ライフサイエンスコーパス: indiscriminate

1 ly heterogeneous but seem to be functionally indiscriminate.

2 negative, and on which the DUX4 biomarker is indiscriminate.

3 ected to midget ganglion cells are similarly indiscriminate.

4 (especially with a magnitude ramp), whereas indiscriminate a sum of techniques application does not

5 upt the mRNA selectivity of Upf1, leading to indiscriminate accumulation of NMD complexes on both NMD

6 Most mammals, including humans, are indiscriminate accumulators of carotenoids but inefficie

7 he lesions to the presence of repetitive and indiscriminate acquisition behaviour and impaired discar

8 This indiscriminate activation necessitates the presence of p

9 Moreover, these results suggest that the indiscriminate activation of CaMKII is able to disrupt p

10 nstrained by insulator elements that prevent indiscriminate activation of nearby genes.

11 Adverse effects, due to indiscriminate activation of other muscarinic receptor s

12 ese results are consistent with a remarkably indiscriminate active site and suggest that the rate of

13 the mechanistic basis for this specific yet indiscriminate activity is not known.

14 The observed indiscriminate activity of NiV and HeV polymerase comple

15 The indiscriminate administration of broad-spectrum antibiot

16 the Ag-Pt-Fe3O4 heterotrimers initiates with indiscriminate Ag nucleation onto both the Pt and Fe3O4

17 n to form dimers and tetramers as opposed to indiscriminate aggregation.

18 Indiscriminate altruists can invade by random drift, how

19 These findings of heightened and indiscriminate amygdala responses to anticipatory signal

20 Inactivation of these cells results in indiscriminate and excessive intake of all compounds, in

21 r delayed rewards reflects both a relatively indiscriminate and hyper-reactive VS circuitry.

22 Indiscriminate and intense fishing has occurred in many

23 Degradation is not indiscriminate, and some mRNAs are selectively protected

24 ment, that larval D. speciosa are relatively indiscriminate, and that H. amazonensis en-tomopathogeni

25 Indiscriminate antimicrobial use has plagued medicine si

26 cs for sepsis is feasible without leading to indiscriminate antimicrobial use.

27 control methods rely on manual labor and the indiscriminate application of herbicides, resulting in i

28 arene substituents, and (3) does not afford indiscriminate attachment.

29 are broadly tuned and uniform, resulting in indiscriminate avoidance of bitter stimuli, or diverse,

30 extinction of social aversive memories; the Indiscriminate-avoiders, showing aversive response gener

31 A new study of glioblastoma discovers indiscriminate awakening in normal cells also and then p

32 Notably, BAFF and APRIL did not cause indiscriminate B cell expansion or an increase in total

33 ions imposed by photodamage, scattering, and indiscriminate background encountered in other UV micros

34 during infection but this activity cannot be indiscriminate because of the critical barrier function

35 This T-cell activation was not indiscriminate because we observed only minimal effects

36 g behaviour, theoretical models have assumed indiscriminating behaviour.

37 Indiscriminate binding can shift alphaSyn's subcellular

38 Hippocampal prediction may initially reflect indiscriminate binding of co-occurring events, with acti

39 Although in vitro experiments showed indiscriminate binding of Hu proteins synthesized in bac

40 vation, autophagy is nonselective, promoting indiscriminate breakdown of cytosolic components.

41 The indiscriminate bulk intercellular transport of inhaled p

42 es, syngamy between gametes is generally not indiscriminate, but rather restricted to occurring betwe

43 ic Cas12-activating strand that sets off the indiscriminate Cas12-mediated cleavage of a fluorogenic

44 lphur species are generally considered to be indiscriminate catalyst poisons, the reaction rate to th

45 ndicapped by large antigen sinks in vivo and indiscriminate cell binding due to ubiquitous expression

46 uding drugs, into cell membranes may produce indiscriminate changes in membrane protein function.

47 ny diverse membrane proteins, they may cause indiscriminate changes in protein function.

48 se sites formed by HNH tetramers, leading to indiscriminate collateral degradation of DNA and protect

49 they are tolerated because of selection for indiscriminate communal brood care in the form of domici

50 play a role in protecting these tissues from indiscriminate complement activation and inflammatory in

51 redominantly between alike individuals, then indiscriminate cooperation can evolve.

52 evels of assortment therefore do not lead to indiscriminate cooperation if tags are available.

53 However, indiscriminate coupling between spectral types could com

54 This indiscriminate coupling blurs the differences between re

55 t are still often avoided due to the risk of indiscriminate covalent reactivity and the resulting adv

56 Indiscriminate cross-linking is minimized by formation o

57 Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome- and

58 but must be very tightly balanced to prevent indiscriminate damage to biological molecules.

59 manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particu

60 ents further plasmid replication through the indiscriminate degradation of host and plasmid transcrip

61 eginning of the 21st century highlighted the indiscriminate deployment of phenyl rings as an importan

62 Ingestion by indiscriminate deposit-feeders has been reported, yet ph

63 ng leukocyte recruitment and the potentially indiscriminate destructive capacity of these cells, we i

64 interpretation, due to high sensitivity and indiscriminate detection of pathogenic, commensal, or co

65 We postulate that indiscriminate dG addition by telomerase occurs by reite

66 The indiscriminate disposal of plastic to the environment is

67 ing, facilitates dsRNA release, and prevents indiscriminate DNA aggregation, suggesting that this aci

68 nerate sites is increased, likely because of indiscriminate DNA cleavage.

69 pports an emerging model that delineates how indiscriminate DNA-binding patterns translate into a con

70 R-mediated abortive mechanism that leverages indiscriminate DNase activity of an RNA-guided single-ef

71 ctors" than by the preferences of relatively indiscriminate DR15 molecules.

72 Aiming to address indiscriminate drug distribution, unwanted toxicity, and

73 ICC-IM in motor neurotransmission have used indiscriminate electric field stimulation of neural elem

74 y can be non-selective - associated with the indiscriminate engulfment of cytosolic components - occu

75 Despite this potential, indiscriminate enzymatic modification of exposed tyrosin

76 -186/+28 SP-10 promoter led to premature and indiscriminate expression of a reporter gene in the semi

77 oth substrates and halogen atom donors in an indiscriminate fashion, generating a high concentration

78 her such regions throughout the genome in an indiscriminate fashion, partly driven by the accessibili

79 g, such that bursts occurred in a temporally indiscriminate fashion.

80 tivation is to produce anxiety manifested as indiscriminate fear of both tone and context.

81 performed poorly in all environments, while indiscriminate flower choice was often the most successf

82 eeding, while LH(VGAT) neurons drove calorie-indiscriminate food intake.

83 at the amygdala, in part, is associated with indiscriminate friendliness and that there might be a do

84 and strangers and increased parent report of indiscriminate friendliness behaviors.

85 Indiscriminate friendliness was assessed with parental r

86 l deprivation has been associated with both "indiscriminate friendliness" toward non-caregiving adult

87 entiation correlated with greater reports of indiscriminate friendliness.

88 ation was associated with greater reports of indiscriminate friendliness.

89 lationship between institutional rearing and indiscriminate friendliness.

90 ith reduced amygdala discrimination and more indiscriminate friendliness.

91 for epileptiform bursting, which occurs with indiscriminate GABAA blockade.

92 encing at other loci in trans and preventing indiscriminate gene silencing throughout the genome.

93 ere, we identify and characterize Gpi, PLE's indiscriminate genome packaging inhibitor.

94 by cellular ATP release and was perturbed by indiscriminate global stimulation.

95 all thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen.

96 The new pHLIP version limits indiscriminate healthy tissue binding, and we demonstrat

97 g dose reduced the strength of activation of indiscriminate host clearance of red blood cells while i

98 to activation loop hyperphosphorylation, and indiscriminate hyperphosphorylation of PknB substrates a

99 hat would be highly efficient while avoiding indiscriminate IKK/NF-kappaB inhibition in normal cells.

100 trictly on DNA sequence recognition provides indiscriminate immunity both to lytic and lysogenic infe

101 Treatment involves the use of indiscriminate immunosuppression, which results in signi

102 relies upon broad-scale corticosteroids with indiscriminate impact.

103 s add to growing evidence that males are not indiscriminate in mating.

104 tality crises, which are often assumed to be indiscriminate in nature.

105 nlike other transport systems, OME is rather indiscriminate in what OM goods are transferred.

106 Although indiscriminate inclusion of social determinants in clini

107 ings suggest that STN-DBS does not act as an indiscriminate informational lesion but rather as a filt

108 nes is a promising therapeutic strategy, but indiscriminate inhibition of both the mutant and wild-ty

109 ay initiate an unpredictable reaction to the indiscriminate inhibition or activation of a single comp

110 These findings suggest that DAHP is not an indiscriminate inhibitor of GTPCH in biological systems;

111 n for myelination results from excessive and indiscriminate initiation of wrapping followed by refine

112 body axis, by differentially integrating an indiscriminate injury response, determines the fate of t

113 We proposed that indiscriminate insertion of dAMP opposite the 3'-T of ea

114 gridless configuration substantially reduces indiscriminate ion losses.

115 The increasing prevalence of indiscriminate iron supplementation during pregnancy als

116 aise important questions about the safety of indiscriminate iron supplementation during pregnancy.

117 Now, the view of neutrophils as indiscriminate killers seems to be changing as evolving

118 iotics tend to be broad spectrum, leading to indiscriminate killing of commensal bacteria and acceler

119 rs responsible for this destruction included indiscriminate killing, loss of access to suitable habit

120 he back-to-back kinetochore geometry and the indiscriminate kinetochore-MT turnover provide strong er

121 man granulocyte migration have been based on indiscriminate labeling of total granulocyte populations

122 nic radicals generated during photolysis are indiscriminate, leading to a large mixture of photoprodu

123 ndom gathering of the genome into domains of indiscriminate length but rather that the genome is gath

124 an ancestral RLN3-like gene that encodes an indiscriminate ligand for LGR7 (RXFP1) and LGR8.

125 lling behaviours in the GI tract relied upon indiscriminate loading of tissues with Ca(2+) dyes.

126 t small solutes within the CC are subject to indiscriminate long-distance transport via the transloca

127 lly discontinued emphasizes the avoidance of indiscriminate long-term use of molecular targeted drugs

128 We also show the focal and indiscriminate loss of calbindin(+), calretinin(+), parv

129 During viral CNS infections, however, an indiscriminate maintenance of CNS immune privilege throu

130 genes encoding ribosomal proteins, but in an indiscriminate manner that did not correspond to their a

131 and that the promoter alone functions in an indiscriminate manner.

132 Indiscriminate mating can facilitate the persistence of

133 scriminate sexual behaviour, by showing that indiscriminate mating is the optimal strategy under a wi

134 hat the conditions that most strongly favour indiscriminate mating were probably present at the origi

135 lls contain protective mechanisms to prevent indiscriminate microtubule severing.

136 Indiscriminate miR-29b overexpression in the B-lineage o

137 ction of apoptosis in C2C12 cells results in indiscriminate miRNA release.

138 several steps; by specific selection from an indiscriminate mixture, by concentration from dilute sol

139 This exogenous Env is an indiscriminate molecular "bridge" between Env-specific A

140 Unlike the indiscriminate multiorgan autoimmune phenotype of the co

141 ied product, with a high frequency of nearly indiscriminate mutations, are produced.

142 ination and suggest a model in which broadly indiscriminate myelination is tailored by inhibitory sig

143 The indiscriminate nature of alternative pathway activation

144 This indiscriminate nature provides one of its main weaknesse

145 in which C. elegans piRNAs provide a broad, indiscriminate net of silencing, competing with siRNAs a

146 Thus, ozone is not an indiscriminate neuronal activator, but rather it potentl

147 Although peroxynitrite caused a fairly indiscriminate nitration of tyrosine residues, reversibl

148 Thus, we caution against the indiscriminate non-supervised use of citizen science dat

149 abortive-infection phenotypes by activating indiscriminate nucleases(3-5).

150 c regulatory outcomes in Mtb despite binding indiscriminate of DNA sequence.

151 le mice exhibit increased mounting frequency indiscriminate of sex, delayed sexual satiety, and incre

152 The 2Cys-peroxiredoxin assembly may prevent indiscriminate oligomerisation, localise ten peroxidase

153 The effects of peroxynitrite were indiscriminate on RyR1 and RyR2.

154 ather than opposition combatants, suggesting indiscriminate or targeted warfare contrary to internati

155 lling evidence to establish whether this was indiscriminate or was screening suitable males.

156 patients at low risk for cardiac events, and indiscriminate perioperative therapy with beta-blockers

157 It deserves neither condemnation nor indiscriminate praise but instead a commitment to help i

158 deling mechanistic pathways, were strong but indiscriminate predictors of a variety of individual CV

159 Uncontrolled and indiscriminate prescribing of opioids has led to an opio

160 lyadenylation in prokaryotes is a relatively indiscriminate process that can occur at all mRNA's 3'-e

161 ke washing of filleted fish with lake water, indiscriminate processing at unhygienic landing sites, u

162 e resulting population demonstrates that the indiscriminate properties of interchromosomal interactio

163 r poorer surgical outcomes in the setting of indiscriminate prophylactic vancomycin use, measures to

164 pression in normal colon did not result from indiscriminate protein or RNA degradation.

165 The indiscriminate rapid bulk transport of brain homogenate

166 in drug discovery because of their presumed indiscriminate reactivity.

167 mitochondria, and endosomes, consistent with indiscriminate sampling of intracellular membranes from

168 Indiscriminate screening for hypothyroidism has led to o

169 beta1 Integrin-null acinar cells displayed indiscriminate secretion to all membrane surfaces, consi

170 the subject exhibits internal flexibility or indiscriminate self-association.

171 cision?" First, Precision Oncology relies on indiscriminate sequencing of genomes in biopsies that ba

172 rategy has received less attention, although indiscriminate sexual behaviour may be the ancestral mod

173 that SSB can be maintained by selection for indiscriminate sexual behaviour, by showing that indiscr

174 a theoretical framework for the evolution of indiscriminate sexual behaviour.

175 nstead hypothesize an ancestral condition of indiscriminate sexual behaviours directed towards all se

176 s with the generality of heating but without indiscriminate side reactions typical of bulk thermolysi

177 o stringent regulatory mechanisms to prevent indiscriminate signalling through innate immune receptor

178 packaging of axonal membrane proteins is not indiscriminate, since another axonal membrane protein (N

179 -->Ala by alkylsulfonates is apparently more indiscriminate, since methane-, ethane-, or propane-sulf

180 to four selected domains of psychopathology (indiscriminate social behavior, posttraumatic stress dis

181 s 2'-deoxy precursor reveal the surprisingly indiscriminate specificity of this transferase.

182 indings disproved the long-standing model of indiscriminate steric occlusion by Sir proteins and led

183 ial resolution of current devices results in indiscriminate stimulation of interleaved cells of diffe

184 As opposed to an indiscriminate stochastic process, we find pronounced de

185 Indiscriminate suppression is unsustainable long term an

186 labels in complex mixtures of cells leads to indiscriminate tagging of nascent proteomes independent

187 We propose that this selectivity limits indiscriminate target selection by E. coli Hfq and enfor

188 sY pre-organized into the Stable mode led to indiscriminate targeting in vitro and disrupted FtsY fun

189 Therapeutically, the indiscriminate targeting of wild-type and point-mutated

190 Alkyne-based inhibitors do not show indiscriminate thiol reactivity but potently inhibit Cat

191 iofrequency or cryothermy is associated with indiscriminate tissue destruction.

192 eEFSec is indiscriminate toward l-serine and facilitates its misin

193 egrade target RNA molecules without inducing indiscriminate trans-cleavage of cellular RNAs, giving i

194 is) single-stranded DNA (ssDNA) cleavage and indiscriminate (trans) degradation of ssDNA, RNA, and ds

195 This regulation minimizes the indiscriminate transmission of mRNAs from mother to daug

196 disseminate intracellular signals and avert indiscriminate transmission of these responses throughou

197 sease, most patients are limited to generic, indiscriminate treatment options: cytotoxic chemotherapy

198 For example, indiscriminate treatment with 0.45% saline cannot be rec

199 ures that can be employed instead of current indiscriminate troves of behavioral data, with better pr

200 tion myocardial infarction patients, but its indiscriminate use in all cases is not feasible.

201 dications and utilization, it is likely that indiscriminate use is cost-ineffective, but that judicio

202 The results of this study do not support an indiscriminate use of amantadine, modafinil, or methylph

203 We highlight the indiscriminate use of AMs that is occurring in poultry i

204 The absence of such data promotes indiscriminate use of antibiotics and delays implementat

205 The indiscriminate use of antibiotics has accelerated the em

206 This difficulty results in the indiscriminate use of antibiotics, which are expensive a

207 ings provide a further rationale against the indiscriminate use of antibiotics.

208 Indiscriminate use of balloons larger than the angiograp

209 mate change adaptation policies based on the indiscriminate use of climate envelope methods irrespect

210 ea behind this incorporation is to lower the indiscriminate use of conventional pesticides to be in l

211 ty and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-az

212 imental model, should raise concerns for the indiscriminate use of G-CSF in the clinic.

213 selection for insecticide resistance due to indiscriminate use of insecticides in public health and

214 ased biomarker that reduces the need for the indiscriminate use of invasive surveillance biopsies and

215 The indiscriminate use of mineral supplements can adversely

216 We find that indiscriminate use of model-generated content in trainin

217 wever, and these findings should not promote indiscriminate use of PDE5 inhibitors, which can also ha

218 edia with confirmed tolerance instead of the indiscriminate use of premedication.

219 hways, these data also raise concern for the indiscriminate use of Rluc and aequorin as reporters in

220 The indiscriminate use of the cumulative exposure metric (th

221 Indiscriminate use of the terms dehydration and volume d

222 ratio in membrane phospholipids, indicating indiscriminate utilization of these precursors by the in

223 or phosphatidylglycerol, caused by itself an indiscriminate vesiculation of uncoated Golgi membranes

224 (PHP)-often plagued with poor facilities and indiscriminate waste management.

225 C areas (1.0 = perfect discrimination, 0.5 = indiscriminate) were minor VSD 0.92 +/- 0.02 and major/i

226 rval relative to pre-odor baseline, but were indiscriminate with regard to sample odor identity.

227 data, micronutrient supplementation is often indiscriminate without regard to nutrient status.