ライフサイエンスコーパス: indan

1 CHCF3] or 1-trifluoromethylated indanes (CF3-indanes).

2 raction-decarbonylation-ISC recloses to give indan.

3 ed to prepare optically active 1-substituted indanes.

4 r; they may form both CF3-alkenes and/or CF3-indanes.

5 how similar efficiency in the preparation of indanes.

6 tric synthesis of 2,3-dihydrobenzofurans and indanes.

7 Here we show that 2-pyridine-3-yl-methylene-indan-1,3-dione (PRT4165) is a potent inhibitor of PRC1-

8 ed on the readily available 2-azido-2-phenyl-indan-1,3-dione is described.

9 vity of a novel series of 2, 2-disubstituted indan-1,3-dione-based PDE4 inhibitors are described.

10 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB) was identified

11 that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volum

12 redistribution process between the 2-(3-oxo-indan-1-ylidene)-malononitrile-derived end-groups (EGs)

13 lar carboamination reactions, which afford 2-indan-1-ylpyrrolidines that result from syn-addition, ar

14 zed carboetherification of alkenes affords 2-indan-1-yltetrahydrofuran products in moderate to good y

15 where Aic(NN) is 2-amino-5-nitronylnitroxide-indan-2-carboxylic acid, have been inserted at positions

16 borolidine catalyst derived from cis-1-amino-indan-2-ol.

17 oH(4)) or 3,3,3',3'-tetramethyl-1,1'-spirobi(indan)-4,4',7,7'-tetrabromo-5,5',6,6'-tetraol (Br(4)spir

18 A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-

19 rotonated 3,3,3',3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetraol (spiroH(4)) or 3,3,3',3'-tetram

20 ]p yrazolo[1,5-a]pyrimidine-7-carbonyl}amino)indan-5-carboxylic acid (1), that is uniquely suited as

21 .3.1.0]-deca-2,4-diene (1Cl and 1F) releases indan and halocarbene amide (2Cl and 2F).

22 Ene-cyclopropenes give functionalized indanes and tetralines in the presence of ruthenium dime

23 roach for the synthesis of amino-substituted indanes and tetralins from readily available alkyne-deri

24 e a diverse library of C-1 amino-substituted indanes and tetralins in good overall yields.

25 enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles.

26 Quenching studies demonstrated that indan, as a primary photoproduct, is derived from a trip

27 tio- and diastereoselective route to complex indanes bearing all-carbon quaternary stereogenic centre

28 Indanes can be isolated as an acetal or alcohol in up to

29 affolds, including tetralins, chromanes, and indanes, can be easily prepared by this protocol.

30 rizontal lineCHCF3] or 1-trifluoromethylated indanes (CF3-indanes).

31 oach, up to 24 new boronic ester substituted indanes, cyclohexanes, and cyclopentanes were prepared i

32 ocol for the synthesis of indole-substituted indanes from o-alkenylbenzaldehydes under acetalization

33 Indanes, fused heteroarenes, and phenol derivatives are

34 nzonitrile substrates into 1,1-disubstituted indanes in 49-85% yield and 92-97% ee.

35 rized into cis-/trans-1,3-di(trifluoromethyl)indanes in yields of up to 100%.

36 or the preparation of 2-sulfonyl indenes and indanes, including: (i) Amberlyst-15-promoted Knoevenage

37 es and can oxidize such compounds as indole, indan, indene, phenetole, and acenaphthene.

38 t arising either from nucleophilic addition (indanes) or loss of a proton beta to the indanyl-type ca

39 e formation and identified the hydrolysis of indan oxide as a key step in maximizing the production o

40 These results confirmed the significance of indan oxide formation and identified the hydrolysis of i

41 ugh a monooxygenase activity forming (1S,2R)-indan oxide, with no dehydrogenation of trans-(1R,2R)-in

42 rylamino) and 1,3-bis(arylthio and alkylthio)indanes, respectively, which are spirolinked to the cycl

43 placement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-

44 eatures included the direct synthesis of the indan skeleton and the radical addition to a quinone.

45 domino reaction for the synthesis of diverse indanes starting from simple cinnamic acid esters is des

46 U-99194A [5, 6-dimethoxy-2-(di-n-propylamino)indan], suggesting that activation of the BDNF pathway v

47 bond activation approach to the synthesis of indans, tetralins, dihydrofurans, dihydroindoles, and ot

48 aphthalene oxide (254 nm) was reexamined and indan was found to be a primary photoproduct, as well as

49 ctivity of naturally occurring and synthetic indanes, we have synthesized a novel indane scaffold tha

50 herein summarize the asymmetric syntheses of indanes with a particular focus on asymmetric catalysis,

51 s (pseudocumene, mesitylene) afford only CF3-indanes with a predominantly cis-orientation of substitu