in place of Sgamma1 undergo I-SceI-dependent class switc
173 M), which uses iterative image deconvolution in place of single- or multiemitter localization to esti
174 etically encoding N-varepsilon-acetyl-lysine in place of six lysine residues in histone H3 enables de
175 mal microarray analysis as a first-tier test in place of standard karyotype for the evaluation of fet
179 recovered viruses with alanine substitutions in place of SWWS residues had second-site, partially com
180 dencing the potential of coffee exocarp dyes in place of synthetic dyes in the manufacture of French
182 (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with
185 t, we found that TNA replication using tCfTP in place of tCTP exhibits 98.4% overall fidelity for the
188 mily, that have evolved a tryptophan residue in place of the (D/E) in the second conserved motif; the
190 d, NT-9-21, which contains dichloro moieties in place of the 3,5-dibromo substituents of NT-7-16, had
192 y histidine is used as an acid/base catalyst in place of the anionic glutamate seen in other GH3 fami
193 otion (TPM) but employs a single fluorophore in place of the bead, allowing TFM to be combined with e
194 e of the unidirectional C31 integrase system in place of the bidirectional Cre recombinase reaction;
198 e of the SH2 domain of Csk is the tight turn in place of the canonical CD loop in a surface site far
200 helices that feature a carbon-carbon linkage in place of the characteristic N-terminal main-chain hyd
201 ase from Vibrio vulnificus employs the anion in place of the commonly observed Asp, reminding us that
202 lls that can be used for tissue regeneration in place of the controversial human embryonic stem cells
203 ng a 2-isopropoxy-3-phenylbenzylidene ligand in place of the conventional 2-isopropoxybenzylidene lig
204 hus, our saw-shaped geometry gate potential (in place of the conventional bar-shaped geometry) leads
209 ts expressing a deregulated bacterial AGPase in place of the endogenous AGPase and in plants containi
217 g an iridium porphyrin cofactor (Ir(Me)-PIX) in place of the heme catalyze enantioselective intramole
218 second and third generation Grubbs catalysts in place of the HG2 catalyst for the polymerization of A
220 immediate early promoter into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene.
221 ]octan-3-one but contains a tert-butyl group in place of the hydroazulene subunit of MacE, was prepar
222 1 (bel1) mutants produce aberrant structures in place of the integuments and WUS is ectopically expre
223 ysine instead of the usual carboxyl group is in place of the internal proton donor to the retinal Sch
225 ed (MgK) or native (NgK) form of the gK gene in place of the latency-associated transcript with a myc
226 imerizing the fused sdAbs, imparting avidity in place of the lower affinity monomeric interactions.
227 A hypothetical flat plain at 3500 m depth in place of the MAR would contain 85.6 kt C, implying an
230 ns reveals that the use of formic acid (1%), in place of the more commonly used perchloric acid, comb
231 c position of the Leavenworthia S locus, and in place of the more typical Lal2 and SCRL sequences.
233 potently antagonized by molecules that bind in place of the native acylated homoserine lactone autoi
234 a modified form of the SARS-CoV-2 spike gene in place of the native glycoprotein gene (VSV-eGFP-SARS-
235 C bearing several amino acid changes, an Arg in place of the native Leu at L185-positioned over one f
238 rmal or chemical inactivation are often used in place of the native toxin; however, the process of de
240 Interestingly, the Dam methylase was found in place of the NgoAXI endonuclease in two of the strain
242 alphavbeta6, which allowed a virus with KGE in place of the normal RGD integrin-binding motif to use
243 Here we utilized Ca(2+) ions and sulfur in place of the nucleophilic oxygen in a 20-residue pseu
245 4-aminocyclohexane-1-carboxylic acid moiety in place of the pentapeptidic tail, was identified as a
247 roup received vildagliptin 50 mg twice daily in place of the placebo and entered study period 2, duri
249 hreonine can be misincorporated into protein in place of the proteinogenic amino acid threonine.
250 utilizing the polymer capture matrix method in place of the solid-phase extraction method is that th
252 hods can advance knowledge alongside or even in place of the standard hypothesis-driven approach, whi
253 ne, 2,6-Diaminopurine or Iso-deoxyGuanosine) in place of the standard T, C, A or G to avoid mismatch
254 ients with left main coronary artery disease in place of the standard treatment, coronary artery bypa
255 cysteine analogue containing a methyl group in place of the sulfhydryl group present in Cys, for the
256 ocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester
258 d an alternative vaccine which could be used in place of the traditional live attenuated RPV strains,
261 icons containing the Gaussia luciferase gene in place of the viral ORF2 or ORF3 genes demonstrated th
262 es expressing Ebolavirus glycoproteins (GPs) in place of the VSV G protein demonstrated protection of
265 nin-like envelope glycoproteins HL17 or HL18 in place of the VSV glycoprotein were generated to ident
266 , which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% effica
268 fibroblasts; the use of phosphomutant Ascl1 in place of the wild-type protein significantly promotes
269 mosquito-borne flaviviruses were substituted in place of the WNV EIII were recovered, although the su
270 rt either the use of a month of IV HDI alone in place of the year-long regimen or the initiation of a
273 use their own tree; provide custom sequences in place of those automatically retrieved from UniProt;
274 mutant carrying a phosphomimetic Glu residue in place of Thr-170 loses TRIM25 binding, Lys-172 ubiqui
276 rine proteinases (MASPs), in synergy with or in place of TMPRSS2, contribute to activate the SARS-CoV
279 o single molecule array (Simoa)-based assays in place of traditional detection antibodies for six cyt
280 (AuNPs), utilizing DNA linkers and diluents in place of traditional self-assembled monolayers, is re
281 e" assay which includes polyvinylpyrrolidone in place of traditional surfactants-improving sensitivit
282 Alternative electrophiles can also be used in place of trifluoromethylsulfonium reagents to effect
283 e of omega-N-methyltryptamine and tryptophol in place of tryptamine led to the enzymatic synthesis of
285 f ritonavir-boosted protease inhibitors (PI) in place of unboosted PIs has made the selection of PI r
289 aCl) was used as a protein suspending medium in place of water, reflecting positive effects of increa
291 ant or an MCPyV-origin mutant was introduced in place of wild-type LT or wild-type viral origin.
293 ne (NO(2)Y, pK(a) 7.1) has been incorporated in place of Y(122), Y(731), and Y(730) to probe how the
294 Y (F(3)Y) was site-specifically incorporated in place of Y(356) in beta2 and 3-NH(2)Y (NH(2)Y) in pla
297 Y (3,5; 2,3; 2,3,5; and 2,3,6) incorporation in place of Y122-beta and the X-ray structures of each r
298 otyrosine was site-specifically incorporated in place of Y356-beta, Y731- and Y730-alpha, and each pr
299 When 3-aminotyrosine (NH2Y) is incorporated in place of Y730, a long-lived NH2Y730* is generated in
300 yl-2, 6-dioxocyclohex-1-ylidene) ethyl (Dde) in place of Z protection on the amino alcohol has allowe