ライフサイエンスコーパス: indoline

1 ne and therefore the rate of buildup of E(Q)(indoline).

2 followed by a very slow reappearance of E(Q)(indoline).

3 e, E(A-A), is formed and the enzyme releases indoline.

4 the high local concentration of sequestered indoline.

5 ng insights into the selectivity afforded by indoline.

6 to the preparation of a 1,2,3-trisubstituted indoline.

7 stereodiscriminations for most of the tested indolines.

8 paration of 2,3-cis- and trans-disubstituted indolines.

9 xaldehyde with the appropriately substituted indolines.

10 well-known blueprint for accessing 2,3-fused indolines.

11 ccess to 2-substituted and 2,2-disubstituted indolines.

12 onding to N and one to the C7 of indoles and indolines.

13 rected C-H borylation to form useful C7-BPin-indolines.

14 ts can be converted in situ into C7-BPin-N-H-indolines.

15 ruction of enantioenriched 2,2-disubstituted indolines.

16 cess to a variety range of three-dimensional indolines.

17 E-H (E=N/C) functionalisation of indoles and indolines.

18 ry-function studies of a series of bioactive indolines.

19 antioselective synthesis of fused polycyclic indolines.

20 dical-mediated regioselective bromination of indoline 12 serving as a key step.

21 group gave either tetrahydroquinolines 18 or indolines 14 in high overall yield and diastereoselectiv

22 A range of densely functionalized indolines (18 examples) is obtained in high yields (up t

23 pargylic alcohols via an allenyl addition to indoline-2,3-diones.

24 These syntheses of indoline-2,3-fused chromans and tetrahydropyrans proceed

25 wo-step, cis-diastereoselective synthesis of indoline-2,3-fused chromans from 3-substituted indoles.

26 step protocol can also be extended to access indoline-2,3-fused tetrahydropyrans.

27 We report that a series of novel indoline-2-carboxamides have been identified as inhibito

28 rahydroisoquinoline-3-carboxylate (Tic), and indoline-2-carboxylate.

29 ence of proline for the trans isomer, making indoline-2-carboxylic acid a good candidate for the desi

30 tudy on the conformational properties of (S)-indoline-2-carboxylic acid derivatives has been conducte

31 ture exploiting the striking tendency of (S)-indoline-2-carboxylic acid to drive the peptide bond con

32 unctionalized benzofuran and lactone bearing indoline-2-one scaffolds under same conditions.

33 uted-thiazolo[3,2-a]indoles from 3-alkylated indoline-2-thiones and 2-halo-ketones has been developed

34 of donor-acceptor cyclopropanes (DACs) with indoline-2-thiones in the presence of Sc(OTf)(3) as a Le

35 ed dihydrothiopyrans has been developed from indoline-2-thiones.

36 drospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues were synthesized and

37 described spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H,7aH)-trione p53 modulators were prep

38 CFM-4 (1(2-chlorobenzyl)-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one), a lead compound

39 and 2,3-allenoate into enantioenriched spiro[indoline-3,2'-pyrrole] derivatives with a quaternary ste

40 as equivalents of alkynes to construct spiro[indoline-3,2'-pyrrole] structure.

41 A series of 1"-(alkylsulfonyl)-dispiro[indoline-3,2'-pyrrolidine-3',3"-piperidine]-2,4"-diones

42 quinolino[3,4-b]quinoxalin-6-ones from spiro[indoline-3,2'-quinoxaline]-2,3'-diones, which are readil

43 '-(cyclohexane carbonyl)-1-methyl-2-oxospiro[indoline-3,2'-thiazolidine] (4n) emerged as the most pot

44 n this case, a 2'-isobutyl-substituted spiro[indoline-3,3'-pyrrolenine] results.

45 ous retro-Mannich fission to produce a spiro[indoline-3,3'-pyrrolenine] with relative configuration d

46 beta-phenyltropane, 6, and 1-methylspiro[1H-indoline-3,4'-piperidine], 7, were synthesized and teste

47 For most of the indoline-3-propionic acid derivatives, introduction of N

48 we prepared a large number of derivatives of indoline-3-propionic acids and esters.

49 rovides, among other products, indole 29 and indoline 30.

50 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the an

51 ome, which is formed through coupling at the indoline 5-position using redox chemistry, exhibits pH-g

52 Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of

53 les including oxindoles, dihydrobenzofurans, indolines, a chromane, and a tetrahydronaphthalene.

54 s of enantiomerically enriched 2-substituted indolines, a substructure found extensively in both hete

55 or the construction of highly functionalized indolines, a substructure occurring in numerous biologic

56 atization is an important strategy to access indolines: a motif present in a variety of natural produ

57 for the concise synthesis of CF(3)-attached indoline alkaloid analogues, i.e., CF(3)-(+/-)-desoxyese

58 red synthesis of a highly diverse polycyclic indoline alkaloid library, that selectively resensitizes

59 ycinyl imine to provide either enantiomer of indoline alpha-amino acids with high ee.

60 ew series of active and selective pyrimidone indoline amide PI3Kbeta inhibitors.

61 atile, amide-directed ortho-acetoxylation of indoline amides enabled our implementation of a unified

62 synthesis of a wide variety of chiral cyclic indoline aminals and indole aminals with aromatic and al

63 and efficient asymmetric synthesis of cyclic indoline aminals was developed with a high level of 1,3-

64 Dehydrogenation of the indoline aminals with potassium permanganate produced th

65 sformation (by making a benzologue) gave the indoline analogue, butabindide (33) as a reversible inhi

66 ange of synthetically important and advanced indoline analogues are selectively functionalized at the

67 oacrylate intermediate with the nucleophiles indoline and 2-aminophenol correlate with an upfield shi

68 labeling studies from the reactions of both indoline and acyclic arylamines with DCCPh showed that t

69 derived imidate led to the identification of indoline and aminoethanol as C3- and C2-selective carbon

70 on/direct arylation cascade reaction between indoline and an arylated agent was efficaciously perform

71 o photochromic compounds incorporating fused indoline and benzooxazine fragments.

72 protocol may be extended to the formation of indoline and chromane derivatives.

73 pounds, named GRL-1720 and 5h, containing an indoline and indole moiety, respectively, which target t

74 Enantioselective synthesis of an indoline and isoquinolines is also demonstrated.

75 quickly through the quinonoid state to give indoline and the alpha-aminoacrylate Schiff base, E(A-A)

76 intermediate in rapid equilibrium with bound indoline and the E(A-A) intermediate before leaking out

77 ion limits the rate of accumulation of free indoline and therefore the rate of buildup of E(Q)(indol

78 zitose, and maltotriose, and lower levels of indoline and various amino acids.

79 nt access to enantioenriched spirocyclohexyl-indolines and -oxindoles.

80 al triarylmethanes through C-H alkylation of indolines and 1,2,3,4-tetrahydroquinolines with aryl ald

81 is of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines.

82 Indolines and 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines w

83 iate conditions, can directly deliver varied indolines and hydroindolines through [4+2] cycloaddition

84 novel pyridyl- or isoquinolinyl-substituted indolines and indoles was designed via a ligand-based ap

85 and 4-pentenylsulfonamides to afford chiral indolines and pyrrolidines, respectively, was investigat

86 ce, which results in the synthesis of chiral indolines and pyrrolidines.

87 cycloaddition substrate for the synthesis of indolines and related heterocyclic systems.

88 idines, pyrrolidines, piperidines, azepanes, indolines and tetrahydroisoquinolines.

89 his method enables atom-economical access to indolines and tetrahydroquinolines in excellent yields,

90 The single-operation deracemization of 3H indolines and tetrahydroquinolines is described.

91 a light-mediated synthesis of functionalized indolines and tetrahydroquinolines is reported.

92 ly catalyzed acceptorless dehydrogenation of indolines and tetrahydroquinolines to afford indoles and

93 gioselectivity, targeting the C5 position of indolines and the C6 position of tetrahydroquinolines ex

94 MVC-free E(A-A) gives very little E(Q)(indoline), and turnover is strongly impaired; the fracti

95 d proficiently constructs dihydrobenzofuran, indoline, and chroman skeletons of biological significan

96 of heterocyclic substrates including indole, indoline, and indazole afford the desired products in mo

97 construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed,

98 e used herein, the reactive indole analogue, indoline, and the l-Trp analogue, l-His.

99 action affords enantioenriched pyrrolidines, indolines, and gamma-amino-alpha,beta-unsaturated carbon

100 xo-trig cyclization to construct the central indoline architecture.

101 reas hydrogen bonding interactions probed by indoline are insensitive to solvent identity and instead

102 2,3-Dihydrobenzofurans and indolines are common substructures in medicines and natu

103 Dihydrobenzofurans and indolines are important constituents of pharmaceuticals.

104 Indolines are important moieties present in various biol

105 2-Substituted indolines are resolved (s=2.6-19) using an atropisomeric

106 brium distribution strongly in favor of E(Q)(indoline) as a consequence of the high local concentrati

107 , hydroarylation reactions with formation of indolines, as well as intramolecular hydroaminations and

108 The Ru(II)-catalyzed C-H amidation of indoline at the C7-position en route for synthesizing th

109 a- connected (related to the nitrogen of the indoline) azobenzene-spiropyran dyads, in which the cent

110 Here, we describe the identification of an indoline-based compound inhibiting both 5-lipoxygenase (

111 i multicomponent reaction for generating two indoline-based subseries, reproducing the captopril bind

112 responding nitroarenes, this method provides indolines bearing pendant functionality and complex ring

113 ereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid n

114 nantioselective approach to the synthesis of indolines bearing two asymmetric centers, one of which i

115 Several indoline, benzofuran, and benzodioxole analogs emerged a

116 + 2] cycloaddition to give the cyclopropa[c]indoline building block present in cycloclavine.

117 pallada(II)cycle, which is converted into an indoline by oxidative addition to the diaziridinone and

118 A catalytic approach for the preparation of indolines by dearomatizing cyclization is presented.

119 The practicality of this indoline C7-acetoxylation is demonstrated using a cinnam

120 Synthetically useful C2- and C3-borylated indolines can be accessed through a simple change in N-p

121 Phenylalanine-betaxanthin and indoline carboxylic acid-betacyanin encapsulated at conc

122 Four betalains, named indicaxanthin, indoline carboxylic acid-betacyanin, phenylalanine-betax

123 Here, we show that the lead indoline CD4mc, CJF-III-288, sensitizes HIV-1-infected c

124 ted cell killing in the presence of a potent indoline CD4mc, CJF-III-288.

125 ed Env regions and combined it with a potent indoline CD4mc.

126 otoxicity (ADCC) in the presence of a potent indoline CD4mc.

127 The indoline CD4mcs also potently sensitize HIV-1-infected c

128 indane scaffold CD4mc, BNM-III-170, several indoline CD4mcs exhibit increased potency and breadth ag

129 Crystal structures indicate that the indoline CD4mcs gain potency compared to the indane CD4m

130 The rational design of indoline CD4mcs thus holds promise for further improveme

131 Recently, new indoline CD4mcs with improved potency and breadth have b

132 II-170, are susceptible to inhibition by the indoline CD4mcs.

133 that was discovered from the optimization of indoline compound 1.

134 A variety of fused indoline compounds are synthesized using this method, in

135 ed to synthesize azetidine, pyrrolidine, and indoline compounds via palladium-catalyzed intramolecula

136 unctionalized cyclopenta- or cyclohexa-fused indoline compounds, which are common structures of many

137 ding a conformationally restrained subset of indolines (compounds 41-50).

138 y enantioenriched 2,3-dihydrobenzofurans and indolines containing molecules from readily available su

139 he method provides access to benzofuran- and indoline-containing products.

140 variety of substituents are tolerated on the indoline-core and the N1-acyl group, the acetoxylation i

141 ifted deeper into the NIR region than common indoline-cyanines.

142 Enzymatic and cellular assays revealed the indoline derivative 43 as a notable 5-LOX inhibitor, gui

143 he presence of DDQ, the aromatization of the indoline derivative was converted to the indole derivati

144 zation of a bromine-substituted, tetracyclic indoline derivative with alkyl groups, employing a mild

145 Oxindoles and their indoline derivatives are common structural motifs found

146 Further, selective C(7)-H alkenylation of indoline derivatives has also been accomplished using ac

147 rless dehydrogenation of tetrahydroquinoline/indoline derivatives in toluene (release of H2) at 130 d

148 strategy for the C(7)-H functionalization of indoline derivatives using first-row transition-metal co

149 uccessfully expanded for C7-acetoxylation of indoline derivatives using pyrimidine as a detachable di

150 ing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation.

151 ic system, the formation of CF(3)-containing indoline derivatives was observed with good yields.

152 A series of 1,6-disubstituted indoline derivatives were synthesized and evaluated as i

153 Indoline derivatives, which are functionalized in positi

154 f GPR17 using molecular docking of over 6000 indoline derivatives.

155 antioenriched, highly substituted indole and indoline derivatives.

156 around pharmaceutically relevant indole and indoline derivatives.

157 Here, we identified a novel indoline-derived phenolic Mannich base as an activator o

158 amolecular N- or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogue

159 cyanines relative to classically researched indoline donor analogues.

160 o-functionalization of C-3 alkyl-/aryllidine indolines even with scale-up investigations.

161 d the synthesis of 2,3-cis-fused tetracyclic indolines featuring a C3 all-carbon quaternary stereocen

162 ve a rapid formation and dissipation of E(Q)(indoline) followed by a very slow reappearance of E(Q)(i

163 te regiocontrol and high chemocontrol in the indoline formation.

164 r is strongly impaired; the fraction of E(Q)(indoline) formed is <3.5% of that given by the Na(+)-bou

165 -geometry trends were observed in the chiral indoline-forming reactions.

166 th molecules fuses a benzooxazine ring to an indoline fragment and can be assembled efficiently in th

167 ovalent attachment of a cyanide anion to the indoline fragment is responsible for these transformatio

168 in the formation of the required pentacyclic indoline framework of the target alkaloid.

169 rmed E(Q)(indoline) occurs due to leakage of indoline from the closed system.

170 ine in the DIT reaction; however, leakage of indoline from the enzyme into solution still occurs.

171 The preparation of trans-2,3-disubstituted indolines from 1-azido-2-allylbenzene derivatives via a

172 d intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds

173 simple synthesis of C(3)-N(1') heterodimeric indolines from the addition of indole nucleophiles to re

174 ly described series of 1-(3-pyridylcarbamoyl)indolines from which they evolved.

175 zed intramolecular cyclization of three such indolines gave tetracyclic lactams in 89, 90, and 61% yi

176 ver, when GP is bound to the alpha-site, the indoline generated by DIT cleavage in the first turnover

177 sphate (GP) binds and closes the alpha-site, indoline generated in the DIT reaction is trapped for a

178 The construction of 2,2-disubstituted indolines has long presented a synthetic challenge witho

179 olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing t

180 1,2-Disubstituted indolines have been prepared in fair to good yields by a

181 l diazoacetates results in the generation of indolines having quaternary substitution at C3 in high d

182 lindole has been prepared in four steps from indoline in 62% overall yield.

183 tic effect that greatly slows the leakage of indoline in the DIT reaction and enhances the trapping e

184 ificantly more effective than GP in trapping indoline in the DIT reaction; however, leakage of indoli

185 ation and cyclization to prepare substituted indolines in a green, metal-free procedure.

186 ves access to a wide variety of cyclopenta[b]indolines in good to excellent yields, with high functio

187 ables the synthesis of a range of polycyclic indolines in good yields and with high enantioselectivit

188 dole boronate as a way to access substituted indolines in high diastereoselectivities is presented.

189 thesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity.

190 hydrogenation reactions to afford new fused indolines in moderate yields.

191 l/photoredox catalysis is used to synthesize indolines in one step from iodoacetanilides and alkenes.

192 talyzed interconversion of diastereoisomeric indolines in the presence of certain quaternary ammonium

193 zed regioselective C(sp(2))-H methylation of indolines in the presence of ethanol has been explored.

194 oach offers a direct route to functionalized indolines in yields of up to 81% under mild photochemica

195 Racemic indolines including a variety of structural motifs such

196 partners for the preparation of 2-subsituted indolines, including sterically demanding substrates tha

197 A diverse range of N- and C3-alkylated indolines/indoles were accessed utilizing a new cooperat

198 les and on the synthesis and modification of indolines, indolin-2-ones, indolin-3-ones, and isatins.

199 is formed at the beta-site, thereby trapping indoline inside.

200 3-indolyl)succinimide to give a key class of indoline intermediates that could be glycosylated stereo

201 electrophile that transforms N-H indoles and indolines into N/C7-diborylated indolines, with N-H bory

202 tocol for the synthesis of 2,3-disubstituted indolines is described.

203 arylboration of indoles to generate diverse indolines is presented.

204 for the preparation of highly functionalized indolines is reported.

205 nds to the alpha-site and E(A-A) and/or E(Q)(indoline) is formed at the beta-site, thereby trapping i

206 synthesize DIT, the quinonoid species, E(Q)(indoline), is formed quickly, while in the reverse react

207 ith the analogous indolyl derivatives, spiro[indoline-isoquinolinoxazine] (3) and spiro[indoline-phen

208 In the forward reaction (indoline + L-Ser) to synthesize DIT, the quinonoid speci

209 Previously we discovered a tricyclic indoline, N-[2-(6-bromo-4-methylidene-2,3,4,4a,9,9a-hexa

210 of Z,E and E,E isomers; substitution of the indoline nitrogen with an N-benzyl group resulted in inc

211 oduce the C7 quaternary stereocenter and the indoline nucleus of the natural product's scaffold.

212 Indole reduction to indoline occurs before C-H borylation and our studies in

213 The decay of the transiently formed E(Q)(indoline) occurs due to leakage of indoline from the clo

214 ion (DIT cleavage), the accumulation of E(Q)(indoline) occurs very slowly.

215 A tricyclic indoline, Of1, was discovered to selectively potentiate

216 ion of the side chain nitrogen as part of an indoline or an indole ring.

217 m cyclization of 1,6-diynes with substituted indolines or indoles through consecutive dual C-H bond a

218 ient syntheses of broadly useful substituted indolines or indoles.

219 rmed from pyrrolidines, N-amino indoles from indolines, orthoquinodimethane intermediates from isoind

220 The synthesis relies on a late stage indoline oxidation which does not racemize the product.

221 o[indoline-isoquinolinoxazine] (3) and spiro[indoline-phenanthrolinoxazine] (4) through XRD analysis

222 The success of the indoline pi-nucleophile that evolved through our studies

223 ough more favorable pai-pai overlap from the indoline pose and by making favorable contacts with the

224 The indoline produced exits the enzyme via the tunnel out th

225 Very high regioselectivity for 3-substituted indoline products is obtained for both aliphatic and sty

226 all library of chiral, enantioenriched spiro(indoline-pyrimidine)-diones derivatives.

227 the chemically rich crystal structure of the indoline quinonoid intermediate in the pyridoxal-5'-phos

228 -A) reacts rapidly with indoline to give the indoline quinonoid species, E(Q)(indoline), which slowly

229 tanidin and a betalain analogue derived from indoline resulted as the most potent inactivators of lip

230 alkyl substitution at the C3 position of the indoline ring enhanced selectivity for the norepinephrin

231 acyl chain-binding chamber of LpxH with its indoline ring situating adjacent to the active site, its

232 ompounds bearing a 3,3-dimethyl group on the indoline ring, 9k, 9o,p, and 9s,t, exhibited potent inhi

233 Indole and indoline rings are important pharmacophoric scaffolds fo

234 , and evaluation of novel CD4mcs based on an indoline scaffold.

235 k cyclization that allows the preparation of indoline scaffolds is described.

236 vides regiodivergent access to 3-substituted indolines, showcasing excellent regioselectivity and rea

237 xylation is most sensitive to the C2- and C6-indoline substituents.

238 In particular, spiropiperidine indoline-substituted diaryl ureas are described as poten

239 natural alkaloids, guide C7-acetoxylation of indoline substrates over a competitive C5-oxidation.

240 Synthesis of challenging indolines, such as those bearing fully substituted carbo

241 synthetic roquefortine C derivatives bearing indoline systems to their respective nitrones.

242 th an asymmetric migratory ring expansion of indoline, tetrahydroquinoline, or tetrahydrobenzazepine

243 ted nitrogen-containing heterocycles such as indolines, tetrahydroquinolines, and tetrahydrobenzazepi

244 Simple benzo-fused nitrogen heterocycles (indolines, tetrahydroquinolines, and their homologues) u

245 ctive C-H functionalization of electron-rich indolines that are otherwise highly reactive toward elec

246 this pathway, we synthesized 120 polycyclic indolines that contain 26 distinct skeletons and a wide

247 s also support a mechanism for the escape of indoline through the alpha-site that is limited by ASL d

248 rgent synthesis of functionalized polycyclic indolines through formal [3 + 2] and [4 + 2] cycloadditi

249 MVC-bound E(A-A) reacts rapidly with indoline to give the indoline quinonoid species, E(Q)(in

250 A novel method for the oxidation of indolines to indoles is described.

251 doles leading to 2,3-dialkoxy or 2,3-diazido indolines under undivided conditions at a constant curre

252 cting as a three-atom component to construct indoline units in a highly regio- and diastereoselective

253 mployed to synthesize the resorcinol and iso-indoline units, respectively, which were efficiently cou

254 ective C-H and N-H bond functionalization of indolines using alcohols in water via tandem dehydrogena

255 ifluoromethylthiolation and thioarylation of indolines using bench-stable reagents have been explored

256 -H activation/amination sequence for forming indolines using di-tert-butyldiaziridinone.

257 y regioselective acylation of carbazoles and indolines using molecular oxygen as the green oxidant.

258 he enantioselective synthesis of tetracyclic indolines using silver(I)/chiral phosphoric acid catalys

259 ound to generate C(3) quaternary substituted indolines via a thionium ylide-initiated [3,3]-sigmatrop

260 construction of spirocyclic indolenines and indolines via dearomatization of the indole moiety.

261 approach for the synthesis of 3-substituted indolines via regio- and stereoselective SN2-type ring-o

262 The indoline was shown to be in equilibrium with the nine-me

263 Diversely substituted indolines were functionalized at C7 position in good to

264 The indolines were obtained from the corresponding indoles v

265 transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee.

266 A wide array of substituted indolines were successfully methylated via the developed

267 to give the indoline quinonoid species, E(Q)(indoline), which slowly converts to dihydroiso-l-tryptop

268 protocol in the synthesis of functionalized indolines, which occurred with high levels of regiocontr

269 1',3',3'-trimethyl-6-nitrospiro[chromene-2,2-indoline], which is linked with an MRI contrast agent, g

270 ol for the cross-dehydrogenative coupling of indoline with sulfonamides, carboxamides, and anilines i

271 be a palladium-catalyzed C7-acetoxylation of indolines with a range of amide directing groups.

272 ed dehydrogenative tandem transformations of indolines with alkenes or aldehydes to afford 3-alkylind

273 ve dual C-7 and C-6 C-H functionalization of indolines with azabenzonorbornadienes has been accomplis

274 directing group-assisted C7 C-C coupling of indolines with aziridines has been developed by merging

275 nd formation for the oxidative annulation of indolines with aziridines is accomplished employing the

276 for the high-yielding construction of chiral indolines with excellent enantioselective control.

277 ) species to provide substituted indoles and indolines with high enantio-, regio-, and diastereoselec

278 m rhodium catalysis gives branched N-allylic indolines with high regio- and enantioselectivity.

279 y important CF(3)-containing 3,3-spirocyclic indolines with moderate to high yields and excellent dia

280 provides densely functionalized cyclopenta[b]indolines with versatile vinyl and nitro-groups.

281 indoles and indolines into N/C7-diborylated indolines, with N-H borylation directing subsequent C7-H

282 iched 2- and 2,2-subsituted pyrrolidines and indolines, without prior derivatization of the alcohol o