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1 s, and histopathologic classification remain incapable in terms of treatment decision and prognosis e
5 s, which preserve polar interactions but are incapable of acid-base chemistry, had little effect on e
6 n of wild-type S1PR2, but not a point mutant incapable of activating downstream signaling pathways, i
7 o produced TF, but (in contrast to ECs) were incapable of activating FX without the exogenous additio
10 olycomb mechanism, the system was frequently incapable of adding new states, whereas with the Polycom
13 Regions smaller than Swi11-32 are either incapable of aggregation or unstably propagate [SWI(+)].
16 ought to be terminally differentiated cells, incapable of altering their gene expression after differ
18 d, lacking in robustness and consistency, or incapable of analysing 5-methylcytosine specifically.
19 g membrane protein endocytic trafficking are incapable of antagonizing TIM-mediated inhibition of HIV
20 ing site leads to variants (E184Q and E184A) incapable of any amino acid transport, pointing to a pot
22 nopore reads, because existing packages were incapable of assembling the long read lengths (5-50 kbp)
23 Most measurement approaches, however, are incapable of assessing stiffness in the presence of phys
24 iting RPE65, whereas an emixustat derivative incapable of atRAL sequestration was minimally protectiv
27 cinated canines, not from a novel CPV strain incapable of being neutralized by current vaccination ef
29 ed irreversibly developmentally locked, i.e. incapable of being reprogrammed in vivo into entirely di
36 omputed for RetGC1/NPRA chimeras, even those incapable of binding GCAP, remained high, and functional
40 ylated STAT1, but not that of a STAT1 mutant incapable of binding its nuclear import adaptor karyophe
41 6A mice carrying a mutant form of fibrinogen incapable of binding leukocyte alphaMbeta2-integrin were
42 hift mutations resulting in a truncated Riz1 incapable of binding PR-Set7 occur frequently in various
43 n atom to carbon appear to render the enzyme incapable of binding the analog in the active conformati
46 residues on B', which when mutated render B' incapable of binding to and stimulating HTLV-1 and -2 IN
51 cells transfected with beta-catenin mutants incapable of binding to TCF/LEF increased BACE1 gene pro
53 failed to replicate within the cytosol were incapable of blocking apoptosis and exhibited reduced vi
54 phosphorylation-mimicking mutant, S381E, was incapable of bundling microfilaments, it retains the abi
55 le hydrogen activation and spillover but are incapable of C-C bond scission that leads to loss of sel
58 as reduced upon infection, and the mice were incapable of Chlamydia-specific immunoglobulin M or immu
59 , B, and L; and MMP-3, -7, -12, and -13 were incapable of cleavage of chondroadherin at this site and
61 n the NCR169 peptide with serine rendered it incapable of complementation, demonstrating an absolute
66 and exogenous (community) viruses, and to be incapable of controlling them as quickly and effectively
67 s of cells, such as liposomes, are typically incapable of cooperation and therefore cannot readily di
74 entire multi-particle capsule or tablet are incapable of detecting pellet-to-pellet variations in co
83 of anti-B5, anti-A33, and anti-A56 MAbs was incapable of directly neutralizing EV, even at high conc
86 ds to measure formaldehyde-induced DPCs were incapable of discriminating between endogenous and exoge
87 his mutant enzyme, whereas still active, was incapable of DNA binding and could no longer be stimulat
89 1 or mt-long alpha/beta 317-323 hOgg1 mutant incapable of DNA repair (mt-hOgg1-Mut) each blocked A549
92 ntrolling individual gene expression, remain incapable of dynamically coordinating complex transcript
93 nfortunately, most gene delivery vectors are incapable of efficient or specific gene delivery to NSCs
94 tion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasil
97 ed IgE binding to FcepsilonRI, rendering IgE incapable of eliciting mast cell degranulation, thereby
98 managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), sug
103 scherichia coli K12 MG1655 DeltamotA that is incapable of encoding the motor torque generator for fla
104 k the intracellular domain and are therefore incapable of endocytosis in the ligand-expressing cell.
105 and slow relaxation time and, therefore, are incapable of ensuring complex inter-pulse dynamics and b
107 , we show that two load-bearing kinesins are incapable of equally sharing the load unless they are ve
108 lly (mono) attractive" meaning that they are incapable of exhibiting multiple steady states, oscillat
111 ation because the recovery of chimeric mice, incapable of expressing p57 in HSPCs, phenocopies blocka
112 In this work, we generated a recombinant MuV incapable of expressing the V protein (rMuVDeltaV).
113 to F-actin in a similar manner to Vt, MVt is incapable of F-actin bundling and inhibits Vt-mediated F
114 sp-AT-PLP-AFPA complex revealed that GabR is incapable of facilitating further steps of the transamin
115 ain-specific conditional knockout (KO) mouse incapable of FAO due to the loss of carnitine palmitoylt
122 A-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pairs
125 monomers, bending them into a shape that is incapable of forming ordered beta-sheets or fibrils.
126 ociated with C1163R C-Proalpha2(I), which is incapable of forming stable trimers and is retained with
129 he stalled fork (fork collapse) rendering it incapable of further DNA synthesis unless recombination
130 or S-sulfonic (Cys-SO(3)H) acids, which are incapable of further participating in homeostatic redox
137 olutionarily related to small GTPases but is incapable of GTP-binding and conformational switching.
139 se-dead RelMtb mutant, RelMtb(H80A), that is incapable of hydrolyzing (p)ppGpp but still able to synt
146 many loosely coupled 'particles', which are incapable of independent locomotion and do not possess i
148 at recognize bacterial ligands were not only incapable of inducing CD8 T cell priming, but they had a
149 iously that encephalitogenic CD4 T cells are incapable of inducing EAE when B cells are the sole APC.
150 ensitized DOV13, an ovarian cancer cell line incapable of inducing REDD1, to orlistat-induced cell de
154 in formation of fewer sporozoites which were incapable of infecting naive mice or hepatocytes in vitr
156 the (-)-JQ1 enantiomer that is structurally incapable of inhibiting BET bromodomains, which resulted
157 p variants that made CHIKV and its replicons incapable of inhibiting cellular transcription and drama
159 these amino acids are mutated, rendering it incapable of inhibiting the transcriptional activity of
160 ly, DCs generated from Ifnar1(-/-) mice were incapable of initiating Th2 responses in vivo These data
161 t to A416P, either A420P or A425P mutant was incapable of interacting and regulating cellular Src.
165 contrast, Par complex recruited by MPP5a is incapable of interacting with Rab11 but might assemble c
166 ation in MLL5-KD cells, whereas MLL5 mutants incapable of interacting with the PBD failed to do so.
167 ng of palmitic acid renders these regulators incapable of interacting with their respective operator
168 a noncytopathic VEEV capsid protein that is incapable of interfering with the innate immune response
169 scription factors (T-bet and Eomes) and were incapable of interferon-gamma production or cytotoxic re
170 nsis subsp. tularensis Schu S4 avirulent and incapable of intracellular replication, owing to an inab
171 merization dynamics will render the parasite incapable of invading a host cell and thereby unable to
172 cking and analysis, but these techniques are incapable of label-free selective nanoparticle recogniti
173 axo-dendritic and axo-spinous synapses, was incapable of long-term potentiation, and less effectivel
174 we report that geriatric satellite cells are incapable of maintaining their normal quiescent state in
175 -type allele, as were FtsN levels in strains incapable of making disulfide bonds (dsb(-) ) exposed to
176 models to convert a naturally occurring ChR incapable of mammalian localization into one that locali
178 kin to general anesthesia (GA), and hence is incapable of meaningful cognitive processing-the sole pu
181 (A795P) enhances NF-kappaB activation but is incapable of mediating TRIF-dependent IFN response facto
182 of 5-aza was dissociated, CHOP ablation was incapable of modulating cytotoxicity; however, neutraliz
183 anti-CD20 during Pneumocystis infection are incapable of mounting a protective immune response when
184 nvertebrates, mammalian somatic cells appear incapable of mounting an RNAi response and few, if any,
190 type single-chain uPA, but not uPA variants incapable of nuclear transport, increases the expression
191 c moieties (4-Me), displaying a Ag(I) center incapable of O2 binding (7-H) or a cationic Pd-H motif (
193 wever, CgrAlcOx and CglAlcOx are essentially incapable of oxidizing galactose and galactosides, but i
194 the capsid protein make this protein almost incapable of packaging the PIV genome, and most of the r
195 the nucleic acids (e.g. pDNA and siRNA) are incapable of passively crossing the endothelium, cell me
196 s incident to a highly scattering medium are incapable of penetrating deep into the medium due to the
197 sing a late-model Q-TOF instrument otherwise incapable of performing electron-based fragmentation, we
198 f translation inhibition, as lamotrigine was incapable of perturbing protein synthesis in vivo or in
199 ble hemagglutinin (HA) proteins are rendered incapable of pH-induced triggering for membrane fusion,
201 by two-photon microscopy that mouse retinas incapable of phagocytosis due to a deficiency of the c-M
202 into mammalian cells that an HP1alpha mutant incapable of phase separation in vitro forms smaller and
206 mice had normal resting heart rates but were incapable of physiological fight or flight heart rate ac
209 ild-type cells expressing a vimentin variant incapable of polymerization exhibit deficient endoplasmi
210 igand-binding pocket and renders the protein incapable of prenyl binding, is supported by molecular d
211 ylori mutants lacking either GGT or VacA are incapable of preventing LPS-induced DC maturation and fa
214 aracterized an msbB in-frame deletion mutant incapable of producing an acyltransferase that is respon
218 erely altered in gametocyte development, are incapable of producing mature-stage gametocytes, and are
219 ordingly, neutrophils from this patient were incapable of producing neutrophil extracellular traps (N
220 Notably, an E. coli rnhA mutant, which is incapable of producing RNase H and thus harbors increase
224 unlike the isogenic wild-type parent, it is incapable of propagating on certain groEL mutant hosts.
226 novel P. gingivalis W50 PPAD mutant strain, incapable of protein citrullination, and serum from dise
228 hnique for all traumatic brain injury, it is incapable of providing long-term prognostic information
230 malaria parasite, Plasmodium falciparum, is incapable of pyrimidine salvage for mRNA biogenesis.
232 the interstellar medium) has been considered incapable of rapidly terminating star formation on galac
237 ural IgG and natural IgA because they appear incapable of recognizing Ags on their own and are percei
238 e murine Anp32 orthologues; murine Anp32A is incapable of recovering IAV polymerase activity, while m
245 formation in ERMES-depleted strains and are incapable of rescuing MDC formation in cells lacking Gem
246 that bare doped silicon microelectrodes are incapable of resolving different grades of attached cell
247 urrent liquid-metal-based strain sensors are incapable of resolving small pressure changes in the few
249 the other hand, are axiomatically considered incapable of responding to damage and healing it, leadin
250 tive in suppressing viral replication, it is incapable of restoring the "leaky gut," which poses an i
253 ly in WT mice, but in B cell-sufficient mice incapable of secreting antibodies, suggesting a predomin
256 al thiols, consistent with C119S/C162S being incapable of sensing H2O2 Similarly, disulfide heterodim
257 s are ineffective at capturing CTC clusters, incapable of separating clusters from single cells and/o
258 g a mutated TNFR1 ectodomain (p55(Deltans)), incapable of shedding and dampen the inflammatory respon
259 subjective, labor-intensive, slow, and often incapable of showing the detailed features of each uniqu
261 According to this hypothesis, individuals incapable of simulating observed movements in their moto
262 which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and pro
264 n) revealed that two of the four clones were incapable of spontaneously activating EMT, whereas the o
266 intracellular parasite Toxoplasma gondii is incapable of sterol synthesis and unremittingly scavenge
267 ed basal ATPase activity, but PC lipids were incapable of stimulating ATPase activity highlighting th
268 rominently the D129G CaM mutation, which was incapable of stimulating Thr(286) autophosphorylation.
269 evalent view that the adult mammalian CNS is incapable of structural reorganization to adapt to an al
270 issions, but would also create a food supply incapable of supporting the US population's nutritional
274 n to recover in lakes that were historically incapable of sustaining wild fish due to acidic conditio
279 at many tropical taxa may be physiologically incapable of tolerating dry conditions, and that their d
280 chromatin remodeling can render splenocytes incapable of transferring diabetes into immunodeficient
281 d with free virus, infected MDMs or DCs were incapable of transferring MeV to HAE when applied to the
284 Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic meth
286 atroviride Furthermore, Deltahda-2 VOCs were incapable of triggering plant defenses to counterattack
290 , we found that beta-catenin null cells were incapable of undergoing acinar to ductal metaplasia, a p
292 Using a genetically engineered mouse model incapable of undergoing STAT3 Ser727 phosphorylation, we
293 ing both permeases, DeltafpuBDeltafatCD, was incapable of using petrobactin as an iron source and exh
295 mental evolution of two isolates lacking (or incapable of using) MaDH to uncover the physiological ch
296 lly, we identified a 1,2,3-triazol-4-yl base incapable of W/C H-bonding that performs well at guide s
297 glutamate to alanine in its active site was incapable of XfDSF production yet enabled a response to
300 o the fraction of beaded dendrites that were incapable to recover during repolarization, thus facilit