ライフサイエンスコーパス: inbred strain

1 HMs) in SV129S6 mice, an Slc11a1/Nramp1(+/+) inbred strain.

2 y correlated with CC size within the BALB/cJ inbred strain.

3 fade away in another as of yet unidentified inbred strain.

4 wheel running (high runner) and the C57BL/6J inbred strain.

5 owed by inbreeding to obtain new recombinant inbred strains.

6 refore would not segregate between classical inbred strains.

7 f the genome of most extant laboratory mouse inbred strains.

8 cinogenesis in the susceptible 129 family of inbred strains.

9 ng male and female mice from three different inbred strains.

10 ercross of the LG/J (Large) and SM/J (Small) inbred strains.

11 of random effect models in gene mapping with inbred strains.

12 ion among individual mice of three different inbred strains.

13 tions that have been lost in some laboratory-inbred strains.

14 expression in the liver of the two parental inbred strains.

15 tistical analysis of genetic crosses between inbred strains.

16 sequenced classical and high-priority mouse inbred strains.

17 7BL/6J as well as other carefully maintained inbred strains.

18 omic scale across 30 commonly used classical inbred strains.

19 the inflammatory response between these two inbred strains.

20 (<90 min) of murine macrophages from certain inbred strains.

21 using a reference population of recombinant inbred strains.

22 m crossing the Large (LG/J) and Small (SM/J) inbred strains.

23 e rsl phenotype arose during the creation of inbred strains.

24 genome shotgun sequencing of five laboratory inbred strains.

25 d with vigorous Il1b responses in a panel of inbred strains.

26 erum IGF-I in a mouse intercross between two inbred strains.

27 ed from an intercross of the Large and Small inbred strains.

28 eported and predicted in panels of classical inbred strains.

29 of macrophages (M phi) derived from certain inbred strains.

30 mal susceptibility to LT differs among other inbred strains.

31 The current focus is on a set of 40 inbred strains.

32 mic cerebral infarct volume observed between inbred strains.

33 les from intact and OVX mice from a panel of inbred strains.

34 (LD) that is characteristic of crosses among inbred strains.

35 imarily from comparisons of 6J mice to other inbred strains.

36 hila Genetic Reference Panel of wild-derived inbred strains.

37 this panel is limited by the availability of inbred strains.

38 tion in rats from immunologically-mismatched inbred strains.

39 tomic data from the mouse hippocampus of six inbred strains (129S1/SvImJ, A/J, C57BL/6J, DBA/1J, DBA/

40 ation model for 28 days to male mice from 14 inbred strains (129S1/SvImJ, AKR/J, BALB/cJ, BALB/cByJ,

41 assessed in 2 animal models of Lassa fever: inbred strain 13 guinea pigs and cynomolgus macaques.

42 l Th2 cytokine, interleukin-10 (IL-10), from inbred Strain 2 guinea pigs using the DNA sequence infor

43 efined lines of mice, including six standard inbred strains, 25 recombinant inbred strains (AXB/BXA),

44 ived strains but was rare among conventional inbred strains (4/33 tested, one of which is DBA/1, the

45 d from reciprocal crosses between the common inbred strains A/J and C57BL/6J.

46 gene targeting and (b) identification of an inbred strain, A/J, bearing a retrotransposon insertion

47 Genetic background variation between inbred strains accounts for different levels of suscepti

48 Furthermore, use of an inbred strain allows for investigation into epigenetic m

49 6/SvEvTAC-Egfrtm1Mag and nine Swiss-derived, inbred strains: ALR/LtJ, ALS/LtJ, APN, APS, ICR/HaRos, N

50 n this study, we asked whether mice of these inbred strains also vary in their requirement for CD4(+)

51 mouse was initially generated in the C57BL/6 inbred strain and has been backcrossed into the BALB/cBy

52 ne mapping study with the SWXJ-9 recombinant inbred strain and the evolutionarily divergent Mus muscu

53 ibility models: (i) BXD advanced recombinant inbred strains and (ii) F2 offspring generated from pola

54 at 21 distinct genomic loci in 13 laboratory inbred strains and 12 wild-derived strains.

55 ration in genetic murine models using common inbred strains and a set of recombinant inbred (RI) line

56 e treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known q

57 was further confirmed by screening multiple inbred strains and by excluding the mutation of nearby g

58 fied the active Bxv1 provirus in many common inbred strains and in some Japanese Mus molossinus mice

59 ying genetic factors we analyzed recombinant inbred strains and linkage backcrosses.

60 All inbred strains and outbred stocks of laboratory mice stu

61 L) line of NIH Swiss mice to three different inbred strains and performed linkage analysis on the DPO

62 cly available genome sequences of 36 popular inbred strains and provide lists for each strain of prot

63 ry gland involution in the 129S1 and C57BL/6 inbred strains and report significant differences at the

64 data from crosses that involve more than two inbred strains and sequence variants in the progenitor s

65 suggest that otolithic function varies among inbred strains and several strains displayed gravity rec

66 heritable trait by using female rats of six inbred strains and six F1 hybrids.

67 ed and induced mutations, as well as 100s of inbred strains and strain panels, valuable for quantitat

68 We used nine inbred strains and two inducible nitric oxide synthase (

69 We also typed inbred strains and wild mouse species for an endogenous

70 ts, explain phenotypical differences between inbred strains, and increase the amount of interesting g

71 nephropathy only occurs among specific mouse inbred strains, and this selective susceptibility to kid

72 Mice of the I/LnJ inbred strain are unique in their ability to mount a rob

73 Inbred strains are a distinctive feature of mouse geneti

74 e methylation patterns seen among laboratory inbred strains are also found in a free-living populatio

75 Genetically diverse inbred strains are frequently used in quantitative trait

76 her males from 17 classical and wild-derived inbred strains are interfertile with DDK females.

77 demonstrates that individual mice of highly inbred strains are not isogenic and suggests other CNVs

78 enetic studies involving a cross between two inbred strains are usually followed by congenic mapping

79 e disease and the popularity of the C57BL/6J inbred strain as a background for the generation and stu

80 Using recombinant inbred strains as a CO library, here we report the ident

81 Here, using the BXD recombinant inbred strains as a crossover library, three new recombi

82 he hybrid mouse diversity panel (HMDP) of 83 inbred strains as a surrogate for human natural immune v

83 enes play an important role when using mouse inbred strains as research models.

84 rotocol that is generally applicable to most inbred strains, as well as a variant for nonpermissive s

85 ked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old.

86 six standard inbred strains, 25 recombinant inbred strains (AXB/BXA), reciprocal F1 hybrids, a chrom

87 Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial

88 f ENPs in Sox10(Dom) embryos were altered by inbred strain background with the most highly significan

89 rom the A/J inbred strain on a host C57BL/6J inbred strain background.

90 However, ground state pluripotency in some inbred strain backgrounds is unstable in the absence of

91 ore, we conducted a comparative study on the inbred strains Balb/c and C57Bl/6 that differ substantia

92 al hearing loss in mice of the C57BL/6J (B6) inbred strain begins at high frequencies during young ad

93 e carry out deep sequencing of 13 additional inbred strains (BUB/BnJ, C57BL/10J, C57BR/cdJ, C58/J, DB

94 defects, which are partially penetrant in an inbred strain but fully lethal in non-inbred mice.

95 in mice have illustrated differences between inbred strains, but the possibility that mitochondrial g

96 eneous stock (HS) mice derive from 8 founder inbred strains by serial intercrossing (n>60), resulting

97 ouse strains, the outbred strain CD1 and the inbred strain C57BL/6.

98 -6 transcription compared with the classical inbred strain C57BL/6J.

99 vered in C57BL/6JOlaHsd, a population of the inbred strain C57BL/6J.

100 relatively suppressed in F1 hybrids between inbred strains C57BL/6 and 129S2.

101 The inbred strains C57BL/6J and DBA/2J (DBA) display strikin

102 tion produced from an intercross between two inbred strains (C57BL/6J and AKR/J) were exposed in uter

103 Mice from two different inbred strains (C57BL/6J and DBA/2J) known to differ in

104 e mice, which are a cross between two common inbred strains (C57BL/6J and DBA/2J).

105 Mom7 was mapped in crosses involving four inbred strains: C57BL/6J (B6), BTBR/Pas (BTBR), AKR/J (A

106 Inbred strains carrying this allele were far more respon

107 Female mice of inbred strain CBA do not reject syngeneic male skin graf

108 y making F1 hybrids of TgFVB with five other inbred strains (CBA, DBA/2, CAST/Ei, C3H/He, BALB/c) and

109 ng crosses from many inbred and wild-derived inbred strain combinations.

110 nbred strains for all 29 loci and found that inbred strains contain only a small amount of the geneti

111 we detected low levels of enzyme activity in inbred strains containing sPLA2-IIA mutations; these str

112 NJ+/+, and LP/J+/+ mice indicated that these inbred strains could be distinguished by their proteomic

113 avioral patterns of mouse genotypes, such as inbred strains, crosses, and knockouts, are characterize

114 rval using collateral traits measured for 15 inbred strains delineated 172-kbp (P=0.00002) and 290-kb

115 region from two sensitive and two resistant inbred strains demonstrated a 400-kb haplotype block con

116 SPRET/Ei is an inbred strain derived from Mus spretus that has approxim

117 inbred mouse strains, and in 25 recombinant inbred strains derived from them, and variations in thei

118 Moreover, variation among inbred strains derives from differences between species

119 Analysis of 213 mice from 31 BXD recombinant inbred strains detected linkage of auditory brain-stem r

120 Mice from five other inbred strains developed fasting-induced steatosis like

121 transgene-positive F1 progeny in particular inbred strains display altered latency, tumor growth rat

122 significantly with outward remodeling among inbred strains (except C3H).

123 Ethiopian inbred strains exhibited much higher frequencies of wing

124 Similar to results from the inbred strain experiments, head dipping was not correlat

125 AC mice on an inbred FVB background to other inbred strains, F1 mice were created that could be analy

126 f focal genes within modules in a laboratory inbred strain, followed by measurements of transcript ab

127 identical to that of any other CC strain or inbred strain for which prior data are available, indica

128 We resequenced classical inbred strains for all 29 loci and found that inbred str

129 Here, we screened a panel of inbred strains for anxiety- and depression-related pheno

130 rains for mapping resolution and recombinant inbred strains for mapping power.

131 or association mapping that combines classic inbred strains for mapping resolution and recombinant in

132 their virus expression patterns, we screened inbred strains for sequence and functional variants of t

133 ligonucleotide arrays in the BXD recombinant inbred strains, for which we have extensive SNP and hapl

134 heterogeneous stock (HS-CC) formed from the inbred strain founders of the Collaborative Cross (CC).

135 Beginning with two highly inbred strains from each of three species in the nematod

136 cted an F(2) intercross between wild-derived inbred strains from Mus musculus castaneus and M. m. dom

137 periaqueductal gray, and cerebellum in eight inbred strains from priority group A of the Mouse Phenom

138 ducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus mu

139 s to study wild house mice and to create new inbred strains from wild populations have the potential

140 r Lman1(-/-) mice, dependent on the specific inbred strain genetic background, suggesting a potential

141 rthermore, we demonstrate that the C3H/HeSnJ inbred strain has late onset cerebellar degeneration due

142 cent from fancy mice and show that classical inbred strains have limited and non-randomly distributed

143 rogeneous stock (HS) formed by crossing four inbred strains (HS4) and a heterogeneous stock (HS-CC) f

144 physiology from an array of BXD recombinant inbred strains identified a segment on chromosome 4 cont

145 of 4.70 distinct segments over 73 classical inbred strains in each region of the genome, suggesting

146 of SNPs in 13 classical and two wild-derived inbred strains in five genomic intervals totaling 4.6 Mb

147 f strains, yet the common use of hundreds of inbred strains in medical research motivates the need fo

148 type 2 expressed in most other commonly used inbred strains, including 129 mice.

149 rus type 1 (MAV-1) infections, whereas other inbred strains, including BALB/cJ, are resistant.

150 n various tissues of aging mice from several inbred strains, including lower p53 transcriptional acti

151 ell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cel

152 hat approximately 97% of the variation among inbred strains is ancestral (between clades) and approxi

153 The imputation accuracy among classical inbred strains is estimated at 99.7% for the genotypes i

154 Although mapping quantitative traits in inbred strains is simpler than mapping the analogous tra

155 The castaneous (CAST) mouse, a wild-derived inbred strain, is highly susceptible to orthopoxvirus in

156 mice from an advanced intercross between two inbred strains (LG/J and SM/J); this GWAS identified 23

157 derived, congenic, consomic, and recombinant inbred strains maintained at The Jackson Laboratory.

158 the controlled complexity of the laboratory inbred strains may provide a means for uncovering the bi

159 ad coverage of approximately 30-fold from an inbred strain medaka (Oryzias latipes), we observed that

160 morphology in an intercross of LG/J and SM/J inbred strains (N = 1040), using QTL analysis on 70 skel

161 Our two maps profile a common wild-derived inbred strain of M. m. domesticus crossed to distinct wi

162 The DBA/2J inbred strain of mice is used extensively in hearing res

163 ed skin and reach draining lymph nodes in an inbred strain of mice.

164 The BTBR (BTBR T+tf/J) inbred strain of mouse, is used to model facets of autis

165 rom eight inbred strains to females from two inbred strains of house mice (Mus musculus domesticus).

166 of the program entailed extensive studies of inbred strains of house mice (Mus musculus) and of deer

167 We report genome sequences of 17 inbred strains of laboratory mice and identify almost te

168 kemia viruses (MLVs) are found in the common inbred strains of laboratory mice and in the house mouse

169 We have crossed inbred strains of M. hapla that differ in DNA markers an

170 However, in more commonly used inbred strains of mice (C57BL/6, FVB/N) that were hemizy

171 e action in 1) a panel of 41 BXD recombinant inbred strains of mice (n = 13.7 +/- .8 per strain; n =

172 s leading to acute heart injury in different inbred strains of mice also suggest that this response h

173 f high-fat and low-fat diets on males of two inbred strains of mice and discovered that C57BL/6J but

174 ng of the unique variation patterns found in inbred strains of mice and how they have arisen through

175 ble trait exhibiting sixfold variation among inbred strains of mice and is used here to identify gene

176 7BL/6J (B6), BALB/cJ (BALB), and DBA/2J (D2) inbred strains of mice and resistant FVB-Tg(Ela-KRAS(G12

177 ata on commonly used and genetically diverse inbred strains of mice and their derivatives.

178 by methyl-donor deficiency among individual inbred strains of mice and to investigate the underlying

179 Inbred strains of mice are valuable tools for determinin

180 However, several inbred strains of mice derived from wild mice, including

181 Similarly, inbred strains of mice differ in their susceptibility to

182 Inbred strains of mice exhibit substantial differences i

183 haracterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mouse Diversity P

184 In this respect, common inbred strains of mice have played a crucial role, and r

185 seeking," we compared the performance of 14 inbred strains of mice in five tests: activity in a nove

186 ted the hypothesis that genetic variation in inbred strains of mice influences the innate variability

187 lsivity measures, 5CSRTT performance, in two inbred strains of mice known to differ in alcohol intake

188 However, the availability of different inbred strains of mice offers an excellent model system

189 ions of virus yields from infected brains of inbred strains of mice showed that E1A null and CR3Delta

190 We had reported earlier that inbred strains of mice such as BALB/cJ could survive a c

191 Thus, the use of inbred strains of mice that are hemizygous for the Drd2

192 with experimental studies of Hb function in inbred strains of mice that carry the alternative Hbb(d)

193 the less potent S-baclofen enantiomer in two inbred strains of mice that display low sociability and/

194 11, we analyzed the immune response of three inbred strains of mice to antigen immunization using two

195 The use of inbred strains of mice to dissect the genetic complexity

196 the highly variable plasma VWF levels among inbred strains of mice to identify 2 major regulators, M

197 Inbred strains of mice vary widely in onset and severity

198 Susceptibility to WNV disease in inbred strains of mice was mapped to a nonsense mutation

199 Hamsters, guinea pigs, cotton rats, and nine inbred strains of mice were inoculated intranasally with

200 r this study, we collected microbiota from 2 inbred strains of mice which differ in adiposity and glu

201 these findings by challenging 12 additional inbred strains of mice with rabbit anti-mouse glomerular

202 We challenged several inbred strains of mice with Y. pestis and found that BAL

203 eptide-specific CD8(+) T cells, varies among inbred strains of mice, and is not mediated by tradition

204 Little or no mortality develops in most inbred strains of mice, but C3H and FVB/N mice exhibit f

205 The 50% lethal doses differed among inbred strains of mice, but within a given mouse strain,

206 In two inbred strains of mice, C57BL/6 and 129Sv, the majority

207 Here we show, by using inbred strains of mice, F1 hybrids, and segregating popu

208 ity and mosaic regularity across recombinant inbred strains of mice, finding that, although both trai

209 In contrast, common inbred strains of mice, including BALB/c and C57BL/6, ar

210 In the 129 family of inbred strains of mice, teratomas initiate around embryo

211 we examined five cognitive functions in two inbred strains of mice, the stress-resilient strain C57B

212 Diversity Panel data, which consisted of 100 inbred strains of mice, we identified 97 DMCs that were

213 NKT cell number and function among different inbred strains of mice, we investigated whether the role

214 We explored this issue in inbred strains of mice, with a special focus on the low

215 that they have not been identified in other inbred strains of mice.

216 using immunocompetent and immunocompromised inbred strains of mice.

217 nensis can cause progressive disease in most inbred strains of mice.

218 l to determine copy number variation between inbred strains of mice.

219 o the more complex tetrabranched peptides in inbred strains of mice.

220 ata on commonly used and genetically diverse inbred strains of mice.

221 ensive map of DNA variation among the common inbred strains of mice.

222 matory responses in two genetically distinct inbred strains of mice.

223 We compared vascular remodeling among 5 inbred strains of mice.

224 ally with clearance of colonization in three inbred strains of mice.

225 differences in regional DNA content between inbred strains of mice.

226 NA gene sequencing in a panel of 110 diverse inbred strains of mice.

227 immunogenicity of PvRMC-CSP in groups of six inbred strains of mice.

228 under genetic regulation and differs between inbred strains of mice.

229 differences between the C57BL/6J and C3H/HeJ inbred strains of mouse.

230 We studied a cross between wild-derived inbred strains of Mus musculus musculus and M. m. domest

231 stitutions and insertions/deletions among 20 inbred strains of Mus musculus, chosen to enable interpr

232 ally cloned an allorecognition gene by using inbred strains of the cnidarian, Hydractinia symbiolongi

233 novel insertions exist in every lab strain, inbred strains of the Drosophila Genetic Reference Panel

234 y is motivated by the hypothesis that common inbred strains of the laboratory mouse are derived from

235 Inbred strains of the laboratory rat are widely used for

236 (+) T cells and neutrophils purified from 39 inbred strains of the Mouse Phenome Database.

237 ry a homologous chromosome pair from the A/J inbred strain on a host C57BL/6J inbred strain backgroun

238 or mapping phenotypic traits that vary among inbred strains onto haplotypic blocks.

239 identifying variation among a large panel of inbred strains or lines.

240 aturally occurring mania models including an inbred strain our lab has recently characterized, the Ma

241 laborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resourc

242 gating at these two loci in C3H/HeJ mice, an inbred strain producing melatonin, suppress the circadia

243 This common inbred strain provides a novel model for studying impair

244 ency of type I NKT cells in the wild-derived inbred strains PWD/PhJ, SPRET/EiJ, and CAST/EiJ.

245 Female mice of 28 inbred strains received this vaccine at 6, 8, and 12 wee

246 The existing panel of common inbred strains reflects historical selection biases, and

247 ated from a 15% reduction in growth rates of inbred strains relative to outcrossed.

248 Mouse inbred strains remain essential in science.

249 domesticus crossed to distinct wild-derived inbred strains representative of two other house mouse s

250 and DBA strains, and a group of wild-derived inbred strains representing several Mus musculus subspec

251 netic model that uses the Wistar-Kyoto (WKy) inbred strain, resistant to developing 7,12-dimethylbenz

252 However, comparison of five common inbred strains revealed a disparity in precursor-product

253 hisms at 44-kb spacing) with phenotype in 15 inbred strains revealed a risk haplotype that was shared

254 Linkage analysis using BXD recombinant inbred strains revealed a single effector locus at a 1.5

255 sting using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates t

256 that simply do not apply to crosses between inbred strains since every animal in a strain is genetic

257 anced intercross line (AIL) derived from two inbred strains (SM/J and LG/J).

258 Inbred strain-specific differences were independent of c

259 1 levels vary significantly in the testes of inbred strains such as 129 and MOLF, and as such Sf1 is

260 re compared to resistant C57BL/6 mice and to inbred strains SWR and SJL of Swiss origin, which have n

261 fficient to distinguish virtually all of the inbred strains tested was selected.

262 ontains proportionately less variation among inbred strains than do the autosomes.

263 By using BTBR mice, an inbred strain that displays behavioral traits that refle

264 Ideally, the parental lines are from two inbred strains that are not closely related to each othe

265 analyzing diallel data on dioecious diploid inbred strains that cleanly decomposes the observed patt

266 With mice from two inbred strains that control retroviruses via adaptive im

267 ese data provide a catalog of miRNA genes in inbred strains that could represent genes involved in th

268 powerful studies based on testing engineered inbred strains that have single, unique, and nonoverlapp

269 ences from individuals of four commonly used inbred strains that were procured from either the colony

270 o the increase in delta power that occurs in inbred strains: the strain that exhibits the most robust

271 Here, we cross males from eight inbred strains to females from two inbred strains of hou

272 n the neonatal lung by exposing mice from 36 inbred strains to hyperoxia (95% O2) for 72 h after birt

273 insights into the proposed use of panels of inbred strains to identify genes underlying quantitative

274 tion that consists of mice of 32 recombinant inbred strains to identify the transcription modules and

275 fter assigning female mice from 29 different inbred strains to normal chow or lithium diet (40 mmol/k

276 ed with 25 AKXD (AKR/J x DBA/2J) recombinant inbred strains to produce F1 progeny with varying metast

277 se genotypes in less-densely typed classical inbred strains to provide a complete view of variation i

278 tent with previous experiments using classic inbred strains to represent M. domesticus.

279 We exposed mice from 20 inbred strains to the prototypical alkylating agent, N-n

280 449 male mice from 33 inbred strains underwent MCAO for 6 hours (215 mice) or

281 duced lung tumorigenesis on 593 mice from 21 inbred strains using 115,904 genotyped and 1,952,918 imp

282 pping due to the limited number of available inbred strains, we are able to identify significantly as

283 dictions from the sPLA2-IIA gene sequence in inbred strains, we detected low levels of enzyme activit

284 lassical laboratory and 4 wild-derived mouse inbred strains, we developed a comprehensive catalogue o

285 th the use of a panel of MHC-III recombinant inbred strains, we found that the 33-kb Ltab-Ncr3 haplot

286 Among inbred strains, we imputed 92% of SNPs genome-wide, with

287 Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concent

288 Three highly susceptible wild-derived inbred strains were identified, of which CAST/EiJ was fu

289 Mice from different inbred strains were immunized with recombinant murine CO

290 multigenerational crosses between and among inbred strains where familial relatedness is often unavo

291 However, most studies of mice use classical inbred strains, whose genomes derive from multiple speci

292 ated between DW/J-Pou1f1dw/+ carriers and an inbred strain with excellent hearing derived from Mus ca

293 ALS is an inbred strain with low antioxidant defenses produced by

294 in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels, spo

295 In BALB/c mice, an inbred strain with spontaneously elevated anxiety and st

296 l or pathological differences among selected inbred strains with a pattern of genetic variation.

297 As located at or near susceptibility loci in inbred strains with different tumor susceptibilities.

298 Ss where the donor strains were derived from inbred strains with more distant origins and discovered

299 ipts showed significant variation across the inbred strains, with 22% of the transcriptome varying by

300 a set of four mouse intercrosses among five inbred strains, with data on HDL cholesterol.