ライフサイエンスコーパス: index case

1 ssessed in 82 SZ individuals (including lung index cases).

2 cases between 8 and 28 d after onset of the index case.

3 on the spleen and brain of the donor to the index case.

4 al coregulator, HCFC1, was identified in the index case.

5 eening radius around each passively detected index case.

6 cluding fatal intracranial hemorrhage in the index case.

7 1, 2 and 3 of phospholipase C-beta 1 in the index case.

8 mial transmission of infection from a single index case.

9 investigations in response to reports of an index case.

10 3) and duration of exposure (p=0.007) to the index case.

11 in a UK school resulted from one infectious index case.

12 nds upon the progression of infection in the index case.

13 te contributed to neural inflammation in the index case.

14 ne cohorts of individuals exposed to cholera index cases.

15 ndary analysis with typing data were assumed index cases.

16 2 household contacts of 487 drug-susceptible index cases.

17 a-like illness than contacts of HIV-negative index cases.

18 derably more secondary cases compared to non-index cases.

19 infection occurred in household contacts of index cases.

20 3804 were diagnosed with CRC and defined the index cases.

21 ence in high-incidence areas, and sex of the index cases.

22 was traced to single clinical contacts with index cases.

23 tations were identified in 56 PCG and 7 ndJG index cases.

24 s (>6%) only occurs from approximately 5% of index cases.

25 h the greatest reported risk to relatives of index cases.

26 erventions were administered within 500 m of index cases.

27 , and there have been no deficiencies in RRC index cases.

28 of training experience, especially for rare index cases.

29 dividuals who were contacts of 177 active TB index cases.

30 rolled 28 HIV-infected and 57 HIV-uninfected index cases.

31 o the clinical features and genotype of NCCM index cases.

32 mission from HIV-infected and HIV-uninfected index cases.

33 e genes are known for fewer than 40% of PCLD index cases.

34 us POLR3A mutations in approximately 3.1% of index cases.

35 berculosis in adult contacts of tuberculosis index cases.

36 n of eleven different CDHR1 variants in nine index cases.

37 = .049) and a mutation frequency of 1.03% in index cases.

38 We enrolled 123 index cases, 124 index controls, and 2415 first-degree n

39 Index cases (12404 children) from all children younger t

40 s historic average of 0.7 child contacts per index case, 14% and 15% of child contacts completed 6 mo

41 018, 23 cases were identified, including the index case; 18 were laboratory confirmed.

42 ions (14 novel) were identified in 34 of 183 index cases (19%).

43 health care personnel (HCP) contacts of the index case, 22 (20%) had known unprotected exposures and

44 Among 5,020 contacts of 1,023 index cases, 25 prevalent secondary cases were identifie

45 Two of seven index cases (28%) harbored the reciprocal RNA chimeras i

46 hythmogenic right ventricular cardiomyopathy index cases, 44 patients received secondary prevention i

47 a study conducted in 277 households with 298 index cases (62% with laboratory-confirmed influenza) an

48 total of 2047 well-characterized familial BC index cases, 628 OC cases, and 2187 geographically match

49 , 2047 well-characterized familial female BC index cases, 628 OC cases, and 2187 geographically match

50 ews were available for 1728 individuals (641 index cases, 800 siblings, 287 controls) with lifetime d

51 DSM-III-R criteria was highly stable in the index cases (90.5% women, 94.7% men) but much less stabl

52 in 5 bacterial variants originating from the index case A1 with 0-2 mutations per transmission event

53 diatric surgeons receive limited exposure to index cases after training.

54 SIs were shortest for older index cases (age 11-14 years) and for younger infected h

55 the entire household versus decolonizing the index case alone.

56 ividual contacts, compared with treatment of index cases alone.

57 Five of the index cases also had mild thrombocytopenia.

58 eatment of individuals in close proximity to index cases, also known as reactive case detection (RACD

59 Between 55 and 70% of index cases analysed have a candidate von Willebrand fac

60 icians involved in diagnosing anthrax in the index case and alerting authorities, we offer our perspe

61 cal, biochemical, and genetic analyses of an index case and her two sons.

62 Platelets from the index case and relatives carrying the K174E defect chang

63 We performed further analyses from the index case and two additional cases to shed light on thi

64 ar irrespective of the sex of the sibling or index case and were particularly strong in siblings of h

65 carrying D4Z4 alleles with 9-10 repeats (134 index cases and 110 relatives).

66 among 1,055 household contacts of 213 MDRTB index cases and 2,362 household contacts of 487 drug-sus

67 nts from 8 institutions across the world (44 index cases and 30 from cascade testing).

68 c death (51%) and cardiomyopathy (72%) among index cases and a high prevalence of composite arrhythmi

69 screening high-risk groups (i.e. siblings of index cases and first degree relatives, patients with Ty

70 coding region of the FANCM gene in familial index cases and geographically matched controls is pendi

71 th VWF gene sequencing was performed for all index cases and healthy control subjects in a central la

72 ed autosomal-recessive mutations in the four index cases and in 12 patients with sporadic IIH.

73 coverage amongst individuals located near to index cases and in areas where spraying has not been con

74 holesterolemia, which reported the number of index cases and number of relatives tested and specified

75 tic CHIKV-infected children were enrolled as index cases and prospectively monitored, alongside 236 h

76 Lung samples from four index cases and skin and nasal samples from workers in t

77 nce with ARVC/D was dominated by symptomatic index cases and sudden cardiac death victims-the overt o

78 tations are responsible for only 20% of FEVR index cases and suggests that the other FEVR loci may ac

79 e and other characteristics of 251 pediatric index cases and their 315 infected household contacts on

80 recorded occurrence of that ST in that herd (index case) and all persistent infections with that PTE

81 ndrial cybrids established from the proband (index case) and offspring, the marked respiratory defici

82 duals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the

83 d to (1) event pigs, (2) other pigs, (3) the index case, and (4) persons without pig or index case ex

84 actly concordant if CHD was identical to the index case, and concordant for the group if belonging to

85 ed characteristics of the exposed child, the index case, and environmental characteristics.

86 pulation, the reproduction number of cluster index cases, and cluster sizes to characterise the dynam

87 n cohort, we identified 2017 contacts of 715 index cases, and median follow-up was 10.7 years (IQR 9.

88 uberculosis infection, the HIV serostatus of index cases, and other variables were performed.

89 Individual-, index case-, and other RACD-level factors were considere

90 Contacts of tuberculosis index cases are at increased risk of developing tubercul

91 rence approach suggests that at least 60% of index cases are likely misidentified by local public hea

92 In this study, we found that index cases are often misidentified, with downstream con

93 ological and genetic data and identified the index case as the major source of the virus, suggesting

94 We also identify the index case as the major source of virus, indicating that

95 Among 14,041 household contacts (of 3,446 index cases) assessed for infection and disease during t

96 The index case at age 10 demonstrated multifocal vitelliform

97 ly produced sputum samples may help identify index cases at high risk of transmission.

98 e, sustained exposure to the index case, the index case being in a male patient, lower community hous

99 ontrols who were individually matched to the index cases by age, gender, neighborhood of residence at

100 ing transitions between stages showed how an index case can escalate into a widespread epidemic in th

101 In CDH1 mutation-negative index cases, candidate mutations were identified in 16 o

102 lmark cell subtype found in the pathology of index cases.Conclusions: Evaluation of a manufacturing f

103 a Cox proportional hazards model to identify index case, contact, and household risk factors for tube

104 All the cases except the index case contracted the infection from hospitals.

105 compared using different distances from the index case/control to define the rings and different tim

106 zoonotic hosts or vectors, identifying where index cases could present.

107 None of the 251 siblings of the index cases developed clinical features of mtDNA disease

108 1,055 (3.3%) household contacts of 213 MDRTB index cases developed tuberculosis disease, while 114/2,

109 adults (>15 yr) with incident pulmonary TB (index cases) diagnosed at 106 public health centers in L

110 ee of heart failure and alive at the time of index case diagnosis and matched on age, year of birth,

111 Cough duration of index cases did not display interaction (P = 0.499 for i

112 The index case died as an infant from progressive and severe

113 The study shows that 54.5% of index cases display a classical FSHD phenotype with typi

114 Minor CHD in the index case does not exclude more severe disease in recur

115 is independently of tuberculin skin test and index-case drug sensitivity results.

116 tween 8 and 28 d after exposure to a cholera index case during the first 2 y was 91% (95% CI 62%-98%)

117 Number of index cases during the preceding year.

118 Family members (N = 2,927) from 755 index cases enrolled in SAFEHEART (Spanish Familial Hype

119 2) contribute to the bleeding tendency in 92 index cases enrolled in the European MCMDM-1VWD study.

120 Index cases (exposed to colonoscopy) were colonoscopy pa

121 Of 8 index case-exposed persons and 10 without exposures, non

122 e index case, and (4) persons without pig or index case exposure.

123 The strain from the male index case expressed both glycoforms and exhibited both

124 Aspergillus fumigatus was recovered from the index case, Exserohilum rostratum was the primary pathog

125 = 0.738, P = 0.538), and different number of index cases (F = 1.749, P = 0.180).

126 thout cholera was randomly selected for each index case from the same population, matched by age grou

127 nd rifampicin-resistant tuberculosis (RR-TB) index cases from 16 clinical research sites in 8 countri

128 edigrees with inherited neuropathies and 163 index cases from Australian, European, and Korean distal

129 for association with type 2 diabetes in 786 index cases from type 2 diabetic families and 619 normal

130 Thirty-three of these 43 index cases had a "Schwartz" score (> or =4) suggesting

131 Approximately 11% (43 of 388) of the index cases had a positive swimming phenotype.

132 in first-degree relatives was higher if the index cases had an unprovoked compared with a provoked V

133 All index cases had mild to borderline ID combined with beha

134 household contacts of HIV-infected influenza index cases had twice the risk of developing secondary i

135 by the time of identification of symptomatic index cases, half of transmission had already occurred,

136 Similar to index cases, Hashimoto thyroiditis, psoriasis, and infla

137 usness of HIV-seropositive and -seronegative index cases have been performed in sub-Saharan Africa.

138 ous right coronary artery despite 2 of the 5 index cases having anomalous left coronary artery.

139 fection causing severe viral pneumonia, with index cases having resided in or recently travelled to t

140 tly transmitted network with probably single index case, high frequency of primary drug resistance an

141 ong household contacts within 1 month of the index case highlights a potential role for antibiotic pr

142 affect the likelihood of being an influenza index case, household contacts of HIV-infected influenza

143 From 278 MDR-TB/RR-TB index case households, 743 HHCs were enrolled; the media

144 , and VWF mutation analysis performed in all index cases (ICs).

145 rst analysis, individuals living around each index case identified during the 5-y period were assembl

146 on ancestor which was closely related to the index case identified in wild boar.

147 We enrolled CPE index cases (identified via population-based surveillanc

148 f ITP, implemented after presentation of the index case, identified all 5 subsequent cases before ser

149 tered) M. tuberculosis genotypes and cluster index cases (ie, the first tuberculosis case in a cluste

150 sing a consecutive sample of 33 cases plus 1 index case in an academic medical center.

151 er for siblings who immediately followed the index case in birth order compared with those later in b

152 he number of secondary cases generated by an index case in the absence of control interventions R0.

153 nvestigation should include HIV-seropositive index cases in high disease burden settings.

154 We show how in these EVD outbreaks the index cases in humans (i.e. spillover from wildlife rese

155 Index cases included 284 098 ambulatory surgical procedu

156 eichoic acid (LTA) was abolished only in the index case individual, the only family member lacking LT

157 ed exome sequencing on germline DNA of eight index-case individuals from eight unrelated kindreds wit

158 Accurate diagnosis of the index case is essential for reliable counseling on patte

159 IMD outbreaks require information about the index case isolate, including (i) the presence of partic

160 al therapy (ART) provided to an HIV-infected index case led to greatly reduced transmission of HIV to

161 HIV-infected influenza index cases may facilitate transmission of influenza wit

162 ldren who had no identified MDR-tuberculosis index case (median delay, 123 vs 58 days; P < .001).

163 CDH1 germline mutations was performed on 183 index cases meeting clinical criteria for HDGC.

164 dividual transmission links, and to identify index cases, missing cases, likely transmitters, and ass

165 ntact patients, after a mean exposure to the index case of 4.3 days.

166 The bacterial metalloregulator MerR is the index case of an eponymous family of regulatory proteins

167 cal characterization of liver tissue from an index case of atabecestat-mediated liver injury revealed

168 The index case of Family A had bulbar ALS and frontemporal d

169 The index case of Family B developed spinal ALS without FTD

170 rs of northern California households with an index case of gastroenteritis were interviewed regarding

171 nvestigation prompted by an unusually severe index case of infectious pulmonary tuberculosis.

172 importantly, once a mutation is found in an index case of the family, relatives can be tested for th

173 ular, we identified the cocirculation in the index case of two viral strains showing a different inse

174 s of the coding regions of the genome in 886 index cases of PID found that disease-causing mutations

175 Families (n=340) of index cases of sudden cardiac deaths who underwent postm

176 Representative index cases of various prostate cancer disease states ar

177 f 13 shared the same country of birth as the index case, of whom ten did not share a strain type or d

178 -resistant variants were detected in treated index cases or contacts.

179 Within households, younger age of either index cases or susceptible contacts elevated the odds of

180 3) compared to 5-14 years, and sleeping with index case (OR 2.7; 95% CI, 1.3-5.5).

181 fections acquired the infections mostly from index cases outside the study population, such as retrea

182 No progression on VF or OCT was noted in the index case over almost 4 years.

183 indoor-outdoor location at the time of each index case participant's homicide.

184 Providing care for the index case patient and watching television with the inde

185 The estimate was significantly higher if the index case patient was a sibling (SIR, 5.01 [CI, 3.30 to

186 ase patient and watching television with the index case patient were risk factors among parents and s

187 xposed cohort) with a first-degree relative (index case patient) previously hospitalized with S aureu

188 The index case patient, nursed in source isolation, develope

189 sease risk in the 30 days postexposure to an index-case patient was highest among individuals aged >=

190 Household contacts of index case patients completed a questionnaire and gave s

191 Older children were index case patients for 11 (73%) of the within-household

192 Index case patients underwent a standard evaluation, and

193 alysis included 2314 healthy contacts of 672 index case patients with Covid-19 who were identified be

194 the highest rates in individuals exposed to index case patients with non-hospital-acquired infection

195 diagnostic specimens obtained from enrolled index case patients.

196 One index case (PD onset age 33) inherited a GIGYF2 mutation

197 g by first-degree relatives of two groups of index cases: people homozygous for the C282Y mutation as

198 hom two or more first-degree relatives, i.e. index case plus one extra have been affected.

199 uitability maps were used to define stage 1, index-case potential, which assesses populations at risk

200 unrelated consanguineous families, where the index cases presented with classical DC or the more seve

201 patients revealed 20 sequence variants in 17 index cases presenting with homozygous or compound heter

202 ubset of these uncharacterized families, the index case presents with severe disease previously defin

203 n a cross-sectional analysis, we studied 139 index cases (probands and unrelated individuals) with FE

204 The potential for index case-, RACD-, and individual-level factors to impr

205 d among smear-positive versus smear-negative index cases (ratio of odds ratios = 5.45, 95% CI: 3.43,

206 ation intervention whereby close contacts of index cases receive malaria testing to inform treatment

207 course stabilized and improved, although the index case recently died from bronchopneumonia.

208 e likely source of infection-but only 40% of index cases referred partners who presented for HIV-1 te

209 We selected 1008 index cases, regardless of family history of cancer, and

210 pouse (OR 6.17, 95% CI 1.05-36.35), if their index case remained CPE-colonized at the time of househo

211 46 (26%) index cases reported at least one coexisting autoimmune

212 imens positive for SIV within 2 weeks of the index case's illness.

213 more likely to be colonized if they were the index case's spouse (OR 6.17, 95% CI 1.05-36.35), if the

214 munities; and (2) identification of imported index case(s) with epidemic genotypes phylogenetically r

215 Outbreaks began with one to three index case(s) with large estimated REi's (range: 1.48 to

216 ut functional motor impairment, and 18.7% of index cases show more complex phenotypes with atypical c

217 ependence varied among the subject groups of index cases, siblings, and community-based controls.

218 tus, contact age, socio-economic status, and index case sputum smear grade, the hazard ratio for tube

219 onsiveness, chronic bronchitis symptoms, and index case status.

220 The index case stayed 4 days in the chalet with 10 English t

221 ncoding the metalloprotease neprilysin in 19 index case subjects diagnosed with axonal polyneuropathi

222 We initially genotyped 134 SNPs on 786 index case subjects from type 2 diabetes families and 61

223 The index case subjects were two brothers, individuals 1 and

224 We screened 51 index case subjects with late-onset CMT2 for mutations b

225 The findings in these index cases support a model in which early development o

226 New cases per index case tended to be greater in studies that used dir

227 Index cases tended to be residents (vs.

228 enumeration area clusters had 1118 eligible index cases that led to 342 interventions covering 8948

229 From this index case the virus was spread by human-to-human contac

230 for atypical mycobacterial infection of the index case, the affected individuals did not have notabl

231 tuberculosis, age, sustained exposure to the index case, the index case being in a male patient, lowe

232 cted data on the smear and culture status of index cases, the age and bacillus Calmette-Guerin vaccin

233 For households with clear index cases, the most likely source of infant infection

234 s enabled confirmatory clinical diagnosis in index cases through exclusion of phenocopies and provide

235 th and without a microbiologically confirmed index case to estimate the age-specific risk of infectio

236 cases do not have adequate contact with the index case to experience additional risk for infection b

237 h the risk of transmission of infection from index cases to contacts and compared this with sputum mi

238 olled 166 related individuals, removing lung index cases to reduce bias, and compared spirometry betw

239 ay allow campaign strategies that respond to index cases to successfully target subpatent infections

240 latives who test positive) and new cases per index case, to facilitate comparison.

241 Eleven of 25 index cases underwent ICD implantation.

242 idate gene haplotypes within pedigrees of 14 index cases, using a covariance components model for mul

243 Of clinical strains from the index cases, veterinary and environmental HEV strains we

244 of 30% to 60.5%, and the mean new cases per index case was 1.65 with a range of 0.22 to 8.0.

245 The index case was a 72-year-old woman who suffered progress

246 Our index case was a patient with common variable immunodefi

247 fter vaccination and was similar whether the index case was a young child (<5 y) or was older.

248 The affected mother of the index case was an obligatory carrier.

249 Proximity to the index case was associated with a dose-dependent increase

250 The index case was compound heterozygous for p.A195V and a n

251 The male index case was diagnosed with HCM after an out-of-hospit

252 HIV infection of index case was not associated with SI.

253 confidence interval [CI], 1.43-3.85), if the index case was younger (OR, 0.97 per year older; 95% CI,

254 e RR for diverticular disease in siblings of index cases was 2.92 (95% confidence interval [CI], 2.50

255 The cause of ESRD in index cases was consistent with hypertension-associated

256 equencing combined with RNA sequencing of an index case, we analyzed a total of six SN-HPCs for mutat

257 ls followed by whole-exome sequencing of the index case, we identified a previously undescribed homoz

258 In a survey of 197 familial ALS index cases, we identified two further missense mutation

259 suggested that household contacts of a DF(+) index case were at greater risk of infection with V. cho

260 detecting a case within the household of the index case were significantly higher than in neighbourin

261 Patients identified as index cases were contacted by mail and asked to reply on

262 Index cases were eligible for this study if they had no

263 A total of 269 child contacts of 140 index cases were evaluated.

264 0-79 years; 46.7% women) identified from 221 index cases were included.

265 On multivariable analysis, HIV-infected index cases were less likely to transmit influenza to ho

266 Index cases were more often symptomatic than affected re

267 Cluster index cases were significantly more likely than other tu

268 10 890 participants residing within 500 m of index cases were tested.

269 Index cases were the first symptomatic person in a house

270 nd 299 paternal half siblings born after ASD index cases were used to calculate recurrence risks.

271 ng Enterobacteriaceae for at least 24 hours (index case) were screened for ESBL carriage by testing o

272 Consecutive patients admitted with CRC (index cases) were prospectively evaluated, and those who

273 lications of our study are illustrated by an index case where deep brain stimulation of estimated pre

274 Five elderly index cases who had died at the stage of mild cognitive

275 identification of an inferred source (i.e., index case), whose identity was revealed at trial to be

276 The high percentage of HHCs of MDR-TB/RR-TB index cases willing to take hypothetical MDR TPT provide

277 seven multiplex kindreds ascertained via an index case with a nonsyndromic solitary kidney or renal

278 uary 2004 to December 2013, contacts of each index case with CDI were screened for toxigenic C. diffi

279 Among first-degree relatives of an index case with factor V Leiden or the prothrombin 20210

280 idate platelet function disorder genes in 13 index cases with a history of excessive bleeding in asso

281 tested 148 healthy relatives of 70 Romanian index cases with biopsy-proven CD (87% of all first-degr

282 Exome sequencing was performed in three index cases with bone marrow failure and neurological dy

283 Systematic screening from index cases with both FH and elevated Lp(a) identified 1

284 We investigated a series of 97 index cases with complex spastic paraplegia referred to

285 nd Palestinian populations, we recruited 220 index cases with cone-dominated diseases, of which 2 car

286 In this household transmission study, index cases with confirmed influenza virus infection and

287 ome-wide rare variant burden analysis of 363 index cases with familial ALS (FALS).

288 Eighty-five of 122 white index cases with FECD (69.7%) harbored the triplet repea

289 Opportunistic screening from index cases with FH, but without elevated Lp(a), identif

290 Of the 1567 index cases with half-siblings in multiple sclerosis cli

291 encoding matrix metallopeptidase 21) in nine index cases with heterotaxy.

292 RTEL1 identified biallelic mutations in 6/23 index cases with HHS but none in 102 DC or DC-like cases

293 s candidate genes from exome sequencing in 3 index cases with imaging features of brain iron accumula

294 Between 2015 and 2018, a total of 335 index cases with influenza A and 1,506 of their househol

295 We recruited 115 index cases with influenza A(H3N2) or B infection and 43

296 We recruited 115 index cases with influenza A(H3N2) or B infection, and 4

297 Importantly all relatives of index cases with no FSHD phenotype were healthy carriers

298 osure prophylaxis (PEP) and treatment of ill index cases with oseltamivir, in an attempt to prevent i

299 recruited contacts aged 15 years or older of index cases with pulmonary tuberculosis who lived in des

300 trospective analysis was performed comparing index cases with the rest of the cases in our institutio