ライフサイエンスコーパス: indole ring

1 and either the nicotinamide ring or Trp-677 indole ring.

2 stituents or nitrogens incorporated into the indole ring.

3 st sensitive to changes at position 5 of the indole ring.

4 d the sterically forbidden region around the indole ring.

5 chain nitrogen as part of an indoline or an indole ring.

6 ect attack of O2 on the C2 atom of the L-Trp indole ring.

7 l group controlled by nucleophilicity of the indole ring.

8 moiety at the C2 position of each side-chain indole ring.

9 ediamine group positioned differently on the indole ring.

10 oxyl/amino groups and the C2-position of the indole ring.

11 ed by replacing the o-bromophenol unit by an indole ring.

12 ocenter attached to the C(2)-position of the indole ring.

13 g and/or positioning via the NH group of the indole ring.

14 volve unpaired electron density at C3 of the indole ring.

15 eraction by stacking the flipped base on the indole ring.

16 as well as at the 2- and 3-positions of the indole ring.

17 re used to assess the geometry of the planar indole ring.

18 nd to occur with systems containing tethered indole rings.

19 rmations stabilized by cross-strand pairs of indole rings.

20 xciton splitting produced by the stacking of indole rings.

21 ect hydrogen bond between the phenol and the indole rings.

22 wo oxygen atoms are inserted into one of the indole rings.

23 ent of conjugation between the maleimide and indole rings.

24 with phenyl, pyridyl, bicyclic aromatic, or indole rings.

25 interaction between the galactopyranosyl and indole rings.

26 anese superoxide dismutase (MnSOD), with its indole ring adjacent to and about 5 A from the manganese

27 e His-435 imidazole ring against the Trp-457 indole ring, allowing an electrostatic interaction that

28 he binding moieties of the inhibitor are its indole ring and a carboxyl group.

29 e insertion of a second oxygen atom into the indole ring and covalently linking betaTrp57 to betaTrp1

30 n differences in the position assumed by the indole ring and differences in agonist activity.

31 ual or multiple Trps by 1-methylation of the indole ring and examined the structural and functional c

32 normal and reverse prenylation at C3 of the indole ring and normal prenylation of N1.

33 terium violaceum, mediates a 1,2 shift of an indole ring and oxidative chemistry to generate prodeoxy

34 scence was due to an interaction between its indole ring and the positively charged guanidino group o

35 containing two aromatic indole rings or one indole ring and two aromatic phenyl groups at a fixed di

36 A)(1) channels to refine the geometry of the indole ring and, specifically, the C2-(2)H bond directio

37 duced at C2, C4, or the nitrogen atom of the indole ring, and the corresponding substrates were react

38 actonization of a diol in the presence of an indole ring; and a late-stage cyclization to complete th

39 genated substituents on the phenyl rings and indole rings are described.

40 bstitutions on the 4- and 6-positions of the indole ring as well as methyl substitution on the cycloh

41 sults in the direct functionalization of the indole ring at the C4-position is developed into a pract

42 In this orientation, the line connecting indole ring atoms N1 and C2 is nearly perpendicular to t

43 3(E7) betaCO subunits and indicates that the indole ring blocks the entrance to the E7 channel, as ob

44 6 degrees with respect to the normal to the indole ring bridge, and the experimental geometry was co

45 identify a common hydrophobic pocket for the indole ring but exhibit unusual heme ligation and substr

46 region of the pi-clouds for the benzene and indole rings but not for the pyridinylmethyl or pyrazin-

47 Our binding studies show that benzene and indole rings, but not pyridinylmethyl nor pyrazin-2-ylme

48 perm whale myoglobin labeled with 13C at the indole ring C-3.

49 ween high and low pH, push the imidazole and indole rings closer together at low pH.

50 Substitution on the indole ring did lead to improved CB 2/CB 1 binding selec

51 residues at the 5- and/or 7-position of the indole rings displayed the highest activity in cAMP assa

52 (a characteristic of average polarity of the indole rings' environments) and integrated fluorescence

53 complex with a p-methoxyphenyl group on the indole ring exhibited stability in air for up to six mon

54 he conserved site of Trp83 indicate that the indole ring flip is common in flaviviral NS2B-NS3 protea

55 xchange of the remaining four protons in the indole ring for deuterium, comparison could be made to d

56 allows quick and atom-economical assembly of indole rings from inexpensive and readily available anil

57 substituents at the 5 and 7 positions of the indole ring gave high affinity for hSERT, and the prefer

58 Replacement of the phenol group of 2 with an indole ring generated the first potent D1/D5 antagonist

59 erimental precision in the definition of the indole ring geometry demonstrates yet another practical

60 oncert with an improved understanding of the indole ring geometry, to analyze prototype 2H NMR spectr

61 e ring and a halogen or a nitro group in the indole ring have enhanced antiplasmodial activity.

62 one, [Formula: see text] attaches Gly to the indole ring in a Gly-tRNA dependent fashion.

63 een an aliphatic or phenyl side chain and an indole ring in a phospholipid environment were investiga

64 f the morpholino group from the plane of the indole ring in compound 1 is essential for cannabimimeti

65 spectra of fd indicate that the plane of the indole ring in each pVIII subunit is close to parallel t

66 (+), the tryptamine NH(2) lone pair, and the indole ring in K(+)(Tryp) favors the formation of these

67 xylation and subsequent methoxylation of the indole ring in position 1 (1-IG modification) or 4 (4-IG

68 B27-31)RLF, clearly indicate that the intact indole ring in position B27 is crucial for high RLF rece

69 kewise, exchanging the 2-methyl group on the indole ring in the ester and amide series with a hydroge

70 oduct was the result of C-2 oxidation of the indole ring, in contrast to other human P450s that gener

71 tions are stabilized largely by cross-strand indole ring interactions.

72 rough its trajectory, whereas at high pH the indole ring is further away from the imidazole.

73 be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (ii

74 The indole ring is positioned correctly for oxygenation at t

75 rance to the binuclear metal center, and the indole ring is positioned to suggest that it could provi

76 f indole-2-carboxamides, the presence of the indole ring is preferred for maintaining the modulator's

77 t the Trp residue, and more specifically the indole ring, is not critical for receptor interaction an

78 aving the ammonium group closer to C4 of the indole ring (labeled C5 in the cis-W3 X-ray structure).

79 naphthalene diimide (NDI) with two annulated indole rings leading to carbazolo[2,3-b]carbazole diimid

80 -3beta, the additional nitrogen atoms in the indole rings may contribute to a significant degree.

81 ne side-chain forms a covalent bond with the indole ring nitrogen atom of Trp51.

82 ations signify that the functionalization of indole ring nitrogen on the silicon surface plays a deci

83 , altered connectivity, and mimicking of the indole ring of 17 failed to maintain A2BAR potency.

84 eled as a decrease in the cone angle for the indole ring of about 12 degrees.

85 d, and two carbonyl oxygens are added to the indole ring of betaTrp(57).

86 ffect to pai-cation interactions between the indole ring of DTA and the NH(4)(+) counterion in the an

87 two carboxylates, at the C2 position of the indole ring of each Trp residue.

88 TDO catalyzes oxidative cleavage of the indole ring of L-tryptophan (L-Trp), converting it to N-

89 ethyltransferase (TsrM) methylates C2 of the indole ring of L-tryptophan during biosynthesis of the q

90 catalyzes the methylation of carbon 2 of the indole ring of L-tryptophan.

91 xploration of substituents introduced to the indole ring of lead compound 1 (MI-136) to identify comp

92 The introduction of chlorine atoms on the indole ring of malbrancheamide differentiates it from ot

93 cytochrome c heme edge is within 4 A of the indole ring of subunit II residue Trp(104), indicating a

94 The indole ring of the critical penultimate Trp-residue of T

95 owever, 6-isothiocyanato substitution on the indole ring of the desmethyl analog provided isothiocyan

96 he atomic-resolution structure of F359W, the indole ring of the tryptophan completely fills the tunne

97 yl side chain of Phe 161 superimposes on the indole ring of Trp 161 in the wild type.

98 e a mannose is linked to the N-1 atom of the indole ring of Trp residue.

99 Excited-state electron transfer from the indole ring of Trp to the carbonyl groups of peptide bon

100 It therefore appears that the indole ring of Trp(143) mediates electron transfer from

101 acyl chain, the six-membered portion of the indole ring of Trp(9) is displaced by about 0.9 angstrom

102 g TTQ are the addition of two oxygens to the indole ring of Trp(beta)(57) and the formation of a cova

103 ivatives as exogenous proton donors with the indole ring of Trp-64; these experiments include pH prof

104 utant is accommodated at the location of the indole ring of Trp-741 in the WT AR bound to dihydrotest

105 then carries out three hydroxylations of the indole ring of Trp.

106 of a mannose residue and the N-1 atom of the indole ring of Trp.

107 d with a slight rotation and shifting of the indole ring of Trp148, which eventually creates a slot f

108 and the 13-methyl group thrusts against the indole ring of Trp182 which tilts in the cytoplasmic dir

109 The indole ring of Trp355 is coplanar with or perpendicular

110 ntgegen-H(N) of the C-terminal amide and the indole ring of Trp6 that stabilizes a face-to-edge indol

111 In particular, the NOE of the indole ring of tryptophan 49, at the tip of the beta-hai

112 ion of a reaction byproduct arising from the indole ring of tryptophan residues.

113 enzyme that catalyzes the oxygenation of the indole ring of tryptophan to afford N-formylkynurenine.

114 Heme dioxygenases oxidize the indole ring of tryptophan to kynurenine which is the fir

115 This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by t

116 uanidinium functionality of arginine and the indole ring of tryptophan, resulting in structural stabi

117 favorable pi-stacking interactions with the indole ring of tryptophan.

118 e of glycine followed by chlorination of the indole ring of tryptophan.

119 For the initial step, HOCl chlorinates the indole ring of tryptophan.

120 n different ways: the -OH group of Y342, the indole ring of W334, and the aromatic rings of F335, Y34

121 ial D-amino acid transaminase shows that the indole rings of the two Trp-139 side chains face each ot

122 Distances between the centers of the indole rings of the two-tryptophan residues, 2 and 4, an

123 al dimeric interface with the two juxtaposed indole rings of Trp-139 is important for optimal catalyt

124 ysis, the magnitude of Szz for the outermost indole rings of Trp13 and Trp15 is indistinguishable fro

125 y four imidazole rings from the top and four indole rings of Trp41 from the bottom, thus explaining t

126 t the orientation in the binding site of the indole rings of tryptophan and 5-methyltryptophan and of

127 ophan residues within MADH, during which the indole rings of two tryptophan side chains are cross-lin

128 tant formation of two new pyridine rings via indole ring opening and double cyclization reactions.

129 We found that EEDs containing two aromatic indole rings or one indole ring and two aromatic phenyl

130 avy chain, which may be coupled to the novel indole ring orientation of the adjacent Trp H103.

131 hannel conductance and lifetime, and average indole ring orientations within the membrane-spanning ch

132 oton-deuterium exchange-out for the resolved indole ring protons of the two tryptophan residues was q

133 xy substitution at 4- and 5-positions of the indole ring, respectively), derived from indomethacin.

134 s catalyze C(4)- and C(7)-prenylation of the indole ring, respectively.

135 at the C4 and C3 positions on pyrazolone and indole rings, respectively, of beta-(2-N-tosylaminoindol

136 imination of the 2-methyl substituent on the indole ring resulted in a 10-fold decrease in binding af

137 pheral substitution at the 5-position of the indole ring resulted in a compound with pK(a) approximat

138 aired or mismatched nucleotides by employing indole ring stacking with the bases as a criterion of de

139 the nature of the substitutions on the basic indole ring structure and correlates well with the obser

140 Indole ring substitutions had varying effects on CB 2 an

141 points for an investigation of the effect of indole ring substitutions on CB 2 and CB 1 binding affin

142 possesses the parent tetrahydropyrrolo[1,2-a]indole ring system characteristic of the mitomycin famil

143 h comprise the unusual coumarin-cyclohepta[b]indole ring system, have been achieved via the biomimeti

144 imed for cyclization to form the cyclopent[g]indole ring system.

145 uinone methide formation from a pyrido[1,2-a]indole ring system.

146 Using benzimidazole and indole ring systems we show the versatility of these vin

147 mately 8-A-diameter axial channel lined with indole rings that is filled with polyethylene glycol 400

148 atom specific modification of the tryptophan indole rings through analogue substitution produced a pr

149 formed during the oxidative cleavage of the indole ring to give kynurenine.

150 substrates suggest the ability of the bound indole ring to mediate what amounts to medium long-range

151 as well as flipping of the conserved Trp205 indole ring to pack on the thiol side chain.

152 scher rearrangement with the formation of an indole ring to produce 3-(indol-2-yl)-quinoxalin-2-ones,

153 arrangement driven by a 2,3-hydride shift on indole ring to ultimately produce 2-oxindole.

154 For example, the ability of benzene and indole rings to bind the Trp(8) binding pocket for SRIF-

155 measured order parameters indicate that the indole rings undergo simultaneous chi1 and chi2 torsiona

156 hanism of OP resistance mediated by a single indole ring (W197) located in an enzyme "acyl pocket".

157 bamates containing a tethered pi-bond on the indole ring were examined as an approach to the iboga al

158 uent appended to the 4- or 5-position of the indole ring were prepared and tested as inhibitors of hn

159 Cu-NHC complexes bearing alkyl groups on the indole ring were stable under a nitrogen atmosphere for

160 dissociative electrophilic alkylation of the indole ring, where orientation of the substrates within

161 Replacement of the indole ring with azaindole conferred a 30-fold increase

162 c acid complexes, suggesting stacking of the indole ring with nucleobases and the simultaneous involv

163 ions of the R84 guanidinium group or the W89 indole ring with the substrates.

164 ations of the orientation of each tryptophan indole ring, with respect to the bilayer membrane normal