ライフサイエンスコーパス: incise

1 NA until all dimers have been recognized and incised.

2 d relaxed forms of the uvDNA are effectively incised.

3 that both the Susquehanna and Potomac Rivers incised 10- to 20-meter-deep gorges along steep, convex

4 aeal Holliday junction resolvases evolved to incise 5' flap substrates and how FAN1 integrates with t

5 ficiently remove sugar-phosphate residues at incised 5' AP sites.

6 that removes 2-deoxyribose-5-phosphate at an incised 5' apurinic/apyrimidinic (AP) sites via a beta-e

7 ing 3' incision were rapidly and efficiently incised 5' to the adduct.

8 hile binding was not observed on a substrate incised 5' to the AP-site.

9 5' of the lesion, or endonuclease XPF, which incises 5' to a lesion, exhibited increased clonogenic s

10 nner identical to the prokaryotic pattern by incising 7 nt 5' and 3 or 4 nt 3' to the photoproduct, a

11 MtTGendo does not incise 8-oxodeoxyguanosine or uracil-containing duplexes

12 se, the base excision repair enzyme known to incise 8-oxoG in DNA.

13 ity of nuclear and mitochondrial extracts to incise 8-oxoG lesion in cell lines H1650 and H226 expres

14 the motif VI of the putative helicase domain incised 8-hydroxyadenine in vitro less efficiently than

15 a DNA glycosylase/AP lyase that specifically incises 8-oxoG opposite cytosine.

16 ir complex from Escherichia coli, is able to incise a variety of types of DNA damage and the repair e

17 GST-Rad2p incises a 5'-flap and a 5'-pseudo-Y structure one base 3

18 Human XPF-ERCC1 is a DNA endonuclease that incises a damaged DNA strand on the 5' side of a lesion

19 cture-selective endonuclease Mus81-Mms4/Eme1 incises a number of nicked joint molecule substrates in

20 double mutant proteins with both intact and incised abasic DNA were significantly more stable than c

21 y was inhibited by the presence of nearby 5'-incised abasic residues, which result from the apurinic/

22 se, DNA Pol beta recognizes and binds to the incised abasic site and promotes recruitment of the DNA

23 Pol beta has a 7-fold higher affinity to the incised abasic site containing substrate than DNA ligase

24 When preformed complexes of APE1 and the incised abasic site product (APE1 product and Pol beta s

25 ouble-stranded oligonucleotide containing an incised abasic site was supershifted by XRCC1 in a gel r

26 ter dissociation of AP endonuclease from the incised abasic site, both DNA polymerase beta (Pol beta)

27 sidue is located near the 5' terminus of the incised abasic site, repair continues as efficiently as

28 strongly to the enzyme incision product, an incised abasic site, which suggested that Ape1 might exh

29 d the duration of the ternary complex on the incised abasic site.

30 ortive ligation reactions that take place at incised abasic sites in DNA.

31 a by specifically inhibiting synthesis on an incised abasic substrate but not on single-nucleotide ga

32 -specific 5'nucleases precisely identify and incise aberrant DNA structures during replication, repai

33 ase activity, implying that the endonuclease incises adjacent to junction branch points to achieve re

34 strength to the upper decimetre to meter of incised alluvium to allow high sinuosity of stream chann

35 of endonuclease IV (Endo IV) to efficiently incise alpha-deoxyadenosine was used as a tool to determ

36 Whereas RnhA does not incise an embedded mono-ribonucleotide, it can efficient

37 eotide when paired to an oxidized base or to incise an oxidized ribonucleotide in a DNA duplex.

38 We found that AP endonuclease 1 incised an abasic site on the nontemplate strand of a TN

39 d that endonuclease IV plays a major role in incising an AP-peptide cross-link within E. coli cell ex

40 ed to the contralateral horn, which had been incised and cleared of its contents, prior to being wrap

41 the first 2 patients the prostate gland was incised and imaged with CLI to visualize the primary tum

42 zed dogs, the skin over the thigh muscle was incised and raised, forming a cradle superfused with hep

43 Various amines can incise AP sites via a similar mechanism, but this non-en

44 itiated repair is delayed at the stage of an incised AP site and the rate of further processing of th

45 ans-4-hydroxy-2-pentenal-5-phosphate at a 3' incised AP site by a Mg2+-dependent hydrolytic mechanism

46 factor responsible for the excision of a 5'-incised AP site in the PCNA-dependent pathway.

47 e and the rate of further processing of this incised AP site is dependent on the position of the rema

48 ose polymerase-1 affinity and turnover on an incised AP site, we find that 8-oxoguanine-DNA glycosyla

49 residue located near the 3' terminus of the incised AP site.

50 sphate from an endonuclease IV (endo IV) pre-incised AP site.

51 rans -4-hydroxy-2-pentenal-5-phosphate at 3' incised AP sites and from intact AP sites.

52 e residues from DNA substrates containing 5'-incised AP sites as well as from DNA substrates containi

53 l-5-phosphate from a substrate containing 5'-incised AP sites occurred via a beta-elimination reactio

54 5-phosphate from the substrate containing 3'-incised AP sites was dependent on the presence of the Mg

55 of this protein on DNA substrates containing incised AP sites was examined.

56 as a deoxyribophosphodiesterase acting on 5'-incised AP sites.

57 n length of 26-27 nucleotides are removed by incising approximately 20 phosphodiester bonds 5' and 5

58 e deoxyribose phosphate (dRP) groups from 5'-incised apurinic/apyrimidinic (AP) sites during base exc

59 a 3'-phosphodiesterase on DNA containing 3'-incised apurinic/apyrimidinic (AP) sites to remove the p

60 During BER, Ape1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP

61 ma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substra

62 duplex genomic DNA, Ape1 has the ability to incise at AP sites in DNA conformations formed during DN

63 the multifunctional human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via si

64 ility to scan nontarget DNA and processively incise at pyrimidine dimers in UV-irradiated DNA.

65 e (mtODE) from rat liver that recognizes and incises at 8-oxoG and abasic sites in duplex DNA.

66 It is specific for 8-oxoG and preferentially incises at 8-oxoG:C base pairs.

67 For base-substitution mismatches, SP incises at all mismatches except those containing a guan

68 UvrABCI incises at both the 5' and 3' sides of the adduct (UvrAB

69 subtilis lacking RNase HII, the enzyme that incises at single rNMP residues initiating RER.

70 Cerenkov luminescence images from incised BCS specimens were analyzed postoperatively by 2

71 oth UvrABC(Bca) and UvrABC(Tma) specifically incised both BPDE-adducted plasmid DNAs and site-specifi

72 UvrABC incised both strands of the cross-linked DNA, although t

73 strand containing the nick is preferentially incised, but the nick influences the cleavage sites.

74 2-Deoxyribonolactone is not incised by any of the 8 AP lyases tested.

75 ving an abasic site that was subsequently 5'-incised by AP endonuclease 1, introducing a single-stran

76 xcision of intercalated TXNA-DNA adducts are incised by AP endonuclease less efficiently than those f

77 d even if the AP site has been previously 5'-incised by AP endonuclease, resulting in a 5' 2-deoxyrib

78 ining a synthetic abasic site; this site was incised by apurinic/apyrimidinic endonuclease creating a

79 in which ICLs are recognized and are rapidly incised by ERCC1/XPF independent of DNA replication.

80 ) in an otherwise identical DNA sequence was incised by exonuclease III or endonuclease IV approximat

81 n C or cisplatin-induced DNA lesions are not incised by global genome nucleotide excision repair (GGR

82 Here we show that streams incised by groundwater seepage branch at a characteristi

83 amma-rays, d(G[8-5m]T) can be recognized and incised by purified Escherichia coli UvrABC nuclease.

84 rate that the DNA damage is less efficiently incised by recombinant AP endonuclease 1 (APE1) when the

85 is most efficient when the ribonucleotide is incised by RNase H2, and further excised by the flap end

86 anscript because 1,N (6)-erA is incompletely incised by RNase H2.

87 The tandem lesion is also incised by the bacterial nucleotide excision repair syst

88 apyrimidinic (AP) site that is subsequently incised by the lyase activity.

89 Although dL residues are efficiently incised by the main human abasic endonuclease enzyme Ape

90 ) DNA-peptide cross-links can be efficiently incised by the NER proteins and (2) DNA-peptide cross-li

91 in DNA duplexes of known conformations were incised by UvrABC nuclease with efficiencies varying by

92 substrates were also equally and efficiently incised by UvrBC nuclease without UvrA.

93 We report here the discovery of a deeply incised canyon of the Yarlung Tsangpo River, at the east

94 preserved atop interfluves above the deeply incised canyons of eastern Tibet.

95 The heads of the shelf-incised canyons preferentially migrate northwestward and

96 are actually fill terraces, and historically incised channels are not natural archetypes for meanderi

97 mplex stability in the presence of EDTA (non-incising conditions) is significantly weaker for ssDNA t

98 Confinement of the Sutlej to its present incised course after 8 ka likely reduced its propensity

99 ask the deficiency in ability of FA cells to incise cross-linked DNA and could account for the report

100 nts is owing to defects in the processing of incised cross links and the consequential failure to ini

101 entical incision, followed by removal of the incised cylinder of skin, leaving a denervated area in w

102 eneration of the nerve fibers that enter the incised cylinder, leaving a defined zone of denervated d

103 MutY does not incise dA from a duplex containing this nucleotide oppos

104 MutY incises dA when it is opposite Fapy.dG and strongly bind

105 o ultraviolet light but are still capable of incising damaged DNA.

106 the shelf edge was reached and subsequently incised, development of the canyon heads was influenced

107 pair and homologous recombination, and which incise distinct non-B DNA structures.

108 orated into the protein complexes capable of incising divergent substrates.

109 alian cell-free extracts incubated with Ape1-incised dL substrates under non-repair conditions give r

110 NER), and knockdowns of ERCC1 and XPG, which incise DNA adjacent to damage, stabilize CAG repeat trac

111 ncoded by the UvrA, UvrB, and UvrC genes can incise DNA containing bulky nucleotide adducts and intra

112 cificities, as evidenced by their ability to incise DNA containing many types of UV and some types of

113 UvrB and UvrC work together to recognize and incise DNA damage during the process of nucleotide excis

114 nguished nuclease active sites to presumably incise DNA damage.

115 y of rectification and directs repair to the incised DNA strand.

116 T4 endonuclease V-incised DNA was processed in the same way.

117 nd activation of the endonuclease MutH which incises DNA at a hemi-methylated GATC site.

118 -Pdg) is a base excision repair protein that incises DNA at cyclobutane pyrimidine dimers that are fo

119 is study, we report that purified MUS81-EME1 incises DNA at the 5' side of a psoralen ICL residing in

120 alpha is a strand-directed endonuclease that incises DNA in a reaction that depends on a mismatch, yM

121 The UvrABC nuclease incises DPCs with a moderate efficiency.

122 Ape1 surface that contacts the 3' end of the incised duplex (downstream of the incision site).

123 g a more relaxed grip on this section of the incised duplex to facilitate the handoff to the downstre

124 Moreover, mimivirus TopIB is capable of incising duplex DNA at the 5'-CCCTT cleavage site recogn

125 ailed duplex DNAs and that MPE can sense and incise duplexes at sites of short mismatch bulges and op

126 In contrast, the Ntg2 protein does not incise duplexes containing 8-OH-Gua mispaired with any o

127 Recently, Ape1 was found to incise efficiently at AP sites positioned within the sin

128 ivation of MutLalpha endonuclease, which can incise either DNA strand.

129 a manganese-dependent DNA endonuclease that incises either linear single strands or the single-stran

130 Here, we test the hypothesis that the incised, enlarged channel downstream of dams provides en

131 systems whose phase diagrams contain deeply incising eutectics can offer opportunities to address th

132 MutY also does not incise Fapy.dA when the lesion is opposite dG.

133 Endo IV incises Fapy.dG to less than 5% under comparable reactio

134 een inundated by sediment, and therefore not incising, for much of the post-glacial period.

135 precursors, especially including abstractly incised fragments of ocher and perforated shells interpr

136 ision provoked by MeG-T is restricted to the incised heteroduplex strand, leading to removal of the M

137 initiate mismatch-dependent unwinding of an incised heteroduplex.

138 y a large number of delicate black, red, and incised hieroglyphs.

139 The inability of Uvr(A)BC to incise highly positively supercoiled uvDNA results from

140 elium after direct application of taurine on incised human gingival samples.

141 cation or transcription, as the GGR does not incise ICL-lesions.

142 However, the incised ICLs are then processed further and DNA double-s

143 Ma allows rivers to compete with uplift and incise into endorheic basins at the plateau edge.

144 vial episodes allowed antecedent drainage to incise into uplifting fault scarps, which in turn genera

145 iteria for groundwater sapping because it is incised into a basaltic plain with no drainage network u

146 lakes periodically drained through channels incised into bed substrate (canals).

147 ediment-infilled depressions that are deeply incised into bedrock that we interpret as giant plunge p

148 the Rising Star cave system in South Africa, incised into the dolomitic limestone walls of the cave.

149 tranded 5' flap and the duplex, whereas FAN1 incised it three to four nucleotides in the double-stran

150 Similarly, endonuclease IV (Nfo) does not incise L or F when they are in tandem with Tg.

151 ce of lake breach floods on Mars for rapidly incising large valleys(7-12); however, on a global scale

152 C2-AP is incised less efficiently by exonuclease III and endonucl

153 nd that offset channels in the Carrizo Plain incised less frequently than they were offset by earthqu

154 UvrABC incised linear substrates containing these intrastrand c

155 ion nuclease system removes bulky lesions by incising mainly at the 22nd-25th phosphodiester bonds 5'

156 Thermally incised meltwater channels that flow each summer across

157 reversed at P10 and P24, as astrocytes from incised mice are smaller and less ramified compared with

158 nd Adelta-fiber input observed in neonatally-incised mice compared with naive littermate controls.

159 At P4, spinal astrocytes in incised mice show increased size and complexity compared

160 ghly S/W-conformeric G(3) and -G(1) duplexes incised more efficiently than the B-type G(2) duplex (G(

161 s adducts on oligonucleotide substrates were incised more efficiently than trans adducts by both UvrA

162 on rainfall is recorded in the meandering of incising mountain rivers in the western North Pacific.

163 heir inference that the western Grand Canyon incised much earlier than previously thought.

164 Like other RNase HI enzymes, RnhP incises Okazaki fragments, ribopatches, and a complement

165 e G*[C8-N3]T* lesions in 17-mer duplexes are incised on either side of G*, that none of the recovered

166 to possess an endonucleolytic activity that incises on the 5' side of damage.

167 mplate at a stalled replication fork site by incising on both sides of the ICL and then translesion s

168 e forked DNA allowing the nuclease domain to incise one arm of the fork.

169 een postulated to require endonucleases that incise one strand of the duplex on either side of the IC

170 injuries to the IVD were produced by either incising one side of the annulus fibrosus or puncturing

171 Remarkably, UvrABC(Bca) incised only at the eighth phosphodiester bond 5' to the

172 of the adduct (UvrABCI cut), while UvrABCII incises only at the 5' side (UvrABCII cut).

173 an ICL dG-MC-dG adduct, we found (i) UvrABC incises only at the strand containing MC-mono-dG adducts

174 y of Ape and the human protein was unable to incise or specifically bind 'bulged' DNA substrates.

175 invasive surgical technique (MIST) and a non-incised papilla surgical approach (NIPSA) in periodontal

176 lling and induced stable hyperalgesia of the incised paw compared with IgG from healthy controls.

177 ime-dependent alleviation of hyperalgesia in incised paws up to 85% of the baseline value at 30 minut

178 With the introduction of the tubularized incised plate technique it is possible to simplify decis

179 The tubularized incised plate urethroplasty has challenged more traditio

180 , Hap1, or Apex), with its DNA substrate and incised product using electrophoretic assays and site-sp

181 umor cells were successfully detected on the incised prostate CLI images as confirmed by histopatholo

182 vers draining the Atlantic passive margin to incise quickly into bedrock beginning about 35,000 years

183 fore the excess, over-replicated regions are incised, resected, and joined.

184 e molecules, the strand opposite the nick is incised, resulting in a more toxic double-strand break.

185 that the "dirty" DNA ends created when Top1 incises ribonucleotides in DNA are responsible for the a

186 nland-directed surge that inundated a deeply incised river channel before accretion of the fine-grain

187 der propagation and sinuosity development in incising rivers.

188 t human apurinic/apyrimidinic endonuclease 1 incises RNA abasic sites in RNA-DNA hybrids.

189 ere, we report that while purified XPF-ERCC1 incises simple ICL-containing model replication fork str

190 clustered DNA damage site, both AP-sites are incised simultaneously, giving rise to double-strand bre

191 The purified enzyme incises single-stranded DNA, RNA, and double-stranded DN

192 as well as from DNA substrates containing 3'-incised sites.

193 modified DNA in the same fashion; i.e., they incise six to eight nucleotides 5' to and three to five

194 x isolated from Escherichia coli, is able to incise specifically and quantitatively DNA fragments mod

195 e find that MutH endonuclease, which in vivo incises specifically the newly replicated strand of DNA,

196 We find that AdnAB incises ssDNA by measuring the distance from the free 5'

197 atch BER subpathway, where the 5'-end of the incised strand is blocked, the intermediate after DNA po

198 and colony persistence in a highly degraded incised stream affects the freshwater production of stee

199 The incised stream channel is bounded on the east by a narro

200 to recover ecosystem function of previously incised streams and to increase the production of imperi

201 omologous recombination (GEN1) paradoxically incise structurally distinct bubbles, ends, or Holliday

202 s with OHVIRA the oblique vaginal septum was incised successfully without any intraoperative complica

203 ferentially to a single-nucleotide gap or 5'-incised synthetic AP site on double-stranded DNA.

204 These rivers also actively erode and incise the bitumen-bearing McMurray Formation, which has

205 that both full-length UVDE and Delta228-UVDE incise the CPD-containing strand immediately 5' to the l

206 The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*, while this base is

207 Engineered nucleases, which incise the genome at predetermined sites, have a number

208 biosphere; they both recognize AP sites and incise the phosphodiester backbone 5' to the lesion, yet

209 nked by basic ones, such as Lys-Trp-Lys, can incise the phosphodiester backbone of duplex DNA at an A

210 ver, if this fails, Fanconi anaemia proteins incise the phosphodiester backbone that surrounds the in

211 nuclease (VRR nuc) domain, enabling FAN1 to incise the scissile phosphate a few bases distant from t

212 Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic.

213 and its homologs remove 5-methylcytosine and incise the sugar backbone at the abasic site, thus initi

214 We tested whether quiescent HSCs could have incised the DNA at loxp sites, but did not finish the re

215 x region because FAN1, unlike EXO1 and FEN1, incised the substrate predominantly beyond the ICL and,

216 igonucleotide product, and the AdnB nuclease incises the 3' strand on which the motor translocates.

217 1Delta cells against a fungal ribotoxin that incises the anticodon loop of cellular tRNAs.

218 The endonuclease ERCC1-XPF incises the damaged strand of DNA 5' to a lesion during

219 d to DNA lesions by interaction with XPA and incises the DNA 5' to the lesion.

220 ay, exhibiting AP endonuclease activity that incises the DNA backbone 5' to an abasic site.

221 It incises the double-stranded DNA without obvious specific

222 The enzyme incises the oligonucleotide 5' to the adduct and generat

223 jor human repair enzyme for abasic sites and incises the phosphodiester backbone 5' to the lesion to

224 rocessed by an AP endonuclease activity that incises the phosphodiester bond adjacent to the AP site

225 ndent activation of MutH endonuclease, which incises the unmethylated strand at the d(GATC) sequence,

226 Laparoscopic myotomy was performed by incising the distal 4 to 6 cm of esophageal musculature

227 ME1 in ICL repair is to unhook the damage by incising the leading strand at the 3' side of an ICL les

228 itiating repair of this common DNA lesion by incising the phosphodiester backbone 5' to the damage si

229 in the genome and initiate their removal by incising the ribonucleotide-containing strand of an RNA:

230 otoproducts in the form of 10- to 11-mers by incising the sixth to seventh phosphodiester bond 5' to

231 g activity for acyclic P-DNA, were unable to incise this substrate in EDTA, pointing to an alternativ

232 is variant was also devoid of the ability to incise thymine glycol-containing oligonucleotide, sugges

233 Furthermore, nuclear extracts incised thymine glycol with a much higher efficiency tha

234 eveloped to decrease the energy necessary to incise tissues and to decrease damage to surrounding tis

235 ment sources increases when bedrock channels incise to produce lower gradient profiles.

236 3+/+ mitochondrial extracts more efficiently incised uracil or 8-oxo-G oligonucleotides, although rec

237 from human cadaveric corneal rim tissue was incised using 3 instruments: (1) novel dual-blade device

238 , in the presence of UvrA and UvrB, actively incise UV-irradiated and CC-1065-modified DNA in the sam

239 d DNA enhances the efficiency of UvrABCII in incising UV-irradiated DNA, it does not enhance UvrABCII

240 crococcus luteus UV endonuclease efficiently incises uvDNA regardless of its topological state.

241 uent rapid aggradation occurred within these incised valleys during deglaciation between ~17 and ~9 k

242 le for eroding at least 24% of the volume of incised valleys on early Mars, despite representing only

243 starting at 6 and peaking at 24 hours after incising which was supported by histological analysis an

244 is predicted as the canyon was progressively incised, which is at odds with the discharges expected f

245 the large Himalayan rivers in Punjab stopped incising, while downstream, sedimentation slowed on the

246 erminus of a complementary primer strand are incised with an efficiency similar (less than twofold di

247 taining a reduced abasic site, which was pre-incised with APE1, was employed to reconstitute the exci

248 The TG*T-43-mer duplexes are incised with consistently greater efficiency by UvrABC p

249 opened, single-stranded DNA region, were all incised with similar efficiencies and with enhanced rate

250 In 14 and 21 d incised wounds and in chronic granulation tissue from no