ライフサイエンスコーパス: indispensable

1 by geographical origin, making traceability indispensable.

2 py evaluation after caustic ingestion is not indispensable.

3 f technologically important film geometry is indispensable.

4 s that only need a single model as input are indispensable.

5 racterize the molecular effects of PPARs are indispensable.

6 ing, spillovers can range from irrelevant to indispensable.

7 The digestible indispensable AA (IAA) score was 1.03 (histidine) for WP

8 and to the perinuclear region, acting as an indispensable adaptor connecting the cytosolic detection

9 Phenylalanine is an indispensable amino acid and, via tyrosine, is the precu

10 otein quality, as measured by the Digestible Indispensable Amino Acid Score (DIAAS), requires the det

11 ned in minipigs, to calculate the digestible indispensable amino acid score (DIAAS).

12 determination of true ileal digestibility of indispensable amino acids (IAAs) in children.

13 protein, but the true ileal digestibility of indispensable amino acids (IAAs) of commonly consumed le

14 m-ion batteries have proven themselves to be indispensable among modern day society.

15 Dimensionality reduction is an indispensable analytic component for many areas of singl

16 Mass spectrometry (MS) is an indispensable analytical tool to capture the array of me

17 Cyanine dyes play an indispensable and central role in modern fluorescence-ba

18 highly conserved H4c residue, Arg(108), was indispensable and crucial for metabolite transport.

19 n via the classical pathway; however, Lyn is indispensable and irreplaceable for B cell activation vi

20 In furthering this indispensable area of daily life and modern-day scientif

21 tides from complicated biological samples is indispensable before MS determinations.

22 owards developing novel solid catalysts with indispensable characteristics for efficient biomass valo

23 ytic isomerization of C-C double bonds is an indispensable chemical transformation used to deliver hi

24 Therapeutic proteins are an indispensable class of drugs and often therapeutics of l

25 Biotherapeutic proteins are an indispensable class of pharmaceuticals that present a hi

26 underlying mechanism for the giant AMR is an indispensable combination of atomic scale giant-MR-like

27 of mother-to-child transmission (MTCT) is an indispensable component in combatting the global AIDS ep

28 iple high-quality sequence assemblies are an indispensable component of a pan-genome infrastructure.

29 5S rRNA is an indispensable component of cytoplasmic ribosomes in all

30 asize that interactive graphics should be an indispensable component of modern RNA-seq analysis, whic

31 quent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses t

32 Flexible sensors, as a kind of indispensable components of flexible electronics, have b

33 Selector devices are indispensable components of large-scale nonvolatile memo

34 Rare earth elements (REEs) are indispensable components of many green technologies and

35 Sulfur, an indispensable constituent of many cellular components, i

36 This study uncovers the indispensable contributions of dopamine and octopamine s

37 Heparin is an indispensable drug in anticoagulation therapy but with a

38 ontribute to the high therapeutic success of indispensable drugs such as aspirin.

39 t the pendent olefin does not only act as an indispensable element for the initial allene attack invo

40 d four classes of slightly beneficial genes: indispensable, enrichable, rescuable, and unrescuable ge

41 orovirus (MNV) have identified CD300LF as an indispensable entry factor for MNV.

42 les, and plant research has been a constant, indispensable facet of these developments.

43 nerally requires only few steps; however, an indispensable factor is the addition of a locking substa

44 of IL-4-activated STAT6, having broad action indispensable for 77% of the induced gene signature of a

45 Thus, PSII activity is indispensable for a sustained process, where it is respo

46 orylate a specific SnRK2/OST1 site, which is indispensable for ABA-induced reactivation of PP2C-depho

47 Ca(2+) flux through the MCU but not NCLX is indispensable for activation of I(CRAC) .

48 acts with known cytoskeletal proteins and is indispensable for Anabaena viability.

49 lysis reveals a trans-arginine finger, R158, indispensable for ATP hydrolysis; (iii) the location of

50 we argue why such simulations will likely be indispensable for bridging the scales between the neuron

51 These data indicate that Runx1 is indispensable for Cbfb-MYH11-induced leukemogenesis by w

52 position Y10 of the SH3-1 domain of CD2AP is indispensable for CD2AP function in vivo.

53 suggest that Scribble/Yap1 copolarization is indispensable for Cdc42-dependent activity on HSC asymme

54 he ATR-stimulating function of ETAA1 becomes indispensable for cell fitness and chromosome stability

55 between the cytosol and mitochondria and are indispensable for cellular homeostasis.

56 ns (HSPs) in response to heat stress (HS) is indispensable for conferring thermotolerance.

57 Thus, although ART was indispensable for controlling viral replication, restori

58 Cell-cell fusion is indispensable for creating life and building syncytial t

59 nd antibody-induced complement activation is indispensable for CRIg-mediated parasite capture.

60 emonstrate in the Drosophila BBB that EcI is indispensable for ecdysone entry into the CNS to facilit

61 s via neurotransmitters and neuropeptides is indispensable for effective immunity and tissue homeosta

62 he pentose phosphate pathway (PPP), which is indispensable for efficient heme detoxification and is r

63 led that the DNA-binding activity of UAF1 is indispensable for enhanced RAD51 recombinase activity wi

64 lasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function.

65 , and biotin conjugation of the peptides are indispensable for forming the cell spheroids.

66 nal m/ z resolution and accuracy of FTMS are indispensable for frontline biological and environmental

67 ven translocation (TET) family of enzymes is indispensable for gene regulation in mammals.

68 repair via homologous recombination (HR) is indispensable for genome integrity and cell survival but

69 ur studies suggest that OSTERIX and SHP2 are indispensable for gut homeostasis, analogous to SOX9's d

70 olonic mucosa create a semipermeable barrier indispensable for gut homeostasis.

71 Whereas SUMO3, but not SUMO2, was indispensable for homology-directed repair (HDR) of DSBs

72 e macromolecules such as nucleotides and are indispensable for human cancer cell growth.

73 anti-inflammatory IL-10 by CD4(+) T cells is indispensable for immune homeostasis, as it allows T cel

74 illation crystals with short decay times are indispensable for improving the performance of numerous

75 that the amino acid residue K59 of nsp11 was indispensable for inducing STAT2 reduction.

76 Oxygen vacancies in complex oxides are indispensable for information and energy technologies.

77 tch motif (ITSM) encompassing Y248, which is indispensable for interaction of SHP-2 and delivery of P

78 known to modulate macroautophagy, a process indispensable for intestinal homeostasis.

79 also acts through direct immune modulation, indispensable for its antitumor activity.

80 on (aa 436-482) preceding the HECT domain is indispensable for its stability and activity and that wi

81 p53 acetylation is indispensable for its transcriptional activity and tumor

82 ng the gH-null mutant, we showed that gH was indispensable for KSHV infection of epithelial, endothel

83 n-specific Bdnf expression, which in turn is indispensable for leptin-induced antidepressant-like eff

84 lex three-dimensional arrangement, which are indispensable for life-sustaining gas exchange(2,3).

85 -derived cells, we show that this lineage is indispensable for lymphatic vessel development.

86 tly suggest that the amygdala's integrity is indispensable for maintaining an unbiased, precise perce

87 Functionally, Klf5 is indispensable for maintaining basal progenitors, their l

88 matogonial maintenance and show that Ddx5 is indispensable for male fertility.

89 Oocytes are indispensable for mammalian life.

90 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeo

91 demonstrate that specific MSR cofactors were indispensable for mannan synthase activity of a coffee C

92 Therefore, normal protein diet is indispensable for maternal musculoskeletal health during

93 trast to mitosis, Cin8 and Kip3 together are indispensable for meiosis.

94 c maturation, the availability of PRKAB2 was indispensable for mesoderm specification as shown by gen

95 The mitochondrial DNA (mtDNA) genome is indispensable for mitochondrial function because it enco

96 Furthermore, Lyn is found to be indispensable for monocyte migration in response to MCP-

97 We conclude that Trpm4-mediated ICAN is indispensable for motor output but not the rhythmogenic

98 orks within cerebellar Purkinje cells and is indispensable for neonatal survival.

99 Synaptic vesicles are indispensable for neuronal communication in mature circu

100 (NCC), precursors of most AS structures, are indispensable for normal AS development and their ablati

101 genetic evidence that OPG-HS interaction is indispensable for normal bone homeostasis.

102 NARE and PX (Phox homology) domains that are indispensable for normal localization and function of Fo

103 In sum, developmental beta1-integrins are indispensable for OFC function later in life.SIGNIFICANC

104 of 3F6-hIgG1 that favors C1q recruitment is indispensable for opsonophagocytic killing of staphyloco

105 pling site for STIM1, the Orai N terminus is indispensable for Orai channel gating.

106 Glucocorticoids are indispensable for PD-1 induction on human NK cells, in c

107 ed global, opening-permissive TM motions are indispensable for pore opening and require clearance of

108 vitro models, we here report that METTL14 is indispensable for postimplantation embryonic development

109 of protein subcellular localization is also indispensable for prioritizing and selecting the right t

110 Given that hGMPK is indispensable for producing the nucleotide building bloc

111 Expression of human mitochondrial DNA is indispensable for proper function of the oxidative phosp

112 Chloroplast biogenesis is indispensable for proper plant development and environme

113 TPases H, K, and NRAS are molecular switches indispensable for proper regulation of cellular prolifer

114 These results suggest that neutrophils are indispensable for protective immunity induced by LdCen(-

115 Thus, gamma synchrony is indispensable for reappraising the behavioral salience o

116 ial protein quality control center, which is indispensable for recovery of epigenetic regulators and

117 racellular matrix (ECM) surrounding cells is indispensable for regulating their behavior.

118 ion of non-constitutive (backup) origins are indispensable for replication to be completed within S-p

119 contributed to the creation of a novel gene indispensable for reproduction in some insects.

120 , a mediator of cell-matrix interactions, is indispensable for retinal angiogenesis.

121 ailed information on extinct species that is indispensable for retracing the evolution of terrestrial

122 Since iron is indispensable for SC maturation, understanding iron meta

123 In vivo, Yap is indispensable for Sca-1(+) cell expansion and early tumo

124 MADS78 and MADS 79 were indispensable for seed development, as a double knockout

125 ways-on energy-harvesting solution, which is indispensable for self-powered systems, is still missing

126 Although the brain areas indispensable for speech and song learning are known, th

127 ortance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm p

128 rom Staphylococcus aureus The serine residue indispensable for SrtB activity may be involved in stabi

129 uctural biology and cell biology, cryo-ET is indispensable for structural cell biology-the study of t

130 d maintains transcriptional output, which is indispensable for survival of the melanocytic lineage in

131 Pyrolysis is indispensable for synthesizing highly active Fe-N-C cata

132 n factor B cell CLL/lymphoma 11B (BCL11B) is indispensable for T lineage development of lymphoid prog

133 h IL-4 and TGF-beta have been reported to be indispensable for Th9 cell-priming and differentiation.

134 As a consequence, noise is indispensable for the acquisition of information in sign

135 of CTB-KDEL, indicating that the pathway is indispensable for the activity.

136 Thus, although STING is indispensable for the antiviral activity of AdrA, type I

137 The mammary epithelium is indispensable for the continued survival of more than 5,

138 works in a cell type-dependent manner and is indispensable for the development of multiple cell types

139 s been previously demonstrated that STAT3 is indispensable for the differentiation of DC from HSC.

140 ement in the HKT1;1 promoter was found to be indispensable for the enhanced expression of the gene in

141 Treg cell-derived IL-10 is indispensable for the establishment and maintenance of i

142 ression of the transcription factor SLUG was indispensable for the establishment of EMT memory.

143 Together with this role, PBS3 is also indispensable for the establishment of salt stress- and

144 with a sensitivity and selectivity which are indispensable for the evaluation of edibility and flavou

145 ranscriptional control of gene expression is indispensable for the execution of developmental program

146 last outer membrane, JASSY, which has proven indispensable for the export of OPDA from the chloroplas

147 hat the ER membrane protein complex (EMC) is indispensable for the expression of viral polyproteins.

148 approach, here we demonstrate that clpC1 is indispensable for the extracellular growth of Mtb and fo

149 strate that insulin sensing by astrocytes is indispensable for the function of the reproductive axis.

150 sferases and deoxysugar synthesis enzymes is indispensable for the generation of glycodiversified ant

151 proteins, collectively known as vigilins, is indispensable for the heterochromatin-mediated gene sile

152 ells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chro

153 Second, we found that ARPC1B is indispensable for the maintenance of TCR, CD8, and GLUT1

154 ein adapter histone deacetylase 6 (HDAC6) is indispensable for the microtubule transport and assembly

155 Hox genes are indispensable for the proper patterning of the skeletal

156 roline-rich motifs, of which at least one is indispensable for the regulation of viral DNA replicatio

157 High-resolution Hi-C data are indispensable for the studies of three-dimensional (3D)

158 shale gas into propene or butenes, which are indispensable for the synthesis of commodity chemicals,

159 We also show that SNW1 is indispensable for the transcriptional elongation of NF-k

160 ent hemogenic activity in the endocardium is indispensable for the valvular tissue remodeling in the

161 stating consequences and imaging studies are indispensable for their diagnosis.

162 ector/inflammatory and repair macrophages is indispensable for tissue repair upon acute sterile injur

163 Our findings that these residues are indispensable for TLS by the purified Pol but are not re

164 inase phosphorylation, with the latter being indispensable for TNF-alpha production by MAIT cells.

165 Voltage-gated sodium channels (Na(V)) are indispensable for transformation and propagation of sens

166 Tregs, we also find that IL-2R signaling is indispensable for Treg homeostasis, whereas Treg lineage

167 aintenance of tumor vasculature integrity is indispensable for tumor growth and thus affects tumor pr

168 uption of ATG4B confirmed that the enzyme is indispensable for viral proliferation in vivo Our result

169 the primary structure of the Sec7 domain, is indispensable for viral replication.

170 double-membrane vesicles formation, that are indispensable for virus replication.

171 Overall, mutant BRCA is an indispensable founding event for some tumours, but in a

172 Thanks to its indispensable function in competition and thus survival,

173 Evidence points to an indispensable function of macrophages in tissue regenera

174 ATAD5-RLC appears to be indispensable, given that Atad5 knock-out leads to embry

175 role for 2'-OH in catalysis by providing an indispensable hydrogen bond; preliminary computational a

176 reen fluorescent proteins (GFPs) have become indispensable imaging and optogenetic tools.

177 at which skyglow depends on distance and is indispensable in any prediction of light-pollution propa

178 kali metals sodium and potassium have proved indispensable in both academia and technology.

179 fic bands, our findings suggest that GPT1 is indispensable in both plastids and peroxisomes.

180 Geological Survey) are indispensable in calibrating an NMR instrument, in order

181 er (WW) reuse is expected to be increasingly indispensable in future water management to mitigate wat

182 cal and chemical properties make the element indispensable in maintaining a prosperous modern electro

183 er drastically, making their identifications indispensable in many applications of life science.

184 IR and Raman) plays an important role and is indispensable in many cases.

185 c carbenes (NHC) are nowadays ubiquitous and indispensable in many research fields, and it is not pos

186 Plastics have become indispensable in modern life and the material of choice

187 oles in governing cellular behaviors and are indispensable in numerous biological processes.

188 Function prediction is indispensable in providing clues for interpreting omics-

189 Proper determination of agonist efficacy is indispensable in the evaluation of agonist selectivity a

190 STAT2 is indispensable in the JAK/STAT signaling since it is also

191 uggest that the Arp2/3 complex is absolutely indispensable in the melanocyte lineage in mouse develop

192 Thermoelectric technologies are becoming indispensable in the quest for a sustainable future.

193 lex dynamics, we anticipate our method to be indispensable in unlocking and deciphering the inner mec

194 Understanding metabolism is indispensable in unraveling the mechanistic basis of man

195 requiring stringent reaction conditions with indispensable inert environment protection and highly sp

196 most common forms of amblyopia have provided indispensable insight into the disorder, which has signi

197 Our results establish NUAK2 as an indispensable kinase for brain development in humans and

198 n of TRPM2 induced by binding of ADPR in two indispensable locations, and the binding of Ca(2+) in th

199 ing these mechanisms could reveal lncRNAs as indispensable mediators of p53 and lay the foundation fo

200 "List of Essential Medicines" includes among indispensable medicines antibacterials and pain and migr

201 Oxygen (O(2)) is both an indispensable metabolic substrate and a regulatory signa

202 absorption spectroscopy (XAS) has become an indispensable method for probing the structure and compo

203 ding polymerase chain reaction (PCR) were an indispensable methodology for diagnosing cancers, viral

204 Selenium (Se) is an indispensable microelement in our diet and health issues

205 their genetic programmability has made them indispensable modern materials.

206 ariants of CRISPR-Cas systems use Cas4 as an indispensable nuclease for selectively processing the pr

207 nsfer, supplying both host and symbiont with indispensable nutrients and biosynthetic precursors to f

208 which, once discovered, would have become an indispensable part of daily life.

209 noglobulin repertoires, B lymphocytes are an indispensable part of humoral immunity.

210 Bioinformatics has become an indispensable part of life science over the past 2 decad

211 nhibitors now emerge as an important, if not indispensable, part of therapy for a large subset of hig

212 of nutrients and disease resistance are two indispensable physiological processes in plants; however

213 oduction and the correct localization of the indispensable piRNA biogenesis factor Armitage (Armi).

214 Wild bees are indispensable pollinators, supporting global agricultura

215 fore, the knowledge of protein termini is an indispensable prerequisite to understand protein functio

216 Dynamin GTPases (Dyn1 and Dyn2) are indispensable proteins of the core clathrin-mediated end

217 will allow MS alone to eventually become an indispensable quantitative tool for clinical and toxicol

218 he purification of membrane proteins and are indispensable reagents in structural biology.

219 Beyond the indispensable refinement of tools and procedures, resolv

220 ), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis.

221 BCR-mediated tonic signaling is an indispensable requirement for the survival of follicular

222 is by RNA sequencing (RNA-seq) has become an indispensable research tool in modern plant biology.

223 Antibodies against AB amyloid are indispensable research tools and potential therapeutics

224 The living stock collections represent an indispensable resource for life scientists.

225 lease almost 20 years ago, ELM has become an indispensable resource for the molecular biology communi

226 Together, these data point to an indispensable role for synaptic-like vesicles at specifi

227 tes MSec as a target of ERp29 and reveals an indispensable role for the ER in TNT formation, suggesti

228 lly targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide

229 BRAF plays an indispensable role in activating the MEK/ERK pathway to

230 -dependent L-type Ca(V) 1.2 channels play an indispensable role in cardiac excitation-contraction cou

231 NF chromatin-remodeling complexes, serves an indispensable role in cold-induced thermogenesis in brow

232 PARPs play an indispensable role in DNA damage repair and small molecu

233 assical fear conditioning, thereby having an indispensable role in learning.

234 The ability to detect food plays an indispensable role in our survival and wellbeing.

235 polynucleotide phosphorylase (PNPase) has an indispensable role in paradoxically stabilizing Hfq-boun

236 The heteroatom dopant plays an indispensable role in the activation of N(2) via an enha

237 on (OER), surface oxygen adsorption plays an indispensable role in the electrocatalysis.

238 nalytical assay, data normalization plays an indispensable role in untargeted LC-MS profiling, yet li

239 This reflects the indispensable role of FANCB protein in the enzymatic act

240 Here we provide evidence for an indispensable role of neddylation, a ubiquitylation-like

241 The indispensable role of Nell-1 in normal craniofacial and

242 These results reveal for the first time an indispensable role of Plk1 in developmental and regenera

243 port in this study a previously unrecognized indispensable role of TLR7-induced IFN-gamma signaling i

244 Collectively, our findings reveal an indispensable role of ZFP36L1 as a posttranscriptional s

245 tion is essential to insect biology, playing indispensable roles during mate-finding, foraging, and o

246 roup 2 innate lymphoid cells (ILC2s) possess indispensable roles during type 2-mediated inflammatory

247 cyte education and illuminate LXRalphabeta's indispensable roles in adaptive immunity.

248 Akt plays indispensable roles in cell proliferation, survival and

249 Swine leukocyte antigens play indispensable roles in immune responses by recognizing a

250 ed microscopy and/or spectroscopy tools play indispensable roles in nanoscience and nanotechnology re

251 Mesenchymal cells in the crypt play indispensable roles in the maintenance of intestinal epi

252 The corpus of Old English verse is an indispensable source for scholars of the Indo-European t

253 ctrometry data, spectral deconvolution is an indispensable step in spectral data analysis, which grou

254 attosecond pulse from streaking trace is an indispensable step in studying the ultrafast electron dy

255 Normalization is an indispensable step of data analysis in all those studies

256 portance in bottom-up glycoproteomics and an indispensable step to understand the function of glycopr

257 Importantly, it has become an indispensable strategy to overcome resistance in antibio

258 delity of dendritic spine analysis and other indispensable techniques for studying neurodevelopment a

259 measurement of the pupillary function is an indispensable test in some eye examinations, being neces

260 Homeostasis is indispensable to counteract the destabilizing effects of

261 rstanding and setting parametric constraints indispensable to develop and enhance the performance of

262 loodstream infections in the neonates, it is indispensable to diagnose the disease properly for appro

263 illes' heel" of current cancer therapies, is indispensable to drug resistance and poor therapeutic ou

264 Many argue that empathy is indispensable to effective nursing practice.

265 rotubule minus-end-directed transport and is indispensable to eukaryotic cells.

266 Fungicides are indispensable to global food security and their use is f

267 ng ability and helicase activity of Dhh1 are indispensable to promote Atg1 translation and autophagy.

268 Doping is indispensable to tailor phase-change materials (PCM) in

269 nucleotide requirements, making this pathway indispensable to the parasite.

270 Essential proteins are indispensable to the survival and development process of

271 kinase activities of LecR-VI.2 and BAK1 are indispensable to their function in SAR.

272 bodies, and extracellular vesicles, has been indispensable to understand their functions in disease d

273 of single neurons and population dynamics is indispensable to understanding cortical circuits.

274 s of great apes provides a dimension that is indispensable to understanding how these microbial commu

275 Crystal structures of enzymes are indispensable to understanding their mechanisms on a mol

276 mediates, photoclick chemistry has become an indispensable tool for a wide range of spatially address

277 ity genome assembly/annotation has become an indispensable tool for better understanding the biology

278 rning and 3D modeling methods will become an indispensable tool for computational drug discovery in t

279 Antibodies have become an indispensable tool for many biotechnological and clinica

280 , these phytopathogens became a powerful and indispensable tool for plant genetic engineering and agr

281 ease make metabolomics-related approaches an indispensable tool for properly answering concerns relat

282 Modeling has become an indispensable tool for scientific research.

283 n techniques, have made top-down analysis an indispensable tool for structural characterization of co

284 -electron microscopy (cryo-EM) has become an indispensable tool for structural studies of biological

285 cade, RNA sequencing (RNA-seq) has become an indispensable tool for transcriptome-wide analysis of di

286 of cellular reactions and, thus, will be an indispensable tool for transforming CRRC from an experim

287 Analysis of motifs has been found to be an indispensable tool for understanding local network struc

288 Fluorescence imaging is an indispensable tool in biology, with applications ranging

289 MDCT is an indispensable tool in quantitative and qualitative evalu

290 Particle accelerators represent an indispensable tool in science and industry.

291 Transport measurements have been an indispensable tool in studying conducting states of matt

292 eted than current approaches, making them an indispensable tool in the clinical armamentarium.

293 lycan-binding proteins (GBPs), has become an indispensable tool in the study of protein-glycan intera

294 Nature uses catalysis as an indispensable tool to control assembly and reaction cycl

295 confocal Raman microspectroscopy becoming an indispensable tool to obtain spatially-resolved data on

296 Genome-scale engineering is an indispensable tool to understand genome functions due to

297 py and electron energy-loss spectroscopy are indispensable tools for characterizing the local structu

298 Reverse transcriptase (RT) enzymes are indispensable tools for interrogating diverse aspects of

299 at rigorous placebo-controlled trials remain indispensable tools in epidemic settings and also provid

300 eted and target recipient cells may offer an indispensable understanding of GBM that holds the potent