ライフサイエンスコーパス: incisor

1 ntiating ameloblast cells of the mouse lower incisor.

2 ifferentiation in the anterior region of the incisor.

3 and their progeny during growth of the mouse incisor.

4 n, and decreased cell migration in the mouse incisor.

5 ion, cell proliferation and migration in the incisor.

6 and 4) root width and length of the central incisor.

7 and repair of the continuously growing mouse incisor.

8 tem cells, signals to several regions of the incisor.

9 ssion defect on the mandibular right central incisor.

10 by the absence of enamel on one side of the incisor.

11 xillary canine, lateral incisor, and central incisor.

12 a, vertebrae, ribs, calvarium, mandible, and incisor.

13 d, we analyzed enamel formation in the mouse incisor.

14 iferation, and enamel formation in the mouse incisor.

15 vertical KT height labial to each mandibular incisor.

16 o plays a role in continuously growing mouse incisors.

17 ruled out resorption of roots of mandibular incisors.

18 he alveolar bone of molars (buccal side) and incisors.

19 periapical radiographs of maxillary central incisors.

20 ntal sites around permanent first molars and incisors.

21 ed severe dental abnormalities affecting the incisors.

22 were downregulated in Wnt1-Cre; Alk5(fl/fl) incisors.

23 ndibular defects including the lack of lower incisors.

24 the epithelial stem cell population in mouse incisors.

25 difference between a portrait's two central incisors.

26 e of enamel formation and degradation of the incisors.

27 res called cervical loops at the base of the incisors.

28 rely reduced or completely missing in mutant incisors.

29 l recession involving both maxillary central incisors.

30 n the facial aspect of her maxillary central incisors.

31 pic enamel formation and deposition in these incisors.

32 r rapidly where they contacted the maxillary incisors.

33 were characterized followed by unloading the incisors.

34 rt-lived anesthesia of the maxillary central incisors.

35 acement of a silk ligature around mandibular incisors.

36 ndibular hypoplasia and malformed mandibular incisors.

37 imb, trunk, tongue, lower incisor, and upper incisors.

38 MSX1second bicuspids and mandibular central incisors.

39 oblast membrane surfaces in developing mouse incisors.

40 different canal configurations of mandibular incisors.

41 manent canines, premolars and to some extent incisors.

42 ing of enamel rods was noted in posteruption incisors.

43 ermanent dentition, particularly the lateral incisors.

44 different canal configurations of mandibular incisors.

45 the ectomesenchymal derivatives of the lower incisors.

46 pped onto the gingiva between the mandibular incisors.

47 es, followed by lateral incisors and central incisors.

48 ent postnatal growth potential of molars and incisors.

49 right central incisor - 33.5%, left central incisor - 30%, right lateral incisors - 33.5% and left l

50 second canals was as follows: right central incisor - 33.5%, left central incisor - 30%, right later

51 %, left central incisor - 30%, right lateral incisors - 33.5% and left lateral incisor - 36.5%.

52 ht lateral incisors - 33.5% and left lateral incisor - 36.5%.

53 The majority of mandibular incisors (66.5%) had a single root with a single canal.

54 o bilateral enamel deposition, thus impeding incisor abrasion and resulting in unchecked tooth elonga

55 ct in the proximal region of the adult mouse incisor after loss of BMP signaling in the Gli1+ cell li

56 tissue (KT) height labial to the mandibular incisors after active orthodontic treatment (AOT) with a

57 In the present study, amongst 102 mandibular incisors, all had one root, 36% of them had a second can

58 ower canine, and small, non-procumbent lower incisors; all more primitive states than in Megantereon

59 espite these differences, pulps from erupted incisors also displayed extensive osteo-dentinogenic pot

60 Bsp(-/-) incisors also erupt at a slower rate, which likely leads

61 uma such as fractured molar roots, distorted incisors, alveolar bone loss and compressed temporomandi

62 e lower second premolar and lower canine and incisor alveoli, reveal a number of derived morphologica

63 human data also predicts waves in the mouse incisor and an ordering transition at the chimpanzee cin

64 ts without a history of periodontal disease, incisor and canine (zone 1), premolar (zone 2), and mola

65 migrate along the proximo-distal axis of the incisor and differentiate into enamel-forming ameloblast

66 ayed exclusive CRE-mediated recombination in incisor and molar ameloblasts.

67 e-forces were measured during right and left incisor and molar biting.

68 ad4 in neural crest derived cells results in incisor and molar development arrested at the dental lam

69 ars, and change in incisor patterning and in incisor and molar size and shape.

70 the differential osteogenic potency between incisor and molar, which can be further attributed to th

71 murine maxillary right diastema between the incisor and the first molar.

72 entify Hh-responsive stem cells in the mouse incisor and we show that sonic hedgehog (SHH), which is

73 ere predominant on noncontacting surfaces of incisors and canines and nonfunctional cusps of posterio

74 III defects) located at the upper and lower incisors and canines were treated with a laterally posit

75 most common at canines, followed by lateral incisors and central incisors.

76 ts has evolved to enable both gnawing at the incisors and chewing at the molars.

77 results in multiple and branched enamel-free incisors and cuspless molars, and change in incisor patt

78 ng is essential for the development of mouse incisors and for maintenance of the CL during prenatal d

79 ortion of teeth with probing depth >=4 mm at incisors and molars and with visible [>=2 mm] recession)

80 Mutant incisors and molars were reduced in size and exhibited h

81 ariable hypodontia, occasional supernumerary incisors and molars, as well as crown and root patternin

82 displayed very thin to absent enamel in both incisors and molars, hereby recapitulating the AI phenot

83 The changes of maxillary central incisors and palatal alveolar bone thickness were measur

84 iameter, 2-mm depth) were prepared in bovine incisors and restored using Bond Force (BF), Scotchbond

85 Cavities (4 x 2 mm) were prepared in bovine incisors and restored using Clearfil SE Protect (SP), Bo

86 nce of ameloblast progenitor cells in rodent incisors and that its deletion results in the absence of

87 e evaluated for teeth 6 (canine), 7 (lateral incisor) and 8 (central incisor) of test and control gro

88 e between the left maxillary canine, lateral incisor, and central incisor.

89 e of convexity, the inclination of the upper incisor, and the occlusal plane (UOP, POP) were signific

90 ae, forelimb, hindlimb, trunk, tongue, lower incisor, and upper incisors.

91 hich produces rapidly growing long tusk-like incisors, and Lef-1 epithelial overexpression partially

92 ically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion

93 th stem/progenitor populations in the rodent incisor apex, the dental pulp, the alveolar bone, the pe

94 he cervical loops of adult Ank (KI/KI) lower incisors are at the level of the third molars, while the

95 Incisors are completely missing, and molars are enlarged

96 lar second molar and their maxillary central incisors are most susceptible to microdontia.

97 FoxJ1(-/-) mice maxillary and mandibular incisors are reduced in length and width and have reduce

98 Using the adult mouse incisor as a model for a continuously renewing organ, we

99 Using the continuously growing mouse incisor as a model of stem cell-based tissue renewal, we

100 n this issue, Ahtiainen et al. use the mouse incisor as a model to advance our understanding of the c

101 Here, we utilized the mouse incisor as a model to study how the MAPK and PI3K pathwa

102 In this study, we used the adult mouse incisor as a model to uncover how BMP signaling maintain

103 Here we report, using the murine incisor as a model, that alphaE-catenin is essential for

104 Using mouse incisor as the model, we discover a population of MSCs n

105 ciated with macrodontia of the upper central incisors as well as distinct craniofacial findings, shor

106 roRNAs are expressed in molars compared with incisors as well as epithelium compared with mesenchyme.

107 l expression on the labial side of the lower incisors, as well as enamel hypoplasia-consistent with t

108 The rodent incisor, because of its unusual morphogenesis and remark

109 metalloproteinase-20 null (Mmp20(-/-)) mouse incisors, because enamel thickness is reduced by approxi

110 erage achievable, with maxillary canines and incisors being associated with the highest outcomes comp

111 ing left molar biting in +DD individuals and incisor biting in men (all p < 0.03).

112 Incisor biting symmetry in muscle organization was signi

113 have normal morphology of erupted molars and incisors but excessive cementum deposition with increase

114 ble at the mucogingival junctions above both incisors but were not an esthetic concern because of the

115 d that after dissociation and reaggregation, incisor, but not molar, mesenchyme exhibits a strong ost

116 cues the development of molars and maxillary incisor, but the rescued teeth exhibit a delayed odontob

117 +/-) mice was nearly normal in the maxillary incisors, but the mandibular incisors were discolored an

118 sessed in 29 interimplant areas in the upper incisor, canine, and premolar regions of 18 patients.

119 of class 3 on the upper lip bite test (lower incisors cannot extend to reach the upper lip; positive

120 P activity was correlated significantly with incisor cementum thickness.

121 and beta-catenin are expressed in the labial incisor cervical loop or epithelial stem cell niche, wit

122 h ratio was 87% to 88% for maxillary central incisors, clearly above the accepted "ideal." In additio

123 The lower incisors collected from 7-d-old and 7-wk-old mice were a

124 n, and immunohistochemical staining of mouse incisors confirmed DPPI expression by ameloblasts.

125 We show that pulps from unerupted incisors contain a significant mesenchymal-stem-cell (MS

126 re predominant on the contacting surfaces of incisors, cusps of canines, and functional cusps of post

127 red dental stem cell proliferation, arrested incisor development and abnormal molar development.

128 x9 interact synergistically throughout lower incisor development and affect multiple signaling pathwa

129 er that inhibits epithelial invagination and incisor development.

130 rning of epithelial signaling centers during incisor development.

131 The murine incisor develops initially but is absorbed independently

132 In general, healthy deciduous incisors displayed a higher degree of crystal organizati

133 Dental pulps from erupted incisors displayed increased percentages of CD45+ and de

134 measured the mineral and chloride content in incisor enamel of amelogenin-knockout (AmelX(-/-)) mice

135 cent whole-genome microarray analysis of rat incisor enamel organ cells derived from the secretory an

136 RNA transcripts for Dra and Slc26a6 in mouse incisor enamel organs, and Western blotting confirmed th

137 Interestingly, in 100-day-old rats, erupting incisor enamel was normal, suggesting amelogenesis is on

138 microhardness and fracture toughness of rat incisor enamel, we mechanically tested specimens in whic

139 mbers Lrig1 and Igfbp5 define populations of incisor epithelial and mesenchymal stem cells.

140 Contrarily in the mouse incisors, epithelial SCs are maintained throughout life

141 l Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkalpha and Irf6 mutant embr

142 tosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkbeta mice.

143 incisor tooth cervical loop, outpouching of incisor epithelium, abnormal morphology of the epithelia

144 family, Irf6 also results in evagination of incisor epithelium.

145 In addition, 61% to 71% of maxillary central incisors exceeded allowable crown width-to-length ratios

146 y male Wistar rats had their maxillary right incisor extracted.

147 with a V-shaped thread design, in maxillary incisor extraction sockets.

148 mplanted orthotopically following mandibular incisor extraction, whereas a human molar scaffold was i

149 odontic proclination or expanding mandibular incisors facially.

150 on of Shh and Bmp2 indicates that a smaller "incisor field" forms in Pax9(+/-);Msx1(+/-) mutants, and

151 ment being highest for the maxillary central incisors, followed by maxillary posterior premolars and

152 The upper deciduous incisor from Grotta di Fumane contains ancient mitochond

153 The lower deciduous incisor from Riparo Bombrini is modern human, based on i

154 intra-tooth variability of a human deciduous incisor from the Middle Pleistocene layers of the Iserni

155 Ultrathin sagittal sections of maxillary incisors from 8-wk-old wild-type (WT), Mmp20-null (KO),

156 Etched enamel surfaces of incisors from Amelx knock-out (AmelxKO) mice appeared ra

157 , ectopic expression of Tbx1 was observed in incisors from mice with upregulated Fibroblast Growth Fa

158 Incisors from Mmp20(+/+) mice expressing the Mmp20 Tg ha

159 Periapical radiographs of mandibular incisors from subjects with > or =10 years of follow-up

160 f 200 patients with 800 permanent mandibular incisors, fulfilling necessary inclusion criteria and ag

161 Likewise, incisor Gli1(+) cells, but not NG2(+) cells, exhibit typ

162 ent at muscle-bite force transmission during incisor gnawing than guinea pigs, and that guinea pigs a

163 Mouse incisors grow continuously throughout life.

164 Rodent incisors grow throughout adult life, but are prevented f

165 ttenuation of signaling resulted in impaired incisor growth, characterized by failure of enamel forma

166 isms that regulate dental stem cell fate and incisor growth.

167 All the permanent mandibular incisors had a single root.

168 ed, cells giving rise to the odontoblasts in incisors have not been fully characterized.

169 Anecdotally, molar incisor hypomineralization (MIH) is increasing concurren

170 oot canal morphology of permanent mandibular incisors in an Indian sub-population of Pune, Maharashtr

171 for the first time the presence of vestigial incisors in Bradypus.

172 example, in contrast to humans, who have two incisors in each dental quadrant, rodents only have one

173 The supernumerary incisors in K5-Ikkbeta mice were found to phenocopy extr

174 5-Ikkbeta mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise.

175 Moreover, the independent development of two incisors in mutants with large decreases in sprouty dosa

176 the embryo and the regenerative capacity of incisors in the adult.

177 Proper alignment of the incisors in the anterior-posterior plane and correct mid

178 Mandibular incisor inclination and prominence explained neither the

179 nosis, high angle class II with normal upper incisor inclination can be signs of high-risk factors.

180 ve small, malformed maxillary and mandibular incisors, indicating that Grem2 has important roles in n

181 The mouse incisor is a remarkable tooth that grows throughout the

182 of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network

183 l and lingual sides of unerupted and erupted incisors is supported by a progenitor population and not

184 Furthermore, the developing incisors lack mesenchymal Notch1 expression at the bud s

185 illa, are flanked by a supernumerary pair of incisor-like teeth.

186 hout periodontitis at the lower-left lateral incisor (LLLI).

187 Immunohistochemistry of mouse mandibular incisors localized ITGB6 to the distal membrane of diffe

188 Soft powder diet reduced severe incisor malocclusion incidence to 3% in Bsp(-/-) mice, s

189 wk of age, Bsp(-/-) mice exhibited molar and incisor malocclusion regardless of diet.

190 iet exhibited high incidence (30%) of severe incisor malocclusion, 10% lower body weight, 3% reduced

191 alveolar bone and tooth root resorption, and incisor malocclusion.

192 likely contributing to the high incidence of incisor malocclusion.

193 in some individuals by cranial asymmetry and incisor malocclusion.

194 lack of FGF retention on the cell surface of incisor mesenchyme appears to account for the differenti

195 Analyses of the Tbx1 null mice reveal incisor microdontia, small cervical loops and BrdU label

196 is issue, we used lineage tracing in a mouse incisor model and identified the neurovascular bundle (N

197 We have identified specific defects in incisor, molar, mandible, bone, and root development and

198 Plaque samples from incisors, molars, and the tongue from 195 children atten

199 ence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages.

200 cult to trace, and the genetic regulation of incisor number remains a largely open question.

201 prouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty do

202 Cervical dentin areas of 6 maxillary incisors of 5 beagles were exposed to a class V-like les

203 Different sets of mouse mandibular incisors of C57BL/6 mice were used for dissections and m

204 tions from unerupted parts of the mandibular incisors of Mmp20 null mice were characterized by scanni

205 Although the incisors of nectin-1-null mice were hypomineralized, the

206 All cultured incisors of Tbx1-/- mice were hypoplastic and lacked ena

207 Incisors of Wnt1-Cre; Alk5(fl/fl) mice lost their abilit

208 (canine), 7 (lateral incisor) and 8 (central incisor) of test and control groups.

209 Agenesis of the lateral incisor on the non-cleft side was the most remarkable ob

210 We designed two approaches using incisor organ culture and bromodeoxyuridine (BrdU) pulse

211 Various factors affect the central maxillary incisor papilla height (PH) and central clinically obser

212 incisors and cuspless molars, and change in incisor patterning and in incisor and molar size and sha

213 each dental quadrant, rodents only have one incisor per quadrant.

214 Although the mandibular incisor phenotype has been briefly described, very littl

215 reased extracellular PPi levels and that the incisor phenotype is likely due to hyperostosis of mandi

216 in Ank (+/+) mice replicate the Ank (KI/KI) incisor phenotype.

217 Two implants in the central incisor positions of one patient demonstrated 2 mm of bu

218 DPCs extracted from rat incisors positive for CD44, alkaline phosphatase activit

219 icular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum

220 tosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell

221 migration for both the human molar and mouse incisor, providing a possible signal for the termination

222 Application of FGF3 to incisor reaggregates inhibits beta-catenin signaling act

223 Rodent incisors regenerate throughout the lifetime of the anima

224 dental-like structures were formed from the incisor region following implantation into immunodeficie

225 atients underwent therapy in their maxillary incisor region.

226 These findings reveal novel mechanisms of incisor renewal and illustrate how gene co-expression an

227 Incisor replacement is prolonged until well after molars

228 The continuous growth of rodent incisors requires the presence of stem cells capable of

229 blast growth factor 10 (FGF10) into cultured incisors rescued dental epithelial stem cells in Wnt1-Cr

230 miR-224 agomir injection in mouse neonatal incisors resulted in normal enamel length and thickness,

231 Upon release of the signaling blockade, the incisors resumed growth and reformed an enamel layer, de

232 se the ability to grow continuously, whereas incisors retain this ability.

233 tive cells in the apical ends of Ank (KI/KI) incisors revealed decreased osteoclast numbers and osteo

234 entum formation on Bsp (-/-) mouse molar and incisor roots, and the cementum deposited appeared hypom

235 In each of 22 rats, an incisor scaffold was implanted orthotopically following

236 new bone regenerated at the interface of rat incisor scaffold with native alveolar bone.

237 mically shaped human molar scaffolds and rat incisor scaffolds were fabricated by 3D bioprinting from

238 uous row of teeth, mice have only molars and incisors separated by a toothless region called a diaste

239 canal and the roots of the central maxillary incisors should be kept in mind during dental-implant tr

240 Furthermore, Ank (KI/KI) incisors show decreased eruption rates, decreased prolif

241 istochemistry of developing mouse molars and incisors showed positive STIM1 and SLC24A4 signal specif

242 ridization and qPCR in mouse and fetal human incisors showed that NBCe1 mRNA was up-regulated as amel

243 -supported restorations in maxillary central incisor sites tends to exhibit an atrophied aspect after

244 t multiple signaling pathways that influence incisor size and symmetry.

245 lement models comprising a maxillary central incisor socket and 4.5 x 13 mm outer-diameter implants w

246 ling regulates both the establishment of the incisor stem cell niches in the embryo and the regenerat

247 vels of E-cadherin are highly dynamic in the incisor, such that E-cadherin is expressed in the stem c

248 oot canal morphology of permanent mandibular incisor teeth in the Indian subpopulation with the use o

249 mensions around molar, premolar, canine, and incisor teeth in upper and lower jaws.

250 program of tooth development in adult rodent incisor teeth.

251 exhibit defective enamel formation in their incisor teeth.

252 ) mice exhibited a solitary median maxillary incisor that developed from a single dental placode, ear

253 milunar incisions over the maxillary central incisors that blended into a frenectomy.

254 ion in dental pulps of unerupted and erupted incisors that give rise to odontoblasts.

255 rage was achieved over the maxillary central incisors that initially presented with 2 mm of recession

256 After extraction of the right upper central incisor the alveoli were filled with SBC hydrated by two

257 For the maxillary right and left lateral incisors, the crestal bone thickness averaged 1.73 and 1

258 terus, skin, and periodontal ligament of the incisors, the latter resulting in dental dysplasia.

259 e bud stage but allowed maxillary molars and incisors to develop to mineralized teeth.

260 ches in the cervical loop (CL) enables mouse incisors to grow continuously throughout life.

261 Here, we use the mouse incisor tooth as a model to study budding morphogenesis.

262 This caused increased proliferation of the incisor tooth cervical loop, outpouching of incisor epit

263 Using mouse incisor tooth epithelia as a model, we show that ciliary

264 uired maxillary premolar, canine, or central incisor tooth extraction.

265 In this study we used early mouse molar and incisor tooth germs that possess distinct tooth-forming

266 The continuously growing mouse incisor tooth offers an excellent model to address the o

267 tant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rath

268 The rodent incisor, unlike human teeth, grows throughout the life o

269 techniques that allow the unharmed growth of incisors until their full maturity.

270 Wise suppresses survival of the diastema or incisor vestigial buds by serving as an inhibitor of Lrp

271 from the CEJ for the maxillary right central incisor was 1.41 mm and for the maxillary left central i

272 s 1.41 mm and for the maxillary left central incisor was 1.45 mm.

273 In five mole-rats the lower right incisor was extracted on either postnatal day 7 or 21.

274 ass V-like lesion, and 1 side of 3 maxillary incisors was adapted with recombinant CPNE7 protein for

275 tion of keratinized gingiva at upper central incisors was measured by spectroradiometer and converted

276 n normal, the enamel covering the molars and incisors was of normal thickness, had clearly defined ro

277 and the inclination of the maxillary central incisor were significantly correlated with before treatm

278 In vivo, rat maxillary incisors were atraumatically extracted (without any toot

279 r, in double heterozygous mutants, the lower incisors were consistently missing and we find that tran

280 n the maxillary incisors, but the mandibular incisors were discolored and tended to wear rapidly wher

281 One hundred mandibular incisors were evaluated for the number of root, root can

282 nectomy in a case in which maxillary central incisors were impinged upon by a broad aberrant frenum,

283 nized gingival width (KGW) around mandibular incisors were included in this study.

284 Only maxillary incisors were included to eliminate any potential volume

285 caused by tooth movement after the maxillary incisors were retracted and intruded during orthodontic

286 Upper incisors were tested by nanoindentation.

287 ical cord blood at birth; and shed deciduous incisors when the child was approximately 7 years of age

288 enamel formation of the continuously growing incisors, whereas molars exhibit increased attrition and

289 enesis, Lhx6/7-deficient animals have normal incisors which, in the maxilla, are flanked by a supernu

290 A well-studied model is the mouse incisor, which contains dental epithelial stem cells in

291 The cervical loop area of the incisor, which contains the niche for the epithelial ste

292 complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamic

293 The rodent incisor-which grows continuously throughout the life of

294 for root coverage over the maxillary central incisors while simultaneously performing a frenectomy.

295 K5-Ikkbeta mice showed supernumerary incisors whose formation was accompanied by up-regulatio

296 t of the first molar mesially to the central incisor with a single injection while avoiding undesirab

297 tem for testing shear bond strength of mouse incisors with AI variants, and analysis of these data ma

298 e observed that Evc2 mutant mice had smaller incisors with enamel hypoplasia.

299 Staining of wild-type and Mmp20(-/-) incisors with pH indicators demonstrated that wild-type

300 ing in the formation of a single fused lower incisor within the hypoplastic fused mandible.