ライフサイエンスコーパス: indole alkaloid

1 er acidic conditions during the synthesis of indole alkaloids.

2 bers of a fascinating class of monoterpenoid indole alkaloids.

3 other members of the Aspidosperma family of indole alkaloids.

4 reaction with tryptamine toward monoterpene indole alkaloids.

5 gue relevant to secoiridoids and monoterpene indole alkaloids.

6 ernary stereocenters of multiple monoterpene indole alkaloids.

7 esis of secondary metabolites, including the indole alkaloids.

8 aoctane core shared among several prenylated indole alkaloids.

9 indolenines, a common motif in many natural indole alkaloids.

10 ecule library, reminiscent of the polycyclic indole alkaloids.

11 s that produces high amount of monoterpenoid indole alkaloids.

12 rstand the biosynthesis of fungal prenylated indole alkaloids.

13 ts, including approximately 3000 monoterpene indole alkaloids.

14 ure eliminates all production of monoterpene indole alkaloids, a class of natural products derived fr

15 Monoterpene indole alkaloids, a class of specialized metabolites tha

16 A linear synthesis of the indole alkaloid (+/-)-akuammicine (2) was completed by a

17 ioselective total synthesis of monoterpenoid indole alkaloid (+)-alstonlarsine A is represented.

18 Total syntheses of the monoterpenoid indole alkaloids (+/-)-alstoscholarisine B and C were ac

19 iwinkle, synthesizes bioactive monoterpenoid indole alkaloids, among which the anti-cancer drugs vinb

20 Yohimbine, a natural indole alkaloid and a nonselective adrenoceptor antagoni

21 l synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is

22 nstitutes the first total synthesis of these indole alkaloids and provides the first regiospecific ro

23 nes, a structural motif embedded in numerous indole alkaloids and synthetic indole derivatives.

24 the synthesis of macroline/sarpagine related indole alkaloids and their antipodes for biological scre

25 cts and a new platform to access monoterpene indole alkaloids and their derivatives.

26 ydroxygeraniol, the precursor of monoterpene indole alkaloids, and cannabigerolic acid, the cannabino

27 nds, focusing on monoterpenoids, monoterpene indole alkaloids, and cannabinoids.

28 f natural products, such as the prostanoids, indole alkaloids, and macrolide antibiotics, provide amp

29 ification of a reductase that yields the bis-indole alkaloid anhydrovinblastine.

30 Indole alkaloids are a class of structurally diverse nat

31 Indole alkaloids are a diverse class of natural products

32 Prenylated indole alkaloids are a diverse group of fungal secondary

33 Monoterpene indole alkaloids are a large class of natural products d

34 The monoterpene indole alkaloids are a large group of plant-derived spec

35 Indole alkaloids are important natural compounds with in

36 Dimeric indole alkaloids are structurally diverse natural produc

37 splendine, and (+)-malagashanol, three other indole alkaloids, are reported.

38 o verify the role of this reverse-prenylated indole alkaloid as an intermediate along the biosyntheti

39 We used vincamine, an indole alkaloid, as a synthetic starting point for drama

40 the formal total synthesis of monoterpenoid indole alkaloids (+/-)-aspidofractinine, (+/-)-limasperm

41 nthesis of the perhydroquinoline core of the indole alkaloid aspidophytine (2), starting from commerc

42 ard the concise total syntheses of classical indole alkaloids (-)-aspidospermidine, (-)-tabersonine,

43 Tryprostatin A 1 and B 2 are indole alkaloid-based fungal products that act in the G2

44 classes of plant natural products, including indole alkaloids, benzylisoquinoline alkaloids, hydroxyc

45 c enzymatic chlorination timing in ambiguine indole alkaloid biogenesis led to the discovery and char

46 and is considered a key step in monoterpene indole alkaloid biosynthesis as it links primary and sec

47 requirement of class II CPRs for monoterpene indole alkaloid biosynthesis with a minimal or null role

48 identification of bottlenecks in monoterpene indole alkaloid biosynthesis, and discovery of new pathw

49 ly hydrolyzes 3 alpha(S)-epimer in terpenoid-indole alkaloid biosynthesis, IpeGlu1 lacked stereospeci

50 e (S)-strictosidine as a key intermediate in indole alkaloid biosynthesis.

51 diversity-generating power of monoterpenoid indole alkaloid biosynthesis.

52 expression profiles similar to known terpene indole alkaloid biosynthetic genes.

53 that produces the anti-cancer monoterpenoid indole alkaloid camptothecin (CPT).

54 We describe herein formal syntheses of the indole alkaloids cis-trikentrin A and herbindole B from

55 62066 (1 microM) and ibogaine (1 microM), an indole alkaloid claimed to be useful in the treatment of

56 Monoterpene indole alkaloids comprise a diverse family of over 2000

57 ral products belong to a group of prenylated indole alkaloids containing a core bicyclo[2.2.2]diazaoc

58 This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazao

59 Novel routes to the naturally occurring indole alkaloid cycloclavine and its unnatural C(5)-epim

60 The synthesis of tetracyclic indole alkaloid ( )-decursivine was accomplished using B

61 ymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, n

62 se-like prenyltransferase as the catalyst of indole alkaloid diketopiperazine prenylation, and a rare

63 ynthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved.

64 the total synthesis of the sarpagine-related indole alkaloids (-)-(E)16-epiaffinisine (1), (+)-(E)16-

65 involved in the biosynthesis of monoterpene indole alkaloids either through multiple isomers of stri

66 iosynthetic intermediate for all monoterpene indole alkaloid enzymatic pathways.

67 The total synthesis of the indole alkaloid ervincidine (3) is reported.

68 of the small class of unusual monoterpenoid indole alkaloids exemplified by alstilobanines A (3) and

69 hesis of congeners in the reverse-prenylated indole alkaloid family related to stephacidin A by takin

70 Prenylated indole alkaloids featuring spirooxindole rings possess a

71 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, w

72 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the West African shrub, Taberna

73 Akuammine (1) and pseudoakuammigine (2) are indole alkaloids found in the seeds of the akuamma tree

74 dy we have identified new halogenated prenyl-indole alkaloids from an invertebrate-derived Malbranche

75 Prenylated indole alkaloids from bacteria, fungi, plants, and anima

76 Bis(indole) alkaloids from Arundo donax were synthesized usi

77 etic precursor of a variety of monoterpenoid indole alkaloids, from d-tryptophan (19) was performed a

78 toward other substrates, including terpenoid-indole alkaloid glucosides.

79 s the reverse prenylation of the tetracyclic indole alkaloid hapalindole U at its C-2 position.

80 members of the vinca and tacaman classes of indole alkaloids has been accomplished.

81 rborisidine, a caged pentacyclic monoterpene indole alkaloid, has been accomplished in both racemic a

82 Ibogaine, a hallucinogenic indole alkaloid, has been proposed as a treatment for ad

83 ng the proposed structure of the tetracyclic indole alkaloid ht-13-B is presented.

84 med in good yields and can be converted into indole alkaloids in only a few steps.

85 leton of the apparicine class of monoterpene indole alkaloids in only four steps in 80% overall yield

86 iwinkle, synthesizes bioactive monoterpenoid indole alkaloids, including the anti-cancer drugs vinbla

87 is the source of several medicinal terpenoid indole alkaloids, including the low-level anticancer vin

88 reas phorbol 12-myristate 13-acetate and the indole alkaloids indolactam and octylindolactam were sel

89 n of these prenylated and reverse-prenylated indole alkaloids is bioinspired, and may also inform the

90 Malbrancheamide is a dichlorinated fungal indole alkaloid isolated from both Malbranchea aurantiac

91 Mattogrossine is an indole alkaloid isolated from Strychnos mattogrossensis

92 The okaramines are a class of complex indole alkaloids isolated from Penicillium and Aspergill

93 The communesins are a prominent class of indole alkaloids isolated from Penicillium species.

94 yntheses of the Strychnos-Strychnos-type bis-indole alkaloids (-)-leucoridine A (1) and C (2) were ac

95 can be expanded to some biologically active indole alkaloids like pityriacitrins, eudistomins Y(1) a

96 sis of the chlorinated [2.2.2]-diazabicyclic indole alkaloid (+)-malbrancheamide B is reported.

97 han, which is then shuttled into monoterpene indole alkaloid metabolism to yield chlorinated alkaloid

98 cs approach, we interrogated the monoterpene indole alkaloid (MIA) biosynthetic pathway in Catharanth

99 s of biologically active monoterpene-derived indole alkaloid (MIA) metabolites and is the sole source

100 l types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Ma

101 ristine are condensed from the monoterpenoid indole alkaloid (MIA) precursors catharanthine and vindo

102 Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic anti

103 kle), the unique source of the monoterpenoid indole alkaloid (MIA)-type anticancer drugs vincristine

104 Monoterpene indole alkaloids (MIA) are a diverse class of plant natu

105 Monoterpene indole alkaloids (MIAs) are a diverse family of complex

106 Monoterpene indole alkaloids (MIAs) are a large and diverse class of

107 Monoterpene indole alkaloids (MIAs) are a large, structurally divers

108 Monoterpene indole alkaloids (MIAs) found in the Rubiaceae have vari

109 The pharmaceutically valuable monoterpene indole alkaloids (MIAs) in Catharanthus roseus are deriv

110 Monoterpenoid indole alkaloids (MIAs) represent a large class of plant

111 Monoterpene indole alkaloids (MIAs) tabersonine and pseudo-tabersoni

112 mily produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patt

113 of structural expansion in the monoterpenoid indole alkaloids (MIAs) yielding thousands of unique mol

114 Three major glycosidic monoterpenoid indole alkaloids (MIAs), cadambine and its derivatives 3

115 Three major glycosidic monoterpenoid indole alkaloids (MIAs), cadambine and its derivatives 3

116 rsion of C3 stereochemistry in monoterpenoid indole alkaloids (MIAs), derived from the central precur

117 The total synthesis of two monoterpenoid indole alkaloids (MIAs), erchinines A and B, is describe

118 biosynthesis of many different monoterpenoid indole alkaloids (MIAs), many of which have powerful bio

119 es more than a hundred different monoterpene indole alkaloids (MIAs).

120 oschizol (4) as well as the opioid agonistic indole alkaloid mitragynine (1).

121 esis of the 9-methoxy-substituted Corynanthe indole alkaloids mitragynine (1), 9-methoxygeissoschizol

122 n linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine.

123 synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-N(a)-methylsarpagine (8), (+)-majvi

124 tures of the sponge-derived dibrominated bis-indole alkaloids, namely, echinosulfone A (2) and the ec

125 aloids are a diverse class of fungal-derived indole alkaloid natural products with potent pharmacolog

126 as the key step in concise syntheses of the indole alkaloids norfluorocurarine and strychnine.

127 olled strategy to the Aspidosperma family of indole alkaloids, one that is readily adapted to the asy

128 idea that Trp biosynthesis and the secondary indole alkaloid pathway are coordinately regulated.

129 es cerevisiae host from 14 known monoterpene indole alkaloid pathway genes, along with an additional

130 anticancer drug produced by the monoterpene indole alkaloid pathway in Camptotheca acuminata.

131 s of the architecturally complex tremorgenic indole alkaloid (-)-penitrem D (4) has been achieved.

132 Prenylated indole alkaloids (PIAs) possess great structural diversi

133 l synthesis of arborisidine, a unique Kopsia indole alkaloid possessing a fully substituted cyclohexa

134 There are approximately 3,000 monoterpene indole alkaloids produced by thousands of plant species

135 provides Trp for both protein synthesis and indole alkaloid production and therefore represents a ju

136 hesis of the unusual cyclopropane-containing indole alkaloid (-)-rauvomine B via a strategy centered

137 Dimeric indole alkaloids represent a structurally unique class o

138 Fungal bicyclo[2.2.2]diazaoctane indole alkaloids represent an important family of natura

139 N-N-linked dimeric indole alkaloids represent an unexplored class of natura

140 nalyte electrochemistry was tested using the indole alkaloid reserpine, which is often used to test t

141 zophenanthridine alkaloids and monoterpenoid indole alkaloids, respectively, in response to microbial

142 The indole-alkaloid scytonemin is the most common and widesp

143 nstrated in the first total synthesis of the indole alkaloid ( )-sorazolon B, which enabled the stere

144 , the first total synthesis of the monomeric indole alkaloids (+)-spegatrine (2), (+)-10-methoxyvello

145 apply this strategy to the synthesis of the indole alkaloid spegazzinidine, it was necessary to addr

146 e early steps for creation of the prenylated indole alkaloid structure and suggest a scheme for the b

147 the 19th century to the present, the complex indole alkaloid strychnine has engaged the chemical comm

148 l synthesis of the bridge-fused Aspidosperma indole alkaloid (+/-)-subincanadine F has been accomplis

149 tral role in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinbl

150 Prenylated indole alkaloids such as the calmodulin-inhibitory malbr

151 Scytonemin is a heterocyclic indole-alkaloid sunscreen, the synthesis of which is ind

152 ontribute to the regulation of monoterpenoid indole alkaloid synthesis in this species.

153 corynantheol and the formal syntheses of the indole alkaloids tacamonine, rhynchophylline, and hirsut

154 Seven new prenylated indole alkaloids, taichunamides A-G, were isolated from

155 Ibogaine, an indole alkaloid that causes hallucinations, tremor, and

156 Ibogaine (IBO) is an indole alkaloid that is reported to facilitate drug abst

157 tural products--specifically the monoterpene indole alkaloids, the benzylisoquinoline alkaloids and t

158 Terpene indole alkaloids (TIAs) are plant-derived specialized me

159 expression of all the genes in the Terpenoid Indole Alkaloids (TIAs) pathway that produces the vinbla

160 s roseus produces a large array of terpenoid indole alkaloids (TIAs) that are an important source of

161 e to the interest in their dimeric terpenoid indole alkaloids (TIAs) vinblastine and vincristine, whi

162 aranthus roseus produces bioactive terpenoid indole alkaloids (TIAs), including the chemotherapeutics

163 ncristine, which are classified as terpenoid indole alkaloids (TIAs).

164 armaceutically valuable, bioactive terpenoid indole alkaloids (TIAs).

165 rived from the dimerization of the terpenoid indole alkaloids vindoline and catharanthine.

166 In our quest to discover new monoterpene indole alkaloids, we demonstrate the utility of the MetW

167 e of CPRs in the biosynthesis of monoterpene indole alkaloids, we provide compelling evidence of an o

168 uld permit entry into many ring-A oxygenated indole alkaloids when coupled with the asymmetric Pictet

169 Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative

170 Tremorgenic mycotoxins are a group of indole alkaloids which include the quinazoline-containin

171 ed Zincke aldehyde cycloaddition approach to indole alkaloids, which permitted the gram-scale synthes

172 The herbindoles are cyclopent[g]indole alkaloids whose structures incorporate a fully su

173 Actinophyllic acid is a biologically active indole alkaloid with a unique structural framework that

174 ne and communesin F are structurally related indole alkaloids with an intriguing polycyclic core cont

175 a general entry into C-6 hydroxy-substituted indole alkaloids with either an alpha or a beta configur

176 Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring system