ライフサイエンスコーパス: indole

1 an shorter chain in their reactivity towards indole.

2 3 position afforded dihydrofuryl-substituted indole.

3 and in a bread model systems using [(13)C-2]indole.

4 oduce an electrophilic C-3 site in N-pyridyl indole.

5 yclization to afford the desired substituted indoles.

6 ow a novel approach toward the allylation of indoles.

7 and transition-metal-free assembly of 2-aryl indoles.

8 on in the case of methoxy (-OMe)-substituted indoles.

9 nce and notably proceeds with C6 substituted indoles.

10 he synthesis of 3-(organoselanyl) selenazolo indoles.

11 tion enabling selective formation of C5-BPin-indoles.

12 -2-ynyl isoquinolinones and then extended to indoles.

13 n of 10-membered O- and N-enediynes fused to indole, 1,2,3-triazole, and isocoumarin was investigated

14 tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione (31a) emerged as a potent (IC(50) =

15 6-bromo-3-(6-bromo-1H-indole-3-carbonyl)-1H-indole-1-sulfonate (2).

16 Among indoles, 2-aryl indoles have been described as privilege

17 pyrrolo[3,2-g]thieno[2',3':4,5]-thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis(5,6-difluoro-3

18 ery of tert-butyloxycarbonyl (Boc)-protected indole-2-carboxyesters as suitable motifs for the interm

19 rresponding 3a-hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic acid (HPIC) in a single, scalable st

20 cid/ester-functionalized pyrrole (2C/3C) and indole (2D/3D) moieties.

21 Indoles 3-5 (to a lesser extent 6) form rather stable te

22 9-Dimethylaminobenzo[ g]indoles 3-6 and 1-dimethylamino-8-(pyrrolyl-1)naphthalen

23 s or administration of the indole derivative indole-3 aldehyde increases proliferation of epithelial

24 seudomonas syringae strain PtoDC3000 uses an indole-3-acetaldehyde dehydrogenase to synthesize the ph

25 rved high ABA-glucose ester (ABA-GE) and low indole-3-acetate aspartate (IAA-Asp) and isopentenyladen

26 y two counteracted teams including (1) auxin/indole-3-acetic acid (AUX/IAA)-histone deacetylase (HDA)

27 y two counteracted teams including (1) auxin/indole-3-acetic acid (AUX/IAA)-histone deacetylase (HDA)

28 Indole-3-acetic acid (IAA) and other hormones were quant

29 mal cells under control conditions and after indole-3-acetic acid (IAA) application.

30 IBA treatments locally increased endogenous indole-3-acetic acid (IAA) content, whereas the combinat

31 Furthermore, exogenous application of indole-3-acetic acid (IAA) or auxin analogues might effe

32 hey were also screened for the production of indole-3-acetic acid (IAA), hydrogen cyanide (HCN), ammo

33 30 specifically transports picloram, but not indole-3-acetic acid (IAA).

34 sion of GRETCHEN HAGEN3.2 (ZmGH3.2, encoding indole-3-acetic acid [IAA] deactivating enzyme), and inc

35 indole-3-aspartic acid (an indicator of high indole-3-acetic acid accumulation, which inhibits lettuc

36 endogenous hormones measured in leaves, both indole-3-acetic acid and abscisic acid contents were dec

37 nutrient acquisition and the accumulation of indole-3-acetic acid and antioxidants in tissues, are al

38 All 16 maize auxin/indole-3-acetic acid repressor proteins were degraded in

39 sitivity to reactive oxygen species, reduced indole-3-acetic acid secretion, reduced biofilm and pell

40 dehydrogenase to synthesize the phytohormone indole-3-acetic acid to elude host responses.

41 Indole-3-acetic acid was detectable in D. dichotoma germ

42 afb5-5, that responds to conventional auxin (indole-3-acetic acid) but has a strongly diminished resp

43 osine, kynurenic acid, indole-3-lactic acid, indole-3-acetic acid, and betaine were observed than in

44 conversion of indole-3-butyric acid (IBA) to indole-3-acetic acid, because ech2 seedlings have altere

45 g abscisic acid, gibberellin, jasmonic acid, indole-3-acetic acid, etc.

46 Overexpression of BADC1 in wri1-1 decreased indole-3-acetic acid-Asp content and partially rescued i

47 th reduction in root length and elevation of indole-3-acetic acid-Asp levels relative to the wild typ

48 homolog RAMOSA1 ENHANCER LOCUS2, maize auxin/indole-3-acetic acids were able to repress AUXIN RESPONS

49 ere fully assigned as tetrahydropentoxyline, indole-3-acetic-acid-O-glucuronide, p-cresol glucuronide

50 tes-indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde-which are derived from gut bacterial m

51 Enhanced levels of indole-3-aspartic acid (an indicator of high indole-3-ac

52 to function in the peroxisomal conversion of indole-3-butyric acid (IBA) to indole-3-acetic acid, bec

53 iet supplemented with the dietary AhR ligand indole-3-carbinol (I3C).

54 dole moiety to furnish 6-bromo-3-(6-bromo-1H-indole-3-carbonyl)-1H-indole-1-sulfonate (2).

55 s been recruited into the WRKY33 regulon and indole-3-carbonylnitrile (ICN) biosynthetic pathway thro

56 volves glutathionylation of the intermediary indole-3-cyanohydrin, which is synthesized by CYP71A12 a

57 ere, we describe roles for three metabolites-indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehy

58 thesis, the reaction catalyzed by the enzyme indole-3-glycerol phosphate synthase (IGPS) starts with

59 synthase, were also up-regulated, as well as indole-3-glycerol phosphate synthase, an enzyme involved

60 butyric acid, d-sphingosine, kynurenic acid, indole-3-lactic acid, indole-3-acetic acid, and betaine

61 We identify Indole-3-propionic acid as an optimal amino acid derivat

62 oles for three metabolites-indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde-which are deriv

63 dine-4,6 diol (2-HTP) and di(5,7-difluoro-1H-indole-3-yl)methane (PSB-16671) as exemplars of each cla

64 ,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CB-5083), was developed and demons

65 yl) piperazine (mCPP), and 5-(2-Aminopropyl) Indole (5IT) were quantified.

66 rough 4pai electrocyclization reactions with indole, 7-methylindole, and 5-bromoindole as coupling pa

67 ne-like moiety present in CVM-05-002 with an indole, a potent pan-PI5P4K inhibitor with excellent kin

68 Below 1 mM indole, a repellent-only response was observed.

69 often complete attenuation, of responses to indole-a commonly occurring volatile associated with bot

70 In the first case, indole acetic acid esters were established as excellent

71 me involved in the biosynthesis of l-Trp and indole acetic acid.

72 uperoxide moiety in facilitating the initial indole activation step.

73 To induce goblet cell differentiation, indole acts via the xenobiotic aryl hydrocarbon receptor

74 Treating an alpha-diazo ester indole addition product with Rh(2) (OAc)(4) caused a rea

75 e (S)-strictosidine as a key intermediate in indole alkaloid biosynthesis.

76 l synthesis of arborisidine, a unique Kopsia indole alkaloid possessing a fully substituted cyclohexa

77 We used vincamine, an indole alkaloid, as a synthetic starting point for drama

78 rborisidine, a caged pentacyclic monoterpene indole alkaloid, has been accomplished in both racemic a

79 Indole alkaloids are important natural compounds with in

80 Fungal bicyclo[2.2.2]diazaoctane indole alkaloids represent an important family of natura

81 ydroxygeraniol, the precursor of monoterpene indole alkaloids, and cannabigerolic acid, the cannabino

82 nds, focusing on monoterpenoids, monoterpene indole alkaloids, and cannabinoids.

83 splendine, and (+)-malagashanol, three other indole alkaloids, are reported.

84 classes of plant natural products, including indole alkaloids, benzylisoquinoline alkaloids, hydroxyc

85 tures of the sponge-derived dibrominated bis-indole alkaloids, namely, echinosulfone A (2) and the ec

86 bers of a fascinating class of monoterpenoid indole alkaloids.

87 lective pyrrole alkylation, enantioselective indole alkylation with ethyl 2-diazopropanoate, and cycl

88 tion sequence, as we proposed in the case of indole alkylation.

89 Molecular dynamics simulation showed that indole allosterically affected the distance between the

90 plements previously reported metal-catalyzed indole allylations in that complete levels of N versus C

91 and obtained a series of new functionalized indole aminals, which are likely to have biological acti

92 core (25) provided moderate affinity but not indole and benzimidazole substitution of the aryl-triazo

93 At 1 mM indole and higher, a time-dependent inversion from a rep

94 Indole and indoline rings are important pharmacophoric s

95 y activity of synthesizing L-tryptophan from indole and L-serine.

96 y of this reaction, model systems containing indole and several 1,2-dicarbonyl compounds were prepare

97 the channeling of the reaction intermediate indole and the mutual activation of the alpha-subunit Tr

98 e-promoted electrocyclization of substituted indoles and 4-arylidene-3,6-diarylhex-2-en-5-ynal deriva

99 and electron-deficient substituents both in indoles and iodoarenes.

100 ovides rapid access to tetrahydropyran-fused indoles and other oxacyclic scaffolds under very low cat

101 indolines and tetrahydroquinolines to afford indoles and quinolones.

102 or geriatric mice with bacteria that secrete indoles and various derivatives or administration of the

103 imidazole, furan, thiophene, benzofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, ind

104 abinoids, synthetic cathinones, piperazines, indole, and amphetamine) in wastewater was developed and

105 rial production of hydrogen sulfide (H(2)S), indole, and indoxyl sulfate.

106 prepared in a straightforward manner through indole- and benzo[b]thiophene synthesis, palladium-catal

107 This approach has been used to synthesize 34 indole- and pyrrole-substituted N-acylsulfonamides in yi

108 able building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronat

109 However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronat

110 iota, acting via secreted factors related to indole, appear to regulate the sensitivity of the epithe

111 xacyclic chromeno[3',4':2,3]indolizino[8,7-b]indole architectures, with six fused rings and four cont

112 4-amino-indoles are amenable to this process, with acyl group in

113 Bifunctionalized indoles are an important class of biologically active he

114 Indoles are privileged heterocycles found in many biolog

115 C7- and C4-borylated indoles are produced by a mild approach that is compatib

116 y and showed that while the C(3)-substituted indoles are selective, high affinity NOP ligands, the st

117 inhibitors we evaluated 7-fluoro-substituted indoles as bioisosteric replacements for the 7-azaindole

118 Using indoles as the N-source and a selection of alkenols as t

119 and NH azaheterocycles (imidazole, pyrazole, indole, azindole, purine, indazole, benzimidazole, pyrid

120 can be introduced into each position of the indole backbone (C4 to C7, and aryl groups at C2), provi

121 o indole, which is an analogue of the potent indole-based anticancer agent.

122 naphthalene dicarboximide and thiophene- and indole-based boronic esters.

123 ffinity selection of a previously unreported indole-based DNA-encoded library (DEL).

124 Selected indole-based kratom alkaloids were evaluated for their o

125 This provides products containing indole-bearing stereocenters in high yield and with exce

126 centration if they had previously adapted to indole but were otherwise repelled.

127 tically related Friedel-Crafts alkylation of indoles, but to our surprise, almost null enantioselecti

128 tion of 1-(2-(sulfonamido)vinyl)indoles (SAV-indoles) by the Rh(II)-catalyzed reaction of 2,2-diaryl-

129 Steric congestion at the indole-C3 position and improved pai-pai stacking interac

130 e synthesis of benzofurans and cyclopropa[cd]indole-carbaldehydes in an operationally simple procedur

131 he case of N-linked triazoles, cyclopropa[cd]indole-carbaldehydes were isolated exclusively.

132 -position of indole to give alpha-diazo-beta-indole carbonyls, and enoxy silanes react to give 2-diaz

133 We developed an indole-carboxamide type mast cell stabilizer, MCS-01, wh

134 ol-4-oles gave various 4-substituted benzo[e]indoles carrying aryl, 2-thienyl, 2-pyridyl, and alkynyl

135 evealed that receptor-mediated adaptation to indole caused a bipartite response-wild-type cells were

136 by forming a alphabetabetaalpha complex with indole channeling taking place.

137 In conclusion, we have identified a specific indole compound that is a substrate for PEN3 and contrib

138 racterized by a high content of phenolic and indole compounds.

139 type cells were attracted to regions of high indole concentration if they had previously adapted to i

140 spectrometry (GCxGC-ToFMS), which estimated indole concentration in E. coli culture to average 32.3

141 e, we exposed Escherichia coli to a range of indole concentrations and measured the dynamic responses

142 on of the 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole core as a novel chemotype of potentiators.

143 es advantage of sequential alkylations of an indole core to rapidly construct the pentacyclic framewo

144 h to the annulation of a pyridine ring to an indole core.

145 ared with 4,6-dichloro-2-methyl-3-aminoethyl-indole (DCAI), a Ras ligand previously described to bind

146 3-triazoles with a Michael acceptor-tethered indole derivative have been achieved for the synthesis o

147 various derivatives or administration of the indole derivative indole-3 aldehyde increases proliferat

148 species, and why high serum levels of these indole derivatives are favorable for the prognosis of di

149 results in alkylation at the C-4 position of indole derivatives exclusively.

150 We demonstrate that these indole derivatives function by acting as de-repressors o

151 ous observations demonstrating that the same indole derivatives inhibit the growth of other pathogeni

152 A subset of indole derivatives of tryptophan catabolism produced by

153 f noncanonical amino acids from l-serine and indole derivatives or other nucleophiles.

154 The synthesis of cyclohepta[b]indole derivatives through the dearomative (4 + 3) cyclo

155 ing of allyl alcohols at the C-4 position of indole derivatives under the C-H activation conditions c

156 ar assembly of an important class of N-fused indole derivatives with versatile functional and structu

157 raquinones, phloroglucinols, phenolic acids, indole derivatives, tyrosine analogues, and quinolines.

158 -SH) provide the corresponding bis-thiolated indole derivatives.

159 Thus, indoles derived from the commensal microbiota regulate i

160 Treatment of breast cancer cells with bis-indole-derived NR4A1 antagonists including 1,1-bis(3'-in

161 ducts to mimic the bioinorganic chemistry of indole dioxygenation by TDO and IDO, challenging the wid

162 We report the total syntheses of two indole diterpenoid natural products, paspaline A and emi

163 ocking of indole on DNA gyrase predicts that indole docks perfectly to the ATP binding site of the Gy

164 Ocular isolates uniformly cannot use indole due to inactivating mutations within tryptophan s

165 brief but intense elevation of intracellular indole during stationary phase entry.

166 brief but intense elevation of intracellular indole during stationary phase entry.

167 and are all carbon-bridged dibrominated bis-indoles: echinosulfone A (2) is a di(1H-indol-3-yl)metha

168 reactivity differences between indazole and indole electrophiles, the latter of which was used in ou

169 Here, we demonstrated that indole enhanced the antibiotic tolerance of Pseudomonas

170 hilic attack to form the pyrrole ring of the indole, followed by a decarboxylation that restores the

171 Acid-promoted synthesis of cyclopenta[ b]indole frameworks from 3-indolylmethanols and alkynes ha

172 ion in the reaction, providing a generalized indole functionalization reaction that bears little stru

173 anates for the construction of dihydro-furan/indole-fused phthalimide scaffolds is discussed.

174 ng PAD3 and IGMT2, involved in camalexin and indole glucosinolate biosynthesis, respectively.

175 site mutants of PCS1 are still functional in indole glucosinolate metabolism.

176 ts in the accumulation of pathogen-inducible indole glucosinolate-derived compounds, suggesting that

177 tes (ascorbigen and methoxyl ascorbigen from indole glucosinolates) may serve as marker compounds for

178 Metabolites from methoxyl-indole glucosinolates, arising from broccoli consumption

179 trical and unsymmetrical 1H,8H-pyrrolo[3,2-g]indole has been developed.

180 However, indole has no effect on the formation of E. coli persist

181 Among indoles, 2-aryl indoles have been described as privileged scaffolds.

182 nthesis of a variety of 1,2,3-trisubstituted indoles having a Z configuration of the (1-aryl-2-(sulfo

183 There is disagreement over the mechanism of indole import and export and no clearly defined target t

184 demonstrate that the uptake of (68)Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than

185 ed regioselectivity at the 2,2'-positions of indole in an operationally simple and inexpensive proced

186 hofurans, naphthodifurans, and a benzo-fused indole in generally good yields are reported.

187 ns on how rhizobacteria sense and respond to indole in the rhizosphere.

188 we illustrate that the relevant property of indole in this context is its ability to conduct protons

189 ki-Miyaura cross-coupling of the C-borylated indoles in an overall two-step, one-pot process providin

190 ent the first chemoselective N-alkylation of indoles in aqueous microdroplets via a three-component M

191 functionalization of the benzenoid moiety in indoles in preference to the more reactive pyrrolic unit

192 esults elucidated the molecular mechanism of indole-induced antibiotic tolerance in Pseudomonas speci

193 c tolerance, suggesting this EmhR-dependent, indole-induced antibiotic tolerance is likely to be cons

194 seudomonas syringae was also responsible for indole-induced antibiotic tolerance, suggesting this Emh

195 Proteomic analysis revealed that indole influenced the expression of multiple genes inclu

196 Consistent with this, indole inhibited cholera toxin and toxin-coregulated pil

197 In the case of O-enediyne annulated with indole, instead of the formation of a 10-membered cycle,

198 addition of an alkanethiol to a 3-alkylidene indole intermediate.

199 pound, 3-(1H-imidazol-1-ylmethyl)-2phenyl-1H-indole (IPI), bound SHBG with an affinity similar to tha

200 Indole is a degradation product of tryptophan that funct

201 Indole is a signalling molecule produced by many bacteri

202 Indole is also produced by toxigenic V. cholerae strains

203 Indole is an aromatic molecule with diverse signalling r

204 Indole is an aromatic molecule with diverse signalling r

205 to prominent microbiota metabolites such as indole is important in the formation of microbial commun

206 However, the basis of chemotaxis to indole is poorly understood.

207 Indole is well known as an interspecies signalling molec

208 genative couplings of N-aryl glycinates with indoles is described.

209 ation reaction between phenacyl bromides and indoles is discovered in a highly regioselective fashion

210 route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reduct

211 ntermolecular C2-allylation of 3-substituted indoles is reported for the first time.

212 iphosgene to afford the new dibrominated bis-indole ketone, bis(6-bromo-1H-indol-3-yl)methanone (3),

213 erform a direct oxidative dearomatization of indoles leading to 2,3-dialkoxy or 2,3-diazido indolines

214 d with a PBD-lipid containing a BODIPY core, indole linker, and PEG length between 1000 and 5000 g/mo

215 Indoles may have utility as an intervention to limit the

216 The indole-mediated reduction in cytoplasmic pH may explain

217 rcaptoethanol, which forms a fluorescent iso-indole-mercaptide conjugate with PE.

218 ysteine, sulforaphane N-acetyl cysteine) and indole metabolites (ascorbigen and methoxyl ascorbigen f

219 ening-ring-closing cascade followed by a 1,3-indole migration process via a spirocyclobutene intermed

220 r consecutive diazenylation and amination of indole moieties has been demonstrated.

221 In this design, having 1 sulfonate on the indole moiety adjacent to EuK ((99m)Tc-EuK-(SO(3))Cy5-ma

222 The cyclopenta[ b]indole moiety represents a key skeletal unit in several

223 hanone (3), followed by N-sulfonation of one indole moiety to furnish 6-bromo-3-(6-bromo-1H-indole-3-

224 yptophans with different substituents at the indole moiety was synthesized employing either enzymatic

225 In silico docking of indole on DNA gyrase predicts that indole docks perfectl

226 We investigated the effects of indole on toxigenic V. cholerae O1 El Tor during growth

227 However, the effects of indoles on goblet cells do not depend on type I IFN or o

228 e followed by regioselective acylation of an indole or pyrrole nucleophile.

229 iates can enable access to functionalized 3H-indoles or benzazepinones.

230 rmation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones.

231 In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin fami

232 diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinedione

233 locations, are involved with the tryptophan/indole pathway, whose malfunctioning has been linked to

234 nt evolution of substrate selectivity toward indole, phenyl, or hydroxyphenyl amino acids in plant AA

235 Here we demonstrate that indole plays a critical role in the regulation of the cy

236 a the biomimetically inspired combination of indole, prenal, and either trans-dehydroosthol or gleina

237 The allylations of different substituted indoles proceed with negligible diastereo- and excellent

238 We propose that the inhibition of indole production offers a potential route to enhance th

239 We show that under conditions permitting indole production, cells maintain their cytoplasmic pH a

240 The oxygenated indole products have been isolated in ~31% yield, and ch

241 reduction in cytoplasmic pH may explain why indole provides E. coli with a degree of protection agai

242 Additionally, we show that the effect of the indole pulse that occurs normally during stationary phas

243 timulation of quinolone persisters is due to indole pulse, rather than persistent, signalling.

244 ubstrates was examined, including indazoles, indoles, pyrazoles, and benzimidazole, featuring both el

245 450 for highly efficient carbene transfer to indoles, pyrroles, and cyclic alkenes.

246 ed alkynes and aromatic nucleophiles such as indoles, pyrroles, and naphthols at room temperature und

247 Bioactives such as indoles, quinolines and cis-(+)-12-oxophytodienoic acid,

248 confused and sometimes contradictory body of indole research literature.

249 factor EmhR, which was demonstrated to be an indole-responsive regulator.

250 two carboxylates, at the C2 position of the indole ring of each Trp residue.

251 This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by t

252 h comprise the unusual coumarin-cyclohepta[b]indole ring system, have been achieved via the biomimeti

253 oxyl/amino groups and the C2-position of the indole ring.

254 e and therefore can synthesize tryptophan by indole salvage.

255 r the preparation of 1-(2-(sulfonamido)vinyl)indoles (SAV-indoles) by the Rh(II)-catalyzed reaction o

256 C3 and C2 carbon atoms, respectively, at the indole scaffold in the presence of catalytic iodine and

257 4,5,6-tetrahydro-1H-1,5-epiminoazocino[4,5-b]indole scaffold is reported.

258 Cyclohepta[b]indole scaffolds are obtained under mild reaction condit

259 Indole showed ability to capture all the tested 1,2-dica

260 physiology; however, it is not clear how the indole signal is perceived and responded to by plant gro

261 Two modes of indole signalling have been described: persistent and pu

262 Two modes of indole signalling have been described: persistent and pu

263 arch published in this area, many aspects of indole signalling remain enigmatic.

264 hether the discovery of a new, pulse mode of indole signalling, together with a move away from the id

265 results from pulse, rather than persistent, indole signalling.

266 We propose that indole spatially segregates cells based on their state o

267 Here we demonstrate that indole stimulates the formation of Escherichia coli pers

268 stituted alpha,beta-unsaturated esters, beta-indole-substituted diazo esters, and dienes are obtained

269 Moreover, the scope of the indole substrate is very broad, extending to previously

270 st, specifically with the most electron-rich indole substrate, underscoring the cruciality of electro

271 ediates the facile conversion of an array of indole substrates into their corresponding 2,3-dioxygena

272 eoselective coupling reaction and simplified indole substrates other than catharanthine that particip

273 e alkaloids corrected herein each contain an indole sulfamate and are all carbon-bridged dibrominated

274 Indole sulfides with internal alkyne functionality produ

275 ch as TCDD, that are carcinogenic to dietary indoles that are anti-inflammatory.

276 epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization f

277 tion occurs selectively at the 3-position of indole to give alpha-diazo-beta-indole carbonyls, and en

278 h catalyzes the condensation of l-serine and indole to l-tryptophan, to synthesize a range of noncano

279 Furthermore, the ability of indole to scavenge Strecker aldehydes was also demonstra

280 Ability of indole to undergo electrophilic aromatic substitution re

281 onic acids as well as 2-carbonyl-3-propargyl indoles to afford the corresponding carbazoles in decent

282 t room temperature with ketones, imines, and indoles to give congested trifluoromethylated homoallyli

283 ount for regioselectivity on the addition of indoles to unsymmetrical silyloxyallyl cations are repor

284 The indole transcriptome was defined by RNA sequencing and s

285 unctionality produced 2H-[1,3]thiazino[3,2-a]indoles under Cu-catalysis.

286 od)Cl](2) (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step.

287 the ToxR periplasmic domain, suggesting that indole was a ToxR agonist.

288 of bifunctionalized 2-halo(Br/Cl)-3-arylthio indole was smoothly diversified with privileged heterocy

289 The obtained cyclopenta[ b]indoles were used as substrates in heterogeneous hydroge

290 to provide 2-(1 H-triazole-1-yl)-3-arylthio indole, which is an analogue of the potent indole-based

291 olerance, and it allows an access to NH-free indoles, which can present a potential utility in medici

292 formal [3 + 2] and [4 + 2] cycloadditions of indoles with 1,2-diaza-1,3-dienes (DDs) is reported.

293 ess, directed C3-selective C-H borylation of indoles with [Ni(IMes)(2)] as the catalyst is reported.

294 Indoles with a deactivated five-membered ring could also

295 ated intermolecular [2 + 2] cycloaddition of indoles with alkenes has been realized.

296 3)P, 10-20 mol %) dearomatization of 3-NO(2)-indoles with allenoates is described.

297 owing borylation of a variety of substituted indoles with B(2)pin(2) in excellent yields and with hig

298 ylative annulation of 2-carbonyl-3-propargyl indoles with boronic acids under sequential palladium/tr

299 reaction of 2-vinylindoles or 4H-furo[3,2-b]indoles with in situ generated oxyallyl cations is repor

300 omain, which chemoselectively C(3)-alkylates indoles with up to 470 turnovers per minute and 18 000 t