ライフサイエンスコーパス: individualization

1 anisms controlling cell-cell cooperation and individualization.

2 called actin cones, which mediate spermatid individualization.

3 r cytokinesis and those that failed in sperm individualization.

4 te-stage spermatid differentiation following individualization.

5 nfusion was modified to 4 hours, with dosage individualization.

6 movement was used to follow the progress of individualization.

7 lk cytoplasm in a process known as spermatid individualization.

8 ontrol of Rho kinase, is essential for sperm individualization.

9 nt of the IC whose function is essential for individualization.

10 cally interacts with pelota during spermatid individualization.

11 interconnected by cytoplasmic bridges until individualization.

12 terility as a result of defects in spermatid individualization.

13 rticipates in membrane reorganization during individualization.

14 ls, a process sometimes referred to as sperm individualization.

15 4, involved in nuclear shaping and spermatid individualization.

16 nary intervention is important for treatment individualization.

17 t to drive mitotic chromosome compaction and individualization.

18 not negatively affected by DPYD-guided dose individualization.

19 that standard defocus strategies may require individualization.

20 iogenesis to align spermatids and coordinate individualization.

21 bsence, elongated spermatids fail to undergo individualization.

22 ing strategies for genomics-guided treatment individualization.

23 would have allowed more effective treatment individualization.

24 rtunities for targeted therapy and treatment individualization.

25 ulation data, without the need of parameters individualization.

26 nd SWNTs and impart effective dispersion and individualization.

27 cones that mediate D. melanogaster spermatid individualization.

28 d in Drosophila male fertility and spermatid individualization.

29 s in MTHFR may offer potential for treatment individualization.

30 dinated migration of investment cones during individualization.

31 sterile due to specific defects in spermatid individualization.

32 elial fluidization towards, ultimately, cell individualization.

33 Dose individualization according to TMTV0 should be evaluated

34 y leukemia prognostic features for treatment individualization across age groups.

35 Individualization also fails in a number of mutants with

36 amined the timing and dynamics of phenotypic individualization among sister cells by scrutinizing and

37 fficient use of donated organs and allow the individualization and better evaluation of adjuvant chem

38 in a helical pattern that imparts efficient individualization and chirality selection.

39 Even if topoisomerase II is required for individualization and condensation of meiotic chromosome

40 in spindle assembly, which delay chromosome individualization and congression, putting the oocyte at

41 at an early time point, permitting treatment individualization and consideration of alternative strat

42 es by H1.8 depletion causes hyper-chromosome individualization and dispersion.

43 essential for efficient daughter chromosome individualization and for preferential association of Mu

44 ication of biobased fibers affords effective individualization and functionalization into nanomateria

45 r that the intervention needs to incorporate individualization and long-term interaction with trained

46 rile and show spermatogenic defects in sperm individualization and nuclear maturation, consistent wit

47 cteristics offer opportunities for treatment individualization and optimal patient selection for anti

48 Use of this tool may allow the individualization and optimization of therapeutic strate

49 r signatures potentially relevant for better individualization and optimization of treatment.

50 ing to cell membrane remodeling during sperm individualization and release.

51 Each trial incorporated individualization and repeated long-term contacts with f

52 osine in the cdt mutant males disrupts sperm individualization and results in decreased fertility.

53 y emerged from the data that highlighted how individualization and socialization are the central tena

54 ces and success, or 'focusing on the person: individualization and socialization during mealtimes'.

55 arable functions: one required for spermatid individualization and the other essential for assembling

56 he final stage of spermatogenesis, spermatid individualization, and causes male sterility.

57 visions to later stages of sperm maturation, individualization, and motility.

58 c activities of condensin (axial compaction, individualization, and resolution of recombination-depen

59 otubes (SWCNTs) and nanographene (NG), their individualization, and their characterization.

60 or ECT and 26% for MST, supporting amplitude individualization as a means of dosing especially for EC

61 g forces and is directly analogous to sister individualization at the prophase to prometaphase transi

62 epsis, interventional therapies will require individualization based on the age of the population.

63 ins and topo II are essential for chromosome individualization, but their functions are tuned by the

64 ulates non-apoptotic caspase activity during individualization by promoting local accumulation of the

65 x of cytoskeletal proteins and membrane, the individualization complex (IC), around the spermatid nuc

66 M1L males is caused by the disruption of the individualization complex and a progressive loss of germ

67 antly retard the assembly of the actin-based individualization complex around the nuclear bundle, (2)

68 low the assembly of a morphologically normal individualization complex around the nuclear bundle, but

69 ion of a major cytoskeletal component of the individualization complex as actin is confirmed with a s

70 ndle, (2) mutations (dud class) in which the individualization complex assembles in/around the nuclea

71 The structure of the individualization complex in a male-sterile clathrin hea

72 Using rhodamine-phalloidin as a probe, the individualization complex is readily visualized forming

73 ver leads to defects in the formation of the individualization complex that is required for spermatid

74 these structures and other components of the individualization complex.

75 otile but morphologically altered or reduced individualization complex.

76 physical scaffolding for the assembly of the individualization complex.

77 id tails, and defects in the assembly of the individualization complex.

78 sruption of the actin cones of the spermatid individualization complex.

79 isplayed a postmeiotic lesion with disrupted individualization complexes scattered along the spermati

80 ed spermatids and impedes the progression of individualization complexes that strip away cytoplasmic

81 bunits are found in numerous ;speckles' near individualization complexes, similar to the previously d

82 Individualization complexes, which consist of 64 cones o

83 nuclei at late maturation stages and stalled individualization complexes.

84 e sterile phenotype derives from a spermatid individualization defect at a late stage of spermatogene

85 ased frequencies of spermatid elongation and individualization defects which, considering the high sp

86 protein 3, knockdown of which causes similar individualization defects, suggesting that Cmb coordinat

87 esis has a high tolerance for elongation and individualization defects.

88 s are sterile and exhibit complete spermatid individualization defects.

89 d relative to wild-type, consistent with the individualization-deficient phenotype of this mutant.

90 nd kl-5 mutations had no effect on spermatid individualization despite the defect in the axonemes.

91 s and recapitulate chromosome compaction and individualization during mitotic condensation.

92 to better understand the mechanism of sperm individualization during spermatogenesis in Drosophila m

93 The whole process of individualization, during which a bundle of 64 syncytial

94 on condensation of chromatin and chromosome individualization from prophase to metaphase transition.

95 Computerized dose individualization improves target concentration achievem

96 eins play an essential role during spermatid individualization in Drosophila melanogaster.

97 ganization also become apparent during sperm individualization in dVps28 mutant testis.

98 in which we can perform live observation of individualization in isolated cysts.

99 des separase activation is prior kinetochore individualization in meiosis I.

100 L, which may have implications for treatment individualization in this disease.

101 rapeutic opportunities for further treatment individualization in this genetically defined subset of

102 I using observations of Drosophila spermatid individualization in vivo.

103 rticular repeated element and its subsequent individualization into a fully functional character.

104 The process of individualization involves the formation of a complex of

105 Furthermore, we find that this individualization is an active process that requires a l

106 ed forces deep into the tissue and that cell individualization is dispensable.

107 reorganization of cyst cytoplasm required at individualization is expected to be a correspondingly co

108 herefore, molecular subtype-driven treatment individualization is needed to help address racial and e

109 The associated process, termed spermatid individualization, is facilitated by the apoptotic machi

110 While DNA analysis provides individualization, it lacks information about the fluid'

111 defects, suggesting that Cmb coordinates the individualization machinery with the microtubular axonem

112 isciplinary DTC management, which emphasizes individualization of (131)I therapy according to the pat

113 fy the variables most relevant to subsequent individualization of a cancer therapy.

114 Drug monitoring allows individualization of a patient's immunosuppressive thera

115 Purported benefits are individualization of adjuvant therapy based on extent of

116 Individualization of antiangiogenic treatment using data

117 ous tumors and to improve the monitoring and individualization of antiangiogenic treatments.

118 baseline platelet hyperreactivity; 2) allow individualization of antiplatelet medication; 3) predict

119 If so, the individualization of antiplatelet therapy, including clo

120 more, quantitative molecular tests allow the individualization of antiviral therapies for prevention

121 Our results suggest individualization of blood pressure targets may depend i

122 or the identity of genes that may enable the individualization of cancer chemotherapy.

123 tion may have important implications for the individualization of cancer chemotherapy.

124 Individualization of cancer management requires prognost

125 of care was a salient theme suggesting that individualization of care that promotes residents' quali

126 lial, and inflammatory cell interactions and individualization of care will result in the eventual de

127 formation sharing; (5) shared goals; and (6) individualization of care.

128 uced cell-cell junction disassembly, causing individualization of cells and acquisition of a spindle-

129 ithin each lineage, then further modified by individualization of cells as they acquire unique morpho

130 om a mere detection method to application in individualization of chemoradiotherapy.

131 In this post-genomic era, the individualization of chemotherapy through the study of p

132 optimization of new drug development and the individualization of clinical therapeutics in the 21st c

133 s has offered compelling evidence toward the individualization of clopidogrel and warfarin therapies.

134 ivity and specificity and by enabling higher individualization of diagnostic concepts.

135 ns in the decision-making process and in the individualization of diagnostic imaging and treatment of

136 ation for the Study of Diabetes, emphasizing individualization of DM medication therapy and treatment

137 of convenience, cost, and safety, but limit individualization of dosing.

138 ion of specialized machinery involved in the individualization of Drosophila spermatids, and of many

139 ggest these reactions may be avoided through individualization of drug therapies based on genetic inf

140 results may aid physicians in evidence-based individualization of edoxaban dosing.

141 salvage ENRT and shows the need for further individualization of ENRT fields.

142 through the removal of common FC components, individualization of FC metrics enhanced the prediction

143 We state the individualization of four low-polarity chemical compound

144 We report the individualization of four polar dipeptides and of four n

145 The individualization of HbA(1c) targets has gained more tra

146 However, all such organizations advocate for individualization of HbA(1c) targets, leaving both healt

147 Attention is increasingly turning toward the individualization of hemodialysis prescriptions through

148 eveal the utility of serial surveillance for individualization of immunosuppression and identify wind

149 This, in turn, may serve as a tool for individualization of immunosuppression protocols in hear

150 The individualization of immunosuppression taper is the key

151 mmatory status may be helpful in prospective individualization of immunosuppression therapy after ren

152 There is an unmet need for increased individualization of in-hospital management, including t

153 ous binary solvent is first reported for the individualization of low-polarity mixture components by

154 Individualization of management and adequate supportive

155 (6) binary NMR solvents are reported for the individualization of mixture components by spin diffusio

156 e of clinical nuclear medicine as a tool for individualization of patient care and for improvement of

157 -sensitive reperfusion strategies, allow for individualization of patient care by predicting relative

158 carcinoma (ccRCC) has the potential to allow individualization of patient care, thereby helping preve

159 thyroid cancer are expected to allow greater individualization of patient care.

160 logy and user interfaces will permit greater individualization of prevention and treatment strategies

161 training adaptations and on its role in the individualization of resistance training frequency.

162 oxifene in endometrial cancer prevention and individualization of SERM therapy.

163 excessive standardization and a decrease in individualization of services.

164 In Drosophila melanogaster, individualization of sister spermatids requires the form

165 nd supportive of our previous proposals that individualization of sisters in E. coli is driven primar

166 CDH2, allowing for segmental de-adhesion and individualization of somites.

167 e prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defe

168 col biopsies provide information that allows individualization of tacrolimus rejection therapy, 2) hi

169 omain was identified related to the need for individualization of the approach to care for AYA patien

170 This recessional trend led to the individualization of the Cerro Rinon glacier by ~ 16.3 k

171 tides was found, suggesting a high degree of individualization of the HLA peptidomes.

172 h-risk subjects could contribute to a better individualization of the pharmacological treatment in ps

173 monitoring techniques emphasize the need for individualization of therapeutic interventions.

174 ial relevance for better prognostication and individualization of therapeutic strategy in endometrial

175 Given the many clinical phenotypes of PD, individualization of therapy and precision of treatment

176 therapeutic concepts in breast cancer aim at individualization of therapy as well as at treatment de-

177 Individualization of therapy based on genetic and enviro

178 use of available resources is expected from individualization of therapy regimens, which comprises t

179 ter identification of endotypes might permit individualization of therapy that can be targeted agains

180 tment education of anticipated side-effects, individualization of therapy, and review of strategies f

181 oaches and provide opportunities for greater individualization of therapy, confirmation of the geneti

182 ircumstances, might have clinical utility in individualization of therapy, early diagnosis and the ri

183 Individualization of therapy, which tailors a therapeuti

184 function of allograft recipients for better individualization of therapy.

185 imaging-based biomarker may facilitate early individualization of therapy.

186 ding of arterial afterload may enable better individualization of therapy.

187 The hallmark of pain management is individualization of therapy.

188 is highly test specific, and does not allow individualization of therapy.

189 d preclinical diagnosis, prognostication and individualization of therapy.

190 d preclinical diagnosis, prognostication and individualization of therapy.

191 in A(1c) (HbA(1c)) targets for patients, and individualization of these goals has more recently been

192 because of its importance clinically for the individualization of thiopurine drug therapy and also be

193 uggest strategies for moving biomarker-based individualization of transplant care from a research hyp

194 he underlying pathophysiology and subsequent individualization of treatment goals are important for i

195 to determine whether it may be useful in the individualization of treatment or evaluation of the resp

196 d performing dosimetry, potentially allowing individualization of treatment schemes.

197 le prevention of VTE recurrence with minimal individualization of treatment.

198 tment, and could allow dose optimization and individualization of treatment.

199 of breast cancer, which in turn aids in the individualization of treatment.

200 ogeneous subpopulations to facilitate better individualization of treatment.

201 tibility to ara-C cytotoxicity may allow for individualization of treatment.

202 l aortic waveform analysis may enable better individualization of vasoactive therapies in chronic HF

203 These results may lead to a better individualization of weight management after transplant.

204 h is due to defects in meiosis and spermatid individualization, phenotypes that are also observed in

205 -apoptotic role for these factors during the individualization process of maturing spermatids.

206 nstrated that long-range control of follicle individualization requires stall gene function in cells

207 utants also have a fully penetrant defect in individualization, resulting in failure to produce matur

208 h within and outside the ovary, for follicle individualization, stalk cell intercalation, and oocyte

209 a prospective, multi-centre, open label dose individualization study.

210 expression is necessary for proper spermatid individualization, the terminal step necessary for produ

211 ility to characterize and predict chromosome individualization, this model can help deepen our unders

212 We further suggest that, after sister individualization, this same stress also promotes chromo

213 Computerized dose individualization using population pharmacokinetic model

214 A novel component highlighting the need for individualization was identified.

215 ly, emerging trends such as connectivity and individualization will also drive new technology, and th

216 A second activity promotes chromosome individualization with the help of Red1 and Hop1, two me

217 An adaptive model enables fast individualization without enormous data sources from the