ライフサイエンスコーパス: inability to

1 uded because of manometer malfunction (n=2), inability to access effusion due to pleural tumour burde

2 r carbon nanotubes (CNTs) in particular, the inability to access structures with specific diameters o

3 However, inability to access these cells from patients, particula

4 We discuss the proposed model's inability to account for culturally emergent normativiti

5 atively small external validation cohort, an inability to account for delayed changes to treatment be

6 This lack of data coherency results in the inability to accumulate a critical mass of metabolomics

7 on DNA sequencing is currently limited by an inability to accurately count the number of input DNA mo

8 ng DXA for the measurement of lean mass, the inability to accurately detect changes over time calls i

9 XI-I decreases stomatal density, owing to an inability to accurately orient a specific subset of ACDs

10 ete knowledge about their physiology and our inability to accurately predict phenotypes.

11 iable tolerance for risk of side-effects and inability to accurately predict treatment response.

12 hnology has not been realized because of the inability to accurately visualize infusates in real-time

13 lated forms of the protein, we show that the inability to acetylate key HBsu lysine residues results

14 velopmental dyslexia is characterized by the inability to acquire typical reading and writing skills.

15 An inability to activate the PIMs caused slightly greater c

16 gment distributions, suggesting a structural inability to adapt rapidly to the light level fluctuatio

17 g clinical challenge, particularly due to an inability to address rampant invasion deep into eloquent

18 ial bias from exposure misclassification, an inability to adjust for all sources of confounding, and

19 Overall there was (1) an inability to align SARS-CoV-2 contaminated surfaces with

20 on nanostructures has remained stunted by an inability to alter the sp(2)-carbon lattice with atomic

21 technical gap of top-down proteomics is the inability to analyze a low amount of biological samples,

22 The inability to appropriately regulate hepcidin production

23 ts of uncertain significance" to reflect our inability to ascribe a phenotypic effect to the observed

24 A key limitation of this study is the inability to assess causality because of its observation

25 Lack of response can be in part due to inability to assess treatment adequacy in real-time.

26 jurious effect of COVID-19 on the liver, the inability to attend regular visits with providers, diver

27 orer prey availability rather than solely an inability to become pregnant.

28 however, remains unexplored due to protein's inability to bind targets covalently.

29 of one of these two motifs, resulting in an inability to bind to host cell protein ALIX.

30 loss of intracellular methionine leads to an inability to biosynthesize spermidine, and spermine.

31 Inability to block translation of faulty mRNAs and subse

32 resentation of homeless youth as well as the inability to capture all nationalities of UAMs in Greece

33 these models, however, is hindered by their inability to capture indirect regulatory influences on o

34 : fear of being infected, inability to rest, inability to care for family, struggling with difficult

35 Physician impairment, the inability to carry out patient care responsibilities saf

36 ms inverting mechanism of the enzyme and its inability to catalyze transapiosylation in syntheses of

37 ect on viral replication in vivo Despite the inability to cause a detectable disease, the double HVD

38 Debugging is frustrated by an inability to characterize parts in the context of the ci

39 tanding of iron cycling in the oceans is our inability to characterize the ligands that control iron

40 unexplored gaps in EV research has been the inability to characterize the spatially and functionally

41 ement error in self-reported dietary intake, inability to classify a few plant foods as healthy and l

42 s during disease progression arises from the inability to clearly distinguish between activated micro

43 Despite its inability to cleave triple-helical collagens, MMP-3 can

44 n patients at higher risk (determined by the inability to climb >=2 flights of stairs, which is <4 me

45 In contrast, in FXS, inability to close developmental c-subunit leak prevents

46 The inability to coculture trophozoites and epithelial cells

47 ribution, shorter circulatory half-life, and inability to communicate with the immune system.

48 icient in host colonization because of their inability to compete with intestinal microbiota.

49 lly expressed genes has been hampered by the inability to completely separate CMLSCs from HSCs, which

50 s in food are often inadequate, due to their inability to completely separate pathogens from food mat

51 itical residue for Brd4 association and that inability to complex with Brd4 does not support episomal

52 to modulate miR but sub-optimal delivery and inability to concurrently target multiple pathways invol

53 dementia, cardiac or intracranial procedure, inability to consent for themselves, or emergency surger

54 However, the inability to control axon guidance, and thus neuronal ne

55 the innate immune compartment results in an inability to control bacterial growth and dissemination.

56 he need to modify the target channel, or the inability to control both on and off switching.

57 this process has remained obscure due to the inability to control encapsidation.

58 sence of depressive symptoms, female gender, inability to control one's schedule, and work setting we

59 This suggests that the inability to control Syt1 expression and trafficking at

60 This suggests that the inability to control Syt1 expression and trafficking may

61 emission is a challenge due to the inherent inability to control the packing of organic molecules in

62 challenge in many biological studies is the inability to control the placement of cells in two and t

63 f knock-out cells was impaired, owing to the inability to cope up with increased energy demands.

64 The inability to correct for axial length on spectral-domain

65 -PD-1) was largely unsuccessful due to their inability to cross blood-brain barrier (BBB).

66 s behind Plasmodium falciparum because of an inability to culture in vitro.

67 seases caused by fastidious pathogens is our inability to culture the pathogens in defined media or a

68 mpt to explore what lies beneath our current inability to deal with complexity.

69 at an exponentially increasing rate, but our inability to decipher their transcriptional wiring limit

70 to micro injury in the brain in vivo and the inability to degrade Abeta oligomers due to a phagolysos

71 The inability to degrade cholesterol becomes evident in the

72 erized by impulsivity, present focus, and an inability to delay gratification.

73 t of defective cells has been limited by the inability to deplete the existing population.

74 etrieving these representations stem from an inability to detect competition in the first place, or f

75 orm on high abundant proteins and not by the inability to detect cross-links due to limitations in cu

76 The inability to detect homology at the sequence level arise

77 indings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA.

78 However, the inability to detect sufficient numbers of mutations in n

79 rong sensitivity to interfering matrices and inability to detect the complete pattern of physiologica

80 Second, the inability to determine a worker's attributes precisely a

81 Inability to determine appropriateness of prescribing or

82 tant limitations of our study-especially our inability to determine whether IRA accounts influenced t

83 The inability to determine which sequences are rereplicated

84 rtially due to reduced responsiveness and an inability to develop stress-associated arousal state.

85 difficult to diagnose in early life, and the inability to diagnose patients with atopic diseases at a

86 Inability to diagnose these infections when the patient

87 IDH-mutant cancer cells show an inability to differentiate but whether 2HG accumulation

88 erturbs cellular homeostasis, leading to the inability to differentiate properly.

89 imited laboratory support contributes to the inability to differentiate the Mycobacterium tuberculosi

90 nctional disorder, while LI is caused by the inability to digest lactose.

91 s, mucinous, and clear cell carcinomas), the inability to directly examine the association of some ov

92 An inability to directly measure HBP flux has hindered our

93 ections have historically been limited by an inability to directly observe wildlife mortality in natu

94 their habitual diet is limited due to their inability to discriminate clearly between individuals wi

95 this hypothesis have been constrained by an inability to discriminate ejaculates of different males

96 itting of current energy functions and their inability to discriminate incorrect designs from correct

97 ber of technological limitations, such as an inability to discriminate the leaving group.

98 We show that this inability to disentangle correlation from causation can

99 The inability to distinguish aggressive from indolent prosta

100 stering can lead to misidentification and an inability to distinguish between 2 or more cell types.

101 aria test results for most survey years, the inability to distinguish between a diagnosis of uncompli

102 Low-discrimination (LD) results with an inability to distinguish between C. auris, C. duobushaem

103 Limitations include the inability to distinguish between exogenous and endogenou

104 rapies in clinical trials is hampered by our inability to distinguish between patients with FTLD-TDP

105 -standing challenge in C-H activation is the inability to distinguish electronically and sterically s

106 r limitation of tumor-only sequencing is its inability to distinguish germline versus somatic mutatio

107 N-glycome analysis, it still suffers from an inability to distinguish linkage isomers of native N-gly

108 ta is facing severe limitations, such as the inability to distinguish plasmids from each other in a b

109 orphogenesis has been challenging due to the inability to distinguish quantitative molecular differen

110 es in catchment population over time and the inability to distinguish the independent effects of the

111 Our inability to distinguish these processes makes it challe

112 means too much diagnosis and stems from the inability to distinguish what is important from what is

113 An inability to do this affected their wellbeing and compas

114 omerize to an iminol/cis-ketoenamine and its inability to doubly tautomerize to a diketoenamine.

115 paired consciousness, 665/2,240 (29.7%) with inability to drink or breastfeed, 317/2,340 (13.6%) with

116 aired consciousness, 665/2240 (29.7%) had an inability to drink or breastfeed, 317/2340 (13.6%) had e

117 The inability to easily identify the animal species in highl

118 t most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells

119 olerant of higher temperatures because of an inability to effectively repress the movement of specifi

120 charge carriers efficiently, owing to their inability to effectively screen charges.

121 This is due in part to an inability to efficiently culture the virus in vitro for

122 Inability to eliminate intramural arrhythmogenic substra

123 Nonmyelinating SCs showed a striking inability to engulf small diameter nerve fibers.

124 r, the efficacy remains limited due to their inability to enter the CNS.

125 rectly inhibit almost any protein, but their inability to enter the cytosol limits inhibitory antibod

126 While the low abundance and inability to enzymatically amplify DNA damage are obstac

127 utics to cure chronic HBV infection is their inability to eradicate or inactivate cccDNA.

128 Inability to establish causality or incidence, variable

129 sitivity in detecting osteolytic lesions and inability to evaluate response to therapy has called for

130 meters in administrative claims data and the inability to evaluate surrogate outcomes, such as immedi

131 The inability to evaluate the immune status of patients with

132 often suffer from severe muscle pain and an inability to exercise due to muscle fatigue.

133 Everyday examples of an inability to exert such control over behavior are the ov

134 lthough with a unique growth profile and the inability to exit host cells.

135 f major depressive disorder is anhedonia, an inability to experience pleasure.

136 rimary limitations of the study included the inability to explore the potential periods of susceptibi

137 n impaired by a number of constraints (e.g., inability to fit local, concurrent, and consecutive even

138 easons described for withdrawing trust were: inability to follow instructions, failure to progress, a

139 ap compound 28-induced Top1cc because of its inability to form a hydrogen bond with compound 28.

140 of ER stress, impaired proliferation, and an inability to form spheroids in vitro, while in vivo they

141 invasive or power-inefficient architectures, inability to form uniform and subcellular interfaces, or

142 A key hurdle has been the inability to generate a homogeneous BAX oligomer (BAX(O)

143 post-antibiotic effect over 10 h, as well as inability to generate resistant mutants.

144 erposition of osseus or vascular structures, inability to go through healthy parenchyma, and lack of

145 es have limitations that include durability, inability to grow in pediatric patients, and lifelong an

146 r molecular structure determination, but the inability to grow suitable single crystals can frustrate

147 tient condition (2.38 [1.74, 3.25]), patient inability to help with lift/transfer (2.38 [1.71, 3.31])

148 of proteins involved in the process and the inability to identify and detect mitoribosomes.

149 This theory has been limited, however, by an inability to identify and isolate individual senescent c

150 SCCA methods are unsupervised, leading to an inability to identify diagnosis-specific genotype-phenot

151 Contemporary treatment is limited by an inability to identify individuals at high risk of APNS i

152 The inability to identify individuals with acute fever at ri

153 in the immediate aftermath of trauma, and an inability to identify optimal treatments for individual

154 rom the market; this is partially due to the inability to identify patients who are at risk(1).

155 The inability to identify resident macrophage populations ac

156 anwhile, the LinRegPCR approach improved the inability to identify sources by the mixed model in 29.5

157 The inability to ignore irrelevant distractors characterizes

158 data curation, sharing, and readability; the inability to illustrate the inner decision-making proces

159 The inability to image EVs in fixed tissues has been a major

160 ion criteria were non-DR retinal disease and inability to image the macula.

161 st in these study designs, among them is the inability to include measures of genetic diversity in ad

162 tion by RIN-deficient tomatoes was due to an inability to induce autocatalytic system-2 ET synthesis,

163 Most notably, despite the inability to induce detectable disease, the designed EEE

164 interesting property of a VISA strain in its inability to induce type I IFN production.

165 Main study limitations were the inability to infer causality due to the cross-sectional

166 vation of some transposable elements and the inability to initiate transgene silencing.

167 rstanding the biological roles of m(6)A, the inability to install m(6)A site specifically in individu

168 t-transcriptional gene silencing, due to its inability to interact with GW182.

169 The inability to interpret the result of finding a drug or m

170 Short duration, missing specimens, and an inability to isolate the effects of specific foods or mi

171 ation markers but paradoxically exhibited an inability to kill bacteria and a defective respiratory b

172 accidental damage/excision of healthy PGs or inability to localize diseased PGs, resulting in postsur

173 nd atovaquone degrades NKA, resulting in the inability to maintain ion transport.

174 of developmental defects that result in the inability to maintain long-term spermatogenesis.

175 Inability to maintain lysosomal acidic pH is associated

176 For Candida species, their inability to maintain plasmids, unusual codon usage, and

177 ients with chronic kidney disease (CKD) have inability to maintain the normal levels of protein metab

178 Main study limitations concern our inability to make any inferences about the relative effe

179 However, dim fluorescence and the inability to make stably-expressing cell lines limit its

180 their suboptimal performance may reflect an inability to make use of the information they have or ev

181 However, an inability to measure endogenous Ras activity in living c

182 pproach are discussed, including the current inability to measure processes involving C-H bonds.

183 Owing to their inability to migrate, plant cells rely on targeted cell

184 imited transport across the membranes and an inability to mimic the dense membrane networks typically

185 ed by a number of limitations, including the inability to model mutations to and from prolines in whi

186 animal models have been challenged by their inability to model the early onset and severity of the d

187 n and recruiting techniques, paired with the inability to monitor patients effectively during trials,

188 ic circuitry, which has been hampered by our inability to monitor serotonin release and transport wit

189 First, the inability to monitor workers perfectly in many occupatio

190 immunological immaturity contributes to the inability to mount a fully protective immune response to

191 y antibody deficiency, which manifests in an inability to mount antibody responses to vaccines and pa

192 d in Nr4a3 (-/-) mice, which resulted in the inability to mount optimal CD8(+) T cell responses to gr

193 e lethal threshold in hydraulic failure - an inability to move water due to drought-induced xylem emb

194 ground shoot competition, is hampered by our inability to observe roots.

195 The inability to obtain a history of FB ingestion and its wi

196 Limitations included the inability to obtain all SIVH records and self-reported m

197 Limitations include the inability to obtain all SIVH records, self-reported medi

198 performance, most notably the quite frequent inability to obtain full-length transcripts from single

199 icroglial functions is largely limited by an inability to obtain human microglia under homeostatic st

200 tcoming of tethered photopharmacology is the inability to obtain optical control with an efficacy com

201 gy centre with bilateral exquisite eye pain, inability to open the eyes, photosensitivity and reduced

202 from medical bills, with 15.6% reporting an inability to pay medical bills at all.

203 stantial energy-efficiency benefits, but the inability to perfectly control intrinsic nanoscale defec

204 ed mitochondrial respiratory capacity and an inability to perform a glycolytic immunometabolic switch

205 malignant bleeding or massive bleeding with inability to perform thermal therapy or hemoclip placeme

206 erence for asymmetric DNA substrates and its inability to perform transposition in cells.

207 This is largely due to our inability to pharmacologically probe circuit level contr

208 gh the approach works well for proteins, the inability to place the label at specific sites has preve

209 at part of our uncertainty stemming from our inability to precisely estimate key model parameters, su

210 The inability to preserve vascular organs beyond several hou

211 by acellular pertussis vaccines and to their inability to prevent nasal colonization and transmission

212 formance differences are not explained by an inability to process the social stimuli and their causes

213 xpression of IL-18Ralpha, extended beyond an inability to produce IFN-gamma, as FcRgamma(-) NK cells

214 uggested that Ldh mutants compensate for the inability to produce lactate by generating excess glycer

215 heir incomplete maturation, particularly the inability to produce proplatelets.

216 Here, we demonstrate that the inability to produce reactive cysteine residues in pairs

217 s to these functions has been stymied by our inability to produce this glycan as a homogenous structu

218 mic and transcriptomic analysis reveals that inability to produce threonine leads to deregulation of

219 nteractions within oysters is limited by the inability to promote high-level uptake of bacteria by oy

220 rize how neurons are isolated, (the signal's inability to propagate to adjacent neurons), an indicato

221 n certain active MS lesions, representing an inability to properly detach from vessels following peri

222 Collectively, these results indicate that an inability to properly exit the competent state disrupts

223 atient-derived iPSC nociceptors exhibited an inability to properly respond to depolarizing stimuli, d

224 in thermogenesis even at 30 degrees C and an inability to protect core temperature.

225 However, the inability to rapidly quantify glycans in a site-specific

226 Inability to rapidly restore microcirculation during the

227 he cell types in which they operate, and our inability to recapitulate the biology of immune diseases

228 ismatch that is likely responsible for their inability to reconstitute into holo V-ATPase in vitro He

229 ing, the focus on a specific population, the inability to record interviews, and possible subtle erro

230 ity, renal replacement therapy-dependence or inability to recover 50% of baseline estimated glomerula

231 ld suboptimal outcomes, partly because of an inability to reduce cue-induced smoking.

232 Inability to reduce the number of medications or the IOP

233 as impaired motor skills, restlessness, and inability to relax exhibited high centrality during the

234 as been limited by technical barriers and an inability to reliably infer heterodimeric chain pairings

235 sion due to pleural tumour burden (n=1), and inability to remain seated (n=1).

236 78%-88%]; LR, 0.21 [95% CI, 0.06-0.65]) and inability to remember behavior prior to syncope (n = 323

237 kely to be commonplace and frequent, but its inability to replicate in plant or human cells suggests

238 ods is hampered by limited resolution and an inability to resolve dynamic components(12,13).

239 t persists, neutrophils through a frustrated inability to resolve the problem can release NETs to exa

240 ng run CI-deficient tumors re-adapt to their inability to respond to hypoxia, concordantly with the p

241 al health disorders: fear of being infected, inability to rest, inability to care for family, struggl

242 rse the landscape globally corresponds to an inability to restructure the ribozyme without losing act

243 f overfitting, low generalization power, and inability to reveal the connections between the underlyi

244 High safety, the inability to revert to wild-type phenotype, and high imm

245 The inability to sample deep-tissue reservoirs in individual

246 bolic disorders, and is characterized by the inability to secrete/sense insulin and abnormal blood gl

247 er, studying this dynamic is hampered by the inability to selectively activate individual TETs with t

248 nal characterization has been impeded by the inability to selectively label and manipulate them.

249 However, an inability to separate Golgi cisternae has meant that the

250 ider supporting microenvironment is unclear; inability to separate intrinsic LC aging from that of th

251 by high frequencies of TP53 mutations and an inability to shield against deregulated X-linked genes t

252 coarse spatial resolution of ESMs and their inability to simulate intense and short rainfall events

253 ronic diabetic foot ulcers is limited by the inability to simultaneously address the excessive inflam

254 Elastic frustration, the inability to simultaneously minimize competing elastic i

255 ents without olfactory experiences/life-long inability to smell).

256 t (7/7), hypotonia (6/7), deafness (7/7) and inability to speak (6/7).

257 ve and carry out angiogenesis, despite their inability to stabilize HIF-1alpha.

258 nt motors displayed reduced force output and inability to stall in optical trap assays but exhibited

259 48-6.06]), hypoxemia (4.40 [2.03-9.51]), and inability to stand (3.59 [1.72-7.50]).

260 An inability to standardize the bioinformatic data produced

261 ence and invasion of epithelial cells and an inability to stimulate IL-8.

262 being the same as an acute perturbation, the inability to study non-European populations, and some sa

263 The main study limitations were the inability to successfully ascertain outcomes in all pati

264 The inability to suppress actions with little to no reward v

265 isease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attr

266 mutant strain, which is concomitant with its inability to survive in human serum.

267 novo lipogenesis is also upregulated by the inability to synthesise glycogen, either when storage is

268 r specific functions has been hampered by an inability to synthesize large numbers of diverse, yet de

269 umans and crown catarrhines evolved with the inability to synthesize the oligosaccharide galactose-al

270 il to avoid obstacles, consistent with their inability to take sideways steps on to neighboring MT pr

271 5% confidence interval] = 4.91 [2.81-8.55]), inability to tan (no tan vs. deep tan, hazard ratio [95%

272 s more strongly related to nevus density and inability to tan than susceptibility to sunburn.

273 An inability to target Cas9 to both nuclei, combined with t

274 Given the inability to target p21RAS directly, here we performed a

275 Given the inability to target p21RAS directly, here we performed a

276 The inability to terminate AT with this first lesion set, th

277 Our data thus demonstrate that an inability to timely destroy CYCA3;4 contributes to disor

278 ar-old woman who suffered from dysphagia, an inability to tolerate a regular diet, and unintentional

279 choice is largely unknown due to the general inability to track birds from specific wintering habitat

280 ocytic pathway with a limitation being their inability to track the apo receptor.

281 in the X-linked ABCD1 gene, resulting in the inability to transport acylated very long chain fatty ac

282 olutions to the problem of catalysis, so the inability to traverse the landscape globally corresponds

283 cost, lack of generality, or inaccuracy and inability to treat complex, strongly interacting systems

284 The inability to tune WL thickness has inhibited researchers

285 s for this phenomenon was complicated by our inability to uncouple protein binding from DNA condensat

286 the impaired retinal vascularization and an inability to undergo pathologic neovascularization obser

287 This is associated with an apparent inability to upregulate glycolysis.

288 g urinary succinate depletion may reflect an inability to upregulate the Krebs cycle following exerci

289 However, the inability to use aldehydes, which usually reduce too rap

290 t infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry

291 This could reflect an inability to utilise compensatory mechanisms, and contri

292 While the inability to utilize the CCR5 receptor maps to a predict

293 Further, our inability to verify the expression of RuBisCO suggests t

294 Previously, the inability to visualise filamentous actin (F-actin) dynam

295 angle closure disease (PACD) was defined as inability to visualize pigmented trabecular meshwork in

296 The angiographic analysis is limited by the inability to visualize the occluded segment and requires

297 ting factor to seemingly recalcitrant cases, inability to wean off immunomodulatory therapy, and long

298 rrhythmia undergoing bailout ablation due to inability to wean off mechanical support were included.

299 (NAcSh) is thought to underlie the cognitive inability to withhold prepotent responses (motor impulsi

300 PLWH with DSPN were more likely to report inability to work [chi2(df = 1) = 10.6; P = .001] and de