ライフサイエンスコーパス: inappropriately

1 re skaters falling down and persons behaving inappropriately).

2 ferentiated febrile illnesses are often used inappropriately.

3 immune response, without activating NK cells inappropriately.

4 d at times the results are often interpreted inappropriately.

5 heir activation or prevented from developing inappropriately.

6 or cell death if left unrepaired or repaired inappropriately.

7 (REMS) to prevent them from being prescribed inappropriately.

8 are high and wasted if devices are implanted inappropriately.

9 ibit abnormal morphology, and are positioned inappropriately.

10 firmed by the manufacturer to be functioning inappropriately.

11 1 from cleaving the stalled replication fork inappropriately.

12 e sensory feedback may engage these reflexes inappropriately.

13 m9(-/-) adult-born dentate neurons localized inappropriately.

14 idance, dentists often prescribe antibiotics inappropriately.

15 e inhibitors of virus assembly that prevent, inappropriately accelerate and/or misdirect capsid forma

16 mechanisms by which cryopyrin mutations can inappropriately activate an inflammatory response.

17 void spurious PhyR protein interactions that inappropriately activate GSR-dependent transcription.

18 Dictyostelium cells lacking WASP inappropriately activate Rac at the rear, which affects

19 Our data thus demonstrate that the AR can inappropriately activate transcription in ADI PCa cells

20 hat prune excess synapses in development are inappropriately activated and mediate synapse loss in AD

21 es in the elimination of stem cells that are inappropriately activated by oncogenic events through in

22 by a variety of cytokine receptors and when inappropriately activated can cause hematopoietic disord

23 s a type of cell death program that could be inappropriately activated during drought, we hypothesize

24 involving PC1 and show that this pathway is inappropriately activated in ADPKD.

25 of cells during metazoan development, and is inappropriately activated in cancer.

26 The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, incl

27 eracts with tuberin, and the mTOR pathway is inappropriately activated in cyst-lining epithelial cell

28 , which promotes proper mitosis, can both be inappropriately activated in human tumors.

29 ecise transcriptional control, which becomes inappropriately activated in many cancer subtypes.

30 sts that cyclin-dependent kinases (Cdks) are inappropriately activated in mature neurons under ischem

31 Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mou

32 tes that cyclin-dependent kinase 5 (Cdk5) is inappropriately activated in several neurodegenerative c

33 death during development in metazoans and is inappropriately activated in several types of cancer.

34 and activator of transcription 3 (STAT3) is inappropriately activated in the majority of breast tumo

35 y doubly mutated immune cells that have both inappropriately activated inflammasomes and enhanced rep

36 Although a number of genes inappropriately activated or suppressed by v-Rel have be

37 e atfs-1 mutant growing on wild-type E. coli inappropriately activated the pattern of mitochondrial r

38 When inappropriately activated, the pathway has been linked t

39 se signaling by the Wnts CWN-1 and CWN-2 are inappropriately activated, whereas ectopic PLR-1 express

40 l help elucidate how this pathway can become inappropriately activated.

41 and shelterin, which protect telomeres from inappropriately activating DNA damage response checkpoin

42 ifically controlling Na(+) transport without inappropriately activating other cell functions.

43 Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair res

44 ion that prevents extraneous light rays from inappropriately activating the photoreceptors.

45 at indicates how in Rad53 or MRX mutants, an inappropriately active Exo1 may facilitate faulty templa

46 nderlying this defect, we found that YAP was inappropriately active not only in the ArpC3 mutant tiss

47 F transcriptional repressor complex remained inappropriately active.

48 at the latter are more routinely and perhaps inappropriately administered.

49 long-term costs of effective control, might inappropriately affect commitments to the goal of eradic

50 uring that one gene's transcription does not inappropriately affect the expression of its neighbors i

51 viduals in industrialized societies to mount inappropriately aggressive inflammatory responses to psy

52 ockdown of PFKFB3/iPFK2 in 3T3-L1 adipocytes inappropriately altered the expression of adipokines, de

53 lity in patients with sepsis results from an inappropriately amplified systemic inflammatory response

54 imit under voltammetric conditions have been inappropriately analyzed by comparison of experimental d

55 vascular disease, this process is activated inappropriately and causes thrombosis, heart attacks and

56 Aberrant siRNAs inappropriately and heritably silence germline-expressed

57 tween RM patients contacted appropriately or inappropriately and patients with usual care.

58 tions, but it can inhibit growth if produced inappropriately and, consequently, its production and ac

59 ities of bat pollinators, invoke Weber's law inappropriately, and cannot predict observed nectar conc

60 If inappropriately applied, however, these processes can me

61 ensive segments of double-layered struts and inappropriately apposed struts at the bifurcation level

62 m species-typical macaque social behavior by inappropriately approaching and remaining in immediate p

63 nt bacterial CRP into humans have still been inappropriately ascribed to CRP.

64 BRCA1 knockdown, tamoxifen-bound ERalpha was inappropriately associated with coactivators, and not ef

65 tional synthesis when RNA polymerase becomes inappropriately associated with the genome without havin

66 he same initiating event: a ribosome stalled inappropriately at a sense codon during translation elon

67 generated those 413 uncivil posts, tweeting inappropriately at least once over a period of six weeks

68 Thus, activated effector cells are inappropriately attracted and/or retained in lymphoid ti

69 al and uncontrolled oxygen is sometimes used inappropriately before the terminal phase.

70 s cannot support phased piRNA production and inappropriately bind mRNA instead of piRNA precursors.

71 r results lead us to propose that telomerase inappropriately binds to and inhibits restart of reverse

72 p57, nascent neurons re-enter the cell cycle inappropriately but later exit to begin differentiation.

73 cancers, E-cadherin (CDH1) is downregulated inappropriately by DNA methylation to promote an invasiv

74 LR7) detects viral RNA, but can be activated inappropriately by self-RNA, leading to autoimmunity.

75 Invasive cellular behavior is also inappropriately co-opted during cancer progression.

76 e the parameters presented in our study were inappropriately combined to draw misguided conclusions.

77 This modest association has been inappropriately conflated with causality, and it has bee

78 es allowed the EP cells to cross the midline inappropriately, consistent with the model that reverse

79 isrepresenting credentials (77%; 37/48), and inappropriately contacting patients (77%; 37/48).

80 tion, or survival of competent cells that it inappropriately contacts.

81 a growing number of diseases associated with inappropriately controlled inflammation in multiple orga

82 In beta-spectrin mutants many axons inappropriately cross the CNS midline, suggesting a role

83 posited that THEMIS prevents thymocytes from inappropriately crossing the positive/negative selection

84 acts in eMNs to prevent follower axons from inappropriately crossing the ventral midline.

85 istakes during their intraretinal growth and inappropriately defasciculate along their pathway.

86 who need wheeled mobility devices may now be inappropriately denied coverage.

87 uncertainty, a lack of EHS and product data, inappropriately designed exemptions and thresholds, and

88 eres in this repair-deficient background are inappropriately detected and processed as DSBs and thus

89 end point was the proportion of SVT episodes inappropriately detected from the time of programming un

90 rain research, it is claimed that values are inappropriately dictating scientific decisions.

91 ippo tumor suppressor pathway to ensure that inappropriately differentiating cells are eliminated dur

92 ir and remodeling mechanisms, they are often inappropriately directed towards relatively innocuous al

93 ides visual feedback of appropriately versus inappropriately disinfected areas of the hand and can al

94 Moreover, selective inhibition of inappropriately dispersed GAPDH rescues antioxidant capa

95 ase conditions, DNA methylation patterns are inappropriately distributed in a manner that supports th

96 ecognition and partially rescue females that inappropriately dosage-compensate.

97 Estimates of the required n may be inappropriately doubled or cut in half.

98 ave had PPI therapy discontinued abruptly or inappropriately due to safety concerns.

99 ory pathways in the lung are cued to respond inappropriately during infection.

100 and htp-1 htp-2 mutants, centrioles separate inappropriately during meiosis II, resulting in spermati

101 1 lacking a functional PIP motif accumulates inappropriately during S phase and is more potent than w

102 with consequences including greater risk of inappropriately early leafing and altered interactions a

103 s require demonstration of hypoglycemia with inappropriately elevated (nonsuppressed) insulin, C-pept

104 Inappropriately elevated endogenous glucose production (

105 contrast, the schizophrenic patients showed inappropriately elevated fear and poor vmPFC responses i

106 Because this condition has inappropriately elevated hepcidin in the presence of hig

107 ly in the presence of high sodium intake, is inappropriately elevated in BK-beta4 null mice.

108 ifferentiate along the osteoblastic lineage, inappropriately elevated levels of signaling can also in

109 Patients with IRIDA have inappropriately elevated levels of the iron regulatory h

110 humans and mice with TMPRSS6 mutations show inappropriately elevated levels of the iron-regulatory h

111 ten(m3m4) model is the first murine model of inappropriately elevated social motivation in the contex

112 re absent, we show that endodermal cells can inappropriately engulf and cannibalize the PGC cell body

113 tion are abundant during infection and could inappropriately enhance T reg cell activity.

114 Furthermore, the absence of CDR leads to inappropriately enhanced heart rate responses of the SAN

115 ely believed that both viral replication and inappropriately enhanced immune responses contribute to

116 acking medullary MHC class II expression had inappropriately enhanced proximal TCR signaling to low-a

117 olecules proposed to disrupt this balance by inappropriately enhancing core assembly.

118 d on this terminology may lead to the use of inappropriately excessive doses of ICS.

119 w glucose levels in the pancreas, leading to inappropriately excessive insulin secretion.

120 te statistical support for their hypothesis, inappropriately exclude important data, and do not consi

121 exception reporting may allow physicians to inappropriately exclude patients for whom targets have b

122 n on CT angiography source images would have inappropriately excluded from reperfusion therapy 44.4%

123 in which a single neuronal fate decision is inappropriately executed.

124 show that PHF7-expressing ovarian germ cells inappropriately express hundreds of genes, many of which

125 d in development and in malignant cells that inappropriately express Ptn.

126 Furthermore, they inappropriately express somatic genes characteristic of

127 In the absence of Eng, yolk sacs inappropriately express the cardiac marker, Nkx2.5.

128 uding Eomes, Elf5 and Sox2, while others are inappropriately expressed (Oct4, Nanog, Gata6, Fgf4 and

129 normally expressed only at 37 degrees C, are inappropriately expressed at RT in the msb2 mutant, sugg

130 ccordingly, mRNA for XY-linked genes remains inappropriately expressed in Raptor-deficient mice.

131 EVI1 is an oncogene inappropriately expressed in the bone marrow (BM) of app

132 Our findings indicate that EVI1, when inappropriately expressed, delays or blocks myeloid diff

133 h the S phase faster than wild-type cells by inappropriately firing late origins of replication.

134 mosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distri

135 organized protein aggregates that arise from inappropriately folded versions of proteins or polypepti

136 cycle progression, and checkpoint kinases to inappropriately force cells through the cell cycle.

137 sister telomeres become deprotected and are inappropriately fused.

138 ptable radiotherapy protocol deviations (ie, inappropriately generous volume contoured) correlated wi

139 where individuals with frontal cortex damage inappropriately grasp affording objects.

140 s and may compromise the causal inference if inappropriately handled.

141 C1, and suggest a new paradigm in which both inappropriately high and inappropriately low levels of T

142 o hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting

143 nscription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and sol

144 that oligodendrocyte progenitors accumulated inappropriately in adult brains.

145 In the absence of RNF17, ping-pong occurs inappropriately in meiotic cells.

146 Many antibiotics are prescribed inappropriately in pediatric emergency departments (PEDs

147 tract infection is common and often treated inappropriately in primary care with antibiotics.

148 of PE in NHEJ repair is to detect and remove inappropriately incorporated ribonucleotides or phosphat

149 ium (Na(+)) during high Na(+) intake despite inappropriately increased levels of mineralocorticoids,

150 Inappropriately increased maternal hepcidin during pregn

151 estment in a planktonic key organism causing inappropriately increased reproduction with potentially

152 Specifically, Smaug2 knockdown inappropriately increases Nanos1 protein, and the Smaug2

153 and hyperactivated wild-type p53, which then inappropriately induced its target genes and triggered c

154 ver, untimely Tws expression stabilizes Plk4 inappropriately, inducing centriole amplification.

155 On the other hand, such evaluations could inappropriately influence decision making in criminal id

156 and there is a danger that existing beliefs inappropriately influence judgments about model assumpti

157 bsence of SpoT, carbon-starved swarmer cells inappropriately initiated DNA replication.

158 The fate of TA proteins that become inappropriately inserted into other organelles, such as

159 Opening the MscL pore inappropriately is detrimental to the bacterial cell, su

160 Opening the large pore of MscL inappropriately is detrimental to the cell, and thus it

161 ypes of biobricks could be discriminated and inappropriately labeled biobricks could be determined, w

162 raphs illustrate discriminated biobricks and inappropriately labeled biobricks.

163 detect data quality issues, e.g. data noise, inappropriately labeled data, etc.

164 f stem and/or progenitor cell populations or inappropriately leading to oncogenesis through the aberr

165 receptors also developed ectopic rhabdomeres inappropriately located in basolateral membrane, indicat

166 chronous advanced neoplasia, resulting in an inappropriately long surveillance interval.

167 ree concentrations of these compounds and/or inappropriately low albumin concentrations may blur the

168 may be involved in the hypophosphatemia and inappropriately low calcitriol levels observed after kid

169 ropy and inotropy may potentially lead to an inappropriately low cardiac output, with a subsequent co

170 is characterized by renal phosphate wasting, inappropriately low circulating levels of the active for

171 ombined effects of abnormal iron metabolism, inappropriately low erythropoietin production, diminishe

172 An inappropriately low erythropoietin response to anemia wa

173 forms of hereditary hemochromatosis involves inappropriately low expression of hepcidin.

174 Inappropriately low expression of the key iron regulator

175 g) and Id1 mRNA (a target gene of Bmp6) were inappropriately low for the body iron burden and Bmp6 mR

176 opoiesis, such as beta-thalassemia, manifest inappropriately low hepcidin production and consequent e

177 t in the most highly edited B cells, and are inappropriately low in autoimmune mouse models of system

178 main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse

179 Serum levels of hepcidin were inappropriately low in patients.

180 on overload syndromes because its levels are inappropriately low in these individuals.

181 Inappropriately low levels of hepcidin, a negative regul

182 y hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietar

183 The inappropriately low levels of the iron regulatory hormon

184 adigm in which both inappropriately high and inappropriately low levels of TORC1 activity can be asso

185 Hepcidin levels that are inappropriately low or high result in iron overload or i

186 itol 3-kinase-Akt signaling pathway owing to inappropriately low phosphatase and tensin homolog phosp

187 telet transfusion refractoriness, defined as inappropriately low platelet count increments after two

188 f the PI3K-Akt-S6K1 signal pathway caused by inappropriately low PTEN activity.

189 sorder characterized by hypophosphatemia and inappropriately low serum levels of 1,25-dihydroxyvitami

190 XLH, are characterized by hypophosphatemia, inappropriately low serum vitamin D levels, increased se

191 ormone and follicle stimulating hormone were inappropriately low.

192 wever, many tumors that retain wild-type p53 inappropriately maintain the MDM2-p53 regulatory loop in

193 ive malignancies that can be misdiagnosed or inappropriately managed.

194 disabling but are often under-recognised and inappropriately managed.

195 Ordering blood cultures inappropriately may be both wasteful and harmful.

196 ryos lacking perineurial glia, motor neurons inappropriately migrated outside of the spinal cord and

197 urrent tumor in cases treated conservatively/inappropriately (n = 15) was necessary in 7 cases (47%).

198 cluding negative feelings about patients, an inappropriately narrow focus on diagnosis and risk asses

199 racterised by hypercalcaemia and elevated or inappropriately normal concentrations of parathyroid hor

200 (KI) mice demonstrated elevated serum TH and inappropriately normal thyroid-stimulating hormone (TSH)

201 iety disorders, in which patients generalize inappropriately (or fail to generalize) between differen

202 elease from pancreatic beta-cells, and, when inappropriately overexpressed, provisioning of certain f

203 period acceleration in the mutant is due to inappropriately phased activity of the CK1epsilon isofor

204 ides a means to indirectly select only these inappropriately placed adenines for excision.

205 in the mouse retina whereby DSCAM eliminates inappropriately placed cells and connections.

206 ions, there continue to be a large number of inappropriately prescribed antibiotics.

207 Antibiotics are often inappropriately prescribed for patients with ARTI.

208 Figs 4B and 6C were inappropriately presented.

209 t cells possess multiple pathways to degrade inappropriately processed or folded tRNAs.

210 e or more key components of the eggshell are inappropriately processed, leading to permeable, inviabl

211 The analysis of cells inappropriately producing Clb3-CDKs during meiosis I fur

212 Inappropriately programmed SAV/PAV intervals was the mos

213 Inappropriately programmed sensed and paced atrioventric

214 ce of LC, CD49a(+) liver NK cells display an inappropriately proinflammatory phenotype that results i

215 stem, axon targeting is inaccurate and axons inappropriately project within the target layer or overp

216 In the absence of CD72, anergic B cells inappropriately proliferated and survived in response to

217 be useful in resolving conflicts that may be inappropriately prolonging nonbeneficial or unwanted tre

218 eplication stress, the mislocalized Stn1 may inappropriately promote Pol alpha in a manner that inter

219 protein recognition of host targets that are inappropriately proteolyzed.

220 Inappropriately raised hepcidin levels, which impair iro

221 Hepcidin was inappropriately raised in IPAH independent of the inflam

222 ms to ensure that no segment of their DNA is inappropriately re-replicated, but the importance of thi

223 In melanoma, Notch1 is inappropriately reactivated and contributes to melanoma

224 e required for stem cell maintenance that is inappropriately reactivated in several cancers.

225 category, and only 1.4% of SCD victims were inappropriately reclassified from high to intermediate r

226 system that prevents non-self branches from inappropriately recognizing each other.

227 otein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to

228 We propose that when Uso1 is inappropriately recruited to secretory vesicles by Ypt1-

229 te stage and that a subset of leukemia cells inappropriately reexpress stem cell genes, including bmi

230 ted pulmonary allergy, suggesting that BMDCs inappropriately reflect the impact of complement on lung

231 Inappropriately regulated expression of interleukin (IL)

232 in the control of excessive inflammation and inappropriately regulated immune responses.

233 e human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces oncogenesis by causin

234 interferes with Pax7 in satellite cells, and inappropriately regulates Pax targets, including myogeni

235 ions in which the IGF-1 receptor is inactive inappropriately replicate in the presence of UVB-induced

236 Fur may now use Mn(II) as a co-repressor and inappropriately repress iron uptake.

237 In the absence of RTEL1, T loops are inappropriately resolved by the SLX4 nuclease complex, r

238 ; changes in legislation and regulation that inappropriately restrict access to opioid medications fo

239 Upon mitotic entry, Nek5-depleted cells inappropriately retained centrosome linker components an

240 ric disorders in which aversive memories are inappropriately retained.

241 ns can cause congenital disease or cancer by inappropriately rewiring promoter-enhancer contacts(1,2)

242 , 144 (25.7%) underscreened, and 109 (19.5%) inappropriately screened.

243 , 204 (27.8%) underscreened, and 190 (25.9%) inappropriately screened.

244 Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia.

245 uency misspecification arising from using an inappropriately selected population and find that, altho

246 itro assays showed that Acvr1(R206H/+) cells inappropriately sense their environment, responding to s

247 ohesive ensembles during development and can inappropriately separate in disease.

248 use in Mdr49 mutant embryos the Hh ligand is inappropriately sequestered in the hh-expressing cells.

249 woman/family dimensions that were drivers of inappropriately short or long stays.

250 Telomeres of RA CD34+ HPCs were age-inappropriately shortened by 1,600 bp.

251 omeres of lymphoid and myeloid cells are age-inappropriately shortened, suggesting excessive turnover

252 However, aurora B is inappropriately silenced as a consequence of the altered

253 il to assemble but the spindle checkpoint is inappropriately silenced due to PP1 activity.

254 the meristem promoted entry into S phase at inappropriately small cell volumes, suggesting that JAG

255 epress genes whose expression would generate inappropriately specified cells.

256 te in the third ventricular wall, die or are inappropriately specified, the shh(+) anterior recess do

257 Dup(DeltaPIP) is inappropriately stabilized during S phase and causes dev

258 These inappropriately stimulate circulating neutrophils adhere

259 might either fail to identify a biased IV or inappropriately suggest that a valid IV is biased.

260 ells develop normally in the bone marrow but inappropriately survive peripheral tolerance checkpoints

261 scarring that is at first protective but if inappropriately sustained can worsen heart disease.

262 Inappropriately sustained inflammation is a hallmark of

263 Heart failure (HF) is a state of inappropriately sustained inflammation, suggesting the l

264 ypes of external globus pallidus (GP) neuron inappropriately synchronise their firing in time with sl

265 Inappropriately synchronized beta (beta) oscillations (1

266 enocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug respons

267 er location combined with the elimination of inappropriately targeted sparse branches.

268 This triggered a spermatogenesis defect by inappropriately targeting the piRNA machinery to mouse m

269 ctor kappa-B (NF-kappaB) signaling, possibly inappropriately throttling antiviral responses.

270 rma cinereum larvae failed to double and was inappropriately timed relative to both environmental cyc

271 etes insipidus) in which the kidney responds inappropriately to AVP.

272 their polarized cell morphology and migrate inappropriately to become dispersed in the larval tail.

273 ifficult to interpret and often extrapolated inappropriately to clinical usage.

274 wever, too often urine concentration is used inappropriately to draw dubious conclusions that could h

275 by Tup1 cause Rap1 to bind specifically and inappropriately to low-glucose targets.

276 An S144A-S146A double mutant not only bound inappropriately to mitotic microtubules but also increas

277 orrect, resistant to correction, and applied inappropriately to new situations.

278 ditions may be missed, or patients subjected inappropriately to potentially toxic drug treatments.

279 Total Txnip knockout (TKO) mice adapted inappropriately to prolonged fasting by shifting fuel de

280 n de (diastereomeric excess) have been used (inappropriately) to quantitate stereoselectivity.

281 not adequately reflect disease biology, may inappropriately treat patients on either side of the cut

282 Untreated and inappropriately treated malaria cases lead to excess mal

283 often misdiagnosed or unrecognized and thus inappropriately treated or untreated in terminally ill p

284 as often confused with diabetes mellitus and inappropriately treated with insulin.

285 ines of evidence indicate that these mutants inappropriately trigger the activation of GerA during sp

286 l provide insight into how these systems are inappropriately triggered in autoimmunity, and, converse

287 maged cells and physical irritants; however, inappropriately triggered or sustained inflammation can

288 te that Shn2(-/-) double-positive thymocytes inappropriately undergo negative selection in response t

289 Forced expression of Cdc25B inappropriately up-regulated the activity of Cdk1 and Cd

290 -specific demethylase 1 (LSD1) expression is inappropriately upregulated in HNSCC and an orthotopic H

291 ression, because Hcn4, Mlc2a, and Bmp10 were inappropriately upregulated in ventricular RNA.

292 ivity of the protein partially constitutive, inappropriately upregulating the activity of autolytic e

293 ceived propofol from anesthesiologist 1, who inappropriately used a single-patient-use vial of propof

294 We inappropriately used discoveries from PDGene and ALSGene

295 aning off HPS was overestimated by 4.4% when inappropriately using the KM method, instead of the cumu

296 red blood cell oxygen saturation was low and inappropriately variable.

297 e ordered for patients who received the test inappropriately with a resulting low yield (0.47%) of CR

298 ns extend across this border and fasciculate inappropriately with other axon tracts.

299 genes prevent dachshund from being expressed inappropriately within the embryonic head.

300 ons, a considerable proportion of them do so inappropriately without first consulting a doctor.