ライフサイエンスコーパス: independent pathway

1 GF-beta acted through a JNK-dependent, Smad4-independent pathway.

2 ins reduce cancer risk through a cholesterol independent pathway.

3 tion of Cl(-) and Br(-) by (3)DOM*, an (*)OH-independent pathway.

4 e nodules in the cortex, probably through an independent pathway.

5 s (cDCs) via a STAT3-dependent but NF-kappaB-independent pathway.

6 d absorption in diabetic mice via an insulin-independent pathway.

7 its activation is not essential for the NOX-independent pathway.

8 old stress signal via an abscisic acid (ABA)-independent pathway.

9 ursor for glutathione synthesis via an NADPH-independent pathway.

10 hesis and enhances autophagy through an mTOR-independent pathway.

11 /Th9 axis operates through a distinct, OX40L-independent pathway.

12 APK blockade reverses senescence via an mTOR-independent pathway.

13 a VEGFR2-dependent but alpha2beta1 integrin-independent pathway.

14 mbryonic surface formation via an ATML1/PDF2-independent pathway.

15 llagen expression through a TGFbeta receptor-independent pathway.

16 ly spn-4 dependent pathway and a later spn-4 independent pathway.

17 e formation, in a CRM-1-dependent, Akt1/mTOR-independent pathway.

18 factors and induces cell death through a Gli-independent pathway.

19 ed through a TLR5-, inflammasome-, and MyD88-independent pathway.

20 ecognition of Mdm2 can be mediated by an S5a-independent pathway.

21 the endoplasmic reticulum in an immunophilin-independent pathway.

22 TNF-alpha activates NF-kappaB through a RIP1-independent pathway.

23 and HD domain-containing protein 1 (SAMHD1)-independent pathway.

24 signaling, which activated a Zap70- and LAT-independent pathway.

25 ough an ACTH- and sympathetic nervous system-independent pathway.

26 ed for heat stability of TIP60.com by a p400-independent pathway.

27 HO cells expressing HSV-1 receptors via a pH-independent pathway.

28 uniporter-mediated, but uncoupling protein 3-independent pathway.

29 e recovered by supplying iron via a lysosome-independent pathway.

30 gers KSHV replication through a distinct RTA-independent pathway.

31 clusively on breast cells, through a steroid-independent pathway.

32 dition, Fe homeostasis is regulated by a FIT-independent pathway.

33 rine cystitis via a noncanonical, interferon-independent pathway.

34 th and induction of cell death through a p53-independent pathway.

35 okine secretion of CD8(+) T cells via a CCR5-independent pathway.

36 G16L1 by a nuclear factor kappaB (NF-kappaB)-independent pathway.

37 intenance of genomic stability through a DDR-independent pathway.

38 ate cancer through a noncanonical and ligand-independent pathway.

39 ensitive K(+) channels mediate FIV via an NO-independent pathway.

40 xpression was significantly reduced by a TOR-independent pathway.

41 ulation when cells were activated via an IgE-independent pathway.

42 am of TLR4, which can also activate an MyD88-independent pathway.

43 that the worms can synthesize PGE2 via a COX-independent pathway.

44 en resistance via both ERalpha dependent and independent pathways.

45 ucose homeostasis via insulin-dependent and -independent pathways.

46 inhibitor directly controlled by p53 and p53-independent pathways.

47 by both complement-dependent and complement-independent pathways.

48 ection through both interferon-dependent and independent pathways.

49 nd ABA-dependent signalling, but also by ABA independent pathways.

50 ion, are carried through the retina by three independent pathways.

51 uces insulin synthesis and secretion via two independent pathways.

52 de human RBCs through the use of sialic acid-independent pathways.

53 diates recycling via retromer-dependent and -independent pathways.

54 tionale for identifying and targeting kinase-independent pathways.

55 ivating B cells through T cell-dependent or -independent pathways.

56 ion has discrete septin-dependent and septin-independent pathways.

57 d redirects signalling to numerous G-protein-independent pathways.

58 and is mediated by both NLRP3-dependent and -independent pathways.

59 lated by mTORC1 but converge to regulate two independent pathways.

60 d an activation of both MyD88-dependent and -independent pathways.

61 -autonomous functions via p53-dependent and -independent pathways.

62 gosomes through enigmatic noncanonical VPS34-independent pathways.

63 apeutic strategies to control these allergen-independent pathways.

64 s are regulated by both DELLA-dependent and -independent pathways.

65 mit virus entry into target cells through gD-independent pathways.

66 gests involvement of both Akt-dependent and -independent pathways.

67 M, but there are also Rip1-dependent, SigKLM-independent pathways.

68 ogen-activated protein kinase-dependent and -independent pathways.

69 induce transformation via activation of PI3K-independent pathways.

70 ncluding Exonuclease 1 (Exo1)-dependent and -independent pathways.

71 include CRTH2(+) cells through IL-4 and TCR-independent pathways.

72 erapeutics, including SMN2-dependent and SMN-independent pathways.

73 yclic guanosine monophosphate-dependent and -independent pathways.

74 in both tryptophan-dependent and tryptophan-independent pathways.

75 c via S1P2R and S1P3R stimulation using Smad-independent pathways.

76 n include both caspase-dependent and caspase-independent pathways.

77 nt pathways and cardioprotection through PKA-independent pathways.

78 ough both histone demethylase-dependent and -independent pathways.

79 ediated via both TRAF binding-dependent and -independent pathways.

80 ng that SIX1 acts through additional, VEGF-C-independent pathways.

81 nce through both LIN28B-dependent and LIN28B-independent pathways.

82 it functions through both mTOR-dependent and independent pathways.

83 n via receptor desensitization-dependent and independent pathways.

84 d through both PKCiota-dependent and PKCiota-independent pathways.

85 fects of CE on Tau and Abeta are mediated by independent pathways.

86 Smad3 in macrophages, without affecting Smad-independent pathways.

87 s against decapentaplegic), and through Smad-independent pathways.

88 noma cell proliferation through angiogenesis-independent pathways.

89 induces mitotic death signalled through two independent pathways.

90 th DNA methylation-dependent and methylation-independent pathways.

91 dent pathways, and monomeric alphaS by actin-independent pathways.

92 ate significant biological effects via ISGF3-independent pathways.

93 ivation of Toll-like receptor-dependent and -independent pathways.

94 EPEAT BINDING FACTOR (CBF)-dependent and CBF-independent pathways.

95 th planar cell polarity (PCP)-dependent and -independent pathways.

96 ect is mediated through pluripotency network independent pathways.

97 ernalization and signaling through G protein-independent pathways.

98 ed heat shock factor 1 (HSF1)-dependent and -independent pathways.

99 PAR(2) can signal through two independent pathways: a beta-arrestin-dependent one that

100 the viral and target membranes by one of two independent pathways: a rupture-insertion pathway leadin

101 We took an unbiased approach to identify p53-independent pathways activated by defects in ribosome sy

102 ndings provide a unifying mechanism by which independent pathways affecting the spatial recruitment o

103 cer, suggesting that noncanonical Smoothened-independent pathways also are clinically relevant.

104 12-LOX-deficient mice indicates that 12-LOX-independent pathways also contribute to PLY-triggered pu

105 SGs can also be activated through interferon-independent pathways, although the precise mechanisms re

106 factor (VEGF)-stimulated, nitric oxide (NO)-independent pathway and a VEGF-stimulated NO-dependent p

107 the sorting nexin 4 (SNX4)-mediated, signal-independent pathway and for a novel signal-mediated path

108 ment, TfR1 was endocytosed in an AP2- and Tf-independent pathway and trafficked to the lysosome for d

109 induces autophagosomes via a Class III PI3K-independent pathway and uses autophagosomal membranes as

110 educed mHLA-DR levels, mediated through IL-6 independent pathways and is reversible with IFN-gamma.

111 ntial pathways scales by the number of fully independent pathways and not by the number of overall re

112 y utilizing both beta-catenin-dependent and -independent pathways and suggest that its modulation cou

113 nsions associated with pain are processed by independent pathways and that there is an overactivation

114 lementarity determining region by two nearly independent pathways and that this preconfiguration acco

115 surface waters yields (*)OH through the H2O2-independent pathway, and the assessment of the relative

116 cally inert product, formed via the template-independent pathway, and the catalytically active replic

117 n event involves both Galphai-dependent and -independent pathways, and is conserved both in X4 and R5

118 11 is thought to mainly act via beta-catenin-independent pathways, and little is known about its role

119 ol secretion through apoB-dependent and apoB-independent pathways, and plasma triglyceride, cholester

120 ting open ends, eDNAs produced via the lysis-independent pathway appeared scattered but in a structur

121 EVs generated through ESCRT-independent pathways are also beneficial to virus spread

122 Two independent pathways are described, along with a simple

123 Therefore, alternative ATX-independent pathways are likely responsible for local ge

124 lack of Ndufaf5, suggesting that novel AMPK-independent pathways are responsible for Ndufaf5 cytopat

125 culosis proteasome contributes to pupylation-independent pathways as well.

126 platform-specific data and one from platform-independent, pathway-based data.

127 tive pathway able to generate in a caspase-1-independent pathway bioactive IL-18 to boost the product

128 d death by additional recruitment of caspase-independent pathways, but this required PI3K class IA an

129 hage programming in response to IL4 via a GR-independent pathway by serving as a coactivator for Krup

130 s through G-protein-dependent, and G-protein-independent pathways by engaging the scaffold protein be

131 genes were additionally induced through IFN-independent pathways by infectious hematopoietic necrosi

132 acid mixtures, suggesting that there are two independent pathways by which bitter compounds are sense

133 e, a computational environment for combining independent pathway calculations.

134 ependent influenza virus vaccine; (ii) a CD4-independent pathway can be an alternative mechanism for

135 Here we show that a third, NADPH-independent pathway can bypass the need for TrxR1 and GR

136 Thus, our results indicate that a proteasome-independent pathway can promote the release of active p1

137 lthough studies have demonstrated that redox-independent pathways can also mobilize Cr, no quantitati

138 rtially reduced HR, demonstrating that UBE2T-independent pathways can compensate for the recombinatio

139 BnAb responses are elicited via a type II T-independent pathway, coinciding with expansion and activ

140 NV infection; and the late, IRF-3- and IRF-7-independent pathway contributes to anti-DENV immunity.

141 support previous studies suggesting an ACTH-independent pathway contributes to the corticosterone rh

142 ronaviruses elicit AhR activation by an IDO1-independent pathway, contributing to upregulation of dow

143 en this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/E

144 al complex (SC) in Drosophila depends on two independent pathways defined by the chromosome axis prot

145 t through microbiota-dependent or microbiota-independent pathways, depending on the type of dietary c

146 PDF in enhancing PER/TIM stability occur via independent pathways downstream of the PDF receptor, the

147 epsilonRI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-couple

148 By activating independent pathways emanating from the VMHdm/c, we demo

149 We identified three independent pathways enabling cluster formation associat

150 However, little is known about the virus-independent pathways engaged by these molecules.

151 tegrated effect of Rab10-dependent and Rab10-independent pathways, establishing a divergence in insul

152 the Fas signaling pathway and a putative Ras-independent pathway first identified in NK cells.

153 activated an alternative caspase- and Panx1-independent pathway for ATP release from Jurkat cells in

154 ce of H2O2 by PRDX4 and a parallel slow H2O2-independent pathway for disulfide formation.

155 ggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1beta maturatio

156 imulates a previously unrecognized, clathrin-independent pathway for LDLR internalization.

157 mmetrically distributed and uncover a thymus-independent pathway for mature T cell production in the

158 s to IFNalpha/beta via activating the ligand-independent pathway for the phosphorylation and subseque

159 Antarctic sponge microorganisms prefer light-independent pathways for CO(2) fixation mediated by chem

160 treatment demonstrates that there are three independent pathways for DPC repair in Arabidopsis.

161 Wnt5a can activate beta-catenin-independent pathways for regulation of various cellular

162 rplay between template-directed and template-independent pathways for replicator formation has signif

163 factors including Prc1 supports kinetochore-independent pathways for spindle bipolarization.

164 mean temperature implications of differing, independent pathways for the decarbonization of global e

165 of experimental and theoretical studies, two independent pathways for this process are proposed, whic

166 he identification of noncanonical (caspase-1-independent) pathways for IL-1beta production has unveil

167 O(*) (considering only the hydrogen-peroxide-independent pathways) for the bulk waters were 4.8 x 10(

168 t, but not the papillae, suggesting that two independent pathways form these defense structures.

169 strate of 160 kDa (AS160), (ii) via an AS160-independent pathway from PKB, and (iii) via an additiona

170 duction is due to an ASC-dependent caspase-1-independent pathway generating IL-18.

171 cle arrest in p53 wild-type cells, and a p53-independent pathway impaired proliferation in cells with

172 Here we identify a STING-dependent, cGAS-independent pathway important for full interferon produc

173 subjects and indicated involvement of the GC-independent pathway in a human IgE-mediated disease.

174 that SOCS1 is expressed via a new, NF-kappaB-independent pathway in Dectin-1-triggered murine BMMs an

175 d duodenal protein synthesis through an mTOR independent pathway in humans.

176 nations associated with the Wnt/beta-catenin-independent pathway in mammary epithelial subpopulations

177 alphaIIbbeta3 regulates Syk through an ITAM-independent pathway in mice and provide novel insight in

178 recent laboratory study proposed a sunlight-independent pathway in which *OH forms during oxidation

179 gic conditions operate through different and independent pathways in AD that reflect dysfunction in d

180 results indicate that Wnd regulates multiple independent pathways in Drosophila motoneurons and that

181 In this work, we identify LiaR-independent pathways in Enterococcus faecalis that regul

182 beta regulate the expression of IL-8 through independent pathways in response to reduced hydration.

183 significant apoptosis, implicating TLR4/TRIF-independent pathways in the death of Yersinia-infected c

184 Moreover, our data support a role for p53-independent pathways in the pathophysiology of DBA.

185 t regulatory node for caspase-dependent and -independent pathways in the regulation of cell-type-spec

186 ngs underscore the clinical relevance of AKT-independent pathways in tumors driven by genetic lesions

187 The role of clathrin and clathrin-independent pathways in vacuolar targeting is discussed.

188 Moreover, Gcn5 regulates multiple independent pathways, including adhesion, cell wall-medi

189 The LAT family-independent pathway involved the SH2 domain of SLP-76 an

190 both mouse and human cells that this Bax/Bak-independent pathway involves dsRNA-induced innate immune

191 responds to the cullin CUL-5 and an anillin-independent pathway involving the kinase PIG-1/MELK.

192 These activities occur in parallel with an independent pathway involving Uba1-UbcH7, but in a spati

193 osed where BA chlorination was driven by two independent pathways involving the anilide ring and amid

194 e that the NO(2)-dependent nitrate reductase-independent pathway is crucial for NO production under s

195 that in the defect of ABCG5/G8, an ABCG5/G8-independent pathway is essential for regulating hepatic

196 The mechanism of the MIO-independent pathway is explored through isotopic-labelin

197 of Smad2 and Smad3, suggesting that the Smad-independent pathway is important for Treg function.

198 ay to NRG stimulation, while the slower JAK2-independent pathway is necessary for the late stage prom

199 t low-salt concentrations, but that a ppk301-independent pathway is responsible for inhibiting egg-la

200 phenotypes, we hypothesized that an insulin-independent pathway is responsible for the enhanced gluc

201 ent and phosphatidylinositol 3-kinase (PI3K)-independent pathway, it is unknown whether DVC insulin a

202 er this imbalance represents an early, Abeta-independent pathway leading to dementia and may reveal t

203 iated Ly49e transcription, and a LTalphabeta-independent pathway leading to elevated, Pro3-driven Ly4

204 moenzymatic strategies were designed through independent pathways leading to both amine antipodes.

205 insulin-IGF-1 signaling (IIS)-dependent and -independent pathways mainly in neurons and the intestine

206 is; however, an alternative UBIAD1/vitamin K-independent pathway may regulate cardiac function.

207 ing alloantibodies, suggesting that antibody-independent pathways may also contribute to pathogenesis

208 Therefore, other STAT2-independent pathways may be induced by the viral infecti

209 e insulin sensitivity among Chinese, obesity-independent pathways may be more relevant in South Asian

210 equired for most effects of Reelin, but Dab1-independent pathways may contribute.

211 y turnover of c-FLIP and the gamma-secretase-independent pathway mediated by PSAP-Bax complex formati

212 in-coupled receptors signal via parallel and independent pathways mediated by G proteins and beta-arr

213 We also show that PI3K- and Akt-independent pathways mediated by mTORC1 regulate the exp

214 Cholesky decomposition, common pathway, and independent pathway models.

215 The Wnt-dependent, beta-catenin-independent pathway modulates cell movement and behavior

216 , the contribution of necroptosis, a caspase-independent pathway of cell death, to HFD-induced liver

217 Here, we describe an inflammasome-independent pathway of IL-1beta production that was trig

218 wed that RIPK3 controls a separate, necrosis-independent pathway of inflammation by regulating cytoki

219 uggest that there is an alternative monocyte-independent pathway of LC differentiation.

220 ce the cause to an alternate PGC-1alpha/beta-independent pathway of nuclear-mitochondrial communicati

221 efine a TRIF-dependent, TLR4- and type I IFN-independent pathway of sterile liver injury in which hep

222 cidating the mechanisms underlying G protein-independent pathways of activating GIRK channels provide

223 n or restrain IP signaling may augment STAT6-independent pathways of allergic inflammation.

224 Independent pathways of bone reduction in opossum and ch

225 ated potassium (KATP) channel-dependent and -independent pathways of insulin secretion.

226 existence of both proteasome-dependent and -independent pathways of PKCalpha processing.

227 ecay, suggesting that one factor may use two independent pathways of post-transcriptional gene regula

228 t studies revealed IFNgamma-dependent, T-bet-independent pathways of resistance to diverse classes of

229 the role of APOC3 as a key regulator of LPL-independent pathways of triglyceride metabolism.

230 To elucidate the effect of the ABCG5/G8-independent pathway on cholelithogenesis, we investigate

231 The ABCG5/G8-independent pathway plays an important role in regulatin

232 bacteria reflects both T-cell-dependent and -independent pathways, plus glycans present on the antibo

233 nterdependence (interactive), and those with independent pathway properties (orthogonal).

234 phorylation of AQP2 and identified a new PKA-independent pathway regulating AQP2 trafficking.

235 Both the Rag-dependent and Rag-independent pathways required the lysosome and lysosomal

236 The SRP-independent pathway requires the Sec translocase-associa

237 nociception and locomotion through an NPR-19-independent pathway requiring an alpha2A-adrenergic-like

238 p through both PKCiota-dependent and PKCiota-independent pathways, resulting in tumors exhibiting dis

239 nesis in both its phosphatase-dependent and -independent pathways, revealing potentially new drug tar

240 Thus, ubiquitin-dependent and -independent pathways robustly contribute to MHC class I-

241 Through an Fgf2-independent pathway, Sdc2 and Tbx16 also control KV cili

242 The two independent pathways stimulated by the fibrils can act i

243 ed piRNA production, an alternative, slicing-independent pathway suffices to generate Piwi-bound piRN

244 k after a short dark pulse through an output-independent pathway, suggesting that SasA can influence

245 ia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival.

246 me termini can be maintained by a telomerase-independent pathway termed alternative lengthening of te

247 LIN-5, is an essential component of a Netrin-independent pathway that acts in parallel to promote mid

248 d Mx2 can be induced via an IRF-3- and IRF-7-independent pathway that does not involve IFN-gamma sign

249 r this phenomenon represents an early, Abeta-independent pathway that facilitates dementia pathogenes

250 Ca(2+) overload or through a Ca(2+) overload-independent pathway that involved reduced activity of AT

251 s through the upregulation of Rab7 and a TAP-independent pathway that prime CTL responses.

252 ISGs or the involvement of alternative, IFN-independent pathways that are also normally blocked by f

253 C pathogenesis, our findings identify mTORC1-independent pathways that are dysregulated in TSC and th

254 of amyloid-beta (Abeta)-dependent and Abeta-independent pathways that are known to be differentially

255 mosis and demonstrate the existence of Flt3L-independent pathways that can mediate infection-induced

256 These data increase our understanding of the independent pathways that can phosphorylate different re

257 This result helps us better understand the independent pathways that can target different AQP2 resi

258 We identified two independent pathways that control polarization of endocy

259 on on pRBs regulates both E2F-dependent and -independent pathways that govern proliferation.

260 ng network of both Smoothened-dependent and -independent pathways that mediates actin reorganization

261 Wsp1p (WASp) and Myo1p (myosin-I) define two independent pathways that recruit Arp2/3 complex, which

262 ly Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins.

263 e findings suggest the existence of multiple independent pathways that share modulation by JNK, Fos,

264 RCC activates EC through VEGF-dependent and -independent pathways, that sunitinib sensitivity correla

265 of epitopes can be presented through the TAP-independent pathway, the precise mechanism for which rem

266 ribute the counterintuitive discovery to two independent pathways: the bottom-up perception of extern

267 rekallikrein, leading to FIX activation by 2 independent pathways: the classic FXIIa-FXI-FIX pathway

268 jority of uptake is via a low-affinity Na(+)-independent pathway there is, in addition, a high-affini

269 nly through an RIG-I/MDA5-mediated, JAK-STAT-independent pathway, thereby revealing the participation

270 e mechanism(s), which could include cereblon-independent pathways, through which IMiDs exert their an

271 a beta-proteobacterium, adopts an oxygenase-independent pathway to degrade cholesterol.

272 retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response.

273 Recent studies identified a UV-independent pathway to melanoma carcinogenesis and impli

274 kely reflecting their retention of an oxygen-independent pathway to produce pseudocobalamin, which is

275 tic to LLS1, and LLS1 works with PALM1 in an independent pathway to regulate the growth of lateral le

276 refore propose an alternate and distinct p53-independent pathway to stimulate programmed cell death i

277 tive sequences use distinct interactions and independent pathways to arrive at a heterochromatic stat

278 t HIV-1 selected multiple, known host factor-independent pathways to avoid IFN-beta-mediated restrict

279 IV-1 can exploit multiple, known host factor-independent pathways to avoid IFN-beta-mediated restrict

280 g suggests that AFB3 is able to activate two independent pathways to control root system architecture

281 Together, these data highlight T-bet-independent pathways to IFN-gamma production and reveal

282 and Sir2 along with Swi6(HP1) operate in two independent pathways to maintain heterochromatin.

283 -III proteins and ER-PM contact sites act in independent pathways to maintain lipid homeostasis.

284 ted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2.

285 integrins use different RIAM-dependent and -independent pathways to undergo activation by talin.

286 an acted through DAF-16-dependent and DAF-16-independent pathways upstream of DAF-12, paralleling in

287 This septin-independent pathway was mediated by phosphatidylinositol

288 Peroxisome-localized CSD3 via a CCS-independent pathway was similar to nematode (Caenorhabdi

289 the time scales of the JAK-dependent and JAK-independent pathways was found to be the main contributi

290 Independent pathways were analyzed in order to select th

291 re, we found that both IKK-dependent and IKK-independent pathways were required for PI-induced Ikappa

292 f Ca(2+) influx through store-dependent and -independent pathways, whereas reciprocal activation of C

293 ates replicator formation through a template-independent pathway, which achieves maximum rate acceler

294 on during MVA infection of the lung via a C3-independent pathway, which enables rapid recruitment of

295 We find that the two products form through independent pathways, which allows us to tune the conver

296 TGF-beta also initiates Smad-independent pathways, which augment gene expression.

297 es, we find that they define two molecularly independent pathways: While EPSIN1 associates with AP-1,

298 Our newly discovered bifunctional oxygen-independent pathway, widespread in bacteria, salvages at

299 dies have shown that Smad-dependent and Smad-independent pathways work redundantly to transduce TGF-b

300 Our results show stepwise contributions of independent pathways working at multiple stages of ULBP1