ライフサイエンスコーパス: inbreeding

1 imited levels of within-band relatedness and inbreeding.

2 r an individual's own inbreeding or maternal inbreeding.

3 ably due to differential levels of drift and inbreeding.

4 ations across Europe, potentially indicating inbreeding.

5 tion and breed formation, rather than recent inbreeding.

6 y the expression of a recessive allele under inbreeding.

7 s but also in their level of relatedness and inbreeding.

8 usceptibility to the genetic perturbation of inbreeding.

9 FP) or by genomic (marker-based) measures of inbreeding.

10 hose that lie between, including selfing and inbreeding.

11 ats, including loss of genetic diversity and inbreeding.

12 l selection, we revealed mutation load using inbreeding.

13 f the recruit families was not due to higher inbreeding.

14 g the highest diversity and lowest levels of inbreeding.

15 of identity disequilibrium (ID), a proxy for inbreeding.

16 ngiosperms to prevent self-fertilization and inbreeding.

17 kers usually provides little power to detect inbreeding.

18 re almost one in ten young result from close inbreeding.

19 angiosperms to reject self-pollen and avoid inbreeding.

20 ed for their genetic structure and degree of inbreeding.

21 introgression schemes had the lowest risk of inbreeding.

22 ases pollen transfer precision and restricts inbreeding.

23 ced by 71% compared with populations with no inbreeding.

24 pecies routinely employ strategies to reduce inbreeding.

25 udy for the observation of skeletal signs of inbreeding.

26 he Parsi reflects their recent isolation and inbreeding.

27 rol the trade-off between diploidization and inbreeding.

28 ated with the loss of SI and/or the shift to inbreeding; (2) a population bottleneck may have played

29 selves be inbred and compute the appropriate inbreeding-adjusted kinship coefficients, which has not

30 onditioned on effects of male coefficient of inbreeding, age and social status.

31 Recent research has found that plant inbreeding alters resistance and tolerance to herbivores

32 forcement to initial colonists, help relieve inbreeding among founders, or increase the hazard of the

33 evealed few sexual differences in biparental inbreeding among other gynodioecious species.

34 which pistils reject self-pollen to prevent inbreeding and accept non-self pollen to promote out-cro

35 e it measures the rates of genetic drift and inbreeding and affects the efficacy of systematic evolut

36 found that domestication is associated with inbreeding and an excess of deleterious mutations.

37 population, we found no associations between inbreeding and any of our six fitness measurements.

38 both ideal and actual conditions (including inbreeding and double reduction) were compared.

39 declining populations, and with high risk of inbreeding and genetic drift.

40 such disruptions in the short term, whereas inbreeding and genetic structure may respond more strong

41 cument multiple instances of father-daughter inbreeding and high levels of intraspecific strife, incl

42 er drought were related to higher population inbreeding and individual homozygosity, respectively, su

43 generally exacerbates the harmful effects of inbreeding and it has been proposed that this could be e

44 Ne ) is a key parameter that shapes rates of inbreeding and loss of genetic diversity, thereby influe

45 was 30, suggesting that rates of increase of inbreeding and loss of genetic variation per generation

46 1995-2013, resulting in increased levels of inbreeding and reduced fitness via inbreeding depression

47 ions are expected to shift towards increased inbreeding and reduced pollen diversity, with fitness co

48 for all populations, we found low levels of inbreeding and relatedness between individuals within po

49 The fitness consequences of inbreeding and the individual behaviors that prevent its

50 ecades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited u

51 election showed rapid fitness declines under inbreeding, and all were extinct after generation 10.

52 Most plants are capable of inbreeding, and also exhibit a remarkable suite of adapt

53 Population bottlenecks, inbreeding, and artificial selection can all, in princip

54 ated groups with high but variable levels of inbreeding, and episodes of interbreeding with other Pal

55 e we assess temporal variation in gene flow, inbreeding, and fitness using longitudinal genomic, demo

56 revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic allel

57 e played a role in driving the transition to inbreeding; and (3) the mutation(s) underlying the loss

58 se the same kin discrimination rule to avoid inbreeding as they do to direct help toward kin.

59 of the populations indicated a low level of inbreeding, as suggested by the high number of alleles.

60 history of the Lacandon population including inbreeding, as well as pathogen selection, may have elev

61 persal is usually driven by a combination of inbreeding avoidance and intrasexual competition.

62 isions in chimpanzees are most influenced by inbreeding avoidance and kin cooperation, instead of com

63 t may confer considerable benefits including inbreeding avoidance and nepotism.

64 To determine whether inbreeding avoidance and/or biparental inbreeding can ac

65 ome were later than expected (a presumptive "inbreeding avoidance delay," or father-induced reproduct

66 sex determination, inbreeding depression and inbreeding avoidance in Neodiprion lecontei, a gregariou

67 the conservation of threatened species, and inbreeding avoidance is thought to be a key driver in th

68 tive behavior may have acted as an important inbreeding avoidance mechanism allowing the species to e

69 ed, is often interpreted as a consequence of inbreeding avoidance mechanisms, but we show that it can

70 This pattern cannot be explained by inbreeding avoidance or as a response to more intense lo

71 ss, may evolve one or more of the following: inbreeding avoidance, functional diploid males or altern

72 nge members, thus facilitating gene flow and inbreeding avoidance.

73 t most a 1-14% increase in seed fitness from inbreeding avoidance.

74 isk of incest and hence selection for active inbreeding avoidance.

75 ce the evolution of mating systems and other inbreeding-avoidance mechanisms.

76 systems, however, there was selection during inbreeding because the diversity patterns of 337 single-

77 ions and cannot be explained by differential inbreeding, but are consistent with relaxed selection ma

78 Despite the potential for inbreeding by facultative self-fertilisation, substantia

79 d and where selection favours a capacity for inbreeding by functional hermaphrodites.

80 caudatus), a cooperative breeder that risks inbreeding by living alongside opposite-sex relatives, i

81 nked portions of the genome owing to extreme inbreeding by self-fertilization.

82 plication via self-fertilization and intense inbreeding by simultaneous hermaphrodites.

83 ether inbreeding avoidance and/or biparental inbreeding can account for female persistence in Geraniu

84 Biparental inbreeding can affect relative female fitness only if it

85 tective care that enables elevated levels of inbreeding can be reduced by inbreeding depression.

86 Furthermore, occasional inbreeding can explain why some multiple-patriline colon

87 These data further illustrate that inbreeding can have a negative effect on lifetime reprod

88 Our results show that inbreeding can have long-term demographic consequences e

89 by living alongside opposite-sex relatives, inbreeding carries fitness costs and is avoided by activ

90 t (IBDG) is predicted better by the pedigree inbreeding coefficient (FP) or by genomic (marker-based)

91 en individuals that produced offspring (mean inbreeding coefficient = 0.07, mean mate kinship = 0.08)

92 gree, finding strong concordance between the inbreeding coefficient and heterozygosity measured at 13

93 success in both sexes, and between maternal inbreeding coefficient and offspring survival.

94 We compared the inbreeding coefficient estimated using known height asso

95 al and joint posterior distributions for the inbreeding coefficient in females and the male to female

96 Historically, computations of the inbreeding coefficient were used to prohibit inbred marr

97 tion in nucleotide diversity, or increase in inbreeding coefficient, relative to history of exposure.

98 eeding date varied with female, but not male inbreeding coefficient, revealing direct, but not indire

99 Here, using genomic inbreeding coefficients (F(ROH)) for >1.4 million indivi

100 ee depth = 6 generations), we estimated both inbreeding coefficients and kinship between individuals

101 sheep population of St Kilda, using genomic inbreeding coefficients based on 37 037 single-nucleotid

102 In contrast, inbreeding coefficients calculated from a deep and compa

103 Cervus elaphus) in Scotland using individual inbreeding coefficients derived from dense Single-Nucleo

104 We observed significantly higher inbreeding coefficients for the height associated varian

105 cess was reduced by 24% for individuals with inbreeding coefficients greater than twice the populatio

106 However, the estimation of individual inbreeding coefficients in natural populations has been

107 Genomic inbreeding coefficients may resolve the long-standing pa

108 Fitness decreased with increasing inbreeding coefficients.

109 ser Cakile maritima has replaced an earlier, inbreeding, colonizer Cakile edentula (Brassicaceae).

110 rate that a careful choice of the measure of inbreeding combined with LDMS stratification improves bo

111 expression of lethal recessive alleles under inbreeding conditions in wild populations.

112 gered bird species suggests that considering inbreeding could be crucial for conservation programmes.

113 idron, with genetic and skeletal evidence of inbreeding, could be representative of the beginning of

114 s, there are few clear examples in nature of inbreeding decreasing the growth rates of populations, a

115 contribute to variability in the strength of inbreeding depression (ID) observed across adverse envir

116 nbreeding measures commonly used to estimate inbreeding depression (ID).

117 ctions with insects can increase or decrease inbreeding depression (the loss of fitness due to self-f

118 n but may also rescue small populations from inbreeding depression [1-3].

119 se data to determine the extent and cause of inbreeding depression across other plant genomes.

120 find strong support for interactions between inbreeding depression and environmental variation compar

121 Here, we investigate sex determination, inbreeding depression and inbreeding avoidance in Neodip

122 Siring probability also showed inbreeding depression and increased with male age, while

123 tically established, despite being linked to inbreeding depression and sexual selection.

124 species may be particularly at risk because inbreeding depression and stochastic fluctuations in mal

125 We propose that the lack of inbreeding depression and the strong subdivision that ch

126 Differential effects of inbreeding depression are also observed between study si

127 esting that genetic variants associated with inbreeding depression are predominantly rare.

128 ought to increase relative female fitness is inbreeding depression avoidance, the magnitude of which

129 We investigated evidence for inbreeding depression by environment interactions in nin

130 depression." There is mounting evidence that inbreeding depression can be exacerbated by environmenta

131 rovided by parents and alloparents mitigates inbreeding depression for early survival.

132 gest evidence to date of an HFC being due to inbreeding depression in a natural population lacking a

133 Here we investigate inbreeding depression in a range of life history traits

134 resolve the long-standing paucity of data on inbreeding depression in adult traits and total fitness.

135 and suggest that, to date, the prevalence of inbreeding depression in adult traits may have been unde

136 We also confirm previous findings of inbreeding depression in birth weight and juvenile survi

137 y, which revealed similar starting levels of inbreeding depression in both breeding systems, but also

138 ing) influence the experimental evolution of inbreeding depression in Caenorhabditis elegans.

139 and comparatively complete pedigree detected inbreeding depression in juvenile survival, but not in a

140 eding provide a powerful tool for evaluating inbreeding depression in natural populations, and sugges

141 populations, and expand the understanding of inbreeding depression in natural subdivided populations.

142 es using modern genomic tools to investigate inbreeding depression in nature have been limited to sin

143 variation, create new species, and alleviate inbreeding depression in small populations.

144 s, and little is known about the dynamics of inbreeding depression in subdivided populations over tim

145 ny genetic disorders in humans and producing inbreeding depression in the majority of sexually reprod

146 y play an important role as a buffer against inbreeding depression in the offspring by alleviating th

147 um effective population size to avoid severe inbreeding depression in the short term is of the order

148 Determining the genetic basis of inbreeding depression is important for understanding the

149 Overall, the effect of inbreeding depression is more intense in men.

150 Experimental studies often find that inbreeding depression is more severe in harsh environmen

151 Inbreeding depression is of major concern for the conser

152 th America except in southern Florida, where inbreeding depression led to reproductive failure [3-5].

153 Inbreeding depression occurs when inbred individuals exp

154 Inbreeding depression refers to lower fitness among offs

155 We observed preliminary evidence for inbreeding depression related to stress caused by fungal

156 non-lethal mutations, reducing the amount of inbreeding depression relative to that expected without

157 Together, these results suggest that inbreeding depression stemming from CSD has shaped matin

158 nding inconvertible evidence of the cause of inbreeding depression still presents a difficult challen

159 may create a benign environment that offsets inbreeding depression, allowing inbred societies to evol

160 anscription play a role in hybrid vigour and inbreeding depression, and also in the absence of parent

161 scue in facilitating adaptation and reducing inbreeding depression, and suggest that demographic resc

162 luding the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutat

163 levels of inbreeding and reduced fitness via inbreeding depression, even as the population remained d

164 inance was responsible for the observed high inbreeding depression, heterozygote advantage could not

165 Inbreeding depression, measured as the decline in fitnes

166 t in captivity may decrease the intensity of inbreeding depression, relative to the stressful conditi

167 as the potential to moderate the severity of inbreeding depression, which in turn may favor inbreedin

168 vated levels of inbreeding can be reduced by inbreeding depression.

169 while simultaneously estimating sex-specific inbreeding depression.

170 or inviable, sl-CSD can generate substantial inbreeding depression.

171 ficient, revealing direct, but not indirect, inbreeding depression.

172 fects on viability, are contributing to this inbreeding depression.

173 to strong genetic drift and at high risk of inbreeding depression.

174 als dynamic genome evolution and hotspots of inbreeding depression.

175 aphroditic selfing rates and the strength of inbreeding depression.

176 reproductive success, a phenomenon known as inbreeding depression.

177 racteristics that can affect the severity of inbreeding depression.

178 lations have rendered the species at risk of inbreeding depression.

179 eduction in fitness-related traits known as "inbreeding depression." There is mounting evidence that

180 lower fertility; (ii) offspring suffer from inbreeding depression; (iii) parents have more grandchil

181 e decline in fitness-related traits per unit inbreeding, did not vary appreciably among populations o

182 Moreover, inbreeding disrupted growth trait responses to damage, i

183 versity remained high, suggesting occasional inbreeding does not impair local population persistence.

184 ges in population size, arbitrary amounts of inbreeding, dominance and distributions of selective eff

185 ing season while reducing the risk of hidden inbreeding due to related founders from the same habitat

186 consequence, populations with more resident inbreeding (due to their demographic history) paid a hig

187 Thus, efforts to guard against inbreeding effects in populations of endangered species

188 Further, we show that inbreeding effects on breeding date can also be sex spec

189 ct) and male (indirect) additive genetic and inbreeding effects on breeding date, and estimated the c

190 eeding, indicating a phytohormonal basis for inbreeding effects on growth and defence trait regulatio

191 Many studies document negative inbreeding effects on individuals, and conservation effo

192 metapopulation to examine the generality of inbreeding effects.

193 nagement methods are performed, one avoiding inbreeding (equalisation of parental contributions (EC))

194 ed and pollen dispersal can create localized inbreeding even within outcrossing plants.

195 Given the high fitness costs of inbreeding, evolutionary biologists have found it challe

196 First, via inbreeding experiments and flow cytometry, we demonstrat

197 African American cohort had a low degree of inbreeding (F ~ 0.006).

198 Populations with high average inbreeding (F ~ 0.2) had population growth rates reduced

199 gether, this evidence strongly suggests that inbreeding, favored by postdomestication selection for c

200 urthermore show how genetic drift coupled to inbreeding following the population bottleneck has large

201 land plants, and the significance of extreme inbreeding for fern evolution has been a subject of deba

202 en -2.3 and -5.2 phenotypic SDs for complete inbreeding; [Formula: see text]).

203 are in contrast to the idea that effects of inbreeding generally depend on ecological factors and ge

204 ariation to facilitate adaptation and reduce inbreeding (genetic rescue).

205 Inbreeding had negative effects, whereas outbreeding gen

206 (SI) and subsequent mating system shifts to inbreeding has intrigued evolutionary geneticists for de

207 onsequences of mating system variation (e.g. inbreeding) have been studied for at least 200 years, ye

208 phenotypes is found to be sex-related, with inbreeding having a significant decreasing effect in men

209 Here, we present a new method for estimating inbreeding IBD tracts from low coverage NGS data.

210 retical examination of the genomic effect of inbreeding in a forest tree and provides an approach to

211 nean for I. fasciculata, with high levels of inbreeding in all locations and bottleneck signs in most

212 We find signatures of close inbreeding in geographically isolated North American pop

213 mechanism to prevent self-fertilization and inbreeding in higher plants and also is known to utilize

214 enetically controlled system used to prevent inbreeding in higher plants.

215 genetically controlled mechanism to prevent inbreeding in higher plants.

216 ntal inbreeding only, the amount of observed inbreeding in natural populations is generally low compa

217 But just how costly is inbreeding in small populations?

218 ect of parental care on the fitness costs of inbreeding in the burying beetle Nicrophorus vespilloide

219 nd the extent of population-level effects of inbreeding in the wild remains controversial.

220 nificant evidence of variation in individual inbreeding in this population, we found no associations

221 are neither a peculiarity of cultivation nor inbreeding in Z. mays.

222 idence indicate that CentC loss is linked to inbreeding, including (i) CEN10 of temperate lineages, p

223 Because inbreeding increases the probability of producing diploi

224 ic acid were all significantly reduced under inbreeding, indicating a phytohormonal basis for inbreed

225 sity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different

226 llen donors occur, an increase in biparental inbreeding is a potential problem.

227 heterozygosity and fitness, indicating that inbreeding is costly.

228 Quantifying the effects of inbreeding is critical to characterizing the genetic arc

229 Thus, measuring individual inbreeding is crucial for ecology, evolution and conserv

230 Inbreeding is often avoided in natural populations by pa

231 ferns to date that the capacity for extreme inbreeding is prevalent in this lineage, and we discuss

232 e population size, rather than just avoiding inbreeding, is a critical factor for preventing the accu

233 lo has been associated with higher levels of inbreeding, leading to an increase in the prevalence of

234 e evaluate the effects of genetic purging of inbreeding load in small populations, assuming genetic m

235 that genetic purging efficiently removes the inbreeding load of both lethal and non-lethal mutations,

236 We found that the population's inbreeding load was low to moderate (0.98-4.66 haploid l

237 d two past bottlenecks that resulted in some inbreeding load.

238 We show that, for the inbreeding loads considered, CM leads to unacceptably hi

239 When there is no inbreeding loop in the pedigree, the Elston-Stewart algo

240 If there are inbreeding loops in the pedigree, we recommend the Bayes

241 ork algorithm that copes with pedigrees with inbreeding loops without losing calculation precision on

242 abilis) to quantify the relationship between inbreeding, mate kinship, and lifetime reproductive succ

243 Inbreeding (mating between relatives) can dramatically r

244 sequent phenotypic changes in inbred plants, inbreeding may alter plant-insect interactions.

245 Inbreeding may increase the extinction risk of small pop

246 trengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding

247 of wheat hybrids is difficult because of the inbreeding nature of wheat and the lack of a practical f

248 t record differences in genetic diversity or inbreeding, nor did we record any differences between ad

249 s, such as the loss of genetic diversity and inbreeding on an evolutionary timescale.

250 ess well studied is the effect of biparental inbreeding on female fitness.

251 nging, and, consequently, the full effect of inbreeding on fitness remains unclear.

252 The total effect of inbreeding on lifetime breeding success (LBS) was substa

253 orophyte level, we observed a weak effect of inbreeding on offspring fitness, but no effect of brood

254 We tested the consequences of experimental inbreeding on phenotypic plasticity in resistance and gr

255 derlying genetic variation in the effects of inbreeding on plant-insect interactions and the conseque

256 gametophytic selfing, is an extreme form of inbreeding only possible in homosporous groups.

257 First, for species with biparental inbreeding only, the amount of observed inbreeding in na

258 ession because of either an individual's own inbreeding or maternal inbreeding.

259 -old specimen did not indicate any increased inbreeding or reduced genetic diversity, suggesting that

260 implications of these diverse mechanisms for inbreeding/outbreeding balance regulation.

261 et of PEGs maintains functional roles in the inbreeding plant Arabidopsis that become evident upon de

262 sex-specific selection coefficients, and to inbreeding populations.

263 but only two, S1 and S19, are shared by most inbreeding populations.

264 pulations (P < 0.01), reflecting a degree of inbreeding possibly due to severe depletion of natural s

265 We find that: inbreeding promotes paternal genome elimination in the h

266 ults demonstrate that SNP-based estimates of inbreeding provide a powerful tool for evaluating inbree

267 aculatum, we measured selfing and biparental inbreeding rates in four populations and the spatial gen

268 ure was found in all populations, biparental inbreeding rates were low and only differed between sexe

269 is disorder have been created by selectively inbreeding rats for absence seizure-like events with sim

270 arwin was one of the first to recognize that inbreeding reduces evolutionary fitness.

271 Because inbreeding results in elevated homozygosity, greater exp

272 athematical model to determine how degree of inbreeding, sex determination, genomic location, pattern

273 ds aimed at enhancing purging by intentional inbreeding should not be generally advised in captive br

274 ive size, with limited kinship and levels of inbreeding similar to HG populations.

275 rived from interspecific comparisons between inbreeding species and their outcrossing relatives, wher

276 In hybridizations between outbreeding and inbreeding species the paternally silenced allele of the

277 ned the joint influence of maternal care and inbreeding status on fitness-related offspring traits to

278 tions spanning nearly 100 years to show that inbreeding substantially reduced per capita population g

279 t this, Hymenoptera with traits that promote inbreeding, such as gregariousness, may evolve one or mo

280 tain gorilla population has led to extensive inbreeding, such that individuals are typically homozygo

281 but it may also increase the probability of inbreeding that can compromise persistence.

282 00) and experienced low levels of biparental inbreeding (tm-ts=0.00-0.04).

283 Recent inbreeding to select for recessive and unusual coat colo

284 breeding depression, which in turn may favor inbreeding tolerance and influence the evolution of mati

285 notyping can be done in the F1 generation by inbreeding two injected founder fish, significantly redu

286 It is more common in association with inbreeding, under male heterogamety, in males, and in th

287 However, successful inbreeding was rare, and genetic diversity remained high

288 neage bred endogamously and, despite intense inbreeding, was ecologically successful and showed trans

289 Using genomic estimates of realized inbreeding, we discovered that inbred individuals had lo

290 Genomic regions recalcitrant to inbreeding were associated with an increased density of

291 ns, they show increased but varied levels of inbreeding, which result in reduced fitness.

292 dentified mating type bias strongly promotes inbreeding, which we consider to be a potential speciati

293 ity, thereby avoiding deleterious effects of inbreeding while maintaining enough variation from which

294 induced responses is negatively affected by inbreeding, with implications for fragmented populations

295 to the distribution of genetic diversity and inbreeding, with northern populations having the highest

296 t to extinction and maintained fitness under inbreeding, with some families continuing to survive aft

297 ext of diversity measures we found a lack of inbreeding within breeds, suggesting the collection repr

298 There was more inbreeding within pasture trees (outcrossing=0.828+/-0.0

299 genetic structure, there was no evidence of inbreeding within the populations, suggesting mechanisms

300 Finally, we investigated the consequences of inbreeding within the SNPRC colony and found clear evide

301 by a larger variance in fitness explained by inbreeding within these populations.