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1 4) ](4-) units and transition metal cations, in which 3-center-2-electron sigma bonding in Ge(2) Zn o
2 human pluripotent stem cell (hPSC) platform, in which 30 isogenic disease lines are pooled in a singl
3 program that sets specific spatial locations in which ~50 um-diameter epithelial tubules form by cell
5 collected in a commercial winter wheat field in which a 5x6 trapping grid had been established with 2
6 y data informed a Bayesian prevalence model, in which a flexible incidence-to-prevalence relationship
7 tructure exhibits an inhibitory conformation in which a large linker domain blocks activation and sub
8 ion from D1-expressing cells (D1-Cre-flTrkB) in which a subset of animals shows repetitive rotations
12 and obesity may exhibit disease reciprocity in which activated neutrophils are mutually shared to cr
14 the adventitia is a dynamic microenvironment in which adventitial and perivascular adipose tissue cel
15 a reaching task under a visuomotor rotation in which, after performing a initial set of trials, they
16 imple model of CD8(+) T cell Ag recognition, in which Ag dose and affinity do not provide any additio
17 ction of tetra-nitro-blue tetrazolium (TNBT) in which all four phenolic rings are nitrated, (6) cytop
18 st addressed in a genetic mapping population in which all molecular polymorphisms are known and for w
19 dimensional tandem mass scan (2D MS/MS scan) in which all precursor ions and their subsequent product
21 pathways with distinct biomarker sequences, in which amyloid-PET and (18)F-FDG-PET are placed at dif
23 , participants were presented with scenarios in which an existing environmental inequality between tw
24 model for tissue-specific enhancer activity in which an HDAC-associated GLI repression complex regul
25 all-fiber modular optical tweezers (AFMOTs), in which an optical trap can be reliably created and fre
26 atalysis to include a dioxygenase reactivity in which an unactivated alkene is converted to a vicinal
27 population activity was higher across blocks in which animals learned the values of novel pairs of ob
28 ers have proposed a more uniformitarian view in which Archean and Hadean continents were only slightl
29 odel of amyotrophic lateral sclerosis (ALS), in which astrocytes expressing mutant superoxide dismuta
30 heless, our data are consistent with a model in which, at the scales probed, the human genome is ofte
32 es promising results in many disease models, in which autophagy upregulation is able to reduce the le
33 parallels to photoredox-catalyzed reactions, in which back-electron transfer and chain propagation ar
35 kynes is a fundamentally new transformation, in which both H atoms of dihydrogen are transferred to t
36 a shared clonal origin, as well as instances in which both NAT tissue and tumor tissue harbor a gain
38 local electron-proton transfer (LEPT) state, in which both the electron and proton transfer from the
40 te the power of a synthetic biology approach in which bottom-up construction of photosystems using na
42 est bryostatin 1 analogues reported to date, in which bryostatin's A- and B-rings are replaced by a g
43 d-type SERCA2b or a redox-insensitive mutant in which C674 is replaced by serine (C674S) were exposed
44 water electrolysis to produce a pH gradient in which CaCO(3) is decarbonated at low pH and Ca(OH)(2)
45 progression, we generated a PDAC mouse model in which CAF plasticity is modulated by genetic depletio
46 ggers de novo lipogenesis in the liver(4-6), in which carbon precursors of acetyl-CoA are converted i
47 ronmental factors in the development of ASD, in which certain brain structures may be more sensitive
51 that glasses containing complex anions, and in which covalent network formation is minimized, may ex
52 ponses of Abi-/Enza-resistant LNCaP-95 cells in which CRISPR-Cas9 was used to knockout AR-FL or AR-V7
53 een in an independent cohort of 24 subjects, in which cultivation revealed Malassezia as viable oral
54 0% each of the WT conformer and an "O" state in which d(z)(2) Ni(p)(I) (g( ) > g(||) ~ 2) surprisingl
55 monium lead triiodide (MAPbI(3)) perovskites in which defects were purposely introduced by fractional
57 al structure of the BRAF(KD)-14-3-3 complex, in which dimeric 14-3-3 enforces a dimeric BRAF(KD) asse
60 er, these results reveal a division of labor in which dissociable neural systems support the learning
61 imethyl sulfoxide (DMSO) into ZnCl(2)-H(2)O, in which DMSO replaces the H(2)O in Zn(2+) solvation she
62 n implied stage of human NK cell development in which DNA demethylation takes place to allow for acti
63 e is the ORC-Cdc6-Cdt1-Mcm2-7 (OCCM) complex in which DNA has been already inserted into the central
65 n pre-implantation embryos are an exception, in which dosage compensation occurs by X-chromosome damp
67 tionation revealed temporal gene regulation, in which early lytic gene expression was terminated in l
68 rs, could have facilitated that first moment in which early RNA molecules with catalytic capability b
69 plexed negative selection screening approach in which edited loci are deep sequenced, and candidate s
70 tients an invasive evaluation was performed, in which electroanatomical voltage mapping and electroan
71 2 study done in Canada, Spain, and the USA, in which eligible patients with multiple myeloma had rec
72 anges create a progressive feed-forward loop in which enhanced matrix deposition and tissue stiffenin
73 dings support a 'bind and discard' mechanism in which enhancers with specific binding sites promote r
74 otein 9 was used to generate HeLa cell lines in which ENT expression was limited to ENT1 or ENT2.
77 nvestigating different prevention strategies in which extensive prospective high-quality data collect
79 us possibly representing one of the pathways in which familial risk is translated into the SCZ phenot
80 Sex differences were noted in control mice, in which female islets showed 5 selenoproteins decreased
81 imal but generic model for a nematic network in which filament sliding is driven by the action of mot
82 ents suffering from ulcerative colitis (UC), in which first-time treatment with vedolizumab was initi
83 lexing method for single-cell RNA sequencing in which fixed cells are chemically labeled by attaching
89 hese recent publications and propose a model in which genes that confer ASD risk operate in signal tr
91 poietic differentiation, and support a model in which genome-wide methylation changes are transduced
92 models by adopting a nonparametric approach in which group-level response trends for logarithmically
93 evelopmental transcription factor, mutations in which have recently been associated with CAKUTHED syn
94 ucing more bone, we use transgenic zebrafish in which Hh levels could be experimentally manipulated u
96 genome is reorganized in a sequential order, in which histone methylations occur first in prometaphas
98 identify distinct mechanisms of resistance, in which HUWE1 loss increases RAD51 levels to partially
99 a minimal chemically-defined culture medium in which IGF1 together with Activin maintain self-renewa
103 ts from large, randomized, controlled trials in which improved renal outcomes occur only in the subgr
104 We employed a model of murine BSM tissue in which increased expression of desmin or vimentin was
105 further explored to establish the conditions in which indirect defence generates a plant-natural enem
106 methylates H3K4 through distinct mechanisms in which individual subunits differentially participate.
107 Group A5312 is a Phase 2A, open-label trial in which individuals with smear-positive pulmonary TB wi
108 ty contraction is stronger in municipalities in which inequality is higher and for those where indivi
109 a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged as criti
110 need to be confirmed in analytical studies, in which information of exposure to chemicals originatin
111 strategy for eradicating metastatic cancers in which initial therapy, by reducing the size and diver
112 ss Spectrometry Sequencing (SIMMS(2)) method in which intact HS saccharides are dissociated in an ion
114 ues revealed patient subgroups for each drug in which inter-patient variability was largely decreased
116 y occurred through induced-folding pathways (in which intermolecular contacts form before or concurre
117 e of the transport process, there is a state in which ions are stably trapped within the permeation p
118 expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for stru
120 t affects reliability solely in the quadrant in which it occurs, with artifact in one quadrant showin
121 vely short latent period (nearly 30 minutes) in which it produced progeny at 72 particles per cell at
123 suggest a revised microtubule-sliding model, in which kinesin-5 tails stabilize motor domains in the
126 ically, this was explained in neonatal mice, in which long-chain, but not short-chain, Vi conjugate i
127 A discontinuous structural change occurred in which low-density liquid domains appeared and grew on
128 HIF biology with diabetes is a complex area in which many further questions remain, especially regar
130 ane system in eukaryotes and highlights ways in which membrane trafficking in protists differs from t
131 urogenesis was transiently increased in mice in which MerTK expression was conditionally downregulate
132 propose a computational model of confidence in which metacognitive performance naturally improves wh
133 duced calcium carbonate precipitation (MICP) in which microbial activity leads to the formation of ca
134 the gap, we develop a population game model in which migrants are allowed to be heterogeneous and de
135 cal especially for some pathological states, in which mitochondrial deficits are prominent and diffic
136 testing artificial intelligence techniques, in which model-based planning approaches have historical
138 y a simple phenotypic model of TCR signaling in which multiple T cell responses share a common rate-l
139 ished and characterized a skin cancer model, in which Mus musculus papillomavirus 1 (MmuPV1) infectio
140 2, participants performed two exercise bouts in which muscle fibre recruitment was manipulated while
141 terially unchanged in a sensitivity analysis in which neonates with missing data were counted as havi
142 hypothesis, we devised a purely visual model in which neurons tuned to letter shape respond to longer
143 elease is a fundamental property of synapses in which neurotransmitter filled vesicles release their
147 f LRRK2 inhibitors in demyelinating diseases in which oligodendrocyte cell-death is one of the pathol
148 broadly relevant for the many human diseases in which oligogenic inheritance is emerging as a mechani
149 We studied WT Cel7A and several variants in which one or two of four highly conserved Trp residue
150 iggers monoubiquitination of the ID complex, in which one ubiquitin molecule is conjugated to each of
152 ential of visGReMLIN, we conducted two cases in which our strategy was compared with previous experim
153 y be of relevance for human amyloid diseases in which oxidative stress is often an associated hallmar
154 und that results were sensitive to the order in which participants entered the Hyperalignment algorit
155 rver model and an approximate Bayesian model in which participants were assumed to attend (and learn
156 ving walking in an omnidirectional treadmill in which participants were guided on two sides of a tria
157 onth double-blind, randomized clinical trial in which participants with PAD were randomized to either
158 This was a prospective, single-arm study in which patients 18 to 65 years of age who completed 4
159 group (CTG) trials were pooled and analysed, in which patients received one of six CBMPs containing r
160 compared the study group to a control group in which patients were fed in a traditional way (traditi
161 ized, double-blind, placebo-controlled trial in which patients with severe asthma (GINA 4-5; n = 121)
162 performed a multicenter, double-blind trial in which patients with type 2 diabetes mellitus who were
163 monstrates the diversity of scientific areas in which PCs are gaining attention but also the opportun
168 ticolor similarity map of the analysis area, in which pixels with similar mass spectra are assigned a
169 ll-watered treatment and a drought treatment in which plants were subjected to three cycles of drough
170 k provides evidence for an anaerobic process in which plasmalogens are formed from their correspondin
171 ted by a time-delayed negative feedback loop in which Plk4 inactivates the interaction with its centr
172 ear and include a sequential addition model, in which polyubiquitin chains are built unit by unit on
173 it on the substrate, or a preassembly model, in which polyubiquitin chains are preformed on the E2 or
174 w that a conformational selection mechanism, in which POT1 binding is coupled to an obligatory unfold
177 haracterized by profound vascular remodeling in which pulmonary arteries narrow because of medial thi
180 42-45]), mostly in food and beverage groups in which regulatory cutoffs were below the 75th percenti
181 rection for brain studies, abdominal studies in which respiratory and cardiac motion is visible, and
182 in predator-prey interactions, discuss ways in which risk effects may impact biocontrol programs and
184 A classic example is contour integration, in which separate line segments are perceived as continu
185 ayments for Care Improvement (BPCI) model 3, in which skilled nursing facilities (SNFs) assumed accou
186 diffusion and promote a discrete population in which small changes in orientation control Ras' compe
187 Taken together, these data support a model in which SNAP23 plays a crucial function as a scaffold f
188 ical modeling suggest an "illumination gap," in which some temporally incident light rays to the nasa
191 In this review, we will highlight the ways in which STEP(61) differentially regulates NMDARs and AM
192 Is it adaptive for individuals to sense in which sub-habitat they find themselves, using environ
193 This suggests a source-and-sink dynamic in which subcamps with greater average infectiousness fe
194 To investigate this, we used a color WM task in which subjects viewed colored stimuli and reported bo
195 over the SMA assessed in neuroimaging scans, in which subjects were cued to increase/decrease activit
196 This Opinion paper considers conditions in which such islands might occur, including ex cranio b
197 energy storage and generation applications, in which superior performance was observed for the NiS s
198 ce of examining NPs in their post-use phases in which surface reactivity and hazard potential can be
199 e treatment failure (the proportion of women in which surgery failed to adequately resolve midline pa
200 c re-organization during the recovery period in which synapse counts recover from 16 to 91% of normal
201 pathogenesis, away from the classical model in which T cells were the sole central actors and toward
202 onse to biotic elicitors and support a model in which TARK1 regulates stomatal opening postelicitatio
203 cal scenarios of TAVR versus SAVR durability in which TAVR failure times were varied to determine the
204 Observers performed a yes/no detection task in which texture spatial frequency and external noise le
205 l as two N-substituted ixabepilone analogues in which the 12,13-epoxide and macrolactam NH moieties w
206 previously unknown quality control mechanism in which the abundant ribosome assembly factor, RbfA, su
207 ly, 'egalitarian' dominance structures occur in which the adult willow tits rank second and the hiera
208 come this limitation, we devised cell models in which the AML1-ETO protein could be quickly degraded
209 at various [ATP]s and discuss rotary models in which the archaellum has characteristics of both the
211 rticle has been through an editorial process in which the authors decide how to respond to the issues
212 biology includes a paper by Korshunov et al. in which the authors describe an elegant strategy that E
213 adigm for the molecular pathogenesis of ETEC in which the bacteria use toxin to drive up-regulation o
214 eriodontal bone loss; Group I (intermediate) in which the border of the furcal lesion has normal char
215 (+) channel Na(v)1.5 (Na(v)1.5(+/)) and mice in which the cAMP-dependent regulation of hyperpolarizat
217 the concepts of primary pseudotumor cerebri, in which the cause cannot be identified (also known as i
219 to a "limited change/induced fit" mechanism in which the clamp first opens, followed by DNA binding,
220 Microbes inhabit ever-changing environments in which the conditions for propagation, whether they be
222 s limitation has led to models of early life in which the first cells used simpler types of membrane
223 ets of beta-strands wrapped into a cylinder, in which the first strand is hydrogen-bonded to the fina
224 (DVR) is organized as a trilayered complex, in which the forming layers-the thalamo-recipient entopa
225 es differs, an amblyopia-like state develops in which the foveal region of one eye is suppressed due
226 TP) delivery system (the TriPPPro approach), in which the gamma-phosphate is covalently modified by t
227 ation can occur is by an accordion mechanism in which the gene copy number increases followed by base
228 e accumulation of exosomes produced by cells in which the gene encoding hnRNPA2B1 has been knocked ou
229 in patients with obesity/metabolic syndrome, in which the GRK2-mediated signaling can be a potential
232 er jaws is important in dental implantology, in which the implant position and dimensions are current
233 h encoder-decoder artificial neural networks in which the input is first compressed and integrated in
234 stigations have taken a 'black box' approach in which the internal structure of themodel used is set
235 Here, we describe a morphogenetic movement in which the intertwined socket and shaft cells of the D
236 ension of the generalized linear model (GLM) in which the linear predictor takes random effects into
237 eloading conformers to the loaded conformers in which the loading of Mcm2-7 on DNA is complete and th
238 was challenged by an alternative mechanism, in which the major reaction of HO(.) with dG was propose
239 directional fly-casting mechanism for KRAS, in which the membrane-distal state of the G-domain can e
240 eres provide a convenient model solid system in which the microscopic dynamics of these defects can b
242 at the striatal cellular/microcircuit level, in which the molecular/subcellular and systems levels me
243 phological transformation during myogenesis, in which the myotubes elongate over several cell diamete
244 mino acid truncated mature frataxin (79-207) in which the N-terminal lysine residue has been lost.
245 e dendrites develop by retrograde extension, in which the nascent dendrite endings anchor to the pres
246 lexes with the R(P)S(P)S(P)R(P) isomer only, in which the orientation of the lone pairs of electrons
247 hophysical method (2-interval forced choice, in which the participant identifies which of two spatial
249 itical drive, time crystal behavior emerges, in which the period of the limit cycles becomes an integ
250 based on non-adiabatic dynamics simulations, in which the photoproduct ratios were determined with ma
252 emains largely untested within living cells, in which the richly multicomponent nature of condensates
253 a single reconstructed color similarity map, in which the spectral similarity between pixels is repre
254 is, a theory of retinal color coding emerged in which the three most common retinal ganglion cell (RG
255 the preclinical, and some clinical, results, in which the top tier includes rapamycin, senolytics, me
257 The transposase forms an asymmetric dimer in which the two central domains synapse the ends while
258 roduction, creating an experimental paradigm in which the wing stops growing at the correct size whil
259 ry frame and applies an intensity correction in which the z intensity profile for each synapse is mod
260 to three groups as follows: Group L (lesion) in which there is a furcal lesion with periodontal bone
261 an unsymmetrical concerted transition state in which there is partial positive charge developing on
265 a periorbital shock (conditioning) or trials in which these stimuli were randomly presented in an unp
266 n of these systems indicates that the manner in which these systems process visual information is lik
267 Auguste et al. generate a mouse model of DCM in which they delete Lmna in cardiomyocytes and discover
268 re trained in a two-alternative choice task, in which they had to associate tastants sampled from a c
271 teria cycle between sessile and motile forms in which they must sense and respond to internal and ext
272 ifferent agricultural practices and the ways in which this knowledge, coupled with improved methods f
274 ignificance is the homodimerization of F-NC, in which this species is revealed as an excellent accept
277 eukaryotic cells have evolved multiple ways in which to process branchpoints connecting DNA molecule
278 m lycopersicum) provides an excellent system in which to study this phenomenon, as its fruit are asto
279 the quantum nature of isomerization, systems in which transitions between the eigenstates occur-such
280 ustain a micro-epidemic in another community in which transmission is too low to be self-sustaining.
282 issues will be crucial for treating diseases in which type 2 immunity is an important component.
283 entiation and supports a developmental model in which Type-I and Type-II hair cells develop in parall
284 ogenetics to stimulate VTA glutamate neurons in which tyrosine hydroxylase (TH), and thus DA biosynth
285 onclusion, this study identified the pathway in which ubiquitinated OAT1 degrades and unveiled a nove
286 r structures but also local probe reactions, in which unstable short-lived products have been synthes
287 st in part via hemovasculogenesis, a process in which vasculogenesis and hematopoiesis occur simultan
288 d to delineate a Vif/CBF-beta/PPP2R5 complex in which Vif is predicted to bind the same PPP2R5 surfac
289 tiation step of HIV-1 reverse transcription, in which viral RNA genome is converted into double-stran
292 nd wide but only about four nanometres thick-in which warp and weft single-chain polymer strands rema
293 o expand the interlayer gap of alpha-MoO(3), in which water molecules take the place of lattice oxyge
294 apply each method to a mesocosm experiment, in which we aim to predict species richness and extincti
295 we conducted two functional MRI experiments in which we dissociated the periods related to perceptua
296 an ex vivo cultured human skin explant model in which we have characterized pathological tissue integ
297 id on its host using a laboratory experiment in which we independently varied daylength and the prese
298 cal Trials in Organ Transplantation-09 study in which we randomized stable kidney transplant recipien
299 ults of two differential expression analyses in which we successfully identified differences and simi
300 ocarcinoma is a rare gastrointestinal cancer in which WNT signalling dysregulation has been previousl