ライフサイエンスコーパス: indirect mechanism

1 gene FIT in response to Fe deficiency via an indirect mechanism.

2 lamydia may promote genital pathology via an indirect mechanism.

3 st which may function through a Fur-mediated indirect mechanism.

4 decrease in BzGSLs and SnGSLs via an unknown indirect mechanism.

5 timulates phosphorylation on S453/3/5 via an indirect mechanism.

6 ed the carbon catabolite protein CcpA via an indirect mechanism.

7 tations ("classics") are cited mainly by the indirect mechanism.

8 appears to be regulated by Nkx2.2 through an indirect mechanism.

9 ted by AvrPphB, a bacterial protease, via an indirect mechanism.

10 direct phospho donor or functions through an indirect mechanism.

11 f1 could induce Runx2 degradation through an indirect mechanism.

12 s by CD137 costimulation through a direct or indirect mechanism.

13 ations in RT may also be in part due to this indirect mechanism.

14 by ACh (but not carbachol), also through an indirect mechanism.

15 e expression at high levels of glucose by an indirect mechanism.

16 ting DLP1 to peroxisome membranes through an indirect mechanism.

17 ivation by c-Jun appears to occur through an indirect mechanism.

18 ultured endothelial cells, which suggests an indirect mechanism.

19 oss-linking and is activated by Z through an indirect mechanism.

20 mation induced by v-Jun may occur through an indirect mechanism.

21 , but further investigation suggested a more indirect mechanism.

22 l promoter element induced by activin via an indirect mechanism.

23 ion with the Cdc2 complex, rather than by an indirect mechanism.

24 vation of CD4+ Th cells, possibly through an indirect mechanism.

25 ng that the effects of IL-12 occurred via an indirect mechanism.

26 3 protein but, rather, cooperates through an indirect mechanism.

27 their ability to produce TNFa, likely via an indirect mechanism.

28 erythropoiesis suppression in vivo is via an indirect mechanism.

29 thology in the genital tract possibly via an indirect mechanism.

30 ing of guanidinoacetate, possibly through an indirect mechanism.

31 or binding and neuraminidase activity via an indirect mechanism.

32 double-negative (DN) T cell death through an indirect mechanism.

33 s bone formation in vivo, perhaps through an indirect mechanism.

34 ne, lysine, and methionine) are sensed by an indirect mechanism.

35 ent of GlyR function through both direct and indirect mechanisms.

36 y influence BamA function by both direct and indirect mechanisms.

37 target genes by employing several direct and indirect mechanisms.

38 nces expression of these genes by direct and indirect mechanisms.

39 ed FOXP3, CD39, CD73, IL-10, and TGF-beta by indirect mechanisms.

40 sequent repression by Rep through direct and indirect mechanisms.

41 hormone-stimulated lipolysis via direct and indirect mechanisms.

42 e dissociation of corepressors by direct and indirect mechanisms.

43 cts on hepatic glucose fluxes via direct and indirect mechanisms.

44 CR4 promotes tumor progression by direct and indirect mechanisms.

45 8 through direct DNA binding, as well as via indirect mechanisms.

46 cient to cause neuronal damage via direct or indirect mechanisms.

47 ous monoclonal antibodies by both direct and indirect mechanisms.

48 urea denatures proteins via both direct and indirect mechanisms.

49 ves, an effect that involves both direct and indirect mechanisms.

50 thma pathophysiology through both direct and indirect mechanisms.

51 lve inhibition of autophagosome formation or indirect mechanisms.

52 te viral replication through both direct and indirect mechanisms.

53 e mechanism is shown to be quite general for indirect mechanisms.

54 vitro, indicating that these inducers act by indirect mechanisms.

55 gh direct interactions with the PPARs or via indirect mechanisms.

56 ntrol DNA replication by multiple direct and indirect mechanisms.

57 ion of soluble mediators and both direct and indirect mechanisms.

58 promoting and maintaining AMR via direct and indirect mechanisms.

59 c acantholytic disorders originate from more indirect mechanisms.

60 so lead to its resolution through direct and indirect mechanisms.

61 syndrome coronavirus 2 (SARS-CoV-2), or from indirect mechanisms.

62 revents NINJ1 clustering by either direct or indirect mechanisms.

63 ion of proinflammatory factors via direct or indirect mechanisms.

64 which dually regulate AS through direct and indirect mechanisms.

65 As promote beta cell expansion by direct and indirect mechanisms.

66 l intercellular junctions through direct and indirect mechanisms.

67 of a wide array of drugs through direct and indirect mechanisms.

68 ytoplasmic dynein activity through direct or indirect mechanisms.

69 es are activated most commonly in disease by indirect mechanisms.

70 ray of cellular processes by both direct and indirect mechanisms.

71 f gene transcription through both direct and indirect mechanisms.

72 s both through direct binding of ligands and indirect mechanisms.

73 sor of transcription through both direct and indirect mechanisms.

74 normally mediated via an extrahepatic (i.e., indirect) mechanism.

75 t this regulation in mouse occurs through an indirect mechanism, 1,25-(OH)2D3 acting on a gene geneti

76 but Aurora B also promotes SAC signaling via indirect mechanisms.(9-12) Here we present evidence that

77 ction of brain cells by HIV, suggesting that indirect mechanisms account for neuropathogenesis in the

78 the creation of double-stranded breaks by an indirect mechanism after quinolone treatment.

79 d serve to distinguish unambiguously between indirect mechanisms and direct binding mechanisms of ane

80 sulfur cluster biogenesis through direct and indirect mechanisms and have distinguishable target spec

81 rved is the likely result of both direct and indirect mechanisms and probably involves multiple recep

82 e: it contributes to maintaining latency via indirect mechanisms, and it may also synergize with Z an

83 et fully resolved, involving both direct and indirect mechanisms, and positive and negative effects.

84 HIV-1 RNase H may occur by either direct or indirect mechanisms, and they provide a framework for id

85 el findings demonstrate that a direct and an indirect mechanism are involved in TLR5-driven RA inflam

86 Indirect mechanisms are also at play; for example, micro

87 s for transactivation of target genes, while indirect mechanisms are also implicated in RTA transacti

88 utations affecting intersubunit geometry via indirect mechanisms are as important as interface sequen

89 Indirect mechanisms are implicated in the pathogenesis o

90 Indirect mechanisms are involved, because only a fractio

91 indicate that ADARs, through both direct and indirect mechanisms, are important for maintaining wild-

92 sin mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment o

93 ycoprotein affects melanin synthesis through indirect mechanisms as well.

94 This compensation probably occurs through an indirect mechanism, as the binding affinity of proteins

95 tissue of rats resulting from the direct and indirect mechanisms at 24 h following blast exposure.

96 enic neuropeptide Y (NPY) neurons through an indirect mechanism based on enhancing GABA-mediated inhi

97 nal end bud regression in virgin animals via indirect mechanisms, but acts directly on the mammary ep

98 These patterns could reflect direct and/or indirect mechanisms, but imply that individual variation

99 investigated the importance of the exogenous indirect mechanism by conducting photoinactivation exper

100 possible to ameliorate this immunopathologic indirect mechanism by developing therapies that target K

101 FV-short inhibits coagulation through an indirect mechanism by forming a complex with tissue fact

102 nhibit activation of tryptic KLKs through an indirect mechanism by inhibition of matrix metalloprotei

103 Here we report an indirect mechanism by which c-Jun can regulate transcrip

104 We have previously reported an indirect mechanism by which c-Jun is able to regulate tr

105 ndings unveil a critical yet underrecognized indirect mechanism by which climate change endangers for

106 d (RA) on KGF expression in vitro provide an indirect mechanism by which RA may regulate the growth a

107 Ocn transcription by TGFbeta, confirming an indirect mechanism by which TGFbeta acts through vimenti

108 200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1

109 These data identify direct and indirect mechanisms by which BCR engagement facilitates

110 We propose two possible indirect mechanisms by which CTLA-4 may function in the

111 In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both M

112 In this review, we summarize the direct and indirect mechanisms by which the microbiota modulates su

113 lts strongly suggest that through direct and indirect mechanisms, CD8(+) T cells in some ES control H

114 s direct, endogenous indirect, and exogenous indirect mechanisms contribute to bacterial photoinactiv

115 It has been proposed that direct and indirect mechanisms contribute to the unresolved issue o

116 Indirect mechanisms derive from inflammation related to

117 ress, but it is unclear whether AMF do so by indirect mechanisms, direct water transport to roots, or

118 ent in the promoter region of miR-98, and an indirect mechanism, down-regulating LIN-28 expression.

119 appear not to be infected, and the possible indirect mechanisms driving the neuronal toxicity have r

120 echanism (vasoconstriction) as well as by an indirect mechanism (e.g., inhibition of exocytosis from

121 s block the coagulation cascade either by an indirect mechanism (e.g., vitamin K antagonists) or by a

122 entation) or whether activation occurs by an indirect mechanism, e.g., via effects on CD4+ cells.

123 Some infections cause intraocular damage by indirect mechanisms (eg, HIV-mediated immunosuppression)

124 n tumor-promoting M2 macrophages may form an indirect mechanism for chemoresistance.

125 To test the indirect mechanism for FGF1 stimulation of PI 3-kinase a

126 pathway and provide further support for the indirect mechanism for FGF1 stimulation of PI 3-kinase i

127 racts with Bcl-XL but not BAX, suggesting an indirect mechanism for promoting Bax translocation to th

128 craniofacial skeletogenesis, and suggest an indirect mechanism for secondary cleft palate in Nog mut

129 tions of the TnC molecule, which provides an indirect mechanism for their pathogenic properties.

130 We identify a number of potential direct and indirect mechanisms for these responses, including the i

131 The indirect mechanism gives a power-law tail.

132 (111) and (100) facets, we predict that the indirect mechanism has a higher onset potential than the

133 Here, we show that the indirect mechanism has properties that are distinct from

134 d Au(111) are the cases where the direct and indirect mechanisms have the same onset potential.

135 to partially repress their expression by an indirect mechanism in the presumptive retina region in w

136 hat MOT1 might activate transcription via an indirect mechanism in which limiting TBP can be liberate

137 tion in polycystic kidneys occurs through an indirect mechanism in which primary cilia trigger macrop

138 etation is possible within the context of an indirect mechanism in which solubilization of an anesthe

139 dylinositol (PI) 3-kinase are mediated by an indirect mechanism in which the docking protein fibrobla

140 The activation proceeded by an indirect mechanism in which thrombin cleaved components

141 Our data implicate indirect mechanisms in CXCL10 and CXCL11 repression by E

142 hat ATM may activate Chk1 by both direct and indirect mechanisms in mammalian cells.

143 cause Ad virions activate complement through indirect mechanisms in vivo.

144 id and occurs up to 70,000 times faster than indirect mechanisms in which heme is released into the s

145 ibitory effect on CYP7A1 transcription by an indirect mechanism, in contrast to the stimulation and b

146 We also show that the indirect mechanism, in which urea acts as a chaotrope, i

147 Such indirect mechanisms include tissue damage, inflammatory

148 isk factors as well as on several direct and indirect mechanisms, including inflammation, atrial isch

149 rial and ovarian cancers, through direct and indirect mechanisms, including modulation of oestrogen m

150 ough endothelial barriers by both direct and indirect mechanisms, including through a mechanism invol

151 ng the potential contribution of alternative indirect mechanisms/interactions between the Ag-SPs and

152 homocysteine is likely to be incorporated by indirect mechanisms into proteins in living organisms.

153 The indirect mechanism involves local ACh release, is potent

154 influence Jak-STAT signaling through a novel indirect mechanism involving a wt p53-dependent gene pro

155 Our results favor an indirect mechanism involving acid sphingomyelinase activ

156 our types this appears to be achieved via an indirect mechanism involving inappropriate expression of

157 es NFAT-dependent gene expression through an indirect mechanism involving induction of cardiac AP-1 a

158 147 expression influences Abeta levels by an indirect mechanism involving MMPs that can degrade extra

159 of III-AC by direct phosphorylation or by an indirect mechanism involving phosphorylation of a protei

160 e regulatory protein or were activated by an indirect mechanism involving Spo0A-mediated relief of re

161 ain why elotuzumab eliminates MM cells by an indirect mechanism involving the activation of NK cells.

162 transcriptional function in part through an indirect mechanism involving the suppression of TBP expr

163 f MHCI expression on immature thymocytes via indirect mechanisms involving IL-10.

164 transport in Aqp1-null mice, suggesting that indirect mechanisms involving other channels or transpor

165 egulates cell migration and adhesion through indirect mechanisms involving posttranscriptional contro

166 Indirect mechanisms involving temperature-dependent grow

167 combination of both physical interaction and indirect mechanisms involving the activation of a second

168 This transcriptional repression can occur by indirect mechanisms involving the time-dependent assembl

169 y mimic BH4 in its inhibition of GTPCH by an indirect mechanism, involving interaction with a recentl

170 central effects of cocaine may occur, via an indirect mechanism, involving peripheral neural elements

171 hat this stimulation was mediated through an indirect mechanism, involving tumor necrosis factor alph

172 The indirect mechanism is found to contribute about one-half

173 Operation of the indirect mechanism is not exclusive of the direct mechan

174 Distinguishing direct from indirect mechanisms is often difficult in multisystem ge

175 chondrocytes, downstream of FGFRs and via an indirect mechanism, is required for normal extension and

176 With respect to indirect mechanisms, it will be important to determine w

177 Moreover, either by direct or indirect mechanisms, KIS counteracts the inhibitory acti

178 We suggest that an indirect mechanism linking Rho GTPases and formins via R

179 This finding suggests that a second indirect mechanism may be responsible for the destructio

180 S-CoV-2 can be useful, as it highlights that indirect mechanisms may play an underappreciated role in

181 on bile acid receptors, and other potential indirect mechanisms, may also contribute to the observed

182 ished during development, suggesting that an indirect mechanism mediated by plant water relations cou

183 that regulatory T cells, by either direct or indirect mechanisms, modulate B cell development and ane

184 y, we find that MS4A4A restrains TREM2 by an indirect mechanism: MS4A4A interacts with MS4A6A and pro

185 This implies an indirect mechanism of action for Bk via the non-neuronal

186 duction in sofosbuvir potency, suggesting an indirect mechanism of action in decreasing sofosbuvir ef

187 nity chromatography experiments implicate an indirect mechanism of action involving direct binding of

188 The indirect mechanism of action rationalizes the persistenc

189 ceptor in murine nociceptors, and suggest an indirect mechanism of action, via immune cells.

190 irectly interact with the APE, suggesting an indirect mechanism of activation through this site.

191 This latter interaction represents an indirect mechanism of agonist activity elicited by sIL-1

192 Taken together, these findings support an indirect mechanism of AHR activation, indicating that AH

193 These results suggest a novel indirect mechanism of androgen action on FHL2 expression

194 transferred to infected mice, suggesting an indirect mechanism of antibody function.

195 These results provide an indirect mechanism of cross-inhibition of TLRs and delin

196 causes cDC2 movement into the MZ through the indirect mechanism of displacing MZ B cells into follicl

197 hell, but also support the involvement of an indirect mechanism of dopamine control, through a concom

198 The indirect mechanism of DZNep via inhibition of AdoHcy-ase

199 close to the P-site is very favorable for an indirect mechanism of eIF1's action by influencing the c

200 ng its antithrombogenic properties, favor an indirect mechanism of endothelial injury mediated locall

201 ore, this study supports the existence of an indirect mechanism of environment-mediated chemoresistan

202 Favoring this indirect mechanism of GAPDH inhibition, the neuroprotect

203 ndings suggest that we initially observed an indirect mechanism of genetic complementation.

204 om the polymerase active site, suggesting an indirect mechanism of inhibition.

205 y the hepatocytes themselves, arguing for an indirect mechanism of liver damage.

206 re of the cells to the ligand, suggesting an indirect mechanism of phosphorylation.

207 ssion of p16 in human pituitary tumors as an indirect mechanism of Rb inactivation.

208 eins, suggesting the possibility of a novel, indirect mechanism of recruitment involving DNA target-s

209 tured mouse myotubes were refractory to this indirect mechanism of S-phase re-entry.

210 eatic acinar cells is likely regulated by an indirect mechanism of stimulation of afferent neurons.

211 rminal transactivation domain, suggesting an indirect mechanism of transcriptional inhibition involvi

212 e in lesions from these mice, implicating an indirect mechanism of tumorigenesis.

213 ereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death.

214 maintaining both normal activity in NTS and indirect mechanisms of enhancing NTS neuronal activity d

215 important expression differences suggesting indirect mechanisms of expression regulation.

216 ements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulat

217 ed involvement of virion surface proteins in indirect mechanisms of HIV-1 pathogenesis.

218 are needed to fully understand the direct or indirect mechanisms of oil-induced metamorphosis in mari

219 tein production, suggesting astrocyte-driven indirect mechanisms of oligodendrogliopathy.

220 Disentangling the direct and indirect mechanisms of population- and community-level r

221 cellular models suggest that both direct and indirect mechanisms of protein aggregation are probably

222 Direct and indirect mechanisms of viral infection lead to the devel

223 ior by decreasing spines selectively, via an indirect mechanism, on a subset of VMH neurons that proj

224 homeostasis although whether this is through indirect mechanisms or via direct, off-target effects on

225 ta plaque production, at least in part by an indirect mechanism, perhaps by increasing steady state l

226 -induced Quin production in MOs occurs by an indirect mechanism, perhaps via cytokines produced by th

227 y deactivation of a negative regulator; this indirect mechanism, pervasive in Akt signaling, has yet

228 proinflammatory responses through direct and indirect mechanisms, pinpointing SQSTM1 as a key mediato

229 a suggest a model in which G-CSF, through an indirect mechanism, potently inhibits osteoblast activit

230 irect mechanism) or with the torso (i.e., an indirect mechanism) presumably causes traumatic brain in

231 rns digits 1-3, anterior to this zone, by an indirect mechanism rather than direct spatial or tempora

232 tion in vivo; however, this effect is due to indirect mechanisms rather than to direct infection of C

233 to the bone marrow niche by both direct and indirect mechanisms, rather than directly altering HSC f

234 postsynaptic neurons, but rather through an indirect mechanism: reduction of endocannabinoid-mediate

235 Both direct cell killing and indirect mechanisms related to immune activation have be

236 ptic connectivity, or whether they act by an indirect mechanism remains unknown.

237 ) inhibits pituitary prolactin release by an indirect mechanism requiring stimulation of dopamine for

238 of recovery from desensitization through an indirect mechanism; responses activated with either chol

239 Several indirect mechanisms restrict RNF168 positive feedback, a

240 pidermal barrier function through direct and indirect mechanisms result in susceptibility to skin com

241 ganization of MVBs in response to direct and indirect mechanisms resulted from the mechanical impact

242 on results in diminished proliferation by an indirect mechanism, resulting from defective receptor ex

243 ation of peribronchial mast cells in vivo by indirect mechanism(s), which include inhibiting the lung

244 4 cells mediate antitumor effects through an indirect mechanism similar to the delayed hypersensitivi

245 may be due to direct antioxidant effects, or indirect mechanisms such as affecting signal transductio

246 hrough both direct viral infection and virus indirect mechanisms, such as immune activation.

247 Fs normally influences axon diameter through indirect mechanisms, such as the slowing of NF transport

248 quired to stabilize the ZNF2 mRNA through an indirect mechanism suggesting that Znf2 and Pum1 each po

249 tion, have an unusually powerful CD4(+) cell indirect mechanism that can cause rejection of both isle

250 tein titration curves is predicted, using an indirect mechanism that couples solute-induced changes i

251 ve, MHC class II-negative cancer cells by an indirect mechanism that depends on IFN-gamma.

252 ode of Na(+)/Ca(2+) exchange, probably by an indirect mechanism that does not involve phosphorylation

253 cumbens (NAc) and caudate-putamen through an indirect mechanism that involves striatal cholinergic in

254 hat Rac1 induces STAT3 activation through an indirect mechanism that involves the autocrine productio

255 affect the sphingolipid organization via an indirect mechanism that involves the cytoskeleton.

256 Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unclear.

257 (IR), by directing attenuating SOD3 or by an indirect mechanism that limited TNFa production, thereby

258 rA activates Eda synthesis, apparently by an indirect mechanism that may be involved in the modest ch

259 HT25 detects a wide range of phages using an indirect mechanism that may involve guarding a host cell

260 on by DAHP in phosphate buffer occurs via an indirect mechanism that requires the presence of GTPCH f

261 pression of Kos1 inhibits Ras activity in an indirect mechanism that results in the downregulation of

262 ting Ezh2 impairs mTORC1 activity through an indirect mechanism that up-regulates the expression of t

263 ent throughout all forms of life, as well as indirect mechanisms that appear to have originated in eu

264 ed leukocytes to kill tumor cells in situ by indirect mechanisms that are dependent upon IFN-gamma.

265 NE deficiency may reduce APL penetrance via indirect mechanisms that are still NE dependent.

266 c beta-cell function through both direct and indirect mechanisms that converge on reduced EP3 signali

267 oes not accurately reflect the importance of indirect mechanisms that have previously been reported i

268 ssay, and their destruction likely occurs by indirect mechanisms that have yet to be determined.

269 ls by acting on them directly, or may act by indirect mechanisms that involve alterations of the host

270 In the indirect mechanism, the author of a new paper finds an o

271 Through direct or indirect mechanisms, these proteins activate BAK and BAX

272 lation observed in CS cells are caused by an indirect mechanism: these cells shut down transcription

273 ary, EGFR signaling can depolarize RIS by an indirect mechanism through activation of the ALA neuron

274 ly by KLF8 binding to the GT box A and by an indirect mechanism through its repression of a potential

275 bile toxin, the repression of nlpA may be an indirect mechanism through which the virulence regulator

276 n overview of the p53 GRN and the direct and indirect mechanisms through which p53 affects gene regul

277 DK1 was in addition to a previously reported indirect mechanism, thus adding a layer to the interacti

278 ndrite, NMDARs must signal to the axon by an indirect mechanism to alter release.

279 modulating the contribution of the exogenous indirect mechanism to the overall bacterial photoinactiv

280 Tumors use a complex set of direct and indirect mechanisms to evade the immune system.

281 H(2) receptor subtypes, utilizes direct and indirect mechanisms to excite septohippocampal GABA-type

282 Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p5

283 therefore alter colonic epithelial cells via indirect mechanisms to promote neoplasia.

284 Diverse direct and indirect mechanisms underlie responses to rainfall, incl

285 However, how these direct and indirect mechanisms vary through time remains largely un

286 ating basal transcriptional machinery) or an indirect mechanism (via regulation of other genes) is un

287 3K9 methylation at the MCAM promoter, and an indirect mechanism, via the Ets1 transcription factor.

288 To distinguish among direct and indirect mechanisms, we developed fluorescent human CD1b

289 id binding to the transcription factor or by indirect mechanisms where fatty acids regulate signaling

290 nitiation and progression of the plaques and indirect mechanisms where inflammation at nonvascular si

291 he TCR to achieve peptide selectivity via an indirect mechanism, whereby the TCR sensed the first res

292 utations RT(Val108Ile) appears to act via an indirect mechanism which in this case is through alterat

293 n of the other IE protein, BZLF1, through an indirect mechanism which we previously showed to require

294 activates Rho/phosphorylated MLC2 through an indirect mechanism, which was confirmed by sensitivity t

295 iciency of rRNA synthesis by both direct and indirect mechanisms, with resulting effects on transcrip

296 LHX8 regulated p57(Kip2) via both direct and indirect mechanisms, with the latter mediated by Forkhea

297 usion protein, and thus prevent fusion by an indirect mechanism without direct fusion loop contact.

298 cell injury and apoptosis through direct and indirect mechanisms without affecting NO levels.

299 positively regulated FOXP3 expression via an indirect mechanism yet to be identified.

300 With comparable parameters, the indirect mechanism yields a broader range of sensitivity