ライフサイエンスコーパス: in vitro assay

1 rs to selectively inhibit Sec18 action in an in vitro assay.

2 of NTHi by macrophages were evaluated by an in vitro assay.

3 to control the dissemination of virus in an in vitro assay.

4 F motif, had no effect on PP1 activity in an in vitro assay.

5 itulated by recombinant human RNase 1 in our in vitro assay.

6 d as the major Gag binding sites by using an in vitro assay.

7 y unrelated drugs, confirmed by skin test or in vitro assay.

8 actor Receptor tyrosine kinase (EGFR-TK), in in-vitro assay.

9 on protein exhibited high enzyme activity in in vitro assays.

10 s of the different apo(a) kringle domains in in vitro assays.

11 tional alterations of sEVs were validated by in vitro assays.

12 f mouse and human melanoma cells in multiple in vitro assays.

13 LMW and HMW fractions were determined using in vitro assays.

14 Eighty-six had data from high-throughput in vitro assays.

15 h was bacterially-expressed and purified for in vitro assays.

16 invasion of prostate cancer cell lines in 3D in vitro assays.

17 viability of luminal breast cancer cells in in vitro assays.

18 ding defects than mutants in clfB in several in vitro assays.

19 ion by using an APP/PS1 transgenic model and in vitro assays.

20 and its peptides was characterized by using in vitro assays.

21 ase activity or RNA recognition in different in vitro assays.

22 l activities of VRC01 as measured by several in vitro assays.

23 r effect on spreading using both in vivo and in vitro assays.

24 e astrogliosis in demyelinating areas and in in vitro assays.

25 invasion of prostate cancer cell lines in 3D in vitro assays.

26 l PFOA-related parameters were obtained from in vitro assays.

27 in a variety of human and cynomolgus monkey in vitro assays.

28 and molecular dynamics (MD) simulations, and in vitro assays.

29 the latter showing activating properties in in vitro assays.

30 8a2 and murine ATDC5 cell lines were used in in vitro assays.

31 ibitors and also blocked their activities in in vitro assays.

32 ckdown are known to inhibit cell invasion in in vitro assays.

33 oad specificity toward ARF family GTPases in in vitro assays.

34 is capable of activating apo-hydrogenase in in vitro assays.

35 ombined data set of 11 ToxCast(TM)/Tox21 HTS in vitro assays.

36 clonal types using in vivo mouse models and in vitro assays.

37 Candidate variants were further validated by in vitro assays.

38 er panel of GBM cells using state-of-the-art in vitro assays.

39 ed using multiple methods and evaluated with in vitro assays.

40 ty and colloidal stability were confirmed by in vitro assays.

41 del were further characterized by functional in vitro assays.

42 Twenty one analogs were further evaluated in in vitro assays.

43 ty of ARN-NPs was determined by colorimetric in vitro assays.

44 or antimicrobial activity were obtained from in vitro assays.

45 ing human samples, in vivo mouse models, and in vitro assays.

46 We utilized in vitro assays, 3D gastric gland organoid cultures, mou

47 haracterized and validated using a series of in vitro assays, a zebrafish model enabling three-dimens

48 Using in vitro assays, ACh and non-hydrolysable ACh analogs re

49 Additional in vitro assays also demonstrated that psoriatic and con

50 We developed a sensitive in vitro assay and demonstrated that Cas1-Cas2-3 catalyz

51 rgic response in 14 of the 16 patients in an in vitro assay and inhibited basophil activation in an a

52 In vitro assays and a crystal structure suggest betaine

53 mber of 2D and 3D proliferation and invasion in vitro assays and an in vivo model.

54 emicals established using results from other in vitro assays and because of the lack of high-quality

55 lf-renewal and multipotency, are observed in in vitro assays and cell transplantation experiments; ho

56 Genetic analysis, conformational studies, in vitro assays and ex vivo flow-cytometry were performe

57 This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 bi

58 celerating wound closure was demonstrated in in vitro assays and in a murine skin wound model.

59 teins, and the predictions were confirmed by in vitro assays and in vivo growth phenotypes of gene de

60 Using mechanistic in vitro assays and in vivo models of invasive pneumonia

61 ompanied by a commensurately large number of in vitro assays and in vivo models to measure their effe

62 ablished and patient-derived GBMs using both in vitro assays and in vivo orthotopic preclinical model

63 ild-type and Flot1(-/-) CD8(+) T cells using in vitro assays and intravital two-photon microscopy of

64 these factors influence motor motility, and in vitro assays and live cell observations often produce

65 Using in vitro assays and mouse xenografts, we show here that

66 etric and infrared spectroscopic analyses of in vitro assays and plant extracts indicate that the fin

67 Using in vitro assays and rescue experiments in autaptic neuro

68 In vitro assays and simulation technologies are powerful

69 is capable of attaching ubiquitin to FDH in in vitro assays and the turnover of FDH was increased wh

70 - and WTalphaA proteins was determined by an in vitro assay, and the levels of intracellular Ca(2+) u

71 ny strains deconjugate primary bile acids in in vitro assays, and a Clostridium scindens strain produ

72 Here, we combined modeling, in vitro assays, and cellular localization studies to in

73 Using high-dimensional flow cytometry, in vitro assays, and RNA sequencing, we concomitantly in

74 opisomers were evaluated through a series of in vitro assays, and shown to have a favorable selectivi

75 StMKK1, as confirmed by multiple in vivo and in vitro assays, and StMKK1 was shown to be a negative r

76 RNase BN directly cleaves 6S RNA as shown by in vitro assays, and the 6S RNA:pRNA duplex is an even m

77 cytokines in peritoneal tissue and fluid and in vitro assays applying macrophages and peritoneal fibr

78 High-throughput in vitro assays are a promising alternative for addressi

79 Overall, results suggest that in vivo and in vitro assays are a useful guide in the development of

80 Various in vitro assays are available to assess adipocyte differ

81 tools that provide antigenic specificity in in vitro assays are needed to functionally assess the ne

82 ses of antibodies provide protection because in vitro assays are not always predictive of in vivo pro

83 In vitro assays are widely used to analyze the antioxida

84 okines IL-6beta, COX2, iNOS, and IL-6 in the in vitro assays at much lower concentrations than pink f

85 ally activated luciferase expression (CALUX) in vitro assays at nine concentrations ranging from 40 t

86 An in vitro Assay based on enzyme activity was used to dete

87 anges to the target surface, we developed an in vitro assay based on reconstituted membrane-coated ta

88 We developed an in vitro assay based on solid-supported 1-palmitoyl-2-ol

89 However, the use of in vitro assays beyond chemical screening is complicated

90 RTICBM-74) had similar potencies as 2 in all in vitro assays but showed significantly improved metabo

91 ould expand the range of BMP signaling in an in vitro assay by competition for HSPG-binding.

92 and finger nail samples, this suggests that in vitro assays can reliably mimic the in vivo processes

93 Consistent with the in vitro assay, chickens fed 0.12 g/kg aspirin diet prot

94 TF binding sites identified via large-scale in vitro assays, chromatin accessibility, evolutionary c

95 In vivo co-expression and in vitro assays combined with nuclear magnetic resonance

96 We used an in vitro assay combining a ribosome-depleted rabbit reti

97 In vitro assays confirmed expression regulation via thre

98 In vitro assays confirmed PhCAT2 can transport Phe, and

99 In vitro assays confirmed that enforced Tek expression i

100 (-) (/) (-) cells within the allografts, and in vitro assays confirmed that Ly6C(hi) myeloid cells mi

101 In vitro assays confirmed that synthetic analogues retai

102 In vitro assays confirmed that VIPER-inferred protein ac

103 In vitro assays confirmed their functionality, and embry

104 o test data, reference chemical information, in vitro assay data (including Tox21(TM)/ToxCast high-th

105 Models based on in vitro assay data perform better in predicting human t

106 Both in vivo and in vitro assays decreased the ability of CDH23-C to inte

107 In vitro assays demonstrate that Cas9 from Streptococcus

108 In vitro assays demonstrated PBB3-positive tau inclusion

109 In vitro assays demonstrated severely impaired mineralis

110 In vitro assays demonstrated that DTMUV infected and rep

111 In vitro assays demonstrated that recombinant SPLUNC1 pr

112 In vitro assays demonstrated that the dinucleotide binds

113 In addition, yeast transposition and in vitro assays demonstrated that the terminal motif and

114 In vitro assays demonstrated that two such compounds sel

115 In vitro assays demonstrated the reactivity of this comp

116 The in vivo animal model and in vitro assays described could augment preclinical safe

117 Computational modeling and in vitro assays do not fully replicate the in vivo envir

118 In addition, our results show that in vitro assays do not fully reproduce in vivo condition

119 In the in vitro assay done with the nanoemulsions, no yeast gro

120 Our in vitro assay enabled us to examine the activity of POR

121 Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and respo

122 piezoelectric biosensor as a cost-effective in vitro assay for the early detection, monitoring or tr

123 Using an in vitro assay for the RNA-dependent RNA-polymerase (RdR

124 We also established an in vitro assay for TIKI2 protease activity using FRET pe

125 In vitro assays for CHMP4C showed that the associated va

126 gion were used to explore the application of in vitro assays for mutagenicity (Salmonella mutation as

127 ive risk assessment of PCB DNT, and identify in vitro assays for screening other environmental pollut

128 e experimentally tested in a patient-derived in-vitro assay for Rheumatoid arthritis (RA), which yiel

129 In vitro assays further confirmed that histamine inhibit

130 In vitro assays further showed that this intron function

131 wever, their incorporation into standardized in vitro assays has been limited by their incompatibilit

132 ptible to the rs6971 genetic polymorphism in in vitro assays, has favorable in vivo characteristics,

133 In vitro assays have demonstrated an intimate associatio

134 0 pathway clients have been identified using in vitro assays, however, the relevance of the TRC40 pat

135 ntibodies can be measured with commonly used in vitro assays; however, the ability of immunogenicity

136 approaches (i.e., in vivo visualization and in vitro assay), HRMAS NMR identified robust and dose-de

137 In vivo and in vitro assays identified precursors with potential to

138 These studies, combined with in vitro assays, identified free fatty acids (FFA) as ci

139 ar endothelial cells and, in a wound-healing in vitro assay, impaired cell motility and cytokinesis.

140 nst A. fumigatus infections, we developed an in vitro assay in which the interactions between human n

141 e-accessible chromatin using sequencing, and in vitro assays in human coronary artery SMCs, with sing

142 Using in vitro assays in transfected cells, we demonstrated th

143 The utility of in vitro assays in water quality monitoring was evident

144 Through in vitro assays, in silico docking and bioinformatics, A

145 h and invasion of BC were confirmed by using in vitro assays including proliferation, migration, apop

146 In vitro assays indicate that CDCP1 mediates formation a

147 In vitro assays indicate that Prp5p directly interacts w

148 In-vitro assays indicate that this bio-nanocomposite is

149 In vitro assays indicated blockage of (11)C-sarcosine up

150 re than 700 organic compounds in 38 streams, in vitro assays indicated generally low estrogen, androg

151 Additional in vitro assays indicated that 13 induces cell death wit

152 In vitro assays indicated that Sl-LIP8 can cleave 18:2 a

153 A combination of in vivo and in vitro assays indicates that LtnA1 and LtnA2 can induc

154 We conclude that the RTgill-W1 in vitro assay is useful for the screening of pH-depende

155 active AFB1 is low in cost and combined with in vitro assay, is quantitative.

156 nd location of methoxy substituents, through in vitro assays: MCF-7 cell proliferation and VM7Luc4E2

157 evant advantages of complex in vivo and fast in vitro assays might prove highly valuable within a tes

158 In vitro assays (mixed lymphocyte reaction and ELISPOT)

159 Antioxidant activity was determined through in-vitro assays namely, DPPH(*), ABTS(*+), hydroxyl radi

160 Using a combination of in vitro assays, NMR, and molecular dynamics simulations

161 ocyclohex-1-en-1-yl 4-methylbenzoate.) In an in vitro assay of anti-inflammatory effects, murine macr

162 in breast cancer modestly correlates with an in vitro assay of proliferation.

163 In vitro assay of TcpP oxidation by VcDsbA showed that V

164 Furthermore, in vitro assays of acyltransferases in microsomal fracti

165 of Zt6 protein on functional ribosomes, and in vitro assays of cells treated with recombinant Zt6 de

166 In vitro assays of complement function identified a sing

167 ly been hampered by inappropriately tailored in vitro assays of drug response.

168 The in vitro assays of free antifungal agents were performed

169 , we also discuss the preliminary results of in vitro assays of HCV protein expression in CCA cell li

170 Using in vitro assays of interferon gamma production (enzyme-l

171 cing, immunoblotting, immunophenotyping, and in vitro assays of lymphocyte and mitochondrial function

172 procedure enables the determination through in vitro assays of the regions exposed in the oligomers

173 Traditionally, ER expression is assessed by in vitro assays on biopsied tumor tissue.

174 In vitro assays on HeLa, MCF-7, and HCT-116 cells confir

175 transcriptomic findings were used to direct in vitro assays on Pten wild-type and Pten(m3m4/m3m4) mi

176 In this in vitro assay, only HSP70 was required, along with its

177 Thus, despite only having a modest effect in in vitro assays, opsonizing Ab had a dramatic effect in

178 oth transgenic and knock-out mice along with in vitro assays, our data show that Zhx2 binds Mup promo

179 In vitro assays pointed to microglia, but not astrocytes

180 Target-specific, mechanism-oriented in vitro assays post a promising alternative to traditio

181 Most of the fast in vitro assays proposed to determine the antioxidant ca

182 is question, we exploited a prion conversion in vitro assay, protein misfolding cyclic amplification

183 In vitro assays proved that recombinant VHR directly dep

184 Coimmunoprecipitation experiments and in vitro assays provided evidence that EHD1 and SNX17 di

185 In vitro assays purport that human GPRC6A(ICL3_KGKY) is

186 ncorporating microparticles into tissues for in vitro assays remains a challenge.

187 The clinical utility of in vivo and in vitro assays remains unclear.

188 We developed an in vitro assay requiring only isolated LDs, Coenzyme A,

189 ts the fibrillation of alpha-synuclein in an in vitro assay; residues 158-180, containing a largely c

190 invasion of prostate cancer cell lines in 3D in vitro assays, respectively.

191 Thus, our in vitro assay results indicate that risks associated wi

192 In vitro assays reveal that PA specifically and directly

193 In vitro assays reveal two single-module non-ribosomal p

194 An in vitro assay revealed that USP14 targeted Ku70 for deu

195 An in vitro assay revealed the downregulation of the angiog

196 Ex vivo and in vitro assays revealed a response against rPru p 3 in

197 In vitro assays revealed exogenous TGF-beta1 increased O

198 Complementary in situ and in vitro assays revealed SCRIB PDZ domains 1 and 4 to be

199 Moreover, in vitro assays revealed that apurinic/apyrimidinic nucl

200 In vitro assays revealed that LCAT-PLAs from the HFA-acc

201 lowing the synthesis of the best candidates, in vitro assays revealed that one member of this chemica

202 In vitro assays revealed that PAI enables light-dependen

203 In vitro assays revealed that the defective response in

204 New work by Ji and Ostap using in vitro assays reveals that 14-3-3beta binding actually

205 In this study, we combined in vitro assays, reverse genetics, quantitative N-termin

206 Cell-based and in vitro assays show that Retro-2 blocks delivery of new

207 Our in vitro assays show that the R21H mutation causes a two

208 Our in vitro assays show that they act as suppressors of the

209 Various results, including in vitro assays, show that the FG/GLFG region of Nup98 b

210 An in vitro assay showed that the region I, region II, and

211 In vitro assays showed binding and rapid internalization

212 In vitro assays showed no donor-specific regulatory T ce

213 In response to microenvironment stiffness, in vitro assays showed that Acvr1(R206H/+) cells inappro

214 In vitro assays showed that IFIH1 effectively restricts

215 In vitro assays showed that inactivation of Alg9 results

216 In vitro assays showed that lutein, both free and nanoen

217 In vitro assays showed that PICH specifically attenuates

218 luciferase constructs/replicons, in vivo and in vitro assays showed that the 5' and YSS-containing 3'

219 In vitro assays showed that the mutations cause loss of

220 In vitro assays showed Zn-dependent proteolytic activity

221 First, we present in vitro assays showing p5RHH-siAXL treatment reduces in

222 oil was assessed by employing two different in vitro assays such as DPPH, ABTS(+) radical scavenging

223 Our in silico predictions and in vitro assays suggest that both alleles destabilize th

224 In vitro assays suggest the PARylation significantly red

225 hI and remained relatively constant over the in vitro assay temperature range 10 degrees C to 40 degr

226 Here, we present the first in vitro assay that accurately recapitulates PORCN-media

227 Our data establishes an in vitro assay that can be used to validate the potentia

228 nding of NCs has been hampered by lack of an in vitro assay that can track NC or NCLP assembly.

229 Here, we describe an in vitro assay that quantitatively measures the assembly

230 sive capacity in MSCs, we developed a robust in vitro assay that uses principal-component analysis to

231 e Quaking-Induced Conversion (RT-QuIC) is an in vitro assay that, for the first time, specifically di

232 ciency and reduce vertebrate animal testing, in vitro assays that identify chemical interactions with

233 hway (AOP) network to link data derived from in vitro assays that measure chemical interactions with

234 bility and for evaluating the performance of in vitro assays that measure estrogenic activity.

235 change activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs

236 (C) During in vitro assay, the greater levels of binding alphaAN101

237 ive interface and abolish Pcdh19 adhesion in in vitro assays, thus revealing the biochemical basis of

238 In this study, we developed a novel in vitro assay to assess whether human NK cell subsets h

239 Here, we developed a novel in vitro assay to characterize the length and position o

240 We used a simple fluorometric in vitro assay to determine clotting activity in platele

241 axis with demonstrated MC involvement and an in vitro assay to evaluate the effect of DS on MCs.

242 To examine this further, we utilized an in vitro assay to measure dicer activity in lepidopteran

243 es to 5 PvDBP variants and used a functional in vitro assay to quantify their binding-inhibitory acti

244 Here, we developed an in vitro assay to quantitatively monitor PCNA monoubiqui

245 We developed an in vitro assay to understand the role of the ER-stress-m

246 We conducted in vitro assays to assess Abeta42 aggregation and glial

247 In vitro assays to assess inhibition of the bile salt ex

248 hemical interactions of this result, we used in vitro assays to demonstrate that nucleotide overhangs

249 out mice, adoptive transfer experiments, and in vitro assays to identify mechanisms underlying persis

250 lar force probes and developed in silico and in vitro assays to measure drugs' bilayer-modifying pote

251 We used mouse models and in vitro assays to provide a mechanistic understanding o

252 We use a combination of cell-based and in vitro assays to show that the interface of the FluPol

253 We developed a pair of simple in vitro assays to systematically measure the DNA-bindin

254 rapeutic molecule was evaluated by combining in vitro assays, to test the antitumoral potential on le

255 Using a leukocyte adhesion in vitro assay under shear forces mimicking blood flow,

256 us neutralization (VN) titers generated by 2 in vitro assays using convalescent plasma samples from 6

257 select model parameters can be obtained from in vitro assays using either quantitative (direct estima

258 ISC-hpNSC population, we conducted sensitive in vitro assays using flow cytometry and qRT-PCR analyse

259 In vitro assays using human monocytes confirmed neutral

260 re, we examine go-or-grow in two-dimensional in vitro assays using melanoma cells with fluorescent ce

261 is mechanism of action was confirmed through in vitro assays using mouse splenocytes and human periph

262 Novel 96-well in vitro assays using neonatal human monocyte-derived DC

263 We performed several in vitro assays using tumor and endothelial cells, along

264 nnels separated by the porous ECM makes this in vitro assay versatile and suitable for a variety of a

265 An in vitro assay was established to measure the associatio

266 Our simple, low-cost, and efficient in vitro assay was used to screen H1/Puerto Rico/8/1934

267 Using a visual in vitro assay we previously showed that efficient prote

268 lets from all patients, and by using a novel in vitro assay, we found that the nucleotide exchange ac

269 Using an in vitro assay, we show that a putative G-quadruplex-for

270 Here, using purified proteins and in vitro assays, we define how the type III-B effector f

271 Using in vitro assays, we demonstrate that Nun cross-links RNA

272 Using cell-based and in vitro assays, we demonstrate that the Hec1 tail domai

273 Using in vitro assays, we demonstrated, for the first time, th

274 of mouse population genetics and functional in vitro assays, we describe here a regulatory circuit i

275 use of recombinant proteins and a variety of in vitro assays, we establish that oxidation inhibits Fe

276 Here, using an array of in vitro assays, we explored the functional effects of T

277 rough rational design and optimization using in vitro assays, we have assembled the first DNA "nanosu

278 +/-, NMIIAD1424N+/-, and NMIIAE1841K+/-) and in vitro assays, we investigated MK distribution in BM,

279 Using various transplantation and in vitro assays, we show here that VKAs alter parameters

280 experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs

281 Using in vitro assays, we show that cells from the engineered

282 g an in vivo mouse model combined with human in vitro assays, we show that the level of serum FH corr

283 Using parallel cellular and in vitro assays, we show that the Nephrin intracellular

284 In vitro assays were conducted in a novel double surface

285 erum after pasta intake or pasta extracts by in vitro assays were considered, thus strengthening effe

286 putational chemistry, organic synthesis, and in vitro assays were employed to develop potent and sele

287 tions of MK+R5020 treatment on angiogenesis, in vitro assays were performed and combinatorial MK+R502

288 In vitro assays were performed with minigene constructs

289 Furthermore, endocrine activity in vitro assays were performed.

290 e structure-activity relationship models and in vitro assays were used to estimate drug-specific phys

291 Functional in vitro assays were used to measure functional MKP-1 in

292 However, here using an in vitro assay where Arp2/3 complex-based actin polymeri

293 bind E1 and did not replicate in a transient in vitro assay, while HPV-31 Y102E binds E1 and was able

294 This new in vitro assay will be useful for further dissecting the

295 esponding recombinant enzymes, and performed in vitro assays with 27 organic acids as potential subst

296 Using in vitro assays with breast cancer cells, we have confir

297 In vitro assays with human enzymes show that PCNA and it

298 In vitro assays with primary or bone marrow-derived eosi

299 ts on ADAR2 enzymatic activity, we performed in vitro assays with recombinant proteins in HEK293T cel

300 ty and its suppression by PI3K activation in in vitro assays with SH-SY5Y human neuroblastoma cell cu