ライフサイエンスコーパス: inactive state

1 te and immune-cell activation to maintain an inactive state.

2 inery, thus effectively trapping VAMP4 in an inactive state.

3 er, existing in an immunologically active or inactive state.

4 med by BBS1 and BBS7 that is occluded in the inactive state.

5 r B, thereby locking in the convertase in an inactive state.

6 ide exchange factors and thus trapped in its inactive state.

7 pon a stimulus reversibly can switch into an inactive state.

8 the viral GPCR to destabilize the receptor's inactive state.

9 ates, with an imbalance of rates favoring an inactive state.

10 n flow reflected the fraction of FimH in the inactive state.

11 tions as an RNA decoy to sequester PKR in an inactive state.

12 native exteins, which lock the intein in an inactive state.

13 which converts them between an active and an inactive state.

14 participate in the early maintenance of the inactive state.

15 each factor separately arriving at a stable inactive state.

16 as with SML-8-73-1 renders the protein in an inactive state.

17 mers that secure a therapeutic payload in an inactive state.

18 ons of the GPCR from the active state to the inactive state.

19 ta for Nlh2-linked GAF-ATPase domains in the inactive state.

20 cycle comprising a poised, an active, and an inactive state.

21 onists and receptor mutations that favor the inactive state.

22 lar contacts that lock the Rap protein in an inactive state.

23 nthesized and transported in a predominantly inactive state.

24 tic domain, allosterically clamping it in an inactive state.

25 ery of oligodendrocytes in a translationally inactive state.

26 at the active PHO5 gene in comparison to its inactive state.

27 tions are important in maintaining AKT in an inactive state.

28 whereas Tyr-559 maintains the receptor in an inactive state.

29 that metavinculin can bind to raver1 in its inactive state.

30 ls in the nucleus, albeit in a deacetylated, inactive state.

31 nce increase characteristic of moving to the inactive state.

32 the active site, thereby locking RNAP in an inactive state.

33 il domain that normally clamp vinculin in an inactive state.

34 idues in maintaining calcium-bound TG2 in an inactive state.

35 jority of these cells stay in a nondividing, inactive state.

36 and can stably adopt either an active or an inactive state.

37 state, and then increased upon going to the inactive state.

38 switching CD81 between a receptor active and inactive state.

39 binding ACV, the enzyme remains in the open, inactive state.

40 ot alter the structure of rhodopsin from the inactive state.

41 n by trapping the convertase in a stable but inactive state.

42 failed to bind PA, consistent with a locked inactive state.

43 Swi6 (HP1 homologs) are recruited during the inactive state.

44 e by which Nb6 stabilizes a ligand-dependent inactive state.

45 ersion of Rab7a from the active state to the inactive state.

46 ate to a highly condensed, transcriptionally inactive state.

47 ytic lysine (K745) in the "alphaC-helix out" inactive state.

48 beta Serine9 would hasten the DFG-flip to an inactive state.

49 (KD) are important for maintaining Akt in an inactive state.

50 containing filaments did not enter the first inactive state.

51 the activated c-KIT back to its structurally inactive state.

52 traps Cas9 in a DNA-bound but catalytically inactive state.

53 s that restrain Ras dynamics and promote the inactive state.

54 by which phyB reverts from the active to the inactive state.

55 hold that allows the kinetic trapping of the inactive state.

56 exported to the cytoplasm in a functionally inactive state.

57 nformational equilibrium of HUWE1 toward the inactive state.

58 formational switching between the active and inactive states.

59 tral pattern generator to produce active and inactive states.

60 nct conformations of GPCRs in the active and inactive states.

61 ctivation mechanism consisting of 10 or more inactive states.

62 and Arf1-bound AP-1 trimer in the active and inactive states.

63 results to define the relationships of these inactive states.

64 a dual-state model consisting of active and inactive states.

65 astic in nature: toggling between active and inactive states.

66 hifts the equilibrium between the active and inactive states.

67 nd CheY contains features of both active and inactive states.

68 ) demonstrated equal affinity for active and inactive states.

69 ructural states that resemble the active and inactive states.

70 ecting the ratio between assembly active and inactive states.

71 (2)A receptor have been solved in active and inactive states.

72 b partitions between small active and larger inactive states.

73 n-induced heme distortions in its active and inactive states.

74 stal structures of EhRho1 in both active and inactive states.

75 otal and nearly instantaneous, producing two inactive states.

76 ive affinities of agonist for the active and inactive states.

77 conformational equilibria between active and inactive states.

78 the thermodynamic balance between active and inactive states.

79 otide-dependent switching between active and inactive states.

80 either a bursting (active) or non-bursting (inactive) state.

81 ng in the loss of Mg(2+) and switch I in the inactive state 1 conformation.

82 tor (beta2AR): 1), the inverse-agonist-bound inactive state; 2), the agonist-bound intermediate state

83 Inactive-state 5-HT(7)-G(s) complexes are required for t

84 Inactive-state 5-HT(7)-G(s) complexes dissociate in resp

85 e than half of P-TEFb are sequestered in the inactive-state 7SK snRNP complex.

86 in three functional states-an 'open', ATPase-inactive state; a 'closed', ATPase-inactive state; and a

87 oenzyme complex of protein kinase A is in an inactive state; activation involves ordered cAMP binding

88 receptor variants stabilized in the intended inactive state among which two exhibit an apparent therm

89 col detergent micelles revealed two distinct inactive states, an activation intermediate state en rou

90 4 in the WRKY domain maintains RRS1-R in its inactive state and also inhibits acetylation of RRS1-R b

91 nce are required for maintaining aPKCs in an inactive state and are targeted by PIP3 for displacement

92 main of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (v

93 ate of an ectotherm in a post-absorptive and inactive state and can constitute a significant portion

94 RE1(LD)) that favours the latter's monomeric inactive state and loss of ERdj4 de-represses IRE1, evid

95 olymerase in a promoter-bound, catalytically inactive state and may additionally ensure polymerase pa

96 p to lock the collagen-binding domain in the inactive state and prevent unwarranted signaling by rece

97 on of the promoter region correlated with an inactive state and prevented Sp1 activation.

98 cycle that uses the fast binding rate of the inactive state and slow unbinding rate of the active sta

99 that the catalyst was stable in the reduced/inactive state and that extended durations in this state

100 They shuttle between the GDP-bound inactive state and the GTP-bound activated state and the

101 ch ligand-binding selects the faster-binding inactive state and then induces the active state.

102 cessible binding configurations: one closed, inactive state and two open, active states.

103 hows the receptor in equilibrium between two inactive states and a pre-active form, increasingly popu

104 iated with enrichment of H3K27me3-associated inactive states and poised (bivalent) enhancer states.

105 ery individual can switch between active and inactive states and, while active, it establishes casual

106 Sre1-Scp1 complex exists under "active" and "inactive" states and that the transition between these s

107 PKC toward the anterior but holds aPKC in an inactive state, and a CDC-42-dependent assembly in which

108 n this transmembrane interface maintains the inactive state, and its disruption leads to constitutive

109 ys300 forms a salt bridge with Asp163 in the inactive state, and releases a proton when a sodium ion

110 map to structural elements that maintain the inactive state, and we provide biochemical evidence that

111 kinase is the transition between active and inactive states, and defining the conformational feature

112 neages, transitions from poised to active or inactive states, and shifts in nuclease accessibility of

113 cular switches that cycle between active and inactive states, and this cycle is linked to GTP binding

114 ', ATPase-inactive state; a 'closed', ATPase-inactive state; and a 'closed', ligand-bound, ATPase-act

115 Reactivation experiments show that two inactive states are formed by interaction with oxygen an

116 tive, and the transitions between active and inactive states are independent of their infectious stat

117 Structures with the nSH2 (inactive state) are featured by collapsed activation loo

118 ations closely resembling natural active and inactive states, as well as modulated the morphodynamics

119 Here, we investigated the inactive-state assembly of heterotrimeric G proteins wit

120 5-HT(7) receptors in their inactive state associate with G(s), as these complexes a

121 CaM suggest that CCaMK is maintained in the inactive state at basal calcium concentrations and is ac

122 m Deinococcus radiodurans, in its active and inactive states at 2.3- angstrom resolution, providing a

123 ferredoxin-like allosteric domain.Active and inactive state ATP-phosphoribosyltransferases (ATP-PRTs)

124 by the redevelopment of fluorescence as the inactive state became populated.

125 nsition of a centromere from an active to an inactive state because of the lack of examples of the sa

126 hysiologically populated in an autoinhibited inactive state, becomes active.

127 gstrom resolution), in its unphosphorylated, inactive state bound to either the ATP analog AMP-PNP or

128 promoter-proximal regions in a catalytically inactive state bound to the 7SK small nuclear ribonucleo

129 tructures of the D4 dopamine receptor in its inactive state bound to the antipsychotic drug nemonapri

130 y embryonic stages maintaining a poised, but inactive state broadly across the distal limb mesenchyme

131 cell surfaces exists in a cryptic coagulant-inactive state but are transformed to a procoagulant for

132 onists as compared with when they are in the inactive state, but the molecular basis for this is uncl

133 ture of the GABA(B) receptor, captured in an inactive state by cryo-electron microscopy.

134 lds the kinase's catalytic subunit (C) in an inactive state by exerting an allosteric inhibitory effe

135 In the absence of ABA, SnRK2s are kept in an inactive state by forming physical complexes with type 2

136 turn, keeps integrin-associated c-Src in an inactive state by phosphorylating Y(529) in its regulato

137 The microsporidian ribosome is kept in an inactive state by two previously uncharacterized dormanc

138 The inactive state can also be activated by decreasing the p

139 omoters between transcriptionally active and inactive states, causing transcription to occur in burst

140 alphas, Galphao and Ga12/13), and that these inactive-state complexes are dissociated by WNTs and reg

141 usly activate G(s) variants that cannot form inactive-state complexes.

142 f TCP, H(2)O(2) alone converts oxy-DHP to an inactive state (compound RH) instead of oxidizing the en

143 subset of conformations including active and inactive state conformations, while inverse agonist cara

144 while inverse agonist carazolol selects only inactive state conformations.

145 landscape links the active state to several inactive states, connected via a structurally diverse in

146 fluorescent behaviour: it equilibrates to an inactive state, converts to an active state under blue l

147 ehaviour of GPCRs not addressable by static, inactive-state crystal structures.

148 alleles of a given locus in both active and inactive states, depending on which X chromosome is sile

149 tching of this terminator between active and inactive states dictates the transcription status of the

150 7me3 levels present during transcriptionally inactive states did not interfere with the transition to

151 wild-type TnI with S45E TnI, that favors the inactive state, did not restore the fluorescence change.

152 during transcription as it stalls at various inactive states due to erratic translocation.

153 NF1 complex is crucial to maintenance of the inactive state during growth on high glucose and that th

154 tive state is stabilized relative to the apo/inactive state, dynamics are consistently quenched in a

155 st that a portion of receptors can remain in inactive states even in the presence of saturating conce

156 rHydA1C169S, the H-cluster was trapped in an inactive state exhibiting g values and vibrational frequ

157 aneously to CRL4A, favouring a deneddylated, inactive state for substrate-free CRL4 complexes.

158 Gi/o proteins and their cognate GPCRs in the inactive state (Gi/o-GPCR preassembly).

159 Structural insight into inactive states highlights how they can be leveraged for

160 mall GTPases and keep them in a biologically inactive state in cytoplasm, through which it affects ac

161 the paternal genome into a transcriptionally inactive state in late-stage spermatids.

162 ATM exists in an inactive state in resting cells but can be activated by

163 also to actively maintain the kinase in its inactive state in the absence of antibiotics.

164 ubunit that function to hold the dimer in an inactive state in the absence of the Fis/enhancer system

165 AP2 dwells in a closed, inactive state in the cytosol, but adopts an open, activ

166 The light receptor is normally locked in an inactive state in the dark by the covalently bound inver

167 is ordinarily maintained in a catalytically inactive state in the intestine and other organs.

168 basal and spinous epidermal cells to a fully inactive state in the keratinized cells of the cornified

169 riven chloride pumps that enter long-lasting inactive states in response to light.

170 the intrinsic equilibrium between active and inactive states in the absence of agonist, and the energ

171 osteric sites on the enzyme, which stabilize inactive states in the conformational ensemble.

172 To examine the interconversion of active and inactive states in the ensemble, we used detection of re

173 ce, shifting its conformation from a closed (inactive) state in water to an open (active) state at th

174 ions restrain integrin family members in the inactive state, including a set of salt bridges on the c

175 entry into, and exit from, transcriptionally inactive states, including pausing and arrest.

176 apo CBD dynamically samples both active and inactive states independently of the adjacent CBD within

177 The enzyme is held in an inactive state inside of the bacterium due to the absenc

178 ays indicated that Galpha13 in its active or inactive state interacts with R7-RGS heterotrimers conta

179 nd hydrogen bonds that regulates hMGL active-inactive state interconversion.

180 he hippocampal alternations reflect a stable inactive state interrupted by transient active states (s

181 These findings suggest the inactive state is a biologically relevant alternate conf

182 An inactive state is identified, which is stabilised by a r

183 The inactive state is less dynamic compared with the interme

184 onstrated that PheVI:09 (6.44), which in the inactive state is locked between the backbone and two hy

185 In the inactive state, KaiC binds KaiB, which not only stabiliz

186 In the dark, OCP assumes an orange, inactive state known as OCP(O); blue light illumination

187 apid engagement by a counterstructure in the inactive state leads to a requirement for a selectin-med

188 on the IL-10 gene because its locus is in an inactive state, likely reflecting a neutrophil-specific

189 t the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of th

190 Glide docking studies in our cannabinoid CB2 inactive state model that were then tested via compound

191 three electrons needed to form the oxidized inactive state "Ni-B" or "Ready" (Ni(III)-OH).

192 The transition between active and inactive states occurs through multiple pathways, facili

193 c and functional sites exists already in the inactive state of all three proteins.

194 'lariat loop' implicated in maintaining the inactive state of beta-arrestin-1.

195 lock and other interactions stabilizing the inactive state of beta2AR are weaker.

196 contributes to the maintenance of the closed inactive state of CARD11 that predominates in the absenc

197 cular dynamics simulations starting from the inactive state of D3R in complex with these enantiomers.

198 dimer-of-dimers configuration represents an inactive state of DUOX1-DUOXA1, suggesting an oligomeriz

199 exposure to UCPH-101 induces a long-lasting inactive state of EAAT1, whereas the inhibition exerted

200 on of the native CheY . FliM(N) complex, the inactive state of free D13K-Y106W CheY, and the MD-based

201 ormational transition between the active and inactive state of hTS.

202 membrane conjointly determine the active or inactive state of K-Ras4B.

203 We found that in the closed inactive state of KcsA (at pH 7) four K(+) binding sites

204 nds that stabilize a previously unrecognized inactive state of KSR.

205 3 histone mark are essential to maintain the inactive state of many of these genes.

206 an outward partially occluded and an outward inactive state of MelBSt.

207 In addition to the inactive state of NF-kappaB, the deficiency in the infla

208 ional change pathways between the active and inactive state of nitrogen regulatory protein C (NtrC).

209 umor cell proliferation and implies that the inactive state of PKM2 is associated with the proliferat

210 previously unrecognized role in forming the inactive state of regulated actin.

211 flip back to the orientation observed in the inactive state of rhodopsin under conditions favoring th

212 he CRD, linker domain and TMD stabilizes the inactive state of Smoothened.

213 lar dynamics simulations we describe a novel inactive state of the adenosine 2A receptor which is sta

214 rine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.

215 e formation of sulfcatalase, an irreversible inactive state of the enzyme, without the intervention o

216 mediate compound II formation, a temporarily inactive state of the enzyme.

217 eak critical interactions that stabilize the inactive state of the kinase, thereby facilitating struc

218 potency and selectivity through targeting an inactive state of the kinases induced by a unique folded

219 these results and an X-ray structure of the inactive state of the M3 receptor bound by the antagonis

220 at were proposed to represent the active and inactive state of the protein, and a domain-forming mode

221 egatively regulates CCaMK by stabilizing the inactive state of the protein.

222 pair that was attributed to a catalytically inactive state of the PTC.

223 egulates the transition from an active to an inactive state of the RAF-1 kinase.

224 Active retinal destabilizes the inactive state of the receptor, whereas the active ensem

225 has a higher Young's modulus compared to the inactive state of the receptor.

226 Using NMR, we solve the structure of the inactive state of the ribozyme in the absence of magnesi

227 Hence, the primed but inactive state of the ZRS is induced by FGF signalling a

228 chemical probe for targeting this particular inactive state of these two p38 isoforms.

229 ECL2 in the N111G mutant was similar to the inactive state of wild-type AT1R.

230 e transition from active to intermediate and inactive states of actin-tropomyosin-troponin.

231 e dynamic auto-inhibitory equilibrium toward inactive states of HCN4 and broadens the free-energy wel

232 a reversible equilibrium between active and inactive states of human MGL (hMGL) that is slow on the

233 al, AAPs cross-linked to both the active and inactive states of kinases but performing phosphopeptide

234 conformational transition between active and inactive states of L1L.

235 ures that distinguish between the active and inactive states of protein kinases are well established,

236 Individual simulations probe active or inactive states of Ras on membranes with or without anio

237 ent crystal structures provide insights into inactive states of several GPCRs.

238 However, unlike the Ni-A and Ni-B inactive states of standard [NiFe]-hydrogenases, both of

239 is required for the modulation of active and inactive states of the 7TM by agonists, but is not neces

240 e present structures representing active and inactive states of the PP2C phosphatase SpoIIE from Baci

241 Thus, our data suggest that signaling and inactive states of the receptor are related by receptor

242 lished by nuclei randomly adopting active or inactive states of transcription, leading to a collectiv

243 lated motifs and facilitate either active or inactive states of transcription.

244 rtantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel

245 oove at Arp3's barbed end to destabilize the inactive state, providing a mechanism by which WASP stim

246 C(ox) and forming a modified version of this inactive state rather than reacting directly with C(red1

247 ell, or refold the cargo-free motors into an inactive state ready for the next cellular calcium flux.

248 helix of the HisKA domain that destroys the inactive state residue contacts and suggests how signal-

249 are presumed to correspond to the active and inactive state, respectively.

250 ble active state is interrupted by transient inactive states (slow waves) while the hippocampal alter

251 The inactive state structures of D(2)R have been described i

252 Comparison with inactive-state structures of beta(1)AR bound to the iden

253 the known microscopic characteristics of the inactive states, such as the ionic lock, the inward posi

254 A structural model of PKCdelta in the inactive state suggests that the nuclear localization se

255 erium tuberculosis may enter a metabolically inactive state that is less susceptible to antibiotics.

256 eatures allow RasGRP1 to be maintained in an inactive state that is poised for activation by calcium

257 laments of DrRecA protein exhibit active and inactive states that are readily interconverted in respo

258 Our data revealed that, in the inactive state, the intracellular lipid/aqueous border o

259 gh prepared from eggs in a transcriptionally inactive state, the process of making NPE resembles some

260 agonist binding by stabilizing the receptor inactive state, the putative binding site of Mg(2+) on t

261 the activated c-KIT by switching back to its inactive state through a sequence of conformational chan

262 lls, also plays a role in maintenance of the inactive state through regulation of BMP/TGF-beta signal

263 tion maintains these catalytic ligases in an inactive state through several mechanisms.

264 ransiently requiring excess molecules in the inactive state to achieve at least one molecule (rather

265 witches the RING domain from a catalytically inactive state to an active one.

266 is conformationally converted from a largely inactive state to an active state upon UPF2 binding.

267 in adapter CARD11 transitions from a closed, inactive state to an open, active scaffold that assemble

268 riggering, CARD11 transitions from a closed, inactive state to an open, active scaffold that recruits

269 es the Trp-356(6.48) rotameric switch in the inactive state to promote the formation of an extensive

270 moves the target protein from an ensemble of inactive states to a well-defined active conformation.

271 lb3 translocase drive cpSRP43 to a partially inactive state, triggering selective release of LHCP's t

272 by mobilizing a pool of syntaxin4 held in an inactive state under basal conditions.

273 Ks) hold the CENP-A assembly machinery in an inactive state until mitotic exit and entry into G1, at

274 ure to rapidly shift ELF3 between active and inactive states via phase transition represents a previo

275 To maintain target promoters in an inactive state, VprBP stably binds to nucleosomes by rec

276 erminal epitope expected to be masked in its inactive state was rendered immunoreactive.

277 more frequent transitions between active and inactive states was associated with equivalent self-repo

278 ng controversy regarding the existence of an inactive state, we explored the proton-coupled dynamics

279 lexibility and to potentially trap a closed, inactive state, we generated a series of disulfide bond

280 affold predicted to stabilize kinases in the inactive state, we generated a series of selective type

281 se-coupled binary complex that maintains the inactive state when agonist is not present.

282 pCas9-HF1 and eSpCas9(1.1) are trapped in an inactive state when bound to mismatched targets.

283 nts: a wild-type FimH variant that is in the inactive state when not bound to its target mannose, and

284 nsitions among the active, intermediate, and inactive states when S1 is rapidly detached from actin-t

285 e hybrid metabolic state and a metabolically inactive state where cells have low activity of both gly

286 onfines GBR1 to the open conformation of the inactive state, whereas an agonist induces its domain cl

287 and preladenant) bound preferentially to the inactive state, whereas neutral antagonists (theophyllin

288 C lipids back shifted the equilibrium to the inactive state, whereas the small-headgroup, highly unsa

289 nal switch allows for the transition from an inactive state (wherein the adamantane protein-binding h

290 rucial to the active state, is absent in the inactive state, which comprises a heterogeneous collecti

291 formational transition between an active and inactive state, which is difficult to capture experiment

292 ucture of the full-length human GLP-1R in an inactive state, which reveals a unique closed conformati

293 rmational equilibrium of RORgammat toward an inactive state, which underlies the molecular mechanism

294 neously decays to that characteristic of the inactive state with a lifetime of approximately 16 min a

295 g(2+) into its place and are locked in their inactive state with dominant negative properties.

296 steric sodium ion and confined mostly in the inactive state with remarkably reduced flexibility.

297 or DNA-PK, all existing structures represent inactive states with resolution limited to 4.3 angstrom

298 (2)-symmetric complexes constitute either an inactive state [with Pb(II)] or a resting state [with Bi

299 p explain how Arp2/3 complex is locked in an inactive state without activators and how autoinhibition

300 phase-transition between globally active and inactive states would emerge near this threshold number