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1 the field are largely empirically driven and incremental.
3 s work establishes Rosetta-guided design and incremental aaRS improvement as a viable and accessible
5 This prompted us to question the effect of incremental [ADP] on respiration in interscapular brown
6 tance of long-term projects characterized by incremental advances involving multiple laboratories can
7 ty-four-hour BP phenotypes conferred a small incremental advantage over clinic BP in predicting cardi
8 ng dried specimens only was dominated in the incremental analysis, due primarily to fewer correct res
9 mal expansion in Asgard and Eukarya has been incremental and iterative, without substantial remodelin
12 ach identifies opportunities to reliably use incremental approaches, enabling adaptation investments
15 lated 30-minute (early phase) and 180-minute incremental area under the curves were calculated as res
16 ch, overall postprandial hyperglycemia (24-h incremental area under the glucose curve) and glycemic v
17 excursions) were reduced with the LCBF (24-h incremental area under the glucose curve: -173 +/- 361 m
18 1.6 compared with 26.8 +/- 3.5 nmol x min/L) incremental area-under-the-curve and delayed gastric-emp
23 however, there is a lack of evidence showing incremental benefit over transthoracic echocardiography.
25 ese treatments, with only marginal to modest incremental benefits using conventional cytotoxic therap
33 We show that CHD risk can be lowered with incremental changes in lifestyle and diet, e.g. fruit-ve
37 the NCI-NCL and EUNCL multi-step approach of incremental complexity to measure particle size distribu
38 = 4, ~50 kg) for 20 procedures guided by 246 incremental conventional CT scans (mean, 12.5 scans per
39 A Markov model was used to determine the incremental cost and effectiveness of extending Medicare
40 thirty-year reductions in TB incidence, and incremental cost effectiveness (cost per quality-adjuste
41 ental cost-effectiveness ratio (ICER) as the incremental cost in dollars per quality-adjusted life ye
42 analysis model was developed to estimate the incremental cost needed to obtain an additional response
43 0.47-1.75) quality-adjusted life-years at an incremental cost of $1 135 000 (872 000-1 377 000), resu
44 raoperative MRI vs 1.16 QALYs without) at an incremental cost of $13 447 ($176 460 with intraoperativ
46 d ibrutinib arm, first-line ibrutinib had an incremental cost of $478 823, an incremental effectivene
47 d to significantly higher health care costs (incremental cost of $612 700), resulting in an ICER of $
48 e interval [CI], $331-$347), resulting in an incremental cost of the intervention of US$77 (95% CI, $
49 rmittent preventive treatment resulted in an incremental cost of US$5657 (95% CI 1827 to 9448) and 10
50 (95% credibility interval 274 to 1517) at an incremental cost of US$7051 (2653 to 13 038) generating
55 ted life expectancy compared with GDMT at an incremental cost per quality-adjusted life-year gained t
60 Using Kenya as a case study, we assessed the incremental cost-effectiveness of continuing PCV use.
64 ared with screening at ages 10 and 20 years (incremental cost-effectiveness ratio $106 841/quality-ad
67 obability that PCDT would achieve a lifetime incremental cost-effectiveness ratio <$50 000/QALY or <$
69 ffectiveness was determined by measuring the incremental cost-effectiveness ratio (ICER) as the incre
70 tal quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) at willingne
71 n-fatal stroke) over a 5-year period and the incremental cost-effectiveness ratio (ICER) from the per
72 onsensus exists about what threshold for the incremental cost-effectiveness ratio (ICER) in dollars p
75 st of US$7051 (2653 to 13 038) generating an incremental cost-effectiveness ratio (ICER) of $8 (2 to
76 showed that compared with no treatment, the incremental cost-effectiveness ratio (ICER) of DAAs at a
79 service care cost per life-year saved as the incremental cost-effectiveness ratio (ICER), based on 20
83 years (QALYs), total cost (in 2018 US$), and incremental cost-effectiveness ratio (ICER; from the hea
84 FujiLAM was considered cost-effective if its incremental cost-effectiveness ratio (USD/year-of-life s
85 cost of $31,156 (95% CI, -$158 to $92,179) (incremental cost-effectiveness ratio = $38,648 per quali
86 ost of $5,242 (95% CI, -$19,035 to $41,019) (incremental cost-effectiveness ratio = $44,615 per extra
87 t effective for all international travelers (incremental cost-effectiveness ratio [ICER] $4.6M/measle
88 curacy 96%, $196 per patient) and long term (incremental cost-effectiveness ratio [ICER] $5,387-$8,43
89 nth testing was cost-effective for both MSM (incremental cost-effectiveness ratio [ICER], $1000/year
91 Cost-effectiveness was evaluated using the incremental cost-effectiveness ratio and net monetary be
93 Model inputs with the greatest variation on incremental cost-effectiveness ratio estimates were the
97 SGA had a 64% to 77% likelihood of having an incremental cost-effectiveness ratio of $100 000 or less
98 net monetary benefit of AUD$1.02 million and incremental cost-effectiveness ratio of $4,684 per QALY
99 rs at a cost of $45 648, yielding a lifetime incremental cost-effectiveness ratio of $40 361 per life
100 $4,949 increase in 1-year care costs, and an incremental cost-effectiveness ratio of $42,120 per qual
101 monetary benefit of AUD$1.02 million and an incremental cost-effectiveness ratio of $4684 per QALY g
102 in microsimulation modeling, resulting in an incremental cost-effectiveness ratio of $76 442 per QALY
103 135 000 (872 000-1 377 000), resulting in an incremental cost-effectiveness ratio of $880 000 (697 00
105 10 (US$237.36) per patient at 1 year, and an incremental cost-effectiveness ratio of approximately po
106 891]) compared with DM, resulting in a mean incremental cost-effectiveness ratio of euro 27 023 ($29
107 0 and costs by euro 670 million, yielding an incremental cost-effectiveness ratio of euro 9,600/QALY.
110 interval [CI] 0.67-0.99, p = 0.017) with an incremental cost-effectiveness ratio of pound 1,359 per
111 produced higher total QALYs and costs and an incremental cost-effectiveness ratio of pound 110 741/QA
112 red with methotrexate alone, resulting in an incremental cost-effectiveness ratio of pound 129 025 pe
115 their stable partners over 10 years, with an incremental cost-effectiveness ratio of US$509 per DALY
119 -719.7 to 904.1) per 1000 women; the average incremental cost-effectiveness ratio was $53 per DALY av
120 tality (hazard ratio of 0.86), the estimated incremental cost-effectiveness ratio was $74 403 per QAL
122 calculated and the empirical 95% CI for the incremental cost-effectiveness ratio was estimated from
123 treatment cost of US$5,850, the mean overall incremental cost-effectiveness ratio was US$92,200 per Q
126 nal $500/person, and was not cost-effective (incremental cost-effectiveness ratio: $420 000/quality-a
127 d total implementation costs; and determined incremental cost-effectiveness ratios (ICER) and benefit
128 al-days, and costs over 180-days, as well as incremental cost-effectiveness ratios (ICER, $/quality-a
132 ID, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) for each c
133 l diversion program and calculated resulting incremental cost-effectiveness ratios (ICERs) from the h
134 ealthcare, and lost-productivity costs), and incremental cost-effectiveness ratios (ICERs) of two pol
136 effectiveness was assessed by calculation of incremental cost-effectiveness ratios (ICERs) using net
137 ICURs) using quality-adjusted life-years and incremental cost-effectiveness ratios (ICERs) using year
138 ts, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) were calcu
144 quality-adjusted life expectancy, costs, and incremental cost-effectiveness ratios (ICERs, $/quality-
145 ortive care in the German model resulting in incremental cost-effectiveness ratios for cabozantinib o
148 tinib and $4630 for best supportive care and incremental cost-effectiveness ratios of $972,049/life y
151 benefits and result in substantially higher incremental cost-effectiveness ratios than the current r
153 ality-adjusted life years (QALYs), cost, and incremental cost-effectiveness ratios were estimated for
154 senting cost per quality-adjusted life year, incremental cost-effectiveness ratios, or cost per life-
158 treated, and cured; cirrhosis cases avoided; incremental cost-effectiveness ratios; DOC costs (2016 U
159 ed included varicella and HZ incidences, the incremental cost-utility ratio (ICURs) over a lifetime h
160 e strategy of extending drug coverage had an incremental cost-utility ratio of $51,694 per QALY gaine
164 eneralized linear model was used to estimate incremental costs (2016 U.S. dollars) and quality-adjust
166 ost-effectiveness ratios (ICERs), defined as incremental costs per quality-adjusted life year (QALY)
167 een the short- and long-term storage groups (incremental costs, -$2,358; 95% CI, -$5,586 to $711) and
171 t of US$5657 (95% CI 1827 to 9448) and 107.4 incremental DALYs averted (-719.7 to 904.1) per 1000 wom
172 we describe requirements for a framework for incremental data integration and propose an implementati
173 ome clinical samples and cataloging them in "Incremental Databases" that maintain individual confiden
176 n and to characterize subclinical AF and the incremental diagnostic yield of 4 versus 2 weeks of cont
182 ients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is
183 s and functions in fibroblasts, although its incremental effect on sarcomeric protein induction was r
184 inib had an incremental cost of $478 823, an incremental effectiveness of 0.05 QALYs, and an ICER of
186 ogonal catalysis in biomedicine is inspiring incremental efforts to design strategies that regulate d
187 d T(H)17 cell-related mediators demonstrated incremental elevations with increasing disease severity,
189 HFrEF patients and controls performed an incremental exercise test to volitional exhaustion to de
190 ix types of feature encoding schemes through incremental feature selection and application of the XGB
192 ottom compared with those in the top half of incremental glycemic responses ranked by Abbott resulted
194 evels of 2.8 mmol/L (50 mg/dl) for 1 hour by incremental hyperinsulinemic clamps using baseline and 2
195 ment durations and washout periods to assess incremental improvement in airway hyperresponsiveness wh
198 ergetics models for shark and ray megafauna, incremental improvements in respirometry systems are use
201 igh-calorie delivery were associated with an incremental increase in the likelihood or mortality.
202 dies against neuronal proteins has led to an incremental increase in use of the term "autoimmune epil
203 This work demonstrates the effects of an incremental increase of nanopillar height on nanostructu
206 le-phase (SP) and two-phase (TP) mode across incremental increases in organic loading rate (OLR) from
207 ovo recruitment or loss; the latter involves incremental increases in the transcriptional elongation
208 643) within 1 month, followed by consecutive incremental increases up to 53% (804 108/1 515 537) by 1
209 tive/radical innovations yet higher rates of incremental innovations; individuals from culturally tig
212 The sparse thalamic firing could promote an incremental integration of recently acquired memory trac
213 ible neural substrate for seamless real-time incremental interpretation on the observed millisecond t
214 and 8 sheep with pacing-induced HF received incremental intravenous boluses of PDE9-I (30, 100, and
216 g continual learning benchmarks (e.g., class-incremental learning on CIFAR-100) without storing data,
218 are consistent over time, we then projected incremental long-term gains in event-free survival and o
223 d Dexcom systems resulting in within-subject incremental mean +/- SD glucose CVs of 91.7 +/- 1.9% and
226 dates and grant applications - words such as incremental, novelty, mechanism, descriptive and impact
227 h only 0.1 wt% of E-CNS in brine resulted in incremental oil production of 20%, highlighting the sign
229 were most sensitive to test volume, whereas incremental outcomes were most sensitive to the number o
231 Ang 1-7/Ang II ratio, as an independent and incremental predictor of beneficial outcomes, higher sur
232 d with increasing exposure duration, with an incremental prevalence increase of 8.2% per 250 exposure
235 erative secretoneurin concentrations provide incremental prognostic information to established risk i
237 e left atrial peak reservoir strain provided incremental prognostic value for major adverse cardiovas
243 k assessment early after reperfused AMI with incremental prognostic value over and above that of LVEF
246 pancreatic ductal adenocarcinoma, important incremental progress has been made particularly for the
247 grafts by utilizing biodegradable scaffolds, incremental pulsatile stretching, and optimal culture co
248 costs, -$2,358; 95% CI, -$5,586 to $711) and incremental quality-adjusted life years: 0.003 quality-a
249 Applying the 8th edition criteria yielded an incremental reduction in survival for each increase in s
250 initial 'loading' dose followed by doses of incremental reductions in antibiotic quantity (dose 'tap
251 within the posterior inner retina following incremental reductions in arteriovenous perfusion pressu
252 Above the critical point, agents exploit incremental refinements to systematically advance toward
253 ments of the cardiac function in volunteers, incremental respiratory motion parameters that were deri
256 al clearance as soon as possible to minimize incremental risk of mortality with each day of positive
261 terotrimeric G proteins has been emerging in incremental steps, but attributing biological significan
262 However, the cascading relationship between incremental stress exposure and neural dysfunctions over
263 ared to resection and ablation, the absolute incremental survival benefit is small over a 5-year time
265 ghest with LT, there are limited data on the incremental survival benefit of LT versus other curative
266 ts, the cediranib toxicity profile and small incremental survival benefit precludes additional develo
267 y status, higher HF risk was observed across incremental tertiles of time-varying total SB (hazard ra
269 Imaging biomarkers can play important roles incremental to conventional clinical factors for risk st
271 fibrillation (P<0.001) and was superior and incremental to interleukin-6, C-reactive protein, procal
272 the prognostic value of GLS was superior and incremental to LVEF and CMR markers of infarct severity.
273 ing synchrotron X-ray tomographic imaging of incremental tooth cementum, that they had maximum lifesp
276 In addition, our calculations articulate incremental URF (IURF) of solvent huff'n'puff based on n
280 to bone mineral (K(i)) by PET/CT can provide incremental value in response assessment of bone metasta
282 for those with a MELD score greater than 30 (incremental value of 0.31 quality-adjusted life years fo
283 or patients with a MELD score of 30 or less (incremental value of 0.54 and 0.36 quality-adjusted life
284 o better understand the process by which the incremental value of each biomarkers is evaluated to det
290 Utilization of LA strain further provided incremental value over CHA(2)DS(2)-VASc scoring (C stati
291 nt score or these 2 domains provided similar incremental values ( P=0.0004 and P=0.0008, respectively
292 re with preserved ejection fraction, but the incremental vascular molecular remodeling mechanisms fro
293 Unadjusted mean Medicare payments for each incremental year of patency were as follows: $71 000 for
296 B-specific test was used as a reference, the incremental yield of LAM over Xpert was 29.6% (45/152) a
299 : To investigate the diagnostic accuracy and incremental yield of Xpert MTB/RIF Ultra (Ultra; Cepheid