ライフサイエンスコーパス: in vivo

1 ble for dissecting miRNA regulatory networks in vivo.

2 gondii infection were examined in vitro and in vivo.

3 th and without cerebral small vessel disease in vivo.

4 sembles of foldable proteins affect function in vivo.

5 nd efficient metabolic adaptation to fasting in vivo.

6 complement C3-dependent synapse elimination in vivo.

7 w that it facilitates oral delivery of phage in vivo.

8 opment inside hepatocytes, both in vitro and in vivo.

9 werful tool to quantify beta-cell mass (BCM) in vivo.

10 ciate from replisomes during DNA replication in vivo.

11 ne rate constants of the AGO2 cleavage cycle in vivo.

12 vature of similar magnitude to that observed in vivo.

13 ation into luminal vasculature was confirmed in vivo.

14 sion tomography can quantify these processes in vivo.

15 n how LSH mediates its function on chromatin in vivo.

16 substrates have not been mapped extensively in vivo.

17 nctionally characterize ASD-associated genes in vivo.

18 infection by coronavirus, influenza and LCMV in vivo.

19 kidney, confirming Mac(TRAP) responsiveness in vivo.

20 ficacious against HSV-2 and HIV-1 infections in vivo.

21 sing class I PI3K inhibitors to modulate CMA in vivo.

22 rons with the characteristics of dorsal NSCs in vivo.

23 hysiological properties of food antioxidants in vivo.

24 bution (antigen and adjuvant) were evaluated in vivo.

25 A4503 likely have off-target binding to NR2B in vivo.

26 r matrix to increase transfection efficiency in vivo.

27 paB at disease-prone sites of disturbed flow in vivo.

28 ffects on c-MYC gene expression in vitro and in vivo.

29 ppocampal microglia revealed similar effects in vivo.

30 s inhibitors that demonstrate LDH inhibition in vivo.

31 iver injury in the absence of the microbiome in vivo.

32 t NiV does not efficiently replicate in EFBs in vivo.

33 of clots decreases survival from hemorrhage in vivo.

34 ion in vitro and tumor growth and metastasis in vivo.

35 and highly efficacious against AR42J tumors in vivo.

36 mune responses yet was generally constrained in vivo.

37 y in vitro and FXR-dependent gene modulation in vivo.

38 Cacna1g expression in the conduction system in vivo.

39 rtion of PC1 undergoes three cleavage events in vivo.

40 thus suppressing bone formation in vitro and in vivo.

41 cult to attain in hard-to-transfect cells or in vivo.

42 producing completely unnatural polypeptides in vivo.

43 promote mitochondrial fission and apoptosis in vivo.

44 vitro and inhibited orthotopic tumor growth in vivo.

45 r NRF2 activation in macrophages in vitro or in vivo.

46 ant GNB to multiple antibiotics in vitro and in vivo.

47 of CML stem cells capable of initiating CML in vivo.

48 ediates is essential for target inactivation in vivo.

49 with IRDye 800CW, was examined in vitro and in vivo.

50 itro, as well as tumor growth and metastasis in vivo.

51 anding how cone-mediated vision is sustained in vivo.

52 riers for bone tissue formation was examined in vivo.

53 ile loss of Trop2 suppresses these abilities in vivo.

54 nvestigate mitochondrial function of the CNS in vivo.

55 tatic mechanisms in the intact central brain in vivo.

56 nabling the measurement of energy landscapes in vivo.

57 more important for endogenous MGC formation in vivo.

58 The lead agent protects neurons from death in vivo.

59 ein PFK-1.1 can dynamically form condensates in vivo.

60 a broad spectrum of neurological conditions in vivo.

61 motion of aggressive phenotypes in vitro and in vivo.

62 occus spec., can mediate robust gene editing in vivo.

63 on brain SHH MB cells in vitro, ex vivo, and in vivo.

64 imited by the extent of CAR-T cell expansion in vivo.

65 vitro stimulation after IFNalpha production in vivo.

66 ogy, used to ablate cells and sever neurites in-vivo.

67 Our optimization strategy culminated with in vivo active RO7101556 (18B) having excellent properti

68 tablish the capacity of our model to uncover in vivo activity for the biotin biosynthesis inhibitor M

69 ADTRP inhibitor, ABD-110207, which is active in vivo Acute treatment of WT mice with ABD-110207 resul

70 vioural and electrophysiological assessments in vivo after mAb injections into the rodent hippocampus

71 In vivo, all tracers revealed uptake in activated hPBMCs

72 We addressed this in vivo, analyzing RNAPI in S. cerevisiae.

73 rease in TCR sensitivity to self-peptide MHC in vivo and an enhanced response to weak agonist peptide

74 ch proteins in regulating cellular processes in vivo and development in metazoans remains to be under

75 ces between compensatory processes operating in vivo and ex vivo.

76 H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-

77 rculosis Tam also replaced E. coli BioC both in vivo and in vitro and complemented biotin-independent

78 Further, single-cell analysis of in vivo and in vitro cardiomyocyte maturation trajectori

79 Analysis of variant proteins both in vivo and in vitro confirmed that residues in sequence

80 these structures are put into the context of in vivo and in vitro data.

81 , are paradoxically effective at restraining in vivo and in vitro models expressing MET(N375S).

82 is of neurodegenerative diseases, using both in vivo and in vitro models.

83 Human and experimental in vivo and in vitro studies show that the adventitia is

84 Despite recent in vivo and in vitro studies supporting this function, a

85 ach other's receptor expression on lung ILC2 in vivo and in vitro.

86 r cisplatin inhibition of murine TNBC tumors in vivo and reduced systemic levels of pro-inflammatory

87 cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connectivity in slice.

88 tic terminal protein levels in schizophrenia in vivo and that antipsychotic drug exposure is unlikely

89 cross-correction does not occur efficiently in vivo and that Galc-deficient Schwann cells autonomous

90 hanisms triggering these post-MI arrhythmias in vivo and their relation to regional myocyte remodelli

91 observed in animal models of BDNF deficiency in vivo, and BDNF is a common downstream intermediary fo

92 p, determining cis- and trans-acting lncRNAs in vivo, and generating new developments in high-through

93 orted across cancer types, both in vitro and in vivo, and implicated in multiple processes associated

94 Preclinical studies, in vivo, and in vitro studies, in combination with mathe

95 , causing regression of the malignant clones in vivo, and inducing molecular remission.

96 t provide quantification of these components in vivo, and none that can isolate and quantify lipids i

97 tion factors to uniquely spaced DNA elements in vivo, and suggest that differential binding affinitie

98 be individually efficacious in RA (in vitro, in vivo, and/or in humans) and provide a strong rational

99 (PAMs) of GABA(A) receptors (GABA(A)Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effe

100 ERK1/2 phosphorylation, cAMP inhibition) and in vivo (anxiety-like behaviors, cannabimimetic effects,

101 of 15 mutually orthogonal split inteins for in vivo applications, 10 of which can be simultaneously

102 The combined in vivo approaches showed that increased cerebral infilt

103 ur and dynamics of leukocytes non-invasively in vivo are lacking.

104 ues, though many considerations are relevant in vivo as well.

105 ATSM signal and levels of reducing molecules in vivo, as well as to evaluate the change in (64)Cu-ATS

106 Both in vitro and in vivo assays showed that TubZIP28 bound to the promote

107 By constructing an in vivo-assembled, catalytically proficient peroxidase,

108 allows facile visualization of drug effects in vivo at single-cell resolution over days.

109 TrkB.T1 enhances PDGF-driven gliomas in vivo, augments PDGF-induced Akt and STAT3 signaling i

110 ntly used as a catalytically inactive mutant in vivo (based on in vitro peptide studies) actually ret

111 In vivo biodistribution data showed the highest tumor up

112 9m)Tc-PHC-102 has previously shown favorable in vivo biodistribution properties in mouse models of CA

113 In vivo BP and regional blood flow were assessed using D

114 cies (ROS) that mediates essential signaling in vivo but may cause irreversible tissue damage under d

115 s BTC demonstrated potent antitumor activity in vivo but was poorly tolerated, which was hypothesized

116 ique peptide that selectively targets tumors in vivo by anchoring to cancer cell surfaces in a pH-dep

117 ivate the TAL1 oncogene, a finding validated in vivo by chromatin immunoprecipitation sequencing of a

118 Here, we test this model in vivo by inactivating Myocardin, which prevented airwa

119 In vivo calcium imaging revealed that different GA drugs

120 In vivo calcium imaging revealed that T4 and T5 neurons

121 n vitro transcription, kinetic analyses, and in vivo cell viability assays, we report that point amin

122 Here, in vivo characterization of tumor-associated USP22 upreg

123 tency and good oral bioavailability but high in vivo clearance.

124 Unique signatures of in vivo competition in gnotobiotic mice include an adhes

125 n of the Babesia microti (B. microti) in the in vivo conditions.

126 The in vivo consequences of both the accessibility of suscep

127 we use multiple mouse models to investigate in vivo consequences.

128 required for growth stimulation and survival in vivo Consequently, B. fragilis acquires essential hem

129 Future work will apply this method to in vivo data, potentially providing an important biomark

130 In vivo deletion or supplementation of LXA(4) identified

131 Evidence in cells and in vivo demonstrates promising results in many disease m

132 Designs were tested in vitro and in vivo, demonstrating alteration of the E2 antigenic pr

133 peptide profile generated after in vitro and in vivo digestion showed clear similarities with specifi

134 Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during

135 rk loop experiments designed to simulate the in vivo dynamics of muscle fibers during swimming.

136 s for using in vitro data to anticipate such in vivo effects exist.

137 BRD4 BD1 inhibitors demonstrated impressive in vivo efficacy and overall promising pharmacokinetic p

138 To evaluate the in vivo efficacy of (212)Pb-daratumumab, mice were engra

139 m of the present study is to investigate the in vivo efficacy of auranofin (rheumatoid arthritis FDA-

140 By using a combination of optogenetics, in vivo electrophysiology, and machine learning analysis

141 ntial responsiveness of IECs to type III IFN in vivo enables selective ISG expression during infectio

142 ssociated with markers of insulin resistance in vivo (euglycemic clamps and HOMA of insulin resistanc

143 of applications, including both in vitro and in vivo experiments.

144 In vivo fiber photometry revealed that these neurons are

145 Here we show by in vivo fluorescence and MR imaging, that LN paracortica

146 In vivo fluorescence and photoacoustic imaging studies h

147 wn to be a promising tool, even transplanted in vivo, for transducing light stimuli to non-functionin

148 uorescence both in dissociated ommatidia and in vivo from intact flies of both sexes.

149 binding sites act as a competitive reservoir in vivo from which transcription factors are released by

150 Finally, we demonstrate that the in vivo function of human-specific lncRNAs can be succes

151 ed human immune/hematopoietic cells has made in vivo functional characterization possible.

152 We previously reported an in vivo gain-of-function screen that identified ~30 gene

153 circumstances, the 2-FDG LC used to quantify in vivo glucose utilization should not be expected to re

154 In vitro and in vivo growth responses of Abi-/Enza-resistant LNCaP-95

155 del, but this compound suffered from a short in vivo half-life and suboptimal potency in whole blood.

156 The lack of tools to reliably detect RanBP9 in vivo has significantly hampered progress in understan

157 TMZ)-induced apoptosis in vitro Likewise, in in vivo human GBM xenograft experiments with immunodefic

158 ration of BK1.3 potently blocks inflammation in vivo Identification and characterization of the chemo

159 rease of the CNV lesion size, as revealed by in vivo imaging and immunohistochemistry from day 3 to d

160 By using in vivo imaging and transfusion experiments, we further

161 The recent demonstrations of in vivo imaging, control and therapeutic medical applica

162 Using in vivo imaging, such as optical coherence tomography, s

163 resonance, a technique which can be used for in vivo imaging.

164 is associated with a series of in vitro and in vivo immune abnormalities consistent with lymphocyte

165 xa, DT-Hepta, and DT-Octa) that were used in in vivo immunization experiments in mice.

166 ficant axonal growth and functional recovery in vivo in a spinal cord injury model through a unique m

167 xicology profiles were assessed and compared in vivo in an adjuvant-induced arthritis (AA) rat model

168 n strategy to demonstrate DapF (Ct) function in vivo in C. trachomatis We reasoned that, because DapF

169 s candidate client proteins that are altered in vivo in disease models and whose degradation is promo

170 ing virus entry and spread and is protective in vivo in mouse models.

171 emical known to induce testicular dysgenesis in vivo in rats).

172 tion in vitro and influences PBG hyperplasia in vivo in the DDC-mediated mouse biliary injury model.

173 and inhibits its toxicity both in vitro and in vivo In this study, we investigate whether the amyloi

174 iferation in response to glucose ex vivo and in vivo in transplanted glucose-infused rats.

175 eptides ex vivo (i.e., to excised tissue) or in vivo (in animals), using antagonists of opioid recept

176 noma cells to radiation therapy in vitro and in vivo (in immunocompetent syngeneic hosts).

177 e properties and drove CNS axon regeneration in vivo, in part via secretion of a cocktail of growth f

178 In the clinical study, 24 in vivo-in vitro pairs were eligible for further analysi

179 the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (I

180 itation-mass spectrometry analysis to detect in vivo interactors of AtGET1 and identified a membrane

181 In vivo interrogation of chromatin architecture and geno

182 VEEV infection in vivo is characterized by extensive systemic inflammat

183 host cells, but their relevance to infection in vivo is undefined.

184 lly defined; however, the efficacy of h5B3.1 in vivo is unknown.

185 tent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust infla

186 oxicity but was not required for in vitro or in vivo leukemia clearance.

187 This strategy is predicated on the in vivo ligation between a trans-cyclooctene (TCO)-beari

188 In vivo, m-RCT was evaluated in mouse models of hypercho

189 Using the in vivo matrigel plug assay, we then found that EC-speci

190 ucture determination approach that relies on in vivo measurements of genetic interactions.

191 afish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposi

192 Several in vitro and in vivo mechanisms involved in PDAC metastases were inve

193 mited medium, resulting in MICs that reflect in vivo meropenem activity.

194 The in-vivo metabolic data were validated by mitochondrial r

195 h-throughput EpiSELEX-seq binding assays and in vivo methylated TFBSs from the MeDReaders database.

196 invasion assay, sphere formation assay, and in vivo mice tumor model were performed to evaluate func

197 Finally, in vitro and in vivo microdosimetry was modeled from experimentally d

198 Collectively, our study establishes an in vivo model for studying how transformed cells migrate

199 using heterologous expression in a tractable in vivo model, the Drosophila melanogaster developing ey

200 ific T cells, and through the generation and in vivo monitoring of defined TCR repertoires, we found

201 articles (ErNPs) was performed for real-time in vivo monitoring of PD-L1 positive tumor cells and CTL

202 signaling like wild type, demonstrating that in vivo monomeric arrestin-1 is necessary and sufficient

203 ted phantoms, ex vivo biological tissue, and in vivo mouse and rat models of cancer with a thermal ca

204 high spatial and temporal resolution through in vivo mouse erythroid differentiation.

205 Preclinical studies using an in vivo mouse model also demonstrated that combining Enz

206 In vivo mouse reconstitution assays resealed that only C

207 ption spectroscopic (XAS) fingerprinting and in vivo mouse relative bioavailability (RBA) measurement

208 This in vivo MT phenotype was reproduced in vitro when cells

209 Indeed, an in vivo network consisting of selected stress-response a

210 Linking ex vivo gene down-regulation with in vivo neuroimaging, we find that transcriptional corre

211 the role of this inhibitory phosphorylation in vivo, new phosphorylation-deficient p53-S180A knock-i

212 In-vivo, newly recruited cells on the vascular lumen exp

213 In vivo observations showed that oocytes undergo a varie

214 In vivo, one single topical deposition of CURC-muPLs out

215 ght and transmission electron microscopy and in vivo ophthalmoscopy, we describe the ultrastructural

216 Moreover, Med19 loss of function experiments in vivo or in cellulo indicate that it is required for P

217 In addition, using an in vivo P. gingivalis-mediated periodontal disease model

218 Many such technologies could use in vivo paternal haploid induction (HI), which occurs wh

219 se and (64)Cu-LLP2A uptake, as quantified by in vivo PET (R = 0.69, P < 0.01).

220 In vivo pharmacokinetic testing of 90 in rats revealed t

221 y, in vitro drug-target residence times, and in vivo PK properties, to identify first-in-class inhibi

222 limitations in faithfully recapitulating the in vivo processes.

223 In vivo proteasome inhibition within neurons, to mimic a

224 might be used to cross-validate and compare in vivo radiologic imaging with ex vivo optical imaging

225 lated human and mouse cells, and ex vivo and in vivo rat models, we uncovered a function of 14-3-3zet

226 arette smoke is the first complex odor whose in vivo receptor response pattern has been measured.

227 In vivo recordings revealed a strong role for hAPP/Abeta

228 ated effector functions have been quantified in vivo relative to the contribution of virus neutraliza

229 to combat CP-mediated Zn limitation and the in vivo relevance of CP-GAS interactions to bacterial pa

230 neural processes that govern cocaine potency in vivo remain unclear.

231 ng in vitro, but its cardiovascular function in vivo remains relatively unexplored.

232 this biomaterial for tissue regeneration and in vivo restoration of organ functions.

233 By coupling in vivo ribosome profiling with genetic screening, we pr

234 We investigated the role of in vivo RNA secondary structure in miRNA cleavage by dev

235 Here we experimentally mapped the in vivo RNA-RNA interactome of the full-length SARS-CoV-

236 In vivo, rtPDT induces cellular damage in tumors, shown

237 and genomic tools that are commonly used for in vivo screens to illustrate their strengths and limita

238 an TfR1 ectodomain (rh-TfR1-ECD) followed by in vivo selection in mouse for brain parenchyma penetrat

239 ells to clonal density, to mimic lung injury in vivo, selects for rare subsets of HBECs that activate

240 ma/RXR signaling in cell-free, cellular, and in vivo settings.

241 by disturbed flow required Nck1 in vitro and in vivo, showing endothelial Nck1 and IRAK-1 staining in

242 To further analyse in vivo signalling interplay, a CCK-1 antagonist (lorglu

243 In vivo silencing of Mcl and Mincle or blockade of their

244 The recent development of an in vivo solid-phase microextraction (SPME) method capabl

245 In vivo-specific deletion of the Sema3E high-affinity re

246 hibitor combination showed enhanced activity in vivo specifically in CA-NRAS models.

247 ith its application to multiple in vitro and in vivo studies across species.

248 Our in vivo studies demonstrated that (a) infants (<18 month

249 In vitro and in vivo studies demonstrated that 20 restored the activi

250 In vivo studies in which the hydrogels were formed in si

251 oduce a live-cell imaging tool to facilitate in vivo studies of cell-cycle control in a wide-range of

252 h in in vitro biochemical binding assays and in vivo studies of differentially methylated isogenic ce

253 In vivo studies uncover that EhActn2 plays an important

254 In vivo studies using a murine model displayed that the

255 In in vivo studies using a syngeneic mouse model bearing or

256 ancer target based on extensive in vitro and in vivo studies with archazolids, complex polyketide mac

257 For in vivo studies, fat fraction was greater for chylous ve

258 Although its pathogenicity precluded in vivo studies, the M. tuberculosis Tam also replaced E

259 brain using genetically encoded sensors for in vivo studies.

260 In conclusion, this in vivo study confirms that Scia highly inhibits SCD1 ex

261 Our in vivo study reveals that 4-AP-induced increase of neur

262 multi-NAI-resistant AIVs is associated with in vivo susceptibility, we infected BALB/c mice with rec

263 onsidered when comparing in vitro results to in vivo systems.

264 Here, we studied how baseline assessments of in vivo tau pathology (measured by 18F-AV-1451 PET), neu

265 ctionally validated by in vitro, ex vivo and in vivo techniques.

266 In vivo testing confirmed the selectivity of C(3)-ZIF(MC

267 ionally, 17syn (+) is markedly more virulent in vivo than KOS.

268 the onset kinetics of competence development in vivo The competence shutoff regulator DprA was highly

269 In vivo, the knockdown of osa and brahma was shown to en

270 The efficiency of GALC cross-correction in vivo, the role of the GALC substrate galactosylcerami

271 ow that if fiber formation is at equilibrium in vivo, the vast majority of cells in most tissues woul

272 ent of tumor selectivity to achieve improved in vivo therapeutic outcomes.

273 to high throughput and practical preclinical in vivo therapeutic testing.

274 are collectively effective both in vitro and in vivo, thereby inducing stem cell differentiation.

275 tagonizes RNase L activity both in vitro and in vivo These studies highlight an ever-evolving arms ra

276 In vivo, these groove mutations were found to significan

277 us helicase on infection in cell culture and in vivo This work provides new insight into how flavivir

278 In vivo, this can be accomplished with a single dose of

279 parameters, kidney disease, and response to in vivo TLR7/9 pathogenic signals.

280 ferentiation, and function, which translates in vivo to an improved ability for T cells to infiltrate

281 ow that LukE targets murine Darc through DR1 in vivo to cause host lethality.

282 Notably, in vivo TPC1 deficiency in mice leads to enhanced passiv

283 However, recent in vivo tracking experiments have revealed the presence

284 re enriched in dosed mouse serum, suggesting in vivo transformation of sulfonamide precursors.

285 N results in ISG expression that mirrors the in vivo type III IFN response.

286 d an accuracy to within approximately 20% of in vivo urinary bladder radiotracer concentrations.

287 tivity and is required for TNBC tumor growth in vivo using an orthotopic xenograft model in immunocom

288 flux mediated by apoA-I or HDL3 in vitro and in vivo Using LC-MS/MS analysis, we analyzed the pattern

289 cterization, as well as disease modeling and in vivo validation capabilities.

290 FR-alpha in HSCs during chronic liver injury in vivo via regulation of HSC survival and migration and

291 globulins may affect C. neoformans virulence in vivo warrants further investigation.

292 Tumor cell expression of IL1beta in vivo was driven by microbial-dependent activation of

293 Both in vitro and in vivo, we find that RFX6 specifically labels a subset

294 Secondly, in vivo, we have investigated its efficacy against infec

295 o mimic the geometry of Spire and Cappuccino in vivo, we immobilized Spire on beads and added Cappucc

296 e antigen-specific CD8(+) T-cell populations in vivo, which may serve prognostic and diagnostic roles

297 We used PET in vivo with (i) 11C-PK-11195, a marker of activated mic

298 Animals treated in vivo with a mimic nanodrug had higher insulin-produci

299 In vitro findings were confirmed in vivo with an angiotensin II-mediated murine model of

300 It co-purifies in vivo with DNMT3L and DNMT3A, components of the de nov