ライフサイエンスコーパス: inability

1 In this case, the inability for transport arises from slow opening of the

2 This inability led to a reduction in AT immunosuppressive reg

3 s suggest that this difference is due to the inability of agonist alone to induce a detectable outwar

4 The inability of avian influenza viruses to effectively bind

5 We hypothesized that the inability of callosal connections to relay ipsilateral e

6 ction is a leading cause of death due to the inability of cardiomyocytes to proliferate and replenish

7 or this condition(1), particularly given the inability of cardiomyocytes to replicate and thereby reg

8 These changes likely account for the inability of ceftriaxone to attenuate cocaine relapse in

9 The inability of cells to adapt to increased environmental t

10 d disruption of this interaction leads to an inability of cells to trim tubulated cytoplasmic membran

11 The inability of conventional electronic architectures to ef

12 Moreover, we show that the inability of CrmD to inhibit human LTalpha is caused by

13 allenging because of their young age and the inability of current risk scores to fully capture their

14 ncorporation of Sec at Cys codons due to the inability of cysteinyl-tRNA synthetase (CysRS) to discri

15 The inability of E1A to interact with E4orf3 has a significa

16 al boundaries have likely contributed to the inability of even well-powered studies to resolve these

17 cular ON/OFF control has been limited by the inability of existing systems to achieve both fast (i.e.

18 on of arterial dilatation or PPE by CSD, the inability of fremanezumab to prevent them suggests that

19 Disabling this connection resulted in the inability of fungal cells to infect plants.

20 were both decreased 2.1-fold, indicating an inability of glycolysis and glycogen synthesis to proces

21 diseased brain and accounts for the ability/inability of healthy tissue to compensate for this press

22 tection is, at least in part, related to the inability of HIV to evade the HLA-B*52:01-restricted p24

23 iduals, OI most likely occurs because of the inability of HSP47 to bind KDELR2 and dissociate from co

24 However, the inability of human adenoviruses to replicate efficiently

25 f TPK3 in isolated thylakoids as well as the inability of isolated chloroplasts to import TPK3 protei

26 EV) is a genodermatosis characterized by the inability of keratinocytes to control cutaneous beta-HPV

27 smission, and this effect concurred with the inability of ketamine to induce a long-lasting decrease

28 nfecting B cells with KSHV in vitro, and the inability of KSHV to transform them.

29 ar affinity and high selectivity despite the inability of l-DNA to interact with native d-RNA via Wat

30 These defects are due to the inability of large cells to scale nucleic acid and prote

31 ted in this experiment, likely because of an inability of liposome particles containing the cytotoxic

32 This oversight reflects the fundamental inability of local, continuum-based models to capture th

33 paramagnetic resonance data demonstrate the inability of MaNifB to serve as a source for cofactor ma

34 The inability of metabolic rate to explain latitudinal varia

35 eric self-association may compensate for the inability of monomeric E2A-PBX1 to stably bind DNA and c

36 classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-n

37 ns of classical microbiology methods and the inability of most molecular techniques to distinguish li

38 hese pathogens is challenging because of the inability of most small molecules to accumulate inside G

39 seen with Pam(3)CSK(4) We speculate that the inability of Mtb LAM to prime PMN may be due to differen

40 ined upregulation of Bmp4 expression and the inability of mutant epicardial cells to transition into

41 The inability of mycolactone-inhibited Sec61 to effectively

42 Notably, the inability of Nef to down-regulate CD3 from infected T ce

43 uctural connectome has been precluded by the inability of non-invasive neuroimaging methods to resolv

44 etes (T2D) is a global disease caused by the inability of pancreatic beta-cells to secrete adequate i

45 lobal health problem caused primarily by the inability of pancreatic beta-cells to secrete adequate l

46 This LTL tracking stems from the inability of person-to-person variation in age-dependent

47 However, the underlying mechanism of the inability of phosphorylated AKT to phosphorylate GSK3bet

48 entation to auditory nuclei demonstrates the inability of physiological processes to restore a tonoto

49 dpole rod photoreceptors, which leads to the inability of rod cells to maintain their OS, is rescued

50 Loss of PEZO-1 also led to an inability of self-sperm to navigate back to the spermath

51 s an underlying reason for this behavior the inability of soft elastomer substrates to resist tractio

52 e possible bias from unmeasured confounders, inability of summary-level MR to investigate a potential

53 rogression to heart failure in humans is the inability of the adult heart to repair itself after inju

54 until no binding was observed because of the inability of the compounds to fit in the active site.

55 major public health problem characterized by inability of the heart to maintain sufficient output of

56 iological features, and both result from the inability of the host's immune system to cope with the i

57 repancy could potentially be explained by an inability of the immune system to kill HIV-1-infected ce

58 Loss of the interaction resulted in the inability of the mRNA degradation machinery to sense cod

59 almic with colobomas, which may underlie the inability of the mutant fish to find food.

60 us is a serious challenge that results in an inability of the pancreas to produce sufficient insulin

61 e pair deletion in the proximal promoter and inability of the upstream DNA sequences to recruit const

62 ylethanolamine substrates and resulted in an inability of these cells to form labeled plasmalogens fr

63 Notably, the inability of V. cholerae to produce and utilize pseudoco

64 This is consistent with the inability of Y102E to bind TopBP1.

65 t the foundational issues that we claim this inability stems from.

66 uded because of manometer malfunction (n=2), inability to access effusion due to pleural tumour burde

67 r carbon nanotubes (CNTs) in particular, the inability to access structures with specific diameters o

68 However, inability to access these cells from patients, particula

69 We discuss the proposed model's inability to account for culturally emergent normativiti

70 atively small external validation cohort, an inability to account for delayed changes to treatment be

71 This lack of data coherency results in the inability to accumulate a critical mass of metabolomics

72 on DNA sequencing is currently limited by an inability to accurately count the number of input DNA mo

73 ng DXA for the measurement of lean mass, the inability to accurately detect changes over time calls i

74 XI-I decreases stomatal density, owing to an inability to accurately orient a specific subset of ACDs

75 ete knowledge about their physiology and our inability to accurately predict phenotypes.

76 velopmental dyslexia is characterized by the inability to acquire typical reading and writing skills.

77 An inability to activate the PIMs caused slightly greater c

78 gment distributions, suggesting a structural inability to adapt rapidly to the light level fluctuatio

79 ial bias from exposure misclassification, an inability to adjust for all sources of confounding, and

80 Overall there was (1) an inability to align SARS-CoV-2 contaminated surfaces with

81 on nanostructures has remained stunted by an inability to alter the sp(2)-carbon lattice with atomic

82 technical gap of top-down proteomics is the inability to analyze a low amount of biological samples,

83 The inability to appropriately regulate hepcidin production

84 A key limitation of this study is the inability to assess causality because of its observation

85 Lack of response can be in part due to inability to assess treatment adequacy in real-time.

86 jurious effect of COVID-19 on the liver, the inability to attend regular visits with providers, diver

87 orer prey availability rather than solely an inability to become pregnant.

88 however, remains unexplored due to protein's inability to bind targets covalently.

89 of one of these two motifs, resulting in an inability to bind to host cell protein ALIX.

90 loss of intracellular methionine leads to an inability to biosynthesize spermidine, and spermine.

91 Inability to block translation of faulty mRNAs and subse

92 resentation of homeless youth as well as the inability to capture all nationalities of UAMs in Greece

93 these models, however, is hindered by their inability to capture indirect regulatory influences on o

94 : fear of being infected, inability to rest, inability to care for family, struggling with difficult

95 ect on viral replication in vivo Despite the inability to cause a detectable disease, the double HVD

96 Debugging is frustrated by an inability to characterize parts in the context of the ci

97 tanding of iron cycling in the oceans is our inability to characterize the ligands that control iron

98 ement error in self-reported dietary intake, inability to classify a few plant foods as healthy and l

99 s during disease progression arises from the inability to clearly distinguish between activated micro

100 n patients at higher risk (determined by the inability to climb >=2 flights of stairs, which is <4 me

101 In contrast, in FXS, inability to close developmental c-subunit leak prevents

102 ribution, shorter circulatory half-life, and inability to communicate with the immune system.

103 s in food are often inadequate, due to their inability to completely separate pathogens from food mat

104 itical residue for Brd4 association and that inability to complex with Brd4 does not support episomal

105 to modulate miR but sub-optimal delivery and inability to concurrently target multiple pathways invol

106 dementia, cardiac or intracranial procedure, inability to consent for themselves, or emergency surger

107 However, the inability to control axon guidance, and thus neuronal ne

108 he need to modify the target channel, or the inability to control both on and off switching.

109 this process has remained obscure due to the inability to control encapsidation.

110 sence of depressive symptoms, female gender, inability to control one's schedule, and work setting we

111 This suggests that the inability to control Syt1 expression and trafficking at

112 This suggests that the inability to control Syt1 expression and trafficking may

113 emission is a challenge due to the inherent inability to control the packing of organic molecules in

114 f knock-out cells was impaired, owing to the inability to cope up with increased energy demands.

115 The inability to correct for axial length on spectral-domain

116 -PD-1) was largely unsuccessful due to their inability to cross blood-brain barrier (BBB).

117 s behind Plasmodium falciparum because of an inability to culture in vitro.

118 seases caused by fastidious pathogens is our inability to culture the pathogens in defined media or a

119 mpt to explore what lies beneath our current inability to deal with complexity.

120 at an exponentially increasing rate, but our inability to decipher their transcriptional wiring limit

121 to micro injury in the brain in vivo and the inability to degrade Abeta oligomers due to a phagolysos

122 The inability to degrade cholesterol becomes evident in the

123 erized by impulsivity, present focus, and an inability to delay gratification.

124 t of defective cells has been limited by the inability to deplete the existing population.

125 etrieving these representations stem from an inability to detect competition in the first place, or f

126 orm on high abundant proteins and not by the inability to detect cross-links due to limitations in cu

127 The inability to detect homology at the sequence level arise

128 indings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA.

129 rong sensitivity to interfering matrices and inability to detect the complete pattern of physiologica

130 Second, the inability to determine a worker's attributes precisely a

131 Inability to determine appropriateness of prescribing or

132 tant limitations of our study-especially our inability to determine whether IRA accounts influenced t

133 The inability to determine which sequences are rereplicated

134 rtially due to reduced responsiveness and an inability to develop stress-associated arousal state.

135 Inability to diagnose these infections when the patient

136 erturbs cellular homeostasis, leading to the inability to differentiate properly.

137 imited laboratory support contributes to the inability to differentiate the Mycobacterium tuberculosi

138 nctional disorder, while LI is caused by the inability to digest lactose.

139 s, mucinous, and clear cell carcinomas), the inability to directly examine the association of some ov

140 An inability to directly measure HBP flux has hindered our

141 ections have historically been limited by an inability to directly observe wildlife mortality in natu

142 their habitual diet is limited due to their inability to discriminate clearly between individuals wi

143 this hypothesis have been constrained by an inability to discriminate ejaculates of different males

144 itting of current energy functions and their inability to discriminate incorrect designs from correct

145 ber of technological limitations, such as an inability to discriminate the leaving group.

146 We show that this inability to disentangle correlation from causation can

147 The inability to distinguish aggressive from indolent prosta

148 stering can lead to misidentification and an inability to distinguish between 2 or more cell types.

149 aria test results for most survey years, the inability to distinguish between a diagnosis of uncompli

150 Low-discrimination (LD) results with an inability to distinguish between C. auris, C. duobushaem

151 rapies in clinical trials is hampered by our inability to distinguish between patients with FTLD-TDP

152 -standing challenge in C-H activation is the inability to distinguish electronically and sterically s

153 r limitation of tumor-only sequencing is its inability to distinguish germline versus somatic mutatio

154 N-glycome analysis, it still suffers from an inability to distinguish linkage isomers of native N-gly

155 ta is facing severe limitations, such as the inability to distinguish plasmids from each other in a b

156 orphogenesis has been challenging due to the inability to distinguish quantitative molecular differen

157 es in catchment population over time and the inability to distinguish the independent effects of the

158 means too much diagnosis and stems from the inability to distinguish what is important from what is

159 An inability to do this affected their wellbeing and compas

160 omerize to an iminol/cis-ketoenamine and its inability to doubly tautomerize to a diketoenamine.

161 paired consciousness, 665/2,240 (29.7%) with inability to drink or breastfeed, 317/2,340 (13.6%) with

162 aired consciousness, 665/2240 (29.7%) had an inability to drink or breastfeed, 317/2340 (13.6%) had e

163 The inability to easily identify the animal species in highl

164 t most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells

165 olerant of higher temperatures because of an inability to effectively repress the movement of specifi

166 charge carriers efficiently, owing to their inability to effectively screen charges.

167 This is due in part to an inability to efficiently culture the virus in vitro for

168 Inability to eliminate intramural arrhythmogenic substra

169 Nonmyelinating SCs showed a striking inability to engulf small diameter nerve fibers.

170 While the low abundance and inability to enzymatically amplify DNA damage are obstac

171 utics to cure chronic HBV infection is their inability to eradicate or inactivate cccDNA.

172 sitivity in detecting osteolytic lesions and inability to evaluate response to therapy has called for

173 The inability to evaluate the immune status of patients with

174 often suffer from severe muscle pain and an inability to exercise due to muscle fatigue.

175 Everyday examples of an inability to exert such control over behavior are the ov

176 f major depressive disorder is anhedonia, an inability to experience pleasure.

177 rimary limitations of the study included the inability to explore the potential periods of susceptibi

178 n impaired by a number of constraints (e.g., inability to fit local, concurrent, and consecutive even

179 easons described for withdrawing trust were: inability to follow instructions, failure to progress, a

180 ap compound 28-induced Top1cc because of its inability to form a hydrogen bond with compound 28.

181 of ER stress, impaired proliferation, and an inability to form spheroids in vitro, while in vivo they

182 invasive or power-inefficient architectures, inability to form uniform and subcellular interfaces, or

183 A key hurdle has been the inability to generate a homogeneous BAX oligomer (BAX(O)

184 post-antibiotic effect over 10 h, as well as inability to generate resistant mutants.

185 erposition of osseus or vascular structures, inability to go through healthy parenchyma, and lack of

186 es have limitations that include durability, inability to grow in pediatric patients, and lifelong an

187 This theory has been limited, however, by an inability to identify and isolate individual senescent c

188 SCCA methods are unsupervised, leading to an inability to identify diagnosis-specific genotype-phenot

189 Contemporary treatment is limited by an inability to identify individuals at high risk of APNS i

190 The inability to identify individuals with acute fever at ri

191 in the immediate aftermath of trauma, and an inability to identify optimal treatments for individual

192 rom the market; this is partially due to the inability to identify patients who are at risk(1).

193 anwhile, the LinRegPCR approach improved the inability to identify sources by the mixed model in 29.5

194 The inability to ignore irrelevant distractors characterizes

195 data curation, sharing, and readability; the inability to illustrate the inner decision-making proces

196 The inability to image EVs in fixed tissues has been a major

197 ion criteria were non-DR retinal disease and inability to image the macula.

198 st in these study designs, among them is the inability to include measures of genetic diversity in ad

199 tion by RIN-deficient tomatoes was due to an inability to induce autocatalytic system-2 ET synthesis,

200 Most notably, despite the inability to induce detectable disease, the designed EEE

201 interesting property of a VISA strain in its inability to induce type I IFN production.

202 Main study limitations were the inability to infer causality due to the cross-sectional

203 rstanding the biological roles of m(6)A, the inability to install m(6)A site specifically in individu

204 t-transcriptional gene silencing, due to its inability to interact with GW182.

205 The inability to interpret the result of finding a drug or m

206 Short duration, missing specimens, and an inability to isolate the effects of specific foods or mi

207 accidental damage/excision of healthy PGs or inability to localize diseased PGs, resulting in postsur

208 nd atovaquone degrades NKA, resulting in the inability to maintain ion transport.

209 of developmental defects that result in the inability to maintain long-term spermatogenesis.

210 Inability to maintain lysosomal acidic pH is associated

211 ients with chronic kidney disease (CKD) have inability to maintain the normal levels of protein metab

212 Main study limitations concern our inability to make any inferences about the relative effe

213 However, dim fluorescence and the inability to make stably-expressing cell lines limit its

214 pproach are discussed, including the current inability to measure processes involving C-H bonds.

215 Owing to their inability to migrate, plant cells rely on targeted cell

216 imited transport across the membranes and an inability to mimic the dense membrane networks typically

217 ed by a number of limitations, including the inability to model mutations to and from prolines in whi

218 n and recruiting techniques, paired with the inability to monitor patients effectively during trials,

219 ic circuitry, which has been hampered by our inability to monitor serotonin release and transport wit

220 immunological immaturity contributes to the inability to mount a fully protective immune response to

221 ground shoot competition, is hampered by our inability to observe roots.

222 The inability to obtain a history of FB ingestion and its wi

223 Limitations included the inability to obtain all SIVH records and self-reported m

224 Limitations include the inability to obtain all SIVH records, self-reported medi

225 performance, most notably the quite frequent inability to obtain full-length transcripts from single

226 icroglial functions is largely limited by an inability to obtain human microglia under homeostatic st

227 tcoming of tethered photopharmacology is the inability to obtain optical control with an efficacy com

228 gy centre with bilateral exquisite eye pain, inability to open the eyes, photosensitivity and reduced

229 from medical bills, with 15.6% reporting an inability to pay medical bills at all.

230 stantial energy-efficiency benefits, but the inability to perfectly control intrinsic nanoscale defec

231 ed mitochondrial respiratory capacity and an inability to perform a glycolytic immunometabolic switch

232 malignant bleeding or massive bleeding with inability to perform thermal therapy or hemoclip placeme

233 erence for asymmetric DNA substrates and its inability to perform transposition in cells.

234 at part of our uncertainty stemming from our inability to precisely estimate key model parameters, su

235 The inability to preserve vascular organs beyond several hou

236 by acellular pertussis vaccines and to their inability to prevent nasal colonization and transmission

237 formance differences are not explained by an inability to process the social stimuli and their causes

238 xpression of IL-18Ralpha, extended beyond an inability to produce IFN-gamma, as FcRgamma(-) NK cells

239 uggested that Ldh mutants compensate for the inability to produce lactate by generating excess glycer

240 heir incomplete maturation, particularly the inability to produce proplatelets.

241 s to these functions has been stymied by our inability to produce this glycan as a homogenous structu

242 mic and transcriptomic analysis reveals that inability to produce threonine leads to deregulation of

243 nteractions within oysters is limited by the inability to promote high-level uptake of bacteria by oy

244 rize how neurons are isolated, (the signal's inability to propagate to adjacent neurons), an indicato

245 Inability to rapidly restore microcirculation during the

246 he cell types in which they operate, and our inability to recapitulate the biology of immune diseases

247 ing, the focus on a specific population, the inability to record interviews, and possible subtle erro

248 ld suboptimal outcomes, partly because of an inability to reduce cue-induced smoking.

249 Inability to reduce the number of medications or the IOP

250 as impaired motor skills, restlessness, and inability to relax exhibited high centrality during the

251 as been limited by technical barriers and an inability to reliably infer heterodimeric chain pairings

252 sion due to pleural tumour burden (n=1), and inability to remain seated (n=1).

253 78%-88%]; LR, 0.21 [95% CI, 0.06-0.65]) and inability to remember behavior prior to syncope (n = 323

254 kely to be commonplace and frequent, but its inability to replicate in plant or human cells suggests

255 ods is hampered by limited resolution and an inability to resolve dynamic components(12,13).

256 t persists, neutrophils through a frustrated inability to resolve the problem can release NETs to exa

257 al health disorders: fear of being infected, inability to rest, inability to care for family, struggl

258 f overfitting, low generalization power, and inability to reveal the connections between the underlyi

259 High safety, the inability to revert to wild-type phenotype, and high imm

260 bolic disorders, and is characterized by the inability to secrete/sense insulin and abnormal blood gl

261 er, studying this dynamic is hampered by the inability to selectively activate individual TETs with t

262 nal characterization has been impeded by the inability to selectively label and manipulate them.

263 However, an inability to separate Golgi cisternae has meant that the

264 ider supporting microenvironment is unclear; inability to separate intrinsic LC aging from that of th

265 coarse spatial resolution of ESMs and their inability to simulate intense and short rainfall events

266 ronic diabetic foot ulcers is limited by the inability to simultaneously address the excessive inflam

267 Elastic frustration, the inability to simultaneously minimize competing elastic i

268 ents without olfactory experiences/life-long inability to smell).

269 nt motors displayed reduced force output and inability to stall in optical trap assays but exhibited

270 48-6.06]), hypoxemia (4.40 [2.03-9.51]), and inability to stand (3.59 [1.72-7.50]).

271 An inability to standardize the bioinformatic data produced

272 The main study limitations were the inability to successfully ascertain outcomes in all pati

273 The inability to suppress actions with little to no reward v

274 mutant strain, which is concomitant with its inability to survive in human serum.

275 novo lipogenesis is also upregulated by the inability to synthesise glycogen, either when storage is

276 r specific functions has been hampered by an inability to synthesize large numbers of diverse, yet de

277 umans and crown catarrhines evolved with the inability to synthesize the oligosaccharide galactose-al

278 il to avoid obstacles, consistent with their inability to take sideways steps on to neighboring MT pr

279 5% confidence interval] = 4.91 [2.81-8.55]), inability to tan (no tan vs. deep tan, hazard ratio [95%

280 An inability to target Cas9 to both nuclei, combined with t

281 Given the inability to target p21RAS directly, here we performed a

282 Given the inability to target p21RAS directly, here we performed a

283 The inability to terminate AT with this first lesion set, th

284 Our data thus demonstrate that an inability to timely destroy CYCA3;4 contributes to disor

285 ar-old woman who suffered from dysphagia, an inability to tolerate a regular diet, and unintentional

286 choice is largely unknown due to the general inability to track birds from specific wintering habitat

287 ocytic pathway with a limitation being their inability to track the apo receptor.

288 in the X-linked ABCD1 gene, resulting in the inability to transport acylated very long chain fatty ac

289 cost, lack of generality, or inaccuracy and inability to treat complex, strongly interacting systems

290 s for this phenomenon was complicated by our inability to uncouple protein binding from DNA condensat

291 This is associated with an apparent inability to upregulate glycolysis.

292 t infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry

293 This could reflect an inability to utilise compensatory mechanisms, and contri

294 While the inability to utilize the CCR5 receptor maps to a predict

295 Previously, the inability to visualise filamentous actin (F-actin) dynam

296 angle closure disease (PACD) was defined as inability to visualize pigmented trabecular meshwork in

297 ting factor to seemingly recalcitrant cases, inability to wean off immunomodulatory therapy, and long

298 rrhythmia undergoing bailout ablation due to inability to wean off mechanical support were included.

299 (NAcSh) is thought to underlie the cognitive inability to withhold prepotent responses (motor impulsi

300 PLWH with DSPN were more likely to report inability to work [chi2(df = 1) = 10.6; P = .001] and de