ライフサイエンスコーパス: inactivity

1 derived sleep efficiency and daytime naps or inactivity).

2 hypertension, diabetes, obesity and physical inactivity.

3 avy alcohol use, unhealthy diet and physical inactivity.

4 ng, unaffected by the confounding effects of inactivity.

5 y patterns after periods of induced neuronal inactivity.

6 the respiratory network following months of inactivity.

7 c flexibility across a range of activity and inactivity.

8 muscular lipids, is associated with physical inactivity.

9 he unpredictable and pathological effects of inactivity.

10 sis with restoration associated with disease inactivity.

11 attributed to a confounding role of physical inactivity.

12 sical activity but not blood pressure during inactivity.

13 kinases, were unaffected by immunoproteasome inactivity.

14 impairment in blood pressure decline during inactivity.

15 e first clinician-reported grading of lesion inactivity.

16 onditions contribute to obesity and physical inactivity.

17 during relatively brief periods of physical inactivity.

18 r, and colon cancer attributable to physical inactivity.

19 ry and environmental exposures, and physical inactivity.

20 ivity, interspersed with extended periods of inactivity.

21 on is highly individualistic and modified by inactivity.

22 olic event, and cerebrovascular disease than inactivity.

23 majority of confounding factors, especially inactivity.

24 cling, the TMs displayed different levels of inactivity.

25 g high WC were similar to those for physical inactivity.

26 inical disorders characterized by behavioral inactivity.

27 eriods of dehydration and relative metabolic inactivity.

28 early identification of groups vulnerable to inactivity.

29 p21, thus sustaining RB phosphorylation and inactivity.

30 insulin during their daily phase of relative inactivity.

31 ing status, alcohol consumption and physical inactivity.

32 approximately 15 and approximately 30 min of inactivity.

33 for patients discontinued because of disease inactivity.

34 r in 18% of patients discontinued because of inactivity.

35 2012 from the group of patients with disease inactivity.

36 itatory synaptic scaling induced by synaptic inactivity.

37 ributes to exercise intolerance and physical inactivity.

38 cerbates the health consequences of physical inactivity.

39 ain alternate between periods of spiking and inactivity.

40 her hominins, which may result from physical inactivity.

41 tegies that might address the global rise in inactivity.

42 al interactions is diluted by generations of inactivity.

43 ental stimuli, such as physical activity and inactivity.

44 tal muscle to adapt to physical activity and inactivity.

45 tified including obesity, diet, and physical inactivity.

46 We assessed associations of adult inactivity 1) with factors within domains, 2) with the 3

47 systolic blood pressure (-36 000), physical inactivity (-12 000), smoking (-10 000), diabetes mellit

48 at follow-up (11%), death (9%), and disease inactivity (20%, 120 eyes).

49 (7.5%, 95% CI 5.2-9.7) followed by physical inactivity (5.5%, 2.1-8.5), history of diabetes (2.8%, 2

50 ting poorer amenities) on a 19-point scale), inactivity (8% higher odds per 1-point reduction in acti

51 verweight (82%), smoking (31%), and physical inactivity (81%).

52 of the pieces are in place to make physical inactivity a national priority, and we now have the oppo

53 Physical inactivity, a common feature of Western societies, is as

54 Diet and physical inactivity accounted for 14.3% (95% UI 12.8-15.9) of UK

55 emerging evidence on brain health, physical inactivity accounts for about 3.8% of cases of dementia

56 It is well known that inactivity/activity influences skeletal muscle physiolog

57 urse of health-related responses to physical inactivity/activity patterns are caused in large part di

58 ly because of the variable amounts of muscle inactivity/activity throughout the day.

59 nalyses indicate that the changes induced by inactivity/activity were not related to fiber-type trans

60 in vivo eccentric contractions, or physical inactivity after mild exercise.

61 ide deaths and risk factors include physical inactivity, age, dyslipidemia, hypertension, diabetes, o

62 ycling are significantly decreased by muscle inactivity, agrin maintained the amount of recycled AChR

63 life were associated with adult leisure-time inactivity, allowing for early identification of groups

64 beta1,2,3delta GABAAR subtypes, ranging from inactivity (alpha4beta1delta), through negative (alpha6b

65 e been monitoring the prevalence of physical inactivity, although evidence of any improvements in pre

66 ificantly contribute to obesity and physical inactivity among nurses.

67 due to impurities and degradation or protein inactivity and aggregation.

68 h as a Western-style diet, obesity, physical inactivity and antibiotic use, especially during the ear

69 t the known effects of drug-induced neuronal inactivity and can be used to investigate the extensive

70 Physical inactivity and constipation were highest in individuals

71 Physical inactivity and disuse are major contributors to age-rela

72 Western" lifestyle characterized by physical inactivity and excess weight is associated with a number

73 ncing is one such mechanism that ensures the inactivity and hence the maintenance of a silenced state

74 ronic diseases that are promoted by physical inactivity and improved by exercise.

75 Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle

76 vironmental transitions have led to physical inactivity and large amounts of time spent sitting.

77 e community who are at high risk of physical inactivity and metabolic syndrome.

78 Inactivity and Nova-2 relocation were connected by a nov

79 tors (alcohol consumption, smoking, physical inactivity and obesity) is associated with disability-fr

80 combating the worldwide epidemic of physical inactivity and obesity.

81 alth) life-style programs targeting physical inactivity and overweight/obesity has been established i

82 redict metabolic flexibility, while physical inactivity and sedentary behaviours trigger a state of m

83 nes the adaptations associated with physical inactivity and semi-isolation and confinement.

84 rast agent during the light phase or time of inactivity and sleep in rats.

85 riate logistic regression analysis, physical inactivity and smoking were found to be independent risk

86 Physical inactivity and smoking were more strongly associated wit

87 n-communicable diseases, especially physical inactivity and smoking.

88 able to curb the global pandemic of physical inactivity and the associated 5.3 million deaths per yea

89 representing an early indicator of beta cell inactivity and the subsequent deficit of more impactful

90 h falls in systolic blood pressure, physical inactivity and total cholesterol providing the largest c

91 take, obesity, alcohol consumption, physical inactivity and unhealthy diet, may explain some of the r

92 stics (BMI, smoking, alcohol abuse, physical inactivity) and social factors (education level) with th

93 ty, smoking, heavy alcohol use, and physical inactivity) and with a 2.25-fold (95% confidence interva

94 ars for hypertension, 2.4 years for physical inactivity, and 4.8 years for current smoking.

95 re have been extensive reports on adiposity, inactivity, and certain diets, particularly those high i

96 lowed walking speed, poor appetite, physical inactivity, and exhaustion.

97 lowed walking speed, poor appetite, physical inactivity, and exhaustion.

98 portion of inactive lesions, quicker time to inactivity, and fewer injections administered in the com

99 alcohol drinking, unhealthy weight, physical inactivity, and insufficient/prolonged sleep.

100 Obesity, physical inactivity, and reduced physical fitness contribute to t

101 itus, smoking, overweight, obesity, physical inactivity, and statin use resulted in a decrease in the

102 uggests that these variants lead to receptor inactivity, and they are mostly mutually exclusive with

103 ss index >27 kg/m(2), self-reported physical inactivity, and/or smoking) were included.

104 The reasons for sertraline inactivity appear to be multifactorial and might be asso

105 le hypertension, smoking, diet, and physical inactivity are among some of the more commonly reported

106 Sedentary behavior and physical inactivity are among the leading modifiable risk factors

107 Our findings argue that obesity and physical inactivity are associated with a higher risk of CTNNB1-n

108 Undernutrition and physical inactivity are both associated with lower bone mass.

109 ng middle-aged PWH; greater BMI and physical inactivity are important modifiable factors that may pre

110 Sedentary behaviors and physical inactivity are not only increasing worldwide but also ar

111 g tobacco use, unhealthy diets, and physical inactivity are prevalent, and obesity in adults and chil

112 Stress, malnutrition and physical inactivity are three maternal behavioral lifestyle facto

113 deleterious health consequences of physical inactivity are vast, and they are of paramount clinical

114 Inactivity, as in disuse or aging, causes atrophy, the l

115 ve impact of sedentary behavior and physical inactivity, as well as the beneficial effects of physica

116 vel and modifiable target to reduce physical inactivity associated with the Western diet.

117 These inactivity-associated health risks are somewhat paradoxi

118 confidence interval, 1.02-1.08), and sexual inactivity at baseline (relative risk, 1.11; 95% confide

119 tently associated with time-varying physical inactivity, baseline weight status, or sociodemographic

120 isk factors of CRC include smoking, physical inactivity, being overweight and obesity, eating process

121 a non-homogeneous Poisson process for longer inactivity between bursts.

122 Center-specific PAF associated with inactivity, body mass index (BMI; in kg/m(2)) (>30), and

123 ncluding tobacco use, poor diet and physical inactivity (both strongly associated with obesity), exce

124 hippocampus occur not only during behavioral inactivity but also during successful visual exploration

125 gher rates of obesity, smoking, and physical inactivity, but not high cholesterol or diabetes mellitu

126 adaptive presynaptic enhancement to neuronal inactivity by two principle mechanisms: First, neuronal

127 lly motivated hypothesis is that a period of inactivity can reduce the threshold for synaptic potenti

128 Inactivity causes muscle wasting by triggering protein d

129 ould help address the public health physical inactivity challenge.

130 idely used to help address the public health inactivity challenge.

131 er of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity r

132 que/kg leg lean mass) after 14 d of bed-rest inactivity (CON compared with LEU: -9% +/- 2% and +1% +/

133 ally, our data suggest that exercise-induced inactivity correlates with loss of sarcolemmal neuronal

134 Conservatively estimated, physical inactivity cost health-care systems international $ (INT

135 sion, diabetes, waist-to-hip ratio, physical inactivity, current smoking, heavy drinking, and oral es

136 risk factors (high alcohol intake, physical inactivity, current smoking, hypertension, diabetes, and

137 t (followed from 1958 to 2008), leisure-time inactivity, defined as activity frequency of less than o

138 life hypertension, midlife obesity, physical inactivity, depression, smoking, and low educational att

139 n and impaired blood pressure decline during inactivity despite obesity.

140 high cholesterol, smoking, obesity, physical inactivity, diabetes, and other factors.

141 nversion of locomotor activity to "Locomotor Inactivity During Sleep" (LIDS), movement patterns are e

142 mains were combined, factors associated with inactivity (e.g., at age 50 years) were prepubertal stat

143 refugia during periods of daily or seasonal inactivity, emerging only during rainfall [1].

144 This dilution of selection by inactivity enhances the role of drift, leading to increa

145 ins of frailty-slow walking speed, weakness, inactivity, exhaustion, and shrinking-as measured by phy

146 betes, fair/poor self-rated health, physical inactivity, food insecurity, and uninsurance were higher

147 ocognitive problems compared with consistent inactivity for both CNS and non-CNS groups (T-score diff

148 le fractions (PAFs) associated with physical inactivity for each disease outcome and all-cause mortal

149 tron-transfer mediator, and showed catalytic inactivity for glucose oxidation, thus potentially enabl

150 Using a combination of objectively measured inactivity from thigh-worn accelerometers, observational

151 Physical inactivity generates muscle atrophy in most mammalian sp

152 on, active repression (hypoacetylation), and inactivity (H3K27me3).

153 Physical inactivity has been associated with higher mortality ris

154 Physical inactivity has been associated with poor oral health.

155 Skeletal muscle wasting attributed to inactivity has significant adverse functional consequenc

156 Age and inactivity have been associated with intramuscular trigl

157 tension, hearing loss, obesity, and physical inactivity have particularly high PAFs and could be init

158 Inactivity (hazard ratio [HR]: 6.59; 95% confidence inte

159 Here we report that chronic inactivity homeostatically increases action potential du

160 ombined contribution of smoking and physical inactivity hovered around 5% between 1990 and 2050.

161 We conclude that food withdrawal-induced inactivity, hypothermia, and reduction in EE are novel p

162 Independent of FEV1, sustained physical inactivity (i.e., PAL(T0andT1) < 1.40) was related to a

163 ultures, which is likely indicative of STAT3 inactivity in 5azD/TSA-expanded grafts.

164 Here, we examined inactivity in a hunter-gatherer population (the Hadza of

165 totic events results in a short pulse of ERK inactivity in both daughter cells that correlates with e

166 Given the prevalence of obesity and inactivity in cancer survivors in the United States and

167 y help reduce the negative health impacts of inactivity in industrialized populations.

168 drawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient

169 l hypothalamus (LH) causes profound physical inactivity in mammals.

170 interventions targeting smoking and physical inactivity in patients with CHD and comorbid depression.

171 Transcriptional inactivity in response to a second LPS exposure in toler

172 signal peptides where one can compensate for inactivity in the other.

173 The highest estimated PAR was for physical inactivity in the USA (21.0%, 95% CI 5.8-36.6), Europe (

174 ed and the abnormalities caused by VEGF/SphK inactivity in these cells are corrected by replenishment

175 We also modeled cofilin inactivity in vitro by using pharmacological and genetic

176 Physical inactivity, inadequate dietary protein, and low-grade sy

177 be several mechanisms responsible for FOXO3a inactivity, including chromosomal deletion (chromosome 6

178 Physical inactivity independently predicts poor outcomes across s

179 The direct effect of physical inactivity induced obesity on periodontitis was higher t

180 The average treatment effect of physical inactivity induced obesity to periodontitis is 14%.

181 e mediation analysis for exposure, "physical-inactivity induced obesity," mediator "dental visiting b

182 y output and lower the threshold for apnoea, inactivity-induced inspiratory motor facilitation (iMF)

183 enced separately, forms of plasticity called inactivity-induced inspiratory motor facilitation (iMF)

184 tivity elicits a form of plasticity known as inactivity-induced phrenic motor facilitation (iPMF), a

185 e of GRIP1-mediated AMPAR trafficking during inactivity-induced synaptic scaling.

186 Thus, MV-induced diaphragm inactivity initiates catabolic changes via rapid activat

187 Physical inactivity is a global pandemic responsible for over 5 m

188 Physical inactivity is a global pandemic with no signs of improve

189 Physical inactivity is a leading cause of obesity and premature m

190 Physical inactivity is an important risk factor in the developmen

191 Sustained physical inactivity is associated with a progression of exercise

192 The pandemic of physical inactivity is associated with a range of chronic disease

193 Physical inactivity is common in patients with chronic obstructiv

194 Our data suggest that the inactivity is ensued by a C-terminal domain that interac

195 of nNOS gene expression by short-term muscle inactivity is independent of the DNA methylation pattern

196 Physical inactivity is one of the leading health problems in the

197 morbidity and premature mortality, physical inactivity is responsible for a substantial economic bur

198 an neuromuscular junctions (NMJs), prolonged inactivity leads to muscle denervation and atrophy.

199 Conversely, high inactivity levels may be associated with increased risk

200 wer injections until first grading of lesion inactivity (<=3 vs. >3 injections: OR, 1.6; 95% CI, 1.2-

201 dly unaffected indicating that in blood EPT1 inactivity may be compensated for, in part, via alternat

202 Based on our results, we introduce the Inactivity Mismatch Hypothesis and propose that human ph

203 e of TOR-eIF4EBP in a novel zebrafish muscle inactivity model.

204 included staining without leakage suggesting inactivity (n = 6) and leakage (n = 2).

205 a 30-60% increase in CRC risk with physical inactivity, obesity and metabolic syndrome.

206 l enrichment, midlife risk factors (physical inactivity, obesity, smoking, diabetes, hypertension, an

207 Inactivity of AMG 416 on the pig CaSR resulted from a na

208 sensitive to the reduction, absence, and/or inactivity of any components of the classical and termin

209 The catalytic inactivity of B-MWW for ODH of propane falsifies the hyp

210 Amino acids 129I and 130N, accounted for the inactivity of chicken ANP32B.

211 The Y114F, R194A, and F261A mutations led to inactivity of diadenosine tetraphosphate and to a reduce

212 Remission was defined as inactivity of disease off all suppressive medications at

213 This mechanism relies on the catalytic inactivity of domain DI, revealing a surprising role of

214 itness costs and the biochemical activity or inactivity of drug-enzyme complexes.

215 rpetually open pores are consistent with the inactivity of hornwort stomata.

216 Catalytic inactivity of KLK7 was however achieved by additional mu

217 Although physical inactivity of many smokers contributes to some alteratio

218 open" conformation not only rationalizes the inactivity of single-chain insulin (SCI) analogs (in whi

219 N activation maintains breathing despite the inactivity of the carotid bodies.

220 demonstrate in situ the relative cell cycle inactivity of the CD200+/K15+ bulge compared to other no

221 had a 3-month or longer documented period of inactivity of the choroidal neovascular lesion with no f

222 Conversely, inactivity of the presynaptic terminal results in remova

223 The absence or inactivity of vcrA-containing Dehalococcoides results in

224 ficacy of Y5-selective peptide agonists, the inactivity of Y1-selective antagonists, and a change fro

225 driving the effects of obesity and physical inactivity on academic underachievement.

226 the differential effects of age and physical inactivity on the regulation of substrate metabolism dur

227 nvironments by entering a state of metabolic inactivity or dormancy.

228 ted into synapses to compensate for neuronal inactivity or removed to compensate for hyperactivity.

229 anzee-like phenotype in response to physical inactivity or sustained pressure loading.

230 c regression, with body mass index, physical inactivity, other breast cancer risk factors, and calori

231 ssociations were weak or modest for physical inactivity, overweight or obesity, and diabetes (ORs of

232 for FLI above 60% were observed for physical inactivity (p < 0.0005 for both genders) and alcohol con

233 re was associated significantly with uveitis inactivity (P = 0.014 for weekday and weekend analyses).

234 so was associated significantly with uveitis inactivity (P = 0.026, Kendall's tau test).

235 similarities than differences, with physical inactivity (PAF 16.5% ELSA; 16.7% SIGa-Bage) and current

236 uce the health burden of the global physical inactivity pandemic.

237 We observe two daily inactivity periods in the people's aggregated mobile pho

238 risk factors (e.g., aging, cigarette smoke, inactivity, persistent low-grade pulmonary and systemic

239 tabolic and cardiovascular responses through inactivity physiology that are not sufficiently prevente

240 ng phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxi

241 Analyses were based on national physical inactivity prevalence from available countries, and adju

242 In addition, physical inactivity related deaths contribute to $13.7 billion in

243 d with a friction cost approach for physical inactivity related mortality.

244 These inactivity-related structural and functional changes may

245 Our data support a cellular cascade in which inactivity relieves EVI1/HDAC-mediated inhibition of miR

246 ease burden, the economic burden of physical inactivity remains unquantified at the global level.

247 In both cases, neuronal inactivity removes tonic block imposed by the presynapti

248 with intense RPA and EPA as well as physical inactivity represents an evolutionary trade-off with pot

249 The global pandemic of physical inactivity requires a multisectoral, multidisciplinary p

250 Much adult physical inactivity research ignores early-life factors from whic

251 o the groundwater despite 18 and 20 years of inactivity, respectively.

252 provide evidence that both age and physical inactivity result in intramuscular lipid accumulation, b

253 Hence, Y191 inactivity results from a potential drop owing to Y191(*

254 onged antioxidant signaling or mitochondrial inactivity, reverts the oxidation of invariant Cys resid

255 e in lifestyle risk factors such as physical inactivity (risk ratio [RR]: 1.19; 95% CI: 1.14, 1.24),

256 Long-term physical inactivity seems to cause many health problems.

257 AF risk factors, including obesity, physical inactivity, sleep apnea, diabetes mellitus, hypertension

258 ccelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts i

259 ecifically elevated blood pressure, physical inactivity, smoking, and poor glucose control) are assoc

260 lence of vascular risk factors (eg, physical inactivity, smoking, midlife hypertension, midlife obesi

261 and later-life smoking, depression, physical inactivity, social isolation, and diabetes) account for

262 SWRs typically occur as cortex emerges from inactivity, spindle ripples typically occur at peak cort

263 h that we do not know how muscle senses its "inactivity status" or whether the proposed drivers of mu

264 Poor diet and physical inactivity strongly affect the growing epidemic of cardi

265 ere clustered in between periods of apparent inactivity, suggesting that problem-solvers were delicat

266 igns of aging yet may be more susceptible to inactivity than younger adults.

267 Physical inactivity that accompanies ageing and disease may haste

268 impacts intermixed with sporadic periods of inactivity; the VI-dormant behavior, which was prevalent

269 as highest for smoking, followed by physical inactivity then socioeconomic status.

270 respiratory motor output following months of inactivity, thereby supporting a major neuroscience hypo

271 n, contrary to simple predictions relying on inactivity to explain skeletal fragility.

272 Most studies use duration of inactivity to measure sleep.

273 MKP-1 oxidation-induced oligomerization and inactivity toward p38MAPKalpha.

274 Inactivity triggered up-regulation of eIF4EBP3L (a zebra

275 Physical inactivity triggers a rapid loss of muscle mass and func

276 RBs-alcohol use; cigarette smoking, physical inactivity, unhealthy diet, and illicit drug use-accordi

277 Recent work has shown that physical inactivity versus activity alters neuronal structure in

278 portion of inactive lesions and mean time to inactivity was 85.3% and 80.7 days (95% CI, 62.8-98.5 da

279 physical activity established that physical inactivity was a global pandemic, and global public heal

280 Physical inactivity was associated with hand weakness and decreas

281 Leisure time inactivity was associated with increased risk of catarac

282 Inactivity was defined as requirement for assistance wit

283 finding specific to LMICs was that physical inactivity was higher in urban (vs rural) residents, whi

284 Unexpectedly, inactivity was not explained by rhabdomyolysis, but rath

285 billion in productivity losses, and physical inactivity was responsible for 13.4 million DALYs worldw

286 Physical inactivity was suggested to be one of the most important

287 Notably, STAT3 inactivity was transient because the transcript levels o

288 r age, black race, greater BMI, and physical inactivity were associated with physical function impair

289 life-years (DALYs) attributable to physical inactivity were estimated with standardised methods and

290 uctures related to OATP1B1/1B3 inhibition or inactivity were identified.

291 KEY POINTS: Physical inactivity, which drastically increases with advancing a

292 Physical inactivity, which drastically increases with advancing a

293 Tonic spiking is prevalent during periods of inactivity while bursting strongly correlates with locom

294 t preventing sedentary behavior and physical inactivity while promoting physical activity, ET, and ca

295 lent in the summer, involved long periods of inactivity with sporadic VI impacts.

296 r and lighter sleep within extended bouts of inactivity, with deeper sleep intensities after approxim

297 is not well adapted to prolonged periods of inactivity, with time spent sitting increasing cardiovas

298 , tobacco use, unhealthy diets, and physical inactivity within LLMICs.

299 Avoiding all inactivity would theoretically reduce all-cause mortalit

300 ce, years of labor market experience, career inactivity, years with the employer, and responsibilitie