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1 h 4-OBzl-indole was neither an indigo nor an indirubin.
2 xyl, isatin) that couple to yield indigo and indirubin.
3 irubin, which was > or =10x more active than indirubin.
4 ve affinity for certain compounds, including indirubin [(2Z)-2,3-biindole-2,3 (1'H,1'H)-dione and que
5         Here, we report the synthesis of new indirubin 3'- and 5'-derivatives in the search of water-
6 We showed previously that the small molecule indirubin-3'-monoxime (I3MO) prevents vascular smooth mu
7 no previously known antiangiogenic activity, indirubin-3'-monoxime (IRO), was identified.
8  glycogen synthase kinase 3 (GSK3) inhibitor indirubin-3'-monoxime and GSK3beta short interfering RNA
9 vity, and incubation with the GSK3 inhibitor indirubin-3'-monoxime protected against this decrease in
10                                Lapatinib and indirubin-3'-monoxime showed moderate hCOX-1 activity (1
11 patinib, SB-202190, RO-316233, GW786460X and indirubin-3'-monoxime were tested against human COX-1.
12  we present the indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) as a promising antimetastatic
13  supplements, the GSK3beta inhibitor 6-bromo-indirubin-3'-oxime (BIO) and the PPARgamma inhibitor GW9
14 abrogated by a small molecule CDK inhibitor, indirubin-3'-oxime (IO), but not a kinase-inactive deriv
15                                              Indirubin also suppressed cytokine-induced cellular inva
16                                              Indirubin also suppressed the NF-kappaB activation induc
17  of these indigoids were the monosubstituted indirubins and 5,5'-dimethoxyindirubin, which was > or =
18  the di(5-methoxy) derivatives of indigo and indirubin, and both of the possible mono 5-methoxy deriv
19 lmaleimide I, bisindolylmaleimide IX, U0126, indirubin, and indigo, inhibited three diverse non-kinas
20                         Together, we present indirubins as novel chemotypes for the development of 5-
21 s and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.
22                  Further studies showed that indirubin blocked the phosphorylation and degradation of
23                                 In addition, indirubins blocked migration of endothelial cells, sugge
24     Our 2.85 angstrom structure of the human indirubin-bound AHR complex with the chaperone Hsp90 and
25 nducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection.
26 '-derivatives in the search of water-soluble indirubins by introducing basic centers.
27 y, suggesting that the antitumor activity of indirubin compounds is at least partially due to inhibit
28                In this study, we present the indirubin derivative 6-bromo-indirubin-3'-oxime (6BIO) a
29                                          The indirubin-derivative, 6-bromoindirubin acetoxime (BIA),
30                       Here, we show that the indirubin derivatives E564, E728, and E804 potently bloc
31                    Evaluation of substituted indirubin derivatives led to the identification of (3Z)-
32 arget genes of Stat3, were down-regulated by indirubin derivatives, followed by induction of apoptosi
33  a strategy to convert the long-known purple indirubin dye into a prolific red-light-responsive photo
34    Here we show that GSK-3 inhibitors of the indirubin family reduce invasion of glioma cells and gli
35                                              Indirubins have been identified as potent ATP-competitiv
36                                              Indirubins improved survival in glioma-bearing mice in w
37                           We also found that indirubin inhibited the expression of NF-kappaB-regulate
38           Overall, our findings suggest that indirubin inhibition of GSK-3 offers a novel treatment p
39              These observations suggest that indirubin is a potent hAHR ligand that is able to select
40                                     Although indirubin is known to exhibit anti-cancer and anti-infla
41 flammatory activities previously assigned to indirubin may be mediated in part through the suppressio
42       In this study, we investigated whether indirubin mediates its effects through interference with
43    We identify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necrosis, as a p
44         We made use of the bisindole core of indirubin, present in GSK-3 inhibitors, to innovatively
45 tryptophan, kynurenine, or synthetic agonist indirubin reduced mycobacterial viability.
46 (BaP), beta-naphthoflavone (BNF), Indigo and Indirubin, reveal an unconventional mode of subunit asse
47  the DNA binding of NF-kappaB, we found that indirubin suppressed tumor necrosis factor (TNF)-induced
48                                              Indirubin, the active component of a traditional Chinese
49 ure of human AHR bound to the natural ligand indirubin, the chaperone Hsp90 and the co-chaperone XAP2
50             These indigoids included indigo, indirubin, the di(5-methoxy) derivatives of indigo and i
51                                              Indirubin therefore represents a unique example of rever
52                     Three active components, indirubin, tryptanthrin and isorhamnetin, were successfu
53                                              Indirubin was also a more potent inducer of Cyp1a1 expre
54 phoretic mobility shift assays revealed that indirubin was more efficient at transforming the hAHR co
55 d from 5-OBzl-indole was mainly 5,5'-di-OBzl-indirubin, whereas the dominant blue dye isolated upon i
56 f the possible mono 5-methoxy derivatives of indirubin, which were all identified by visible, mass, a