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1 y because of their small size and anatomical inaccessibility.
2 t detected in preformed chromatin due to its inaccessibility.
3 osomes have been hampered by the organelle's inaccessibility.
4 icipate in catalysis, despite their presumed inaccessibility.
5 resumably due to substrate unavailability or inaccessibility.
6 s driven in cis, partially overcoming tissue inaccessibility.
7 us in vivo have been limited by its relative inaccessibility.
8 lencing and reversing Xist-induced chromatin inaccessibility.
9 viding a rationale for its current synthetic inaccessibility.
10 g plants has been hampered by their size and inaccessibility.
11 operties have been hindered due to synthetic inaccessibility.
12 mputational science has added a new layer of inaccessibility.
13  community is limited by their computational inaccessibility.
14 rchitecture mainly attributable to synthetic inaccessibility.
15 c ecosystems remain poorly understood due to inaccessibility and a lack of detailed observations befo
16 f the human IgG3 hinge mitigates the epitope inaccessibility and additionally facilitates Env spike p
17 alid biomarkers have been scant owing to the inaccessibility and complexity of human brain tissue and
18 t with technical difficulty due to issues of inaccessibility and instability of the requisite heteroc
19 is poorly understood, chiefly because of the inaccessibility and poor optical qualities inherent in m
20 otion in vivo are severely restricted by its inaccessibility and sensitivity to surgical trauma, so,
21  great challenge in volcanology due to their inaccessibility and the severe hazard of collapse or exp
22 r half remain unexchanged because of solvent inaccessibility and/or hydrogen-bonded structure.
23 of high meteorological variability, physical inaccessibility, and the complex interplay between clima
24 ent repressive characteristics and chromatin inaccessibility are established.
25 ethylation associates with the silencing and inaccessibility at promoters.
26 shaped configuration is assumed based on its inaccessibility by extracellular matrix probes, caveolin
27                    Apart from insecurity and inaccessibility challenges, the substantial shift of uni
28                                    Chromatin inaccessibility decreases dCas9 binding to other sites w
29 ta indicate that this might be due to target inaccessibility determined by sequences flanking target
30 ce sites that sorb organic species and cause inaccessibility due to physical isolation and chemical s
31                      War-related health care inaccessibility explained a greater percentage of the va
32 NHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its
33 psulating guest molecules into MOFs, such as inaccessibility for larger guest molecules due to limita
34                                 Human tissue inaccessibility has impeded a molecular understanding of
35                            Their paucity and inaccessibility has limited the search for otoprotective
36 reduced amplification efficiency or template inaccessibility; however, exactly how these contribute t
37  pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study
38 t D segment accessibility and that J segment inaccessibility in the enhancerless minilocus resulted i
39 investigation of CSMN is severely limited by inaccessibility in the heterogeneous cortex.
40 24 in the transition state, coupled with its inaccessibility in the native state, promotes fast unfol
41 ng implantation are poorly understood due to inaccessibility in utero and the remaining challenges to
42 g limited expert annotations, slide scanning inaccessibility, inter-institutional variability, and th
43  recent years, their high costs and relative inaccessibility make their use limited.
44 ross all races/ethnicities (eg, medical care inaccessibility, non-Hispanic White women: OR, 1.8; 95%
45  end of the spore, indicating the absence or inaccessibility of Alr in this region.
46 use models remains hampered by the technical inaccessibility of an accurate input function (IF).
47 ves may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of en
48  fixation, the paucity of antibodies and the inaccessibility of antigens.
49 al T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of
50 been difficult primarily due to the relative inaccessibility of BCs to standard AAV vectors.
51                                 Owing to the inaccessibility of beta1-4-N-acetylgalactosaminyltransfe
52 signaling have been severely hindered by the inaccessibility of bioactive proteins.
53 coupled with the arbitrary incompleteness or inaccessibility of code, markedly intensifies the obstac
54                                          The inaccessibility of cognitive processes to direct manipul
55  beta allelic exclusion does not result from inaccessibility of D beta gene segments.
56 s are the lack of appropriate models and the inaccessibility of datasets for model training.
57 pressive microenvironment and by the greater inaccessibility of deeper intratumoural cells.
58 arrier to research on Parkinson's disease is inaccessibility of diseased tissue for study.
59 nt has been limited, at least in part due to inaccessibility of early stages of human development to
60 lopment is poor, at least in part due to the inaccessibility of early stages to genetic and developme
61 ructures were found to be complicated by the inaccessibility of electrolyte counterions due to the co
62   Double mutant analysis suggests a possible inaccessibility of eye-specific protein kinase C to NORP
63 uate knowledge among health-care workers and inaccessibility of facilities) and the demand for servic
64 l coupling strength is determined due to the inaccessibility of gap junctions on the dendritic tree.
65 ell development are limited in large part by inaccessibility of germ cells during development.
66 -cell formation and differentiation owing to inaccessibility of germ cells during fetal development.
67 orly understood, at least in part due to the inaccessibility of germ cells to study especially during
68 flowcell of a biosensor chip, confirming the inaccessibility of Gly 1 and Lys 27 when IGF-1 is bound
69 hromosome V, RE increases HML usage, but the inaccessibility of HML without RE apparently depends on
70 ributes to neurodevelopmental disorders, the inaccessibility of human fetal brain tissue during devel
71  disease are not fully understood due to the inaccessibility of human tissues for detailed analysis a
72 understanding of these stages because of the inaccessibility of implanting embryos and the lack of su
73 the tongue (TOT) state refers to a temporary inaccessibility of information that one is sure exists i
74  necessity by the complexity, fragility, and inaccessibility of intact nervous systems, such that inv
75                                     However, inaccessibility of interacting surfaces in mature protei
76 e problems related to slow mass transfer and inaccessibility of internal space in MOFs.
77                                 The relative inaccessibility of intracellular calcium stores in the n
78 in immune regulation are unclear, due to the inaccessibility of intracellular phagocytic receptors.
79 rol that PT domains exert is hindered by the inaccessibility of intrinsically unstable poly-beta-keto
80 tracellular calcium concentration due to the inaccessibility of its C1A domain, whereas PKCgamma rapi
81 reesC results, at least in part, from steric inaccessibility of its N-terminal arginine.
82                                          The inaccessibility of living bone marrow (BM) hampers the s
83                                              Inaccessibility of medicines in low- and middle-income c
84 e openings, if any are available at all, the inaccessibility of mental health care has become increas
85 rmation of the beta 4-beta 5 loop results in inaccessibility of Met-100, thought to catalyze chromoph
86                 A major barrier, however, is inaccessibility of metastatic tissue.
87 blastoma has been hindered by the widespread inaccessibility of molecular subgroup testing and paucit
88  The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the
89 n to develop a particular disease and by the inaccessibility of most disease-relevant tissues in livi
90 ding sites are unoccupied, demonstrating the inaccessibility of most of the nuclear DNA.
91 mmon source of self-knowledge failure is the inaccessibility of much of the mind to consciousness, in
92                            To circumvent the inaccessibility of MXene phases derived from mid-to-late
93 ed to understand Earth's behavior and by the inaccessibility of nearly all of Earth's subsurface to d
94 cult to obtain because of the small size and inaccessibility of nerve terminals in the central nervou
95  play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recordi
96 nogenic diabetes is not yet clear due to the inaccessibility of patient samples.
97 is area has been particularly limited by the inaccessibility of peptides and proteins that are phosph
98 e in the Ca2+ release channel which leads to inaccessibility of phase 1 sulfhydryls to NEM alkylation
99 y epithelial cells to NO could be due to the inaccessibility of PKR, which is bound to inhibitor p58.
100 ons in ComGG that prevent processing and the inaccessibility of pre-ComGG to externally added proteas
101                                 However, the inaccessibility of primary human and chimpanzee tissues
102                  A key obstacle has been the inaccessibility of PrP27-30 epitopes.
103 ause of the time needed for degradation, the inaccessibility of pure compounds, and the need to handl
104                                          The inaccessibility of PV1 to host cell nutrients may explai
105 emistry did not go according to plan (due to inaccessibility of reagents such as SF(5) Cl at the time
106 ine Young's (elastic) modulus, E, and by the inaccessibility of relevant mechanical engineering proto
107  associated morbidities, invasive nature and inaccessibility of seizure foci.
108                        Other reasons include inaccessibility of services and difficulties experienced
109                   In the UK, the expense and inaccessibility of services to improve mobility through
110 terizing the vacancy networks of PBAs is the inaccessibility of single crystals(16).
111                                          The inaccessibility of SMLM to life scientists for technical
112                        However, the relative inaccessibility of somatic cells in adult animals greatl
113               Unfortunately, the expense and inaccessibility of specialized pupilometers that image i
114                                 The inherent inaccessibility of sweat in sedentary individuals in lar
115                                 The relative inaccessibility of the 13A5 epitope likely reflects eith
116 nd entry data using primary isolates suggest inaccessibility of the 2F5 and 4E10 epitopes on the vira
117 methylation, but are likely due to either 1) inaccessibility of the 5'-enhancer region in HepG2 cells
118 otein at the cell surface rather than to the inaccessibility of the antigens to Kell antibodies.
119 n connection has been challenging due to the inaccessibility of the body's interior.
120                                    Given the inaccessibility of the brain, efforts have focused on ce
121 atial resolution, because of the geometrical inaccessibility of the brain.
122    Despite the theoretical concern regarding inaccessibility of the central nervous system to systemi
123                                          The inaccessibility of the clamp binding motifs in the CDP-b
124 s complicated in adulthood by the structural inaccessibility of the cochlea, which is embedded within
125 ude the instability of the gp120 trimer, the inaccessibility of the conserved sequences, highly varia
126                               The rarity and inaccessibility of the earliest primordial germ cells (P
127  development has remained elusive due to the inaccessibility of the early conceptus.
128 tion remain poorly understood because of the inaccessibility of the early postimplantation human embr
129 embryo is still lacking, mostly owing to the inaccessibility of the embryo in vivo for direct observa
130 er implantation, owing to the small size and inaccessibility of the embryo.
131 icult to predict and monitor, because of the inaccessibility of the endocrine pancreas, the integrate
132                      Because of the relative inaccessibility of the enthesis, the inflammatory, micro
133 r staining FFPE tissue, primarily due to the inaccessibility of the epitopes.
134  brain development in mammals because of the inaccessibility of the fetal brain in the uterine enviro
135  Collisional quenching by iodide showed more inaccessibility of the fluorophore in the myristoylated
136 ing trips has been poorly studied due to the inaccessibility of the foraging site-the open ocean-to r
137                                       Steric inaccessibility of the grooves to large CoHex ions leads
138                                          The inaccessibility of the gut and inter-connections between
139                     However, the fundamental inaccessibility of the human brain for invasive studies
140 try have been constrained by the fundamental inaccessibility of the human brain for invasive studies.
141 osis and drug screening in humans due to the inaccessibility of the human brain.
142                              The fundamental inaccessibility of the human neural types affected by di
143 E1 endonuclease domain, explained by solvent inaccessibility of the imine bond in the enzyme-inhibito
144 ryo in vivo have remained elusive due to the inaccessibility of the implanted conceptus for biochemic
145  remains challenging because of the relative inaccessibility of the infected tissue and the difficult
146 mains unknown, primarily due to experimental inaccessibility of the initial stages of the living huma
147 earing loss (ASNHL) has been hindered by the inaccessibility of the inner ear to biopsy and the lack
148     Potential mechanisms for latency include inaccessibility of the integrated viral genome, absence
149  a noninvasive manner because of the optical inaccessibility of the mammalian liver.
150                                          The inaccessibility of the Mott critical point in NiS(2) par
151 mplexed monomers, together with the relative inaccessibility of the P14 hinge residue in the oligomer
152 sence of symptoms during this period and the inaccessibility of the pancreas for sampling.
153 a replicase; this was shown to be due to the inaccessibility of the partially base-paired CCCA.
154 que stability of MIDA boronates to a kinetic inaccessibility of the potentially reactive boron p-orbi
155 P) in the CA1 region of hippocampus, but the inaccessibility of the presynaptic terminal has prevente
156 we establish a correlation between predicted inaccessibility of the pyrimidine tract and IRES activit
157 cine products could be due to the absence or inaccessibility of the relevant epitopes.
158  mutant toward peroxides was not a result of inaccessibility of the remaining thiol as demonstrated b
159 ed on the operative situs is hindered by the inaccessibility of the small pelvis and the tumor bulk i
160 use of the high spatial variability of R(S), inaccessibility of the soil medium and the inability of
161 ormational changes on the ensemble level and inaccessibility of the structural details from experimen
162 rks is challenging due to the complexity and inaccessibility of the system.
163 studies, with limited study in humans due to inaccessibility of the target brain tissue.
164 lished crystal structure showing the solvent inaccessibility of the target lysines.
165  The reason is probably, in part, due to the inaccessibility of the targeted extracellular structures
166 und in plant genomes, diverse reactivity and inaccessibility of their substrates and products.
167                                   Due to the inaccessibility of these cavities, it is unclear how the
168 synaptic terminals have been hampered by the inaccessibility of these synapses to soluble reagents.
169 nd live intact Salmonella because of surface inaccessibility of this determinant.
170 the C1'-position of nucleotides, despite the inaccessibility of this hydrogen in duplex DNA.
171                    This is mainly due to the inaccessibility of this process to longitudinal imaging
172                                          The inaccessibility of U8 in the canonical L-shaped form of
173 st that tight Cdh1 binding combined with the inaccessibility of ubiquitinatable lysines contributes t
174                                          The inaccessibility of uniform-diameter, single-chirality ca
175 he assembly process has been hampered by the inaccessibility of unstable intermediates.
176                                     Template inaccessibility, on the other hand, leads to a different
177 lifespan of less than 6 months, geographical inaccessibility precluded return for follow-up visits, t
178                           However, given its inaccessibility, studying human hypothalamic gene regula
179 in a manner previously impossible because of inaccessibility to early human embryonic tissues.
180                                              Inaccessibility to individual data and time-to-event dat
181 omplexity of phenotypes, and until recently, inaccessibility to large numbers of genes that might und
182 site spatiotemporal resolution; however, the inaccessibility to light of widely distributed neuronal
183 ription activation concomitant with promoter inaccessibility to restriction enzyme digestion.
184 ystem has been hampered by their paucity and inaccessibility to single-cell measurements.
185 me ligands such as cyanide, indicating their inaccessibility to the heme.
186 cted, and for many of the more severe irAEs, inaccessibility to the tissue site hampers mechanistic i
187 ricular tachycardia (VT) can fail because of inaccessibility to the VT substrate.
188                           Lack of adherence, inaccessibility to viral reservoirs, long-term drug toxi
189                                         This inaccessibility, together with the generally low mobilit
190                     An assay based on biotin inaccessibility was used for alpha1 subunits.
191  Additionally, due to central nervous system inaccessibility we undertook quantification of phosphati
192             Only in situ imaging unveils the inaccessibility when compared to the industry-accepted e
193 nd show that they induce both cell death and inaccessibility when transiently expressed in Mla10 and
194 omen: OR, 1.9; 95% CI, 1.8-2.1; medical care inaccessibility, women: OR, 1.7; 95% CI, 1.6-1.9; unempl

 
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