ライフサイエンスコーパス: inactive form

1 yclic guanosine monophosphate (GMP) to their inactive form.

2 n of H12 is ligand-inducible to an active or inactive form.

3 osttranscriptional accumulation of DXS in an inactive form.

4 Rac1 without interacting with the GDP-bound inactive form.

5 ot grow because RNR remains in its oxidized, inactive form.

6 functionally encapsulate biomolecules in an inactive form.

7 ined within cytoplasmic tubulovesicles in an inactive form.

8 o express c-fos, and Rb is maintained in its inactive form.

9 allowing formation of active TFIIIC from the inactive form.

10 ctive oxidized form of cyclo-oxygenase to an inactive form.

11 inus in the active form of ERK2, but not the inactive form.

12 activated kinase in a readily available, but inactive form.

13 reas cytoplasmic ATF2 probably represents an inactive form.

14 e due to a greater balance of PDH toward the inactive form.

15 modimerization, thus constraining CAR in its inactive form.

16 protein builds up in the hyperphosphorylated inactive form.

17 ne, by cleaving membrane hemojuvelin into an inactive form.

18 the nucleus in a truncated and enzymatically inactive form.

19 In growing cells, it is found in active and inactive forms.

20 pre-existing equilibrium between active and inactive forms.

21 tor undergoes transitions between active and inactive forms.

22 e NTD but not the CTD in both the active and inactive forms.

23 (2) and switch regulators between active and inactive forms.

24 t, cooperative transition between active and inactive forms.

25 riants including wild-type and catalytically inactive forms.

26 homeostasis by catabolizing AR agonists into inactive forms.

27 In cells, P-TEFb exists in active and inactive forms.

28 n growing cells, P-TEFb exists in active and inactive forms.

29 ractions that keep the molecule in a closed (inactive) form.

30 ed much Rb protein in a hyperphosphorylated (inactive) form.

31 abine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine.

32 The N-terminal ATPase domains are inactive, forming a symmetric D1 ring, whereas the C-ter

33 (active form) and of phosphorylated 4E-BP1 (inactive form), a translation repressor.

34 PI(4,5)P2, which is loaded into cells in an inactive form and activated by light, allowing sub-secon

35 the CaSR by the transition between its open inactive form and closed active form.

36 CysSOH, and CysSO(2)(-) both in the NO-bound inactive form and in the photolyzed active form.

37 pothesized that UL16 is initially made in an inactive form and is artificially transformed to the bin

38 vored the active alphavbeta3 rather than the inactive form and showed little affinity for other integ

39 y of ARD1 GTPase to cycle between active and inactive forms and its autoubiquitination both appear to

40 ion of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migrat

41 GAPC1 protein accumulation in enzymatically inactive form, and (5) strong relocalization of GAPC1 to

42 n, many metallocofactors can be converted to inactive forms, and pathways for their repair have recen

43 exists in an equilibrium between active and inactive forms, and the effector, cAMP, shifts that equi

44 cense origins by loading Mcm2-7 complexes in inactive form around DNA.

45 We found that there is less phospho-TTP (inactive form), as well as phospho-p38, in old than in y

46 of the Mcm2-7 helicase that is loaded in an inactive form at origins of DNA replication, suggesting

47 h contains active structures, and two common inactive forms, BLBplus and ABAminus.

48 along the cell membrane and maintained in an inactive form by DivK~P.

49 oteins governs the transition from active to inactive forms by regulating DNA binding.

50 escribe the 1.8 A resolution structure of an inactive form (by replacing the catalytic nucleophile Se

51 of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding

52 y grown cells is expressed exclusively in an inactive form containing only the as-isolated [2Fe-2S](2

53 FAM20C wild-type (WT) and its kinase inactive form D478A proteins were generated.

54 Normally, in its inactive form, DFF is a heterodimer composed of a 45-kDa

55 LF4 proteins indicate that transcriptionally inactive forms do not increase involucrin expression.

56 mESCs but accumulates in the cytoplasm in an inactive form due to AKT1-dependent nuclear export and i

57 This finding confirms the existence of the inactive form E* in essentially the same incarnation as

58 earlier biochemical data suggesting that the inactive form exists in an equilibrium among different c

59 ated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and

60 nct in the structure of its unphosphorylated/inactive form from IR/IGF-1R.

61 he translocation of phosphorylated FoxO3 (an inactive form) from nucleus to cytoplasm and the release

62 ion of diverse protein modules, typically in inactive form, from various cellular subsystems.

63 lls anergic, however, when the enzymatically inactive form H2N2 GRAIL was expressed, it functioned as

64 in lymphocytes (GRAIL), or an enzymatically inactive form, H2N2 GRAIL, allowed analysis of the role

65 However, an inactive form has also been isolated that lacks one of t

66 g the pool of nuclear beta-catenin toward an inactive form, having reduced binding to TCF/LEF transcr

67 K1 increased, whereas expression of a kinase-inactive form (HIPK1-D315N) or small interference RNA of

68 r factor I-mediated cleavage of C3b into the inactive form iC3b and thus prevents formation of inflam

69 virion-associated C3 component includes the inactive form iC3b, suggesting that SV5 may have mechani

70 ection is lost when CORM-3 is replaced by an inactive form (iCORM-3) that is incapable of liberating

71 an be further cleaved into a smaller and yet inactive form if matriptase-mediated proteolysis persist

72 logical conditions AMPK mainly exists in its inactive form in complex with Mg.ATP, which is much more

73 ated form in malignant cells but in a latent inactive form in normal tissues, suggesting that inhibit

74 that the photoswitch quickly relaxes to its inactive form in the dark.

75 aments dynamically switch between active and inactive forms in response to changes in substrate and p

76 e form composed of cyclin T1 and CDK9 and an inactive form, in which cyclin T1/CDK9 is sequestered by

77 eir thermodynamic properties relative to the inactive forms, including free energy, partial molar vol

78 Levels of phospho-FoxO3a (inactive form) increased in the cytosolic fraction of ce

79 equires the enzyme PO that is present in its inactive form inside haemocytes.

80 aintaining microbial virulence factors in an inactive form inside the pathogen until secretion.

81 Because active AtMCP2d can cleave its inactive form, intermolecular cleavage (autolysis) of At

82 The dATP-induced inactive form is an alpha4 complex, which can interact w

83 or substitution of jmj2 with a catalytically inactive form is correlated with increased reporter gene

84 The inactive form is favored while unbound but the active fo

85 The balance between its active and inactive form is tightly controlled to ensure cellular i

86 nograft model and may have an advantage over inactive form kinase inhibitors due to equal potency aga

87 and SIRT1, increased PGC-1alpha acetylation (inactive form), lower AMPK activity, and overactive mTOR

88 uggested that a compact and more symmetrical inactive form may predominate in solution in the absence

89 tutively active mutant Ras into functionally inactive forms may be accessible via subtle perturbation

90 -sheet-rich, protease-resistant, aggregated, inactive form (Mcc(ia)), and a soluble, protease-sensiti

91 a tetramer, mR1(4a), which isomerizes to an inactive form, mR1(4b), and ATP binding to the hexameriz

92 ated protein) 4-1, but not its catalytically inactive form NEDD4-1-C867A, increased Cavalpha1c ubiqui

93 her due to the generation of a catalytically inactive form of 5-LO, which assumes a new function.

94 inhibition is mediated by the enzymatically inactive form of 5-LO, which hinders nuclear translocati

95 reviously that a knockin mouse expressing an inactive form of ABIN1 (ABIN1[D485N]) develops lupus-lik

96 ly, we show that a soluble and catalytically inactive form of ACE2 potently blocked infection by S-pr

97 knock-in mice, which express a catalytically inactive form of AOC3, were also protected from lung fib

98 A proteolytically inactive form of APC with reduced anticoagulant activity

99 IAR3 hydrolyzes an inactive form of auxin (indole-3-acetic acid [IAA]-alani

100 s for the unphosphorylated and catalytically inactive form of biotin-p38alpha.

101 type mice, enhanced expression of the kinase-inactive form of BMPR-IB mediated by an adenovirus vecto

102 ATR and FA core complex, and represents the inactive form of both proteins.

103 oters and that expression of a catalytically inactive form of BRG1 results in derepression of PRMT7 t

104 Expression of a kinase-inactive form of c-Src (K(-) c-Src) or pharmacological i

105 Molecularly, mSH3BGRL specifically bound the inactive form of c-Src phosphorylated at Tyr527, promoti

106 he Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small int

107 pression of dominant-negative, catalytically inactive form of c-Src.

108 This process was abolished when a dominant inactive form of CaMKIV was expressed in normal T cells.

109 ISPR-dCas9 epigenetic editing tool, where an inactive form of Cas9 is fused to DNA methyltransferase

110 t Cdk sites triggers the stabilization of an inactive form of Cdh1 that accumulates in the cytoplasm,

111 ppocampal neurons, the expression of DNcdk5 (inactive form of cdk5) or of the triple alanine mutant (

112 rylation is blocked by a dihydroceramide, an inactive form of ceramide, and manumycin, an inhibitor o

113 ntional amplicon DNA were associated with an inactive form of chromatin immediately after infection.

114 Interestingly, an inactive form of CORM-A1 that is incapable of releasing

115 ction of acetaminophen in mice expressing an inactive form of Cot/tpl2 compared with Wt mice, suggest

116 Spores of a strain producing an inactive form of CotH, like those formed by a cotG delet

117 mulated in G2/M showed elevated levels of an inactive form of cyclin B1/p-Cdc2 (Tyr15) complex that w

118 Although the inactive form of cyclin-dependent kinase (CDK-1) is dete

119 liposomes reconstituted with a catalytically inactive form of Drs2p showed no translocation activity.

120 tion: Krz can directly bind and sequester an inactive form of ERK, thus preventing its activation by

121 endent inhibitors using either the active or inactive form of ERK2.

122 icial effects were less apparent for a redox-inactive form of Ero1.

123 The second form, a tetramer, may be an inactive form of FRP.

124 tural information is available for the free, inactive form of FVIIa that circulates in the blood prio

125 suggested the existence of a membrane-bound inactive form of FXa.

126 The structure of an inactive form of gelsolin shows that the equivalent acid

127 ctivity, since expression of a catalytically inactive form of GK did not alter endogenous hepatic GK

128 lycogen synthase kinase 3 beta (pGSK-3B), an inactive form of GSK-3B degrading glioblastoma 2 (GLI2),

129 the CDP-bound Hda dimer likely represents an inactive form of Hda.

130 Structural implication on how the inactive form of HrcA may be converted to the active for

131 phants with an mRNA encoding a catalytically inactive form of human DNMT1.

132 is effect, we also expressed a catalytically inactive form of human EL (ELS149A); unexpectedly, expre

133 Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal

134 Our results demonstrate that MeIAA is an inactive form of IAA, and the manifestations of MeIAA in

135 enzyme that hydroxylates JA to 12-OH-JA, an inactive form of JA that accumulates after wounding and

136 They bind to the active or inactive form of kinases, compete with ATP, stabilize in

137 Moreover, a methyltransferase-inactive form of KsgA, which we show to be deleterious t

138 domain of an exogenously added enzymatically inactive form of LytA revealed a potential substrate for

139 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2).

140 We used a kinase inactive form of MEKK3 (MEKK3(KI)) in an in vitro assay

141 e absence of adenosylcobalamin but due to an inactive form of methylmalonyl-CoA mutase.

142 wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell differentiation a

143 d accelerating MPO compound II formation, an inactive form of MPO.

144 trans expression of the non-phosphorylated, inactive form of MtrA in wild-type M. smegmatis resulted

145 In the inactive form of MtrA, these two domains form an extensi

146 nable to bind CD3e, possibly representing an inactive form of Nck in cells.

147 cted, thus representing the NCC bound to the inactive form of NOP.

148 OCE, we generated mice expressing a mutated, inactive form of Orai1 in blood cells only (Orai1(R93W))

149 ssues from mice expressing the catalytically inactive form of p110delta (p110delta(D910A)).

150 Previously we showed that the inactive form of p90 ribosomal S6 kinase 1 (RSK1) intera

151 Furthermore, a full-length kinase-inactive form of PAK2 blocked both TCR-induced CD69 up-r

152 nificant correlation between MICU1 and pPDH (inactive form of PDH) expression with poor prognosis.

153 Expressing a catalytically inactive form of Pet PLC1 in pollen tubes caused expansi

154 Whereas an inactive form of PKC-theta or knockdown of endogenous PK

155 agmentation, which was inhibited by a kinase inactive form of PKD.

156 ctivation, as did overexpression of a kinase-inactive form of PKD1.

157 hese results demonstrate that the glycolysis-inactive form of PKM2 plays a crucial role in the pathog

158 In contrast, a catalytic inactive form of PP2A or PP2A small interfering RNA blun

159 Surprisingly, expression of a catalytically inactive form of Psd1 still supported PDR5 transcription

160 suggest that stabilization of the oxidized, inactive form of PTP1B with appropriate therapeutic mole

161 ts PTP1B activity by increasing the oxidized inactive form of PTP1B.

162 A1 binding is preferential for the GDP-bound inactive form of Rab14.

163 y, a switch to expression of a catalytically inactive form of RASA1 resulted in impaired LVV and VV d

164 channels can catalyze the conversion of the inactive form of Rho to the active form, we show mathema

165 ormation is consistent with the dimer of the inactive form of rhodopsin modeled with constraints from

166 g, we introduced wild type Rip1 and a kinase-inactive form of Rip1, Rip1D138N, into rip1-/- murine em

167 decline following transient expression of an inactive form of RNMT (DeltaN-RNMT), likely due to degra

168 small organic molecules such as glucose, an inactive form of SA is generated which can be transporte

169 Overexpression of the phosphatase-inactive form of SHP-2 inhibited EGFRvIII pTyr by decrea

170 partially prevented by the expression of an inactive form of SNAP-25.

171 sses HBV replication, while an enzymatically inactive form of TAK1 exerts no effect.

172 ress other T cells by converting the latent, inactive form of TGF-beta1 into active TGF-beta1.

173 vivo Accordingly, exogenous expression of an inactive form of the 5-HT2C receptor in the locus cerule

174 uscle-specific transgenic mice expressing an inactive form of the AMPK alpha2 catalytic subunit (alph

175 ke persists in transgenic mice expressing an inactive form of the AMPKalpha2 catalytic subunit in ske

176 Together with the inactive form of the CaS extracellular domain, these sit

177 itrosoamino)-2,4-dinitrobenzene (C6') and an inactive form of the compound [1,5-bis-(dihexylamino)-2,

178 chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is as

179 A nearly inactive form of the enzyme, ALDH2*2, is found in about

180 of ATR kinase and overexpression of a kinase-inactive form of the enzyme, I show here that ATR promot

181 The other pathway leads to an inactive form of the enzyme, which was shown by chemical

182 histidine, an arrangement consistent with an inactive form of the enzyme.

183 nd between these residues might stabilize an inactive form of the enzyme.

184 ors of human RR which act by stabilizing the inactive form of the enzyme.

185 PI recruitment to membranes by expressing an inactive form of the GBF1 guanine nucleotide exchange fa

186 urons of the active, but not a catalytically inactive form of the Grx1 homolog rescued the exacerbate

187 suggest that our structure may represent an inactive form of the HrcA repressor.

188 Mice expressing a kinase-inactive form of the inhibitor of kappa B kinase alpha (

189 ordetella pertussis, preferentially binds an inactive form of the integrin complement receptor 3 (CR3

190 nerated from mice expressing a catalytically inactive form of the p110delta subunit of phosphatidylin

191 LR (LSCQLYQR), allosterically stabilizes the inactive form of the protein and inhibits ovarian cancer

192 Because the ligand binds to an inactive form of the protein in which an Asp-Phe-Gly str

193 st the toxin, it is imperative to achieve an inactive form of the protein which preserves the overall

194 sults in the accumulation of a catalytically inactive form of the protein, which may contribute to ag

195 ind to the dimer interface and stabilize the inactive form of the protein.

196 (Pdk2) and the product of its activity, the inactive form of the pyruvate dehydrogenase complex (P-P

197 ns 2, 3, and 7 that appears to stabilize the inactive form of the receptor.

198 Cells expressing the enzymatically inactive form of the secreted isoform, ADAM12-S, had tum

199 By combining J8-DT with an inactive form of the streptococcal CXC protease, S. pyog

200 d with its allosteric inhibitor AMP shows an inactive form of the tetramer, in which the dimer pairs

201 OriP-dependent DNA replication, while a PARP-inactive form of TNKS2 (M1045V) was compromised for this

202 A relatively inactive form of tPA was constructed by conjugating tPA

203 y generated mouse strain expressing a kinase-inactive form of TPL-2, we demonstrated that stimulation

204 Over-expression of a catalytically inactive form of USP14 rescues the PPF deficit and resto

205 diminished by expression of a catalytically inactive form of Usp14.

206 educed in animals expressing a catalytically inactive form of VAP-1, implicating enzyme activity in t

207 The circulating, inactive form of vitamin D, 25(OH)D(3), is generally use

208 However, TIMP-1JD38 cells expressed an inactive form of XBP-1, lacking antibody production/secr

209 n proliferative granulosa cells, whereas the inactive form of YAP1 (cytoplasmic YAP1) was mainly dete

210 escued with catalytically active but not the inactive forms of ADAMTS5 or ADAMTS15.

211 ression of either wild-type or catalytically inactive forms of AKR1C3 partially rescued AR activity a

212 Inactive forms of all G protein alpha subunits can be pr

213 When catalytically inactive forms of CaI were used in CdS-CaI complexes, ET

214 , this effect is observed with catalytically inactive forms of Cdc9p protein, but only if they posses

215 r the protective effects of CORM-2 in AP, as inactive forms of CORM-2 were ineffective.

216 receptors MiD51 and MiD49 appear to recruit inactive forms of Drp1, because their overexpression inh

217 it adopts a tethered conformation similar to inactive forms of ErbB1 and ErbB3.

218 In both active and inactive forms of ERK2, protection from hydrogen exchang

219 n ELMO1 interaction with both the active and inactive forms of ERM proteins and implying a possible r

220 Overexpression of dominant inactive forms of ezrin leads to fragilization of the me

221 acterize the conformations of the active and inactive forms of full-length AfGcHK in solution, we inv

222 nteracts with Gbeta3 and with the active and inactive forms of Galphao.

223 of RGS14 outside of the RGS domain can bind inactive forms of Go and Gi to confer previously unappre

224 t of exosome secretion because enzymatically inactive forms of heparanase, even when present in high

225 fects of overexpressing wild-type or mutated inactive forms of HER2 in primary human breast cells.

226 , as exosome-mediated delivery of active and inactive forms of HIF1alpha results in reciprocal change

227 dox-dependent conversions between active and inactive forms of hydrogenase, but the voltammetric sign

228 by coexpression of wild-type but not kinase inactive forms of IKKalpha, suggesting that IKKalpha may

229 ferent pocket present in both the active and inactive forms of KRAS.

230 e that simultaneously targets the active and inactive forms of KRAS.

231 dies suggest that cycling between active and inactive forms of KrsB may provide the dynamic regulatio

232 h slightly greater flexibility is present in inactive forms of MntR.

233 These inactive forms of OhrR can be reactivated by thiol-disul

234 1Delta mutant cells expressing catalytically inactive forms of Pah1p and dgk1Delta mutant cells with

235 reoxygenation and promoted an association of inactive forms of PKC with Bax.

236 ignaling, the wild-type or the catalytically inactive forms of PLD1 or PLD2 were stably overexpressed

237 he interaction of RhoGDI with the active and inactive forms of prenylated and unprenylated RhoA.

238 Inactive forms of Rac, including the human Rac2(D57N) mu

239 t other RPTP family members or catalytically inactive forms of RPTP-beta, reduces hepatocyte growth f

240 Phosphatase-inactive forms of SCP interfere with REST/NRSF function

241 subfamily, GRK5/6 effectively phosphorylate inactive forms of several GPCRs, including beta2-adrener

242 he Shp2 catalytic domain and result in open, inactive forms of Shp2.

243 Constitutively active or inactive forms of STAT1 did not promote lumen maturation

244 permitting completion of splicing generates inactive forms of TER1 and causes progressive telomere s

245 atinib and GNF-2 or overexpression of kinase-inactive forms of the Abl family kinases also impairs pa

246 nzyme quickly to form hydrolytically stable, inactive forms of the enzyme that have been characterize

247 nts can differentiate between the active and inactive forms of the enzyme, indicating that they are a

248 Modulation of the active versus inactive forms of the Galpha protein is critical for the

249 y provide models for the proposed active and inactive forms of the H. influenzae and E. coli enzymes.

250 ed by constitutively active c-Src but not by inactive forms of the kinase.

251 ne, possibly corresponding to the active and inactive forms of the receptor, and can "switch" between

252 The modeled systems include the active and inactive forms of the wild-type Galpha(t) and three of i

253 ild type GRK2 or GRK5, whereas catalytically inactive forms of these kinases were without effect.

254 ll death, indicating that viruses expressing inactive forms of these proteins can contribute to the C

255 filaments, resembling polymers formed by the inactive forms of this protein.

256 erologous expression of wild-type and kinase-inactive forms of TLK-1 suppresses the lethality of temp

257 strains that secrete functionally active or inactive forms of YopJ.

258 that selectively bind the nonphosphorylated (inactive) form of extracellular signal-regulated kinase

259 detectable increases in the CaM-free (i.e., inactive) form of iNOS within the first 2 h; it remains

260 Both reduced (active) and disulphide bonded (inactive) forms of IL-33 can be detected in lung lavage

261 yze the interconversion of the GDP-bound, or inactive, form of Rab to the GTP-bound, or active, form.

262 Rab9 is likely sequestered in an inactive form on Niemann-Pick type C membranes, as catio

263 m of RNA polymerase 2 (RNAPII) compared with inactive forms only in interactions between promoters an

264 , however, represent the open, catalytically inactive form or harbor nonproductive substrate analogs.

265 ock divisome activity by locking FtsA in the inactive form or preventing FtsA from communicating with

266 mplexes either with sigmaF, holding it in an inactive form, or with the anti-anti-sigma factor SpoIIA

267 tively regulate the CPC and/or stabilize its inactive form, preventing CPC autophosphorylation and re

268 tractant circulates in blood in a relatively inactive form (prochemerin) and is activated by carboxyl

269 shift of the equilibrium between active and inactive forms raises constitutive activation in one rec

270 Chd7 or overexpression of its catalytically inactive form recapitulates all major features of CHARGE

271 y shRNA or overexpression of a catalytically inactive form rescued neurons from zinc-induced cell dea

272 On the other hand, expression of a kinase-inactive form reverted the anchorage-independent growth

273 al using the crystal structure of MOR in the inactive form showed a unique binding mode with the two

274 host sec system, where they accumulate in an inactive form tethered to the membrane by their N-termin

275 The Dd FDH is suggested to be purified in an inactive form that has to be activated through a reducti

276 , we engineered the same antibody in an ADCC-inactive form that is similarly capable of blocking HGF/

277 nocyte-stimulating hormone (alpha-MSH) to an inactive form that is unable to inhibit food intake.

278 nusually, these toxins are synthesized in an inactive form that requires posttranslational activation

279 , Mot1-TBP complexes can exist in active and inactive forms that are regulated by environmental stres

280 In the soluble, inactive form, the alphaE helices are constrained into u

281 In its inactive form, the prototype SAR endolysin, Lyz(P1), of

282 The structure is in an inactive form; the side-chain of His409, one of the cata

283 of this neurotrophin receptor, favoring the inactive form throughout multiple corticolimbic brain re

284 ptor conformation exists in equilibrium with inactive forms, thus giving rise to basal activity of th

285 AMPK is converted from an inactive form to a catalytically competent form by phosp

286 eutral pH conformation or its switch from an inactive form to an activated form.

287 opose the basis for the stabilization of the inactive form to be through a salt interaction between A

288 ystal structure of CSN5 in its catalytically inactive form to illuminate the molecular basis for its

289 tch for transitioning beta-arrestin from its inactive form to its active receptor-binding state.

290 itionally, IL-18 processing of its precursor inactive form to its bioactive state is inhibited by LXR

291 the pocket remains open in the catalytically inactive form upon removal of an inhibitor from the pock

292 76, ADAP, or Pyk2, or expressing Pyk2 kinase-inactive forms, we show that SLP-76 and ADAP stimulate c

293 Major differences between the active and inactive forms were observed on the heme-proximal side (

294 C-helix of the N-terminal lobe-and DFGout-an inactive form where Phe occupies the ATP site exposing t

295 exists in two forms in cells as follows: an inactive form where the core components cyclin T1 and CD

296 toxin, which poses a threat to life, to the inactive form which can bind to antibodies but show no t

297 P-TEFb is found in two major complexes: the inactive form, which is associated with inhibitory subun

298 T represents an oxidized, previously unknown inactive form, whilst ScKAT is the reduced and active en

299 erts cellular cullin 3 into an un-neddylated inactive form with no or minimum effect on other cullin

300 of G-proteins switch between the active and inactive forms without a GEF.