ライフサイエンスコーパス: inactivation

1 to link the cell chains formed upon Tol-Pal inactivation.

2 sensitive to combined sunitinib and PI3Kbeta inactivation.

3 assium channel KcsA in the context of C-type inactivation.

4 se phenotypes in ways that extend beyond p53 inactivation.

5 low inactivation and impairing recovery from inactivation.

6 to induce gene silencing during X-chromosome inactivation.

7 .2 V) LEEFT significantly enhances the ozone inactivation.

8 selectivity filter and therefore to channel inactivation.

9 changes such as imprinting and X-chromosome inactivation.

10 ons, but becomes entirely alpha-helical upon inactivation.

11 via DNA breaks and HP1-dependent epigenetic inactivation.

12 isrupted Na(V) 1.5's ability to recover from inactivation.

13 ds in series yielded greater improvements in inactivation.

14 layed negative shifts in both activation and inactivation.

15 ., to take up diamino-PC (PC2) for red light inactivation.

16 assezia species complex through breakage and inactivation.

17 d to manipulate isoforms independent of gene inactivation.

18 on network was altered in AD due to parietal inactivation.

19 velope into the nucleoplasm following Erk1/2 inactivation.

20 served by cryo-ET, potentially owing to AT-2 inactivation.

21 chemical transformation is a known driver of inactivation.

22 hat is central to Jpx's role in X chromosome inactivation.

23 ulin (CaM), which mediates Ca(2+) -dependent inactivation.

24 erent extent for uroporphyrinogenesis and UV-inactivation.

25 hrotic syndrome in only one case of skewed X-inactivation.

26 ectric field strength for efficient bacteria inactivation.

27 oided by the enigmatic process of centromere inactivation.

28 and deactivation; and bimodal recovery from inactivation.

29 t linger in regions that escape X chromosome inactivation.

30 cyst cell proliferation in ADPKD due to Pkd1 inactivation.

31 open reading frames as well as conventional inactivation.

32 that may contribute to the calcium-dependent inactivation.

33 bsequently leads to JNK activation and Hippo inactivation.

34 he model can satisfactorily describe the PPO inactivation.

35 ultaneous sputum liquefaction, bacteria heat inactivation (99 degrees C/30 min), and enrichment for m

36 by loss of centromere DNA and (b) centromere inactivation accompanied by changes in DNA sequence foll

37 Ds impede RAG scanning(3-5); however, their inactivation allows scanning to proximal V(H)s, where ad

38 Redox-mediated HIF-1alpha inactivation also decreased the expression of TGF-beta1

39 X-chromosome inactivation analysis may be useful for identifying cand

40 teria or bacterial polysaccharides, limiting inactivation and aiding transmission.

41 play increased resistance to mTORC1-mediated inactivation and are more stable under prolonged stress

42 , which speeds the activation and slows the inactivation and deactivation of a second potassium cond

43 ts, including accelerating the onset of slow inactivation and impairing recovery from inactivation.

44 shift the reading frame generally cause gene inactivation and in essential genes cause loss of viabil

45 outh of the selectivity filter (SF) disrupts inactivation and K(+)-selective transport in hERG1, lead

46 ty of the RAS-RAF axis has been obtained and inactivation and signal transduction mechanisms indicate

47 covered a complex relationship between TORC1 inactivation and vacuole biogenesis.

48 ); voltage-dependent kinetics of activation, inactivation, and deactivation; and bimodal recovery fro

49 USP9X escapes X inactivation, and in female subjects de novo heterozygou

50 regation, stabilized LPL against spontaneous inactivation, and made it resistant to inactivation by t

51 rnations in diastolic cytosolic Ca(2+), RyR2 inactivation, and sarcoplasmic reticulum Ca(2+) release

52 activated during the day, not differences in inactivation, and was eliminated by Bay K8644.

53 f the phenotypes associated with MAGP-1 gene inactivation are consistent with dysregulation of the tr

54 hytohormones and enzymes for brassinosteroid inactivation are present only in spermatophytes.

55 The rates of PFOR and fumarase inactivation are similar, suggesting that superoxide dis

56 n viable PRCV is primarily due to UV-C based inactivation, as opposed to physical collection of virus

57 , as well as through an in vitro translation-inactivation assay.

58 hat reducing pond depth can increase the log inactivation at the cost of larger land area, but increa

59 daptive threat responses in mice, with their inactivation attenuating both unconditioned behavioral r

60 himine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechanism.

61 Incomplete viral inactivation by D. magna was observed through recovery o

62 ts low stability, short half-life, and rapid inactivation by enzymes in physiological conditions affe

63 ns, because of parallel PP2A:B55 phosphatase inactivation by Greatwall kinase.

64 al hydrogen production is their irreversible inactivation by oxygen.

65 Rh50 inactivation by RNA interference selectively in muscle c

66 = R(2) <= 0.99), but the model overestimated inactivation by small-dose DUV on wet SS.

67 neous inactivation, and made it resistant to inactivation by the LPL antagonists angiopoietin-like pr

68 The salt coatings retained the pathogen inactivation capability at harsh environmental condition

69 rmore, DOT1L loss, rather than its catalytic inactivation, causes defects in glial cell specification

70 Ca(2+)-dependent inactivation (CDI) is a regulatory feedback mechanism th

71 Upon Erk1/2 inactivation, COP1 is rapidly released from the nuclear

72 the qPCR-based method to establish a UV(254) inactivation curve for HuNoV (inactivation rate constant

73 Inactivation curves dependency on heating technology sug

74 d and particle-associated FC well fitted the inactivation data with determined k(d) and particle-asso

75 fers; however, the impact of residence time (inactivation/death) versus removal (pore-scale delivery

76 vlPFC inactivation deteriorated the quality of late-phase (>15

77 The resultant RyR2 inactivation diminishes sarcoplasmic reticulum Ca(2+) re

78 PL inactivation disrupted active but not inhibitory avoidan

79 Further, comparison of simulated sunlight inactivation efficacy in maturation ponds under differen

80 While recent lesion and inactivation experiments have provided hints about how v

81 fect (i.e., activity-dependent release sites inactivation), extending a model explaining PC_DCN relea

82 that Ca(2+) flux produces activity-dependent inactivation for both GluN2A and GluN2B receptors and th

83 ensors are partially activated, and the fast-inactivation gate is partially closed.

84 -phenylalanine-methionine (IFM) motif to the inactivation-gate receptor.

85 e of the SF signature sequence in the U-type inactivation gating of hKv2.1 and hKv3.1.

86 In contrast, sustained mesoaccumbal inactivation greatly reduced motivation for performing a

87 These data suggest that PI3K inactivation has a conserved effect of upregulating mito

88 ued appetitive go/no-go task, both IL and PL inactivation impaired inhibitory but not active reward-s

89 Zeb2 genetic inactivation impaired the differentiation potential of t

90 is that-in organisms with early X chromosome inactivation-imprinted X chromosome inactivation prevent

91 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage repair, and mut

92 aque monkeys before and during unilateral SC inactivation in a spatial attention task.

93 Here we show that Nf1 gene inactivation in adult oligodendrocytes (Plp-Nf1 (fl/+) m

94 eine on Na(+) current (I(Na)) activation and inactivation in intact loose-patch clamped murine skelet

95 X chromosome before and during X chromosome inactivation in preimplantation female embryos(15).

96 on of the receptor leading to its functional inactivation in primary sensory neurons and to an effica

97 ritical and selective role for K(v)1 channel inactivation in synaptic facilitation of excitatory hipp

98 Using conditional inactivation in the embryonic mouse eye, our data indica

99 Distinct patterns of gene inactivation in the four near-complete sequences show th

100 s Nav1.6 current and shifts the steady-state inactivation in the hyperpolarizing direction.

101 itroso intermediates is essential for target inactivation in vivo.

102 s were investigated using tissue-specific GA inactivation in wild-type (Col-0) or rescue of GA-defici

103 Mechanistically, GPX4 inactivation increased production of lipid peroxidation,

104 on with pharmacological JAK inhibition, YBX1 inactivation induces apoptosis in JAK2-dependent mouse a

105 a(v)1.5 structure, pharmacology, activation, inactivation, ion selectivity, and arrhythmias.

106 C-type inactivation is attributed to a nonconductive conformati

107 ecreased particle/PFU ratios.IMPORTANCE Gene inactivation is considered to be an important driver of

108 t been fully assessed, partially because NMD inactivation is lethal in many organisms.

109 ate constant of hydrolysis, k(h), and enzyme inactivation, k(d).

110 We studied the inactivation kinetics and localized oxidation caused by

111 Inactivation kinetics in TLF and on dry SS followed the

112 In this study, the inactivation kinetics of murine norovirus (MNV) by PFA,

113 f acai-berry pulp and its perishability, the inactivation kinetics of peroxidase (POD) and polyphenol

114 h qPCR- and culture-based methods to measure inactivation kinetics with UV(254) treatment.

115 very rapid voltage-dependent activation and inactivation kinetics, and isoform-specific sensitivity

116 e diagram due to the impacts of complex slow inactivation kinetics.

117 However, what inactivates RyR2 and how RyR2 inactivation leads to Ca(2+) alternans are unknown.

118 We also found that Stat3 inactivation led to increased expression of the inflamma

119 The novel addition-aromatization inactivation mechanism for 9 contributes to its signific

120 peptide is responsible for a ball-and-chain inactivation mechanism.

121 A1 fails to block Cas9 due to its multi-step inactivation mechanism.

122 ances in our understanding of drug block and inactivation mechanisms are noted, but a full picture wi

123 hibitors of hOAT, which exhibit two distinct inactivation mechanisms resulting from the difference of

124 unique insights into channel activation and inactivation mechanisms.

125 performance of the EDTA-modified carbapenem inactivation method (eCIM) in tandem with the modified c

126 eCIM) in tandem with the modified carbapenem inactivation method (mCIM) against a large collection of

127 A variant of the modified carbapenem inactivation method (mCIM) was developed to detect carba

128 d later CPF, we used the Daun02 chemogenetic inactivation method in c-fos-lacZ transgenic male and fe

129 a purification protocol compatible with this inactivation method was developed.

130 Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammali

131 duplication events and the phenotype of fast inactivation observed in mammalian TRPV6 channels.

132 and MYCN represent an unusual example, where inactivation of a tumor-suppressor gene and activation o

133 The combined inactivation of acetaldehyde detoxification and the FA p

134 In contrast, inactivation of AdeB leads to a focused cellular respons

135 s were Mf clearance at 6, 12, and 24 months; inactivation of adult worm nests; and safety.

136 Inactivation of all three loci in the mesothelial lining

137 cA mutant to near wild-type (WT) size, while inactivation of AlsT does not.

138 ssion of a dominant negative form of AMPK or inactivation of AMPK alpha1 and alpha2 subunit genes in

139 In vivo conditional inactivation of an essential m(6)A writer component, MET

140 and genetically engineered mouse models with inactivation of any of several SWI/SNF subunits.

141 Inactivation of any of these genes reduces DBL-1/BMP sig

142 Inactivation of AP1 or AP2 (A-function genes) in hua-pep

143 ates that combined partial loss of c-Cbl and inactivation of APC significantly contribute to CRC tumo

144 Inactivation of Ataxia-telangiectasia mutated (ATM) gene

145 Inactivation of BbSre1 resulted in a significant increas

146 e destruction complex, eventually leading to inactivation of beta-catenin degradation.

147 The time constant of recovery from inactivation of Ca(2+) current was 40 to 70 ms in atrial

148 The inactivation of cbsa affects eye development by increasi

149 As a consequence, inactivation of CDK7 reduced organ size and inhibited tu

150 Inactivation of clpP or simultaneous inactivation of clpC and clpE stabilized the GFP::SpxA2(

151 Inactivation of clpP or simultaneous inactivation of clp

152 thrombin-induced phosphorylation and thereby inactivation of Cofilin1, an actin-depolymerizing protei

153 ith nested LCR22C-D deletions have CTDs, and inactivation of Crkl in mice causes CTDs, thus implicati

154 transfer of DREADDs, we show that transient inactivation of dMSNs or activation of iMSNs is capable

155 Inactivation of Doc2a and Doc2b in Syt1-deficient neuron

156 of neural progenitor cells, while catalytic inactivation of DOT1L has a lesser effect.

157 rom VMHvl(vGlut2) to lPAG(vGlut2) cells, and inactivation of downstream lPAG(vGlut2) populations resu

158 ap of GP1 may allosterically protect against inactivation of EBOV by premature triggering of GP2.

159 and antimicrobial peptide production, so the inactivation of ecdysone by glycosylation results in a f

160 Inactivation of either complex reduced neuron growth and

161 We further show that allele-specific inactivation of either of two essential genes (PRIM1 and

162 Inactivation of either programmed death ligand 1 or IFNG

163 (4) and characterized by universal biallelic inactivation of ELP1 owing to somatic loss of chromosome

164 We report that inactivation of Epas1 in adult mice resulted in selectiv

165 Additionally, inactivation of epidermal PIF4 or auxin signaling, and o

166 We previously demonstrated that the inactivation of fakA leads to decreased alpha-hemolysin

167 ins, and (iii) thermoprotection against heat inactivation of firefly luciferase, and (iv) sequence ho

168 These analyses were complemented with inactivation of FOXA1 and PTEN in intermediate and lumin

169 Given that inactivation of FOXO1 has been reported in many types of

170 Genetic inactivation of FTO using multiple orthogonal approaches

171 This study investigated the inactivation of Gram-negative Escherichia coli (E. coli)

172 We discuss how inactivation of IFNAR1 in CAFs acts to stimulate stromag

173 in patient-derived explants where enzymatic inactivation of IKBKE reduced cell proliferation and AR

174 l epithelial cells was observed upon genetic inactivation of IL-17RD.

175 This effect was phenocopied by dual genetic inactivation of KDM6A/B using CRISPR/Cas9.

176 stigated the consequences of early postnatal inactivation of Kif11 in vascular endothelial cells (ECs

177 viruses results in lysosome deacidification, inactivation of lysosomal degradation enzymes, and disru

178 Towards this goal, the inactivation of members of the HIPM and DIPM gene famili

179 of either Leu-395 or Phe-396 with Ala led to inactivation of MGAT4D-L inhibitory activity.

180 Sunlight-mediated inactivation of microorganisms is a low-cost approach to

181 decay followed first-order kinetics and the inactivation of MNV was governed by the exposure of micr

182 stabilizes ARE mRNAs by phosphorylation and inactivation of mRNA decay factor, Tristetraprolin (TTP)

183 This is an essential requirement for inactivation of multiple copies of disease-associated RN

184 Inactivation of neuronal ERalpha did not alter the body

185 AV infectivity as assessed by methylene blue inactivation of non-encapsidated RNA.

186 Here, we show that inactivation of OpuD restores the cell size of a dacA mu

187 Specifically, inactivation of p120ctn combined with overexpression of

188 Biallelic inactivation of PALB2 and MLH1 was observed in tumors fr

189 Direct pharmacological inactivation of parietal cortex increased minimum integr

190 Inactivation of parietal cortex not only caused pronounc

191 Inactivation of Pin1 can establish BRCAness in cancer ce

192 means of slowing ADPKD progression caused by inactivation of Pkd1.

193 statement was also observed with ipsilateral inactivation of PL and RMTg, but not with unilateral ina

194 tion of PL and RMTg, but not with unilateral inactivation of PL or RMTg alone, indicating that both i

195 Genetic inactivation of PLDgamma1 resulted in increased resistan

196 equired PP2A phosphatase and correlated with inactivation of PLK-1 (Polo kinase) and SPD-2 (Cep192).

197 Inactivation of Pten gene through deletions and mutation

198 Indeed, we observed that optogenetic inactivation of PV neurons during one tone counterintuit

199 n in LB mice was rescued through optogenetic inactivation of PV-positive cells in the BLA.

200 Therefore, both activation and inactivation of PVCV occurred in aged plants.

201 T inhibits food intake, and chemical genetic inactivation of PVT neurons diminishes SF1 neural inhibi

202 oss of cell-cell adhesion is correlated with inactivation of RAP1 confirmed by 2 different biochemica

203 Here we show that light-induced inactivation of ribonucleoprotein attenuates genome edit

204 Our results demonstrate that inactivation of RyR2 by Ca(2+)-CaM is a major determinan

205 ion of neurodevelopmental processes, such as inactivation of SHANK2, are key mediators of tumorigenes

206 Inactivation of Syt1 (synaptotagmin-1), the main Ca(2+)

207 We hypothesized that monoallelic inactivation of the allele retained in tumors can select

208 or cells, depletion of extracellular ATP, or inactivation of the ATP-gated P2X7R channel also comprom

209 ss, phenotypes that are partially rescued by inactivation of the ATR and Chk2 kinases.

210 toma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate

211 , usually thought to be a consequence of the inactivation of the canonical SHH pathway, is, at least

212 S5806 suppressed the current and accelerated inactivation of the channels when cells were co-transfec

213 The inactivation of the ciliary proteins polycystin 1 or pol

214 ivity, and chicken colonization in C. jejuni Inactivation of the CjNC110 ncRNA led to a statistically

215 th this study we aimed at clarifying whether inactivation of the cytoplasmic immunoglobulin tail tyro

216 1 compared to ABT, efficient mechanism-based inactivation of the enzyme evidenced by a K(I) = 2.2 muM

217 erts irreversible NO poisoning and reductive inactivation of the enzyme.

218 However, Abeta-induced inactivation of the eukaryotic initiation factor 2alpha

219 g axis that promotes the phosphorylation and inactivation of the F-actin depolymerization factor cofi

220 Furthermore, inactivation of the ferric uptake regulator (fur) in P(t

221 Fragile X syndrome (FXS) is caused by inactivation of the FMR1 gene and loss of encoded FMRP,

222 ncers that are predominantly associated with inactivation of the gene SMARCB1, a conserved subunit of

223 Inactivation of the methyltransferase gene negatively im

224 death after a delayed mitosis was rescued by inactivation of the mitotic surveillance pathway.

225 tion commenced shortly after egg laying, and inactivation of the more abundant piRNA resulted in fail

226 ulation of dysfunctional CI arising from the inactivation of the N-module subunits due to attrition c

227 brains of patients with AD, and that genetic inactivation of the NLRP3 inflammasome improves behavior

228 Skewed XCI toward inactivation of the normal RPGR allele was associated wi

229 ase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb.

230 factor-beta signaling in BRAF melanomas and inactivation of the SWI/SNF complex in (N)RAS melanomas,

231 Inactivation of the TMEM189 gene in human HAP1 cells led

232 due to activation of a MAP kinase pathway or inactivation of the tumor suppressor p53, two alteration

233 (V)1.7 and NaChBac but affect activation and inactivation of the two channels to different extents.

234 Inactivation of these CoV interferon antagonists is a ra

235 ed silencing of ESRRB triggers the selective inactivation of these units within SEs.

236 Inactivation of this protein results in the loss of the

237 ight inactivation of viruses, we modeled the inactivation of three-human adenovirus and two bacteriop

238 nd available tumors showed biallelic somatic inactivation of TP53.

239 d in PDAC tumors upon activation of KRAS and inactivation of TP53.

240 Here we show that combined inactivation of Trp53 and Rb1, a defining genetic featur

241 We discover inactivation of tumor suppressors in intron regions and

242 odel of colorectal cancer initiation through inactivation of two tumor suppressor genes and activatio

243 mong the environmental factors promoting the inactivation of viral pathogens in surface waters.

244 lity, and engineering design in the sunlight inactivation of viruses, we modeled the inactivation of

245 These data suggest that inactivation of Zbtb20 may offer an approach to enhance

246 at the lysosomal dysfunction induced by gene inactivations of lysosomal biogenesis or acidification f

247 We show that silencing, or gene inactivation, of endothelial Tie-2 results in leak forma

248 The dependence of the subsequent, I(Na) inactivation on V(1) was examined by superimposed, V(2),

249 Strikingly, Bmp5 gene inactivation or BMP signaling inhibition with a small mo

250 a(2+)], luminal regulation, Ca(2+)-dependent inactivation, or physical coupling between RyRs when Ca(

251 romosome inactivation-imprinted X chromosome inactivation prevents biallelic X silencing.

252 ssium (Kv) channels display several types of inactivation processes, including N-, C-, and U-types.

253 In PB, the values of the inactivation rate constant (k(d)) decreased with an incr

254 with determined k(d) and particle-associated inactivation rate constant (k(p)).

255 icivirus) but degraded much faster than MS2 (inactivation rate constant = 0.14 cm(2) mJ(-1)).

256 lish a UV(254) inactivation curve for HuNoV (inactivation rate constant = 0.27 cm(2) mJ(-1)).

257 tioned the variability of predicted sunlight inactivation rate constants to different factors.

258 Aminopeptidase showed second-order inactivation rate constants with (1)O(2) comparable to t

259 X-chromosome inactivation ratios were determined in genomic DNA isola

260 ptogenetic activation increased, and genetic inactivation reduced, female aggression.

261 ntly reduced lipolytic activity (>90% enzyme inactivation), resulting in a stable emulsion.

262 VHL inactivation results in the constitutive activation of t

263 umor suppressors we applied CRISPR/Cas9 gene inactivation screens to a cellular model of early-stage

264 vation are resistant to ferroptosis and AMPK inactivation sensitizes these cells to ferroptosis.

265 We show that signal inactivation sharpens signals, reducing variability in t

266 sequent superimposed positive activation and inactivation shifts, following 0.5 mM caffeine challenge

267 Optogenetic inactivation showed that the somatosensory cortex was ne

268 SC inactivation significantly altered the attention-related

269 nfection by-product formation with a broader inactivation spectrum, which facilitates the application

270 , for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (c

271 ndria calcium homeostasis with hepatic HAX-1 inactivation suggest that this may be a potential therap

272 bination of V991L with D1908G, shows reduced inactivation, suggesting that peripheral nerves were mor

273 ith integrase phylogenetic analysis and gene inactivation tests, revealed 19 new cases of genes whose

274 fundamentally different mechanism of AcCYP51 inactivation than only blocking the active site.

275 tials; however, they also exhibited enhanced inactivation: that is, F302L causes both gain- and loss-

276 flux through NMDA receptors leads to channel inactivation through a process mediated by resident calm

277 arrier, we derive a simple formula for virus inactivation time as a function of temperature.

278 ntion of URO/PC2-medated double-photodynamic inactivation to ascertain its complete loss of viability

279 onfer unusually sensitive, voltage-dependent inactivation to inhibit responses to non-prey signals, s

280 n cells with EGFR overexpression and p120ctn inactivation, Twist2 is significantly upregulated.

281 well as their resistance to dissociation or inactivation under cytosolically relevant concentrations

282 We tested this mechanism for inactivation using a KcsA mutant (H25R/E118A) that exhib

283 sely, genes for gibberellin biosynthesis and inactivation using methyltransferases are found in all l

284 long a spectrum that represents tolerance to inactivation, validate this classification using data fr

285 a(V)1.7 and shift activation (aconitine) and inactivation (veratridine) respectively.

286 nal likely pathogenetic mutations beyond RB1 inactivation was associated with aggressive histopatholo

287 Presynaptic K(v)1 channel inactivation was mediated by the K(v)beta1 subunit and h

288 tal stability at pH 7.0; thus, extracellular inactivation was unlikely to attenuate the Y17H virus.

289 teristics needed for high fidelity molecular inactivation, we have designed and synthesized a new C(2

290 of projection neurons and focal optogenetic inactivation, we studied mice performing a whisker-based

291 consideration of nitric oxide production and inactivation when investigating vascular function in hum

292 timulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic br

293 rt of Na(V) 1.5 that is required for channel inactivation with high affinity.

294 Taken together, EC PI3Kbeta inactivation with sunitinib inhibition reduces microvess

295 ve shifts in the voltage dependence of I(Na) inactivation (within 10 min) and subsequent superimposed

296 cks positive-sense single-stranded RNA virus inactivation without relying on culturing methods.

297 Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phenomena that

298 We focus on X-chromosome inactivation (XCI) as a paradigm for fHC but also relate

299 iverse proteins(3-5) to achieve X-chromosome inactivation (XCI)(6,7).

300 wn as an essential regulator in X-chromosome inactivation (XCI).