ライフサイエンスコーパス: increased activity

1 apamycin complex 1 (mTORC1) complex allowing increased activity.

2 d with digging for winter forage, moderately increased activity.

3 roup activity whereas optogenetic activation increased activity.

4 uscular parameters (e.g., size) improve with increased activity.

5 is regulatory region exhibits constitutively increased activity.

6 to arginine (K68R), mimicking deacetylation, increased activity.

7 lexibility in favor of an extended conformer increased activity.

8 s, which represent ensembles of neurons with increased activity after memory formation, could underli

9 Because of their increased activity against activating mutants, first-gen

10 The compounds showed increased activity against clinical isolates of P. aerug

11 To design drugs with increased activity against Gram-negative bacteria in the

12 Recent epidemiological studies show increased activity among GI NoVs, with some members show

13 We propose that the increased activity and a switch to quadramodal magnetic

14 roved consistent micrographia accompanied by increased activity and connectivity in the basal ganglia

15 Increased activity and energy alongside mood change are

16 We show increased activity and O2 tolerance for a protein fusion

17 d Mn bipyridine electrocatalysts in terms of increased activity and reduced overpotential, a bulky bi

18 s poly-4-vinylpyridine leads to dramatically increased activity and selectivity for CO(2) reduction.

19 point mutations H221F and R312L resulted in increased activity and specificity toward poly-ManA and

20 ecruited to accelerate membrane retrieval at increased activity and temperature.

21 gh the underlying mechanisms responsible for increased activity are not well understood.

22 However, the mechanisms responsible for the increased activity are unknown.

23 tumours remodel the neuronal milieu towards increased activity are unknown.

24 ions were found that may have contributed to increased activity as a result of greater Shannon entrop

25 d medial temporal areas, risk-takers instead increased activity as stakes became more costly.

26 regions of the Posterior Medial network show increased activity at event boundaries, but these bounda

27 we found that almost all ACC neurons showed increased activity before hippocampal ripple activity; m

28 t was mediated not by caloric restriction or increased activity, but by increased energy expenditure,

29 lidine reduced the lipophilicity and further increased activity by 10-fold, affording LEI-401 as a na

30 nput through whisker trimming nor moderately increased activity by environmental enrichment affects c

31 histamine, induced anxiety-like behavior and increased activity (c-Fos expression) in the amygdala in

32 of these analogues demonstrate their 6-fold increased activity compared with that of latrunculin B a

33 2 (10 of 17) edible tissue samples exhibited increased activity concentrations of (137)Cs (234-824 mB

34 Fe incorporation and increased activity correlate with an anodic shift in the

35 trast to this task-negative pattern, we show increased activity during a large and demanding switch i

36 Distinct groups of BL neurons displayed increased activity during appetitive (CS-R) versus avers

37 ike activity, mediate cell death and display increased activity during pathogen infections.

38 ction error deficit correlated strongly with increased activity during silence and with reduced volum

39 adult prefrontal cortex is characterized by increased activity during the delay period of the task b

40 ing VTA(Vgat) neurons intensify wakefulness (increased activity, enhanced alertness and motivation),

41 expressed, while the original study reported increased activity (Figure 3D; Tay et al., 2011).

42 PAM neurons show increased activity following caffeine administration, an

43 the dorsal anterior cingulate cortex, showed increased activity following errors in the impaired grou

44 The dlPFC, but not the hippocampus, showed increased activity for altered images compared with old

45 arting material and that previous reports of increased activity for beta-NiOOH are due to incorporati

46 on 190 was identified that had significantly increased activity for the aldol reaction of erythrose w

47 and pyrrolidinyl substituents that exhibited increased activity for the C-H borylation of unactivated

48 s greatly altered substrate specificity with increased activity for the oxyimino-cephalosporin, cefta

49 Fourteen hits showed increased activity (improved >4.5-fold in lysate; kcat i

50 in its LPZ in the first weeks postlesion and increased activities in its periphery from 1 month onwar

51 Furthermore, increased activity in bilateral caudate nucleus and hipp

52 herent speech production was associated with increased activity in bilateral inferior prefrontal cort

53 deficits in BNST synaptic potentiation, and increased activity in BNST-CRF neurons known to drive ne

54 In experiment 2, emotional voices evoked increased activity in both the auditory cortex and the i

55 od psychosocial functioning mediated through increased activity in brain regions in response to mater

56 ta suggested that asynchronous delays led to increased activity in Broca's area and its right homolog

57 N]) known as the sevenmaker mutation, causes increased activity in cells and evades inactivation by d

58 Near-infrared stimulation increased activity in cones, ganglion cell layer neurons

59 ehydroepiandrosterone and testosterone, with increased activity in congenital adrenal hyperplasia var

60 However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized.

61 active GSSG efflux mechanism, showed 2-fold increased activity in EOMA compared with MAE cells.

62 Previous fMRI studies have found increased activity in frontoparietal cortex when task sw

63 We found that increased load not only increased activity in frontoparietal network, but also h

64 However, the TPJ showed increased activity in IED on escitalopram compared with

65 Increased activity in ipsilateral secondary motor areas

66 vid remembering is typically associated with increased activity in lateral parietal cortex (LPC)--"re

67 ed goal-directed behavior was accompanied by increased activity in median but not dorsal raphe, impli

68 This increased activity in mPFC was not observed during encod

69 Whole-brain fMRI analysis revealed increased activity in multiple cortical areas with incre

70 The white noise effect in LA was driven by increased activity in neurons projecting from ipsilatera

71 r-related metabolic network characterized by increased activity in pons, thalamus, medial frontal and

72 Synchronous speech was associated with increased activity in posterior and anterior auditory fi

73 ce activity was reduced in visual cortex but increased activity in precuneus, frontopolar, and premot

74 Itch stimuli also increased activity in projection areas to the amygdala,

75 3, both L290P and L290V mutants have greatly increased activity in promoting cancer cell migration an

76 esonance imaging in a rodent model, we found increased activity in regions known to depress cortical

77 ced novelty detection in the hippocampus and increased activity in saliency networks.

78 lphavbeta6 integrin causes androgen receptor-increased activity in the absence of androgen and conseq

79 Results indicated that increased activity in the amygdala, a region involved in

80 nterior cingulate cortex that corresponds to increased activity in the auditory cortex, whereas botto

81 nterior cingulate cortex that corresponds to increased activity in the auditory cortex.

82 ng and connectivity, which is accompanied by increased activity in the BLA in response to social stim

83 ventional moral reasoning is associated with increased activity in the brain's frontostriatal system,

84 CO(2) reduction mechanism accounting for the increased activity in the catalyst-polymer composite.

85 creased neuronal activity, but paradoxically increased activity in the caudal hindbrain.

86 eral distinct neural processes, most notably increased activity in the default mode network (DMN), su

87 Challenges to political beliefs produced increased activity in the default mode network-a set of

88 dant personality disorder patients exhibited increased activity in the dorsal anterior cingulate cort

89 Antidepressants increased activity in the dorsolateral prefrontal (dlPFC

90 Increased activity in the forelimb peri-infarct cortex v

91 ced neuronal activity in the hippocampus but increased activity in the ipsilateral lateral amygdala (

92 tion and optogenetic studies have shown that increased activity in the lateral hypothalamus (LH) prom

93 he neural level, nursing was associated with increased activity in the lateral septum and preoptic ar

94 amygdala bilaterally revealed significantly increased activity in the left amygdala in paranoid pati

95 ingulate gyrus, right PrCS and right PPC and increased activity in the left PFC and left insular (INS

96 of auditory stimuli and was associated with increased activity in the left superior temporal sulcus

97 Hypoglycemia is associated with increased activity in the low-frequency bands in the ele

98 hyperactivity in the hippocampus that drives increased activity in the midbrain and basal ganglia.

99 h the same task on clear speech demonstrated increased activity in the midline frontal cortex in the

100 -hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU g

101 individual choice in several regions (i.e., increased activity in the nucleus accumbens [NAcc] and m

102 with an abundance mindset, participants had increased activity in the orbitofrontal cortex, a region

103 he frontal and parietal lobes, but also with increased activity in the subcortical PAG and other midb

104 This social value signal was associated with increased activity in the ventral striatum and medial pr

105 ning (regardless of its timing) demonstrated increased activity in visual regions associated with the

106 s to Galphao-R243H, an oncogenic mutant with increased activity in vitro and in cells due to rapid nu

107 onto GluN2D(-/-) BNST-CRF cells ex vivo and increased activity in vivo Using a GluN2D conditional KO

108 This increased activity, in turn, is followed by a reduction

109 dulated by absolute reward value, exhibiting increased activity, increased gamma-band power and decre

110 st or both helices resulted also in strongly increased activity indicating that the N-terminal domain

111 hat mimics homeostatic scaling up induced by increased activity, indicating that activation of this p

112 o "filling-in" of the target location due to increased activity induced by the flankers.

113 Increased activity is a consequence of both a larger fra

114 accharides, but the molecular basis for this increased activity is not known.

115 We identified distal cCREs with age-increased activity linked to SARS-CoV-2 host entry gene

116 based on cued attention conditions revealed increased activity mainly in somatosensory and cerebella

117 ower outputs, decreased food availability or increased activity may render some populations energetic

118 textualizes the independent origins of their increased activity metabolism.

119 as present in bilateral anterior PT, with no increased activity observed in posterior PT or parietal

120 tants or inhibition of GSK3 in psrA(-) cells increased activities of both PKBR1 and PKBA, but only th

121 strains of C. jejuni exhibited significantly increased activities of catalase and superoxide dismutas

122 agent combination strongly activated Bax and increased activities of cytochrome c and caspase-9 and -

123 N-end-rule-insensitive Delta13RAP2.12 led to increased activities of fermentative enzymes and increas

124 Increased activities of inducible nitric oxide synthase

125 , a decline in liver triglycerides alongside increased activities of NAD(P)H:Quinone Oxidoreductase 1

126 The increased activities of the desaturases resulted in sign

127 ated sirtuin 1 inhibition was accompanied by increased activities of two vital inflammatory regulator

128 Increased activity of 5-aminolevulinate synthase 2 (ALAS

129 messenger, cyclic diguanylate (c-di-GMP), by increased activity of a c-di-GMP specific phosphodiester

130 cul-6, suggesting that pals-22 mutants have increased activity of a CUL-6/cullin-containing ubiquiti

131 ifts in diel nitrogen fixation patterns, and increased activity of a potentially regulatory DNA methy

132 influx across an unstable sarcolemma due to increased activity of a STIM1-Orai1 complex is a disease

133 We found increased activity of androgen receptor (AR) signaling i

134 ent in the production of osmoprotectants and increased activity of antioxidant enzymes.

135 allele confers cancer susceptibility through increased activity of APOBEC-dependent mutational proces

136 These findings also imply that the increased activity of APOBEC3B may contribute to PyV-med

137 in tonoplast CsHMA5.2 is consistent with the increased activity of ATP-dependent copper transport int

138 epetitive spiking is maintained, through the increased activity of barium-sensitive potassium channel

139 to specifically identify a mechanism linking increased activity of BLA glutamatergic neurons to aberr

140 e neurohormonal derangements may act through increased activity of both NHE1 and NHE3.

141 connected the induced CD44(Hi) phenotype to increased activity of both the glycolytic and oxidative

142 The presence of this exon leads to increased activity of both vesicular monoamine transport

143 This is secondary to increased activity of calpain 1, the primary enzyme resp

144 se pathological phenotypes correlate with an increased activity of cAMP-mediated PKA and ERK1/2 signa

145 We demonstrated that increased activity of casein kinase 2 (CK2) observed in

146 masome as demonstrated by the processing and increased activity of caspase-1 and secretion of IL-1bet

147 s and apoptosis and decreased the HI-induced increased activity of caspase-3.

148 parallel with apoCcp1 export, cells exhibit increased activity of catalase A (Cta1), the mitochondri

149 amatergic neurons in the mPFC of KO rats and increased activity of central amygdala somatostatin-posi

150 Increased activity of cholinergic neurons are mediators

151 -coenzyme A and dihydroxy LCB substrates but increased activity of class II ceramide synthases that u

152 output, biliary bile salt hydrophobicity, or increased activity of dedicated cholesterol and phosphol

153 sphorylation of Replication Protein A due to increased activity of DNA2 and WRN at the DNA interstran

154 hat activation of the reward system involves increased activity of dopaminergic (DA) neurons in the v

155 Increased activity of efflux transporters, e.g., P-glyco

156 Additionally, obesity is associated with increased activity of endocannabinoid system (eCB).

157 erature, impairment in biofilm formation and increased activity of enzymes detoxifying reactive oxyge

158 Nerve injury increased activity of euchromatic histone-lysine N-methy

159 Thus, increased activity of excitatory DH interneurons coupled

160 es in intracellular Ca(2+) oscillations, and increased activity of extracellular cathepsin L and D.

161 Amplification of FGF19 resulted in increased activity of FGF19 only in tumor cells that kep

162 The increased activity of Fur under anaerobic conditions led

163 Persistently increased activity of G protein-coupled receptor kinase

164 The increased activity of GIRK channels is likely to lead to

165 n of learned fear responses and suggest that increased activity of GluN2C receptors may underlie the

166 nal mechanisms of steroid resistance include increased activity of GR phosphorylating kinases which m

167 These data suggest that increased activity of HIF-alpha isoforms regulate Th1/Th

168 axa associated with warmer temperatures, and increased activity of hydrolytic enzymes.

169 common finding in human cancer and leads to increased activity of hypoxia-inducible factors (HIFs),

170 s by a dual mechanism that involves both the increased activity of individual cells and the recruitme

171 tically, the decrease in XBP1s resulted from increased activity of inducible nitric oxide synthase (i

172 Using transcriptome analysis, we found increased activity of innate immune response pathways an

173 Increased activity of Kir channels results in the genera

174 11), infections (six), mucositis (four), and increased activity of liver enzymes (three).

175 before and during movement, owing in part to increased activity of local parvalbumin-positive interne

176 We found that the increased activity of low voltage activated T-type calci

177 In addition, the increased activity of macrophages, osteoclasts, and mega

178 Increased activity of matrix metalloproteinases (MMPs) i

179 These changes in gene expression result from increased activity of MEKK3, a mitogen-activated protein

180 of SLC7A5 to Salmonella-containing vacuoles, increased activity of mTORC1, and increased survival of

181 As a result of increased activity of mutant ryanodine receptor type 2 c

182 ting in phenotypic changes, as determined by increased activity of myosin light chain kinase in the c

183 enhanced actin dynamics, characterized by an increased activity of n-cofilin and profilin 1, leading

184 hronic obstructive pulmonary disease (COPD), increased activity of neck inspiratory muscles has been

185 induction of CD44 by DLX4 was attributed to increased activity of NF-kappaB that was stimulated by t

186 sm or normal levels of aldosterone exhibited increased activity of NLRP3 inflammasome, suggesting tha

187 lastomic strains overexpressing NDA2 show an increased activity of nonphotochemical reduction of plas

188 owed increased phosphooccupancy, pointing to increased activity of one or more MAP kinases in PKA kno

189 concentrations in cord blood may support the increased activity of one-carbon metabolism in infants.

190 accompanied by crystal decomposition and by increased activity of oxalate oxidase that converts oxal

191 These findings suggest that increased activity of P-gp could be responsible for incr

192 in the presence of hydrogen peroxide showed increased activity of p53 at Serine 15.

193 atidylinositol 4-kinase IIIbeta and PKC; the increased activity of phosphatidylinositol 4-phosphate 5

194 Here, we demonstrate that gossypol rapidly increased activity of phospholipase A2 (PLA2), which led

195 the CCM is able to acclimate to cold through increased activity of PPDK and RuBisCO.

196 reased stability of PDCD4 protein as well as increased activity of PRMT5 toward PDCD4.

197 tion factor binding motif analysis showed an increased activity of pro-inflammatory upstream signalin

198 resulting in altered input organization and increased activity of proopiomelanocortin (POMC) neurons

199 Increased activity of protein clearance pathways in the

200 Increased activity of protein kinase CK2 is associated w

201 ses show disturbed signaling pathways due to increased activity of proteins within the epigenetic mac

202 ontributes a developmental mechanism for the increased activity of Pten-depleted neurons.

203 suppression of excitatory mPFC networks via increased activity of PV+ FSIs may enhance reward-relate

204 Merlin loss-of-function is associated with increased activity of Rac and p21-activated kinases (PAK

205 enhanced recycling of microbial residues via increased activity of residue-decomposing enzymes.

206 e of hexoses also contributes to sustain the increased activity of respiratory metabolism to fuel pla

207 In enterocytes of AEG-1KO mice, we observed increased activity of RXR heterodimer partners, liver X

208 rom the combined action of enhanced IICR and increased activity of sarcolemmal Na(+)-Ca(2+) exchange

209 ne kinase 1 (WNK1), which, in turn, leads to increased activity of serum and glucocorticoid-inducible

210 Increased activity of SIRT3 was evidenced by normalizati

211 essed the activity of polyphenol oxidase and increased activity of superoxide dismutase enzyme.

212 geted by microRNA-21, which in turn leads to increased activity of Syk and Erk in CLL cells.

213 Increased activity of T follicular helper (Tfh) cells pl

214 Taken together, our data suggest that the increased activity of T-type calcium channels induced by

215 Here, we show that the increased activity of T-type calcium channels induced by

216 gm to determine the relationship between the increased activity of T-type channels in SCI-nociceptors

217 We also observed significant increased activity of the Anterior Cingulate Cortex (ACC

218 hibition induces prosurvival signals through increased activity of the autophagy/lysosomal network.

219 eta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-ma

220 sented a remarkable elevation of cGMP and an increased activity of the cGMP-dependent protein kinase

221 in intrinsic excitability was in part due to increased activity of the channels underlying the fast a

222 istically, miR-294 represses Wee1 leading to increased activity of the cyclin B1/CDK1 complex confirm

223 At the mechanistic level, CFA increased activity of the Epac target Rap1 in dorsal roo

224 Increased activity of the epigenetic modifier EZH2 has b

225 bers selectively in hippocampal area CA1 and increased activity of the filamentous actin severing pro

226 taepsilon) tetramers, which may underlie the increased activity of the former.

227 p3 DNA remethylation, which may be due to an increased activity of the glutaminolysis pathway.

228 tral carbon metabolic network, as well as an increased activity of the glyoxylate bypass and the 3-hy

229 Our results show that increased activity of the IDOL pathway in the liver can

230 ad decreased plasma ghrelin and demonstrated increased activity of the left anterior cingulate cortex

231 Mechanistically, we noted increased activity of the mechanistic target of rapamyci

232 Increased activity of the microtubule severing protein k

233 n for the p.R384X, supported by the fourfold increased activity of the most probable readthrough-medi

234 Increased activity of the multi-ligand scavenger recepto

235 ory activation through a mechanism involving increased activity of the NADH-sensitive transcriptional

236 These traits were associated with increased activity of the noncanonical Wnt/Ras homolog f

237 ted in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholip

238 We also found that isoflurane increased activity of the parvalbumin interneurons, and

239 Therefore, increased activity of the PI3K/AKT signaling pathway in

240 emic hypertension is mainly a consequence of increased activity of the renal Na(+)-Cl(-) cotransporte

241 This shows that increased activity of the renin-angiotensin-aldosterone

242 Enhanced IICR, however, together with an increased activity of the sodium-calcium exchange mechan

243 Conversely, miR-132 increased activity of the STAT3 and ERK pathways, thereb

244 Increased activity of the sympathetic nervous system is

245 eys of TBS targeting the hippocampal network increased activity of the targeted (left) hippocampus du

246 Furthermore, NSP activities unleashed increased activity of the tissue-destructive proteases m

247 common to LasR-defective (LasR-) strains is increased activity of the transcription factor Anr, rela

248 Increased activity of the transcription factor CREB in H

249 These mechanical stimuli are associated with increased activity of the transcriptional coactivator YA

250 ossible mechanism for the involvement of the increased activity of the tricarboxylic acid cycle in ca

251 Increased activity of the tumour suppressor p53 is incom

252 The mechanism was dependent on increased activity of the tyrosine phosphatase CD45 and

253 of medial prefrontal neurons correspond with increased activity of their striosome-predominant striat

254 Increased activity of these and the plasma protease, hep

255 esis and that this upregulation is caused by increased activity of Torc1.

256 Fura-2 experiments demonstrated increased activity of TRPV5 in response to dobutamine, w

257 han depletion in pregnancy is facilitated by increased activity of tryptophan-depleting enzymes [i.e.

258 Obesity is associated with increased activity of two lipid signaling systems (endoc

259 Bloom decline is also accompanied by increased activity of viruses other than AaV, including

260 Moreover, cytokines IL-22 or IL-17A induced increased activity of Yes-1.

261 ecombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the trea

262 Surprisingly, variant p.G214R had increased activity on a small chromogenic peptide substr

263 We aimed to understand the impact of this increased activity on the strand-specific role of Pole i

264 The findings confirm that including increased activity or energy as part of DSM-5 criterion

265 When the new DSM-5 criterion of increased activity or energy was added as a coprimary sy

266 ritable mood and abnormally and persistently increased activity or energy" as a primary criterion for

267 DSM-IV criteria plus the DSM-5 criterion of increased activity or energy) and those who did not meet

268 DSM-IV criteria plus the DSM-5 criterion of increased activity or energy) and those who did not meet

269 phenotype characterized by elevated mood and increased activity or energy.

270 Infants had increased activity over right dorsal lateral PFC when ru

271 icarbazones can lead to a more than 100-fold increased activity, probably due to interactions with ce

272 mbrane-tethered cytokine had a substantially increased activity profile compared to non-targeted TR3.

273 x raises the interesting question of whether increased activity recruits ATP-independent mechanism(s)

274 g RVF5, we show that Tsc1 KO neurons exhibit increased activity relative to wild-type neurons and add

275 Increased activity requires cleavage of IL-1alpha by cal

276 states is consistent with a model where the increased activity results from an increased rate-consta

277 ound 27 (MI-538), which showed significantly increased activity, selectivity, polarity, and pharmacok

278 n allele of hnoX that encodes a protein with increased activity severely delayed wrinkled colony form

279 r stoichiometry of copper-bound PmoC exhibit increased activity, suggesting that the PmoC copper site

280 ases activity, while ferrous RsbR results in increased activity, suggesting that the V. brasiliensis

281 such that increased IIV was associated with increased activity, the MAP+ group displayed this relati

282 anticancer therapeutic antibodies for their increased activity through Fc receptors (FcgammaRIIIa).

283 reas graded cross-link lengthening gradually increased activity, thus defining the conformational con

284 ods, whilst halving the time taken to detect increased activity to 1.3 days.

285 on, we further identified derivatives having increased activities toward Oct3/4 induction.

286 nd D117V mutations resulted in significantly increased activity toward (R)-3-hydroxybutyryl-CoA.

287 contrast, FKBP19, FKBP22, and FKBP65 showed increased activity toward hydroxyproline-containing pept

288 reduced activity in response to glucose and increased activity under starvation conditions.

289 DRN DA neurons show increased activity upon social contact following isolati

290 alogues with several modifications providing increased activity versus S. aureus and other bacterial

291 acids at the same position showed that this increased activity was not achievable with any of the 20

292 However, connector nodes do exhibit increased activity when more cognitive functions are eng

293 asing daily physical activity, assuming that increased activity will lead to corresponding increases

294 GF-R inhibitor with clinical data supporting increased activity with dose titration.

295 PW/R) complexes, which are short episodes of increased activity with superimposed high-frequency osci

296 Increased activity within known reward-processing neuroc

297 Relative to controls, amputees also showed increased activity within the former cortical sensorimot

298 decreased metastability was associated with increased activity within the frontoparietal control/dor

299 4) if NAT was available and the donor had no increased activity within the window period (P < 0.001).

300 iated signaling in BNST VGAT neurons and saw increased activity within ventral midbrain structures, i