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1 function, from fully competent to completely incompetent.
2 Their loss renders neutrophils functionally incompetent.
3 s II presentation pathway in this population incompetent.
4 t of their mating (a/alpha), which is mating-incompetent.
5 n an open conformation that is translocation-incompetent.
6 tive and -negative Rho GTPase are comparably incompetent.
7 oocytes are ovulated, they are fertilization incompetent.
8 framework that is initially cargo transport incompetent.
9 Hence, the neck is limb-incompetent.
10 both arms of the palindrome were replication incompetent.
11 chains on p27(Kip1) that are proteolytically incompetent.
12 ting that they were rendered translationally incompetent.
13 harbour organized sarcomeres but are fusion-incompetent.
14 pleted from endosomes, rendering them fusion-incompetent.
15 ies formation, whereas the presence of redox-incompetent 7,8-dihydrobiopterin demonstrates little que
16 Upon transfection of MEFs with replication-incompetent 8OG constructs, we observed a marked increas
18 from its ability to stabilize an inhibition-incompetent activation intermediate distinct from both a
19 ples both C-binding competent (inactive) and incompetent (active) conformations within a nearly degen
21 ortions of HA from a recombinant replication-incompetent adenoviral vector, achieving vaccine product
22 on, three structurally different replication-incompetent adenoviral vectors were engineered that expr
24 hanced expression of AEG-1 via a replication-incompetent adenovirus (Ad.AEG-1) in HeLa cells markedly
25 ectopic expression of MDA-5 via replication-incompetent adenovirus (Ad.Mda-5) initiates multiple sig
26 ostates or prostatic tumors as a replication-incompetent adenovirus (AdTSTA-sr39tk) and imaged using
27 al RSV vaccine, Ad26.RSV.preF, a replication-incompetent adenovirus 26 vector encoding the F protein
29 tigens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors markedly augm
30 nogens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors to process an
31 prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors
32 fficacies of several multivalent replication-incompetent adenovirus serotype 5 (Ad5) vaccines were ex
34 In this study, we designed a replication-incompetent adenovirus type 5 to deliver a LANA-specific
35 the FGF-4 transgene carried by a replication incompetent adenovirus type 5, Ad5FGF-4, was developed o
36 when administered by means of a replication-incompetent adenovirus, Ad.mda-7, several colorectal car
37 L-24, administered by means of a replication-incompetent adenovirus, as a gene therapy for cancer has
38 oreskin fibroblasts, infected by replication-incompetent adenoviruses carrying EGFP gene, as the test
43 ter attack on the thioester (Glu(161)) by an incompetent analog (Gln(161)) gave a UGDH variant (E161Q
44 14 in human CD4-TLR4 rendered them signaling-incompetent and blocked TLR4 tyrosine phosphorylation.
45 rho(0)] cells) are oxidative phosphorylation incompetent and displayed loss of the Mcl-1 protein unde
48 ells to PK1 cells, they gradually became R33 incompetent and swa sensitive, unless the transfer was i
49 virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8(+) cel
50 esemble their counterparts of the scrambling-incompetent anion channel mTMEM16A, yet with distinct di
51 could promote immune tolerance by acting as incompetent antigen-presenting cells (APC), as well as a
52 NMDAR GluN2B subunit that is CaMKII binding-incompetent, any tatCN21 effects that are specific to th
53 g either catalytically inactive or packaging-incompetent APO3G variants suggest that wild-type APO3G
58 xpressing CaMKII phosphorylation- or binding-incompetent beta(2a) subunits were incapable of entering
59 toward conformers that are substrate-binding incompetent (BI), while TMAO shifts the ensemble toward
63 aracterized by ischemia, neovascularization, incompetent blood-retinal barrier, and vascular occlusio
65 he R753Q polymorphism renders TLR2 signaling-incompetent by impairing its tyrosine phosphorylation, d
66 d with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an
67 her retention of SP might render CA assembly incompetent by testing the ability of Rous sarcoma virus
69 tive astrocytes have been proposed to become incompetent bystanders in epilepsy as a result of cellul
70 served between binding-competent and binding-incompetent can be explained by changes in solvation and
71 ative phosphorylation (OXPHOS)-competent and incompetent cancer cell pairs to demonstrate that treatm
72 fused with different transport-competent or -incompetent cargo complexes, and then the permeability b
73 r define a novel population of proliferation-incompetent CD4+ T cells that are generated in the prese
74 ion kinetics are greater in interferon (IFN)-incompetent cells and that the virus is unable to suppre
76 rofiles of clearance-competent and clearance-incompetent cells revealed that mesenchymal genes are en
77 arvations (in both respiratory competent and incompetent cells) to show that successful starvation re
80 istant mutations thus may arise from binding-incompetent changes in the conformational equilibrium.
81 tudy of a new malaria vaccine, a replication-incompetent chimpanzee adenovirus 63 (ChAd63) encoding t
82 synergistically to switch these regeneration-incompetent CNS neurons into a regeneration-competent ph
83 tment to report all instances of impaired or incompetent colleagues in their medical practice to a re
84 ed that physicians should report impaired or incompetent colleagues to relevant authorities, 45% of r
87 otein synthesis by stabilizing a translation-incompetent complex for select messenger RNAs (mRNAs) wi
91 nding locks TmCorA in a symmetric, transport-incompetent conformation and loss of intracellular Mg(2+
94 ide of gammaTuRC is in an "open," nucleation-incompetent conformation, leading to a structural asymme
97 y "conformationally trapping" CA in assembly-incompetent conformational states induced by H-site bind
99 beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ineffective in inducing food al
100 IAP3 knockdown caused accumulation of fusion-incompetent DCVs in BON neuroendocrine cells and lysosom
101 e co-expressed different types of signalling-incompetent DDR1 mutants ('receiver') with functional DD
102 1,3-glucan phagosomes expressing a signaling incompetent Dectin-1 failed to mature as demonstrated by
103 y occurring tail regeneration-competent and -incompetent developmental stages of Xenopus tadpoles.
104 ing COS1 cells engrafted into a regeneration-incompetent digit amputation wound resulted in a locally
107 nes rendered both Fas incompetent and ICAM-1 incompetent displayed significantly higher numbers of tu
111 We also demonstrate that a catalytically incompetent EST2 protein can suppress such overhang accu
112 +CD4+ T cells were found to be proliferation incompetent, even after strong mitogen stimulation.
113 its (Rpt1-4) with ATP binding mutations were incompetent for cellular assembly into 26 S proteasome.
114 thyroglobulin devoid of the ChEL domain was incompetent for cellular export; however, a recombinant
115 reorganization renders IA afferent synapses incompetent for efficient motoneuron synaptic depolariza
117 lexes (C1-Zr2, Zr2, and Zr1) are found to be incompetent for ethylene-styrene copolymerization, yield
118 st that activated mutated B-Raf proteins are incompetent for folding in the absence of Hsp90, thus su
119 nt sperm have reduced oocyte binding and are incompetent for in vitro fertilization, but they can sti
120 embrane domain (A14L and W22A), rendering it incompetent for interaction with human BST-2, was able t
122 inactive conformation that is catalytically incompetent for phosphotransfer from small molecule phos
123 ile the ccm knockout mutants were completely incompetent for photosynthesis, the Cu-unresponsive muta
127 h may decay into a more stable catalytically incompetent form (O) in the absence of electron donors.
128 lly slow equilibrium between a catalytically incompetent form of enzyme and an active species that ca
129 TcpB also does not affect a mutant, signal-incompetent form of MAL that cannot be phosphorylated.
135 41L, F359L, F368L) and generated RNA-binding-incompetent FUS mutants with and without ALS-causing mut
136 The ABP-PEG-HCBP1-conjugated replication incompetent GFP-expressing ad, (Ad/GFP)-ABP-PEG-HCBP1, s
141 CE1-containing intermediates, while assembly-incompetent HIV-1 GagZip proteins harboring mutations in
142 pe of the hrpJ mutant expressing a secretion incompetent HrpJ derivative and were reduced in their im
143 ementation of the hrpJ mutant with secretion incompetent HrpJ derivatives restores the secretion of H
145 ith coaching]?" P009), worry about appearing incompetent ("I think it would be perceived as either a
148 ted recombinant MVA, ADS-MVA, is replication incompetent in mammalian cells and highly immunogenic in
150 raditional search-based optimization methods incompetent in terms of both searching efficiency and re
154 subunit cytochrome b, which are respiratory incompetent, increase ROS levels and stabilize the HIF-1
155 d reverse genetics to generate a replication-incompetent influenza virus carrying the sequence for th
156 is strategy, which is based on a replication-incompetent influenza virus possessing the antigenic reg
157 t of bivalent vaccines, based on replication-incompetent influenza virus, against pathogens that caus
158 ly, we demonstrated that several replication-incompetent influenza viruses efficiently elicit IgG in
160 strate-binding pocket encode a catalytically incompetent kinase, thereby preventing emergence of resi
161 potential for select retrotranspositionally-incompetent L1 loci to generate genomic instability.
162 gest that a subset of retrotranspositionally-incompetent L1s, previously considered to be harmless to
163 is required for sumoylation, and sumoylation-incompetent La(K41R) shows only anterograde transport, w
164 l-length H chains and Dmu, whereas secretion-incompetent lambda1 L chains could only do so with full-
167 vac2, as shown by coinfections of interferon-incompetent lymphatic cells with viruses expressing diff
170 n of wild-type mBMSCs but not of mutant, GJC-incompetent mBMSCs or mBMSCs with dysfunctional mitochon
171 these mutations render the virus replication-incompetent, MCV is not a "passenger virus" that seconda
172 Generation of the E1 homotrimer on fusion-incompetent membranes identified an intermediate conform
174 geometry holds the enzyme as a catalytically incompetent metal complex and may represent a previously
175 highly susceptible 129/SvEv mice and immune incompetent mice (IFN-gamma-/-, SCID) were resistant to
176 able tolerant chimeras onto syngeneic immune-incompetent mice, graft-infiltrating T cells migrated fr
177 s grafted under the kidney capsule of immune-incompetent mice, which allowed the development of human
180 owed generation of suppressor-competent and -incompetent molecules and uncoupling of the VSR and part
181 inducers, tau protein behaved as an assembly-incompetent monomer with little tertiary structure.
182 n mutations are located in the enzymatically incompetent monomer, suggesting a "dominant" or regulato
183 of mouse bone marrow cells with replication-incompetent murine stem cell virus (MSCV) expressing onl
186 e is similar to that of another transmission-incompetent mutant DeltaUL54, which also affects the spl
187 n macrophages expressing Lps(d), a signaling-incompetent mutant form of TLR4, suggesting that the enh
191 tion velocity of mice expressing KSP phospho-incompetent NF-M were also indistinguishable from wild-t
192 ed region of the tailpiece binds to assembly-incompetent NMII-C fragments, inducing filament assembly
193 ysteine residues also formed a catalytically incompetent octanoyl adduct, indicating the presence of
194 In conclusion, we found that mitotically incompetent ocular tissue cells contain adult NCDPs that
195 plexes, there are always PSII subpopulations incompetent of oxygen evolution, but are in the process
196 e formation of other off-pathway and amyloid-incompetent oligomers that are isomeric with amyloid-com
198 d PKA constructs we show that in meiotically incompetent oocytes PKA is distributed throughout the cy
200 oes not render the viral episome replication incompetent: our model predicts that concurrent delivery
203 ad as the result of either a developmentally incompetent paternal pronucleus or asynchrony between th
204 ct, providing no demonstrable benefit to the incompetent patient and complicating the psychological p
205 not clearly reflect the prior values of the incompetent patient and is likely to intensify rather th
206 withholding life-prolonging treatment for an incompetent patient who had left no advance directive or
207 ng treatment is withdrawn or withheld for an incompetent patient who has indicated no prior wishes re
210 ENGWEGMIDG, and its two point-mutant, fusion-incompetent peptides G1E and G13L, in mixtures with hydr
211 and less than 20% of these cells show import-incompetent, peroxisome-like structures (peroxisome remn
212 p alteration that underlies the inflamed and incompetent polarization of neutrophils leading to sever
215 esistant/R33-competent and swa-sensitive/R33-incompetent prions had different conformational stabilit
216 converts ERBB3 into a passive and signaling incompetent probe of its immediate receptor environment.
217 thin this domain also produced translocation incompetent proteins and the conversion of MF to a trans
218 ze of the reservoir by detecting replication-incompetent proviruses; however, viral outgrowth assays
219 default cyclization/release route for redox-incompetent R* domains embedded in NRPS assembly lines.
223 gh normal respiration to deliver replication-incompetent recombinant adenoviral vectors expressing ge
224 Despite the widespread use of replication-incompetent recombinant adenovirus (Ad) vectors as candi
226 Delivery of F and G proteins via replication incompetent recombinant vesicular stomatitis viruses (VS
227 hat intramuscular injection of a replication-incompetent, recombinant adeno-associated virus (rAAV) d
228 plore the protective efficacy of replication-incompetent, recombinant adenovirus serotype 35 (rAd35)
229 ither regeneration-competent or regeneration-incompetent regions are transplanted into the neck.
231 within this zone, we injected a replication-incompetent retrovirus, encoding the enhanced green fluo
232 We report that pseudotyped, replication-incompetent retroviruses can be used in axolotls to perm
233 tions in the early chick retina, replication-incompetent retroviruses were utilized to over-express a
234 In contrast, mice expressing phosphorylation-incompetent RyR2 displayed depressed AM sarcomere shorte
235 s obtained from db/db mice were functionally incompetent secondary to the increased proportion of apo
236 , coq1-coq9 deletion mutants are respiratory-incompetent, sensitive to lipid peroxidation stress, and
237 neration in both regeneration-competent and -incompetent sensory neurons in the peripheral nervous sy
239 es, pro- and anti-angiogenic genes, and RNAi-incompetent siRNAs all suppressed CNV in mice comparably
241 Salmonella strain expressing a catalytically incompetent SopAC753S mutant had reduced Salmonella-indu
242 ules, leaving the complexes in an elongation-incompetent state and effectively suppressing HIV-1 repl
243 propose that E-cadherin, when in an adhesion-incompetent state at the lateral domain, serves as targe
244 preferentially interacts with the C-binding incompetent state of the adjacent cAMP-binding domain (C
250 he free RNA, including binding competent and incompetent states that have distinct fluorescence decay
251 establish the X state by permitting lysis of incompetent streptococci, uptake of DNA fragments, and i
252 es of NCR-CD3zeta assemblies: 1) a signaling incompetent structural NKp30-CD3zeta complex and 2) a li
256 S1) could only replicate in interferon (IFN)-incompetent systems, suggesting that the NS1 protein is
257 stration of soluble tubulin into an assembly-incompetent T2S complex (two alpha:beta tubulin dimers p
259 urally occurring regeneration-competent and -incompetent tadpoles, we identified a previously unrecog
261 r effects, but its poor water solubility and incompetent targeting property largely limit its clinica
262 n rescues the polymerization of the assembly incompetent tethramethyl rhodamine (TMR)-actin and T203C
265 scription factors renders Arabidopsis plants incompetent to floral inductive signals, including long-
266 es the intermediate cell mass, callus, to be incompetent to form shoot progenitors, whereas induction
267 phalic cells lacking Foxg1 are intrinsically incompetent to generate the ventral telencephalon has re
268 ferent activities, whereas CAP-Gly-1 appears incompetent to mediate either +TIP behavior or MT nuclea
269 l knowledge of a physician colleague who was incompetent to practice medicine in their hospital, grou
270 ing physicians who are impaired or otherwise incompetent to practice, but data suggest that the rate
272 eat and rendering the porphyrins kinetically incompetent to readily perform useful photochemistry.
274 cells at 11.5-19.5 days postcoitum (dpc) are incompetent to support full-term development of cloned m
276 port surveillance factor that retains export-incompetent transcripts near their transcription site.
277 analyses of these replication-competent and -incompetent truncation mutants suggest potential roles f
279 profile, eliminates aspartate only in OXPHOS-incompetent tumors, and prevents their growth and metast
280 -7/IL-24, administered through a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA
283 ariants of SOD1 is shown to be catalytically incompetent: unable to bind superoxide in a way comparab
284 of wild-type US2 with those of a dislocation-incompetent US2 mutant, and identify signal peptide pept
286 and evaluation of attenuated and replication-incompetent vaccinia strains being tested for variola an
289 complexes, we generated native and signaling-incompetent versions of each receptor by site-directed m
290 We also identified a clearly replication-incompetent viral sequence in multiple memory T cells in
291 tein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic aci
292 us 1 blocks apoptosis induced by replication-incompetent virus mutants, proapoptotic members of the B
296 gellar export apparatuses that are secretion incompetent, we determined that formation of the apparat
298 pregulated mating-associated genes in mating-incompetent white cells without causing G1 arrest or shm