ライフサイエンスコーパス: incapacitate

1 ), averaged 19 episodes of 13 days, and were incapacitated 8 months over 14 years.

2 But they are also maladaptive in that they incapacitate a coccinellid beetle (Hippodamia convergens

3 indicating that the liver does not uniformly incapacitate activated CD8+ T cells.

4 While the mechanisms underlying these incapacitating acute symptoms remain partially understoo

5 Chronic viral infections incapacitate adaptive immune responses by "exhausting" v

6 Family decision makers of incapacitated adult ICU patients completed the Brief COP

7 rogates of making treatment decisions for an incapacitated adult.

8 e and Aedes (Ae.) aegypti Kir1 channels that incapacitates adult female mosquitoes from representativ

9 gate consent and other safeguards to protect incapacitated adults in research.

10 , and other safeguards in research involving incapacitated adults.

11 ces and limits on risks in studies involving incapacitated adults.

12 e consequences for needed research involving incapacitated adults.

13 's call for safeguards in research involving incapacitated adults.

14 imits on research risks in studies involving incapacitated adults: 15% disallow any research regardle

15 make or help to make treatment decisions for incapacitated adults; however, the effect of this practi

16 inol (3Q), a marker for the riot control and incapacitating agent quinuclinidyl benzilate (BZ), using

17 toxic shock syndrome and act as a lethal and incapacitating agent when used as a bioweapon.

18 hus, small molecule inhibitors of CARM1 will incapacitate all of the enzyme's cellular functions.

19 mpaired the PI3K-AKT-GSK-3beta-mTOR pathway, incapacitating anabolic support required for attaining t

20 Snake venom is well known for its ability to incapacitate and kill prey.

21 For elderly people who live alone, becoming incapacitated and unable to get help is a common event,

22 Because the proton release group is incapacitated, and early proton release is eliminated in

23 s in the posterior group considered the pain incapacitating, and the mean time to return to work was

24 KV) is an alphavirus that causes chronic and incapacitating arthralgia in humans.

25 es that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalit

26 . rudis consistently becomes physiologically incapacitated at minimum and maximum temperatures 2 degr

27 tion, disruption of cellular homeostasis and incapacitating ataxia.

28 -1 may have developed multiple strategies to incapacitate autophagy to ensure replication.

29 The formation of an incapacitating biofilm on Caenorhabditis elegans by Yers

30 phylococcal enterotoxin B (SEB), a potential incapacitating bioterrorism agent and a major cause of f

31 e in 1 s (FEV1) less than 50% predicted, and incapacitating breathlessness (Medical Research Council

32 ession and, with evolutionary time, ERVs are incapacitated by accumulating mutations and deletions.

33 all while translating cytosolic proteins are incapacitated by incomplete nascent chains, termed "arre

34 rug discovery opportunities for this common, incapacitating chronic disease.

35 Neuropathic pain is a common and often incapacitating clinical problem for which little useful

36 eldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relaps

37 nylalanine (L-DOPA)-induced dyskinesia is an incapacitating complication of L-DOPA therapy that affec

38 y range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives.

39 r even latent disease to life-threatening or incapacitating conditions.

40 rognosis by individuals making decisions for incapacitated critically ill patients (surrogates) are c

41 es were between clinicians and surrogates of incapacitated, critically ill adults.

42 s were 179 surrogate decision-makers for 142 incapacitated, critically ill patients at high risk for

43 ted daily with surrogate decision-makers for incapacitated, critically ill patients at high risk of d

44 mation is important to the family members of incapacitated, critically ill patients, yet little is kn

45 oding laminin alpha2 chain), is a severe and incapacitating disease for which no therapy is yet avail

46 Peripheral artery disease is a potentially incapacitating disease for which pharmacological options

47 emerging mosquito-borne pathogen that causes incapacitating disease in humans characterized by intens

48 allei is the causative agent of glanders, an incapacitating disease with high mortality rates in resp

49 ategies for stopping the progression of this incapacitating disease.

50 Despite the enormous societal costs of this incapacitating disorder, it is largely unknown how the l

51 iring DsbA-mediated disulfide bond formation incapacitates diverse beta-lactamases and destabilizes m

52 talized for HFNEF are most often chronically incapacitated elderly women with a history of hypertensi

53 ggests that all of these enzymes function to incapacitate essential homeostatic pathways during the e

54 alities present in a subset of patients with incapacitating fecal urgency and associated urge fecal i

55 Sexual transfer of 20E appears to incapacitate females physically from receiving seminal f

56 ectricus) are legendary for their ability to incapacitate fish, humans, and horses with hundreds of v

57 l block of AeKir1 and renders the mosquitoes incapacitated (flightless or dead) within 24 hours.

58 s 2) is resulting in high fatality rates and incapacitated health systems.

59 The surrogates and physicians of 275 incapacitated ICU patients at high risk of death.

60 Many patients who develop incapacitating illness have not expressed clear treatmen

61 f-life were seldom used when the patient was incapacitated: imputation (19%), assigning fixed utiliti

62 only the Deltaasl null mutant was profoundly incapacitated in its ability to infect mice.

63 The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific

64 Individuals with a terminal illness, incapacitated individuals, including those with a severe

65 on by cutaneous innate immunity may avoid an incapacitating infection of the host that would limit op

66 he desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-tox

67 n that is negated by a Fes-R483K mutant that incapacitates its Src homology 2 domain.

68 Patients infected with CHIKV suffer from incapacitating joint pain that severely affects their da

69 e study of 230 surrogate decision makers for incapacitated, mechanically ventilated patients at high

70 e unusual case presented in middle life with incapacitating muscle cramps associated with calf hypert

71 imulated in a low-Na(+) solution designed to incapacitate Na(+)-Ca(2+) exchange, irrespective of whet

72 balism and biofilm defence, since this would incapacitate neighbouring cells by inhibiting motility a

73 Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia

74 generated with precise knock-in mutations to incapacitate NLS function.

75 deliver multiples of standard neuromuscular incapacitating (NMI) discharge that matched the waveform

76 pools, algal blooms can produce toxins that incapacitate or kill animals and humans and even the ter

77 s are only deployed when the tmRNA system is incapacitated or overwhelmed by stalled ribosomes.

78 Patients who presented with severe or incapacitating pain and a large number of lesions were l

79 amp on the prey's head until it is killed or incapacitated, particularly when dispatching larger liza

80 ed in decisions to limit life support for an incapacitated patient in the ICU have high rates of adve

81 d life-sustaining treatment decisions for an incapacitated patient near the end of life.

82 e about the decision-making process for each incapacitated patient without a surrogate or advance dir

83 (19%), and surrogates reporting on behalf of incapacitated patients (5%).

84 fy the treatment preferences of decisionally incapacitated patients and can experience significant di

85 he United Kingdom, while attempts to protect incapacitated patients in the United States have attract

86 Mentally incapacitated patients were also excluded.

87 ve care units have withdrawn life support in incapacitated patients who lack surrogate decision maker

88 s (13 of 49) during the study period were in incapacitated patients who lacked a surrogate (95% CI, 1

89 f deaths in intensive care units occurred in incapacitated patients who lacked a surrogate decision m

90 t presume to make thrombolysis decisions for incapacitated patients with acute ischemic stroke becaus

91 Incapacitated patients without surrogates accounted for

92 The number of incapacitated patients without surrogates in the study i

93 nd how clinicians talk with surrogates about incapacitated patients' preferences and values.

94 fy the treatment preferences of decisionally incapacitated patients.

95 o high-quality surrogate decision making for incapacitated patients.

96 Since even decisionally incapacitated persons cannot be enrolled in studies agai

97 Shigella also translocates via M cells and incapacitates phagocytes, but subsequently re-enters the

98 large epidemics worldwide and leads to acute incapacitating polyarthralgia.

99 ized by two terms: regulation power (RP) and incapacitating power (IP).

100 verning treatment decisions for decisionally incapacitated pregnant women.

101 have evolved diverse molecular mechanisms to incapacitate prey and defend against predators.

102 Electric eels can incapacitate prey with an electric discharge, but the me

103 ctively target ion channels and receptors to incapacitate prey.

104 tiple proteins that collectively function to incapacitate prey.

105 R-targeted peptides used by Conus species to incapacitate prey.

106 uding procoagulants to defend themselves and incapacitate prey.

107 new mechanism by which a eukaryotic pathogen incapacitates proinflammatory cytokine production during

108 In particular, infection incapacitates PRRSV-susceptible CD14(pos) antigen-presen

109 n lungs and to define virulence factors that incapacitate pulmonary cells.

110 In vitro, antibody to PVL incapacitated PVL-mediated activation of PMNs, indicatin

111 Incapacitated regulatory T cells (Tregs) contribute to i

112 Incapacitating ROS-generating NADPH oxidase or the recep

113 pid disease progression, at least in part by incapacitating SIV-specific CD4(+) T cell responses.

114 that males can both physically displace and incapacitate stored sperm from earlier-mating males.

115 rane composition influences ERAD function by incapacitating substrate extraction.

116 n, allowing for management before physically incapacitating symptoms appear.

117 consequences of HCM such as sudden death and incapacitating symptoms have been emphasized for the you

118 no or mild symptoms and 69 (25%) experienced incapacitating symptoms or HCM-related death; 53 (19%) o

119 ependent and commonly associated with highly incapacitating symptoms.

120 emely contagious disease, and it can quickly incapacitate the healthcare systems if infected cases ar

121 n uptake and delivery when low pH conditions incapacitate the highly pH-sensitive Root effect hemoglo

122 n CARD15 do not underlie this phenotype, but incapacitate the NOD2 pathway that can compensate for im

123 deficiency of either TLR4 or LBP completely incapacitated the ability of macrophages to secrete IL-2

124 cks of porphyria, reputedly the disease that incapacitated the British sovereign King George III (see

125 TAT5, NFIB and ELF5 in the proximal enhancer incapacitated the entire super-enhancer.

126 After we surgically incapacitated the MTM as a vibratory source, zebra finch

127 me host, however, if rapid viral replication incapacitates the host, this fast-replicating virus may

128 event in eukaryotes, is a key mechanism that incapacitates the mitotic checkpoint at anaphase.

129 e presence of O(2)-an intruder that normally incapacitates the sulfur- and electron-rich active site.

130 in ESX, suggesting a therapeutic approach to incapacitating the Her2 gene by small organic molecules.

131 ields, hijacking host RNA stability factors, incapacitating the host decay machinery and changing the

132 ir survival, which often involve blinding or incapacitating the immune response, thereby gaining batt

133 Incapacitating the NDH-like pathway only slightly change

134 1 (RIPK1) recruitment at the TNFR1 complex, incapacitating the TNFR1-NFkB signaling and consequently

135 m in "exhausted" T cells that extends beyond incapacitating them.

136 on had tremor-related disability and 10% had incapacitating tremor.

137 The active site-incapacitated variant FXII-W268R/S544A reveals that intr

138 Incapacitating venous claudication noted in 62.5% (10 of

139 pattern of tumor antigen gene mutation that incapacitates viral DNA replication.

140 s a potentially valuable strategy to prevent incapacitating vision loss later in life.

141 and "new" nerve agents), and blistering and incapacitating warfare agents.

142 trophils, are recruited to the lungs but are incapacitated when they enter the airways by the P. aeru

143 render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly un

144 more likely to cough in public before being incapacitated with fever.