ライフサイエンスコーパス: inductive signal

1 omously; only later development requires the inductive signal.

2 icating that left coelom is required for the inductive signal.

3 toplasmically localized in the absence of an inductive signal.

4 haryngeal endoderm that is the source of the inductive signal.

5 ession in the mesenchyme is contingent on an inductive signal.

6 petence of the cells to respond to the LIN-3 inductive signal.

7 m of the RAS pathway to regulate response to inductive signal.

8 VPCs reduces the sensitivity of all VPCs to inductive signal.

9 ild-type animals to respond to activation of inductive signal.

10 nsmit and receive a make-ligule-make-auricle inductive signal.

11 Here, we explore the nature of this inductive signal.

12 in proportion to the strength of the floral inductive signal.

13 ctivation when repression is relieved by the inductive signal.

14 VPC specification EGF signaling is the major inductive signal.

15 iorly derived asymmetrically acting positive inductive signal.

16 progenitors and is a key mediator of the Wnt inductive signal.

17 sistent with a downstream role responding to inductive signals.

18 t are consistent with having received floral inductive signals.

19 y proteins before myelination in response to inductive signals.

20 ding of how pluripotent stem cells interpret inductive signals.

21 meres and does not require micromere or veg2-inductive signals.

22 ed by changes in the spatial distribution of inductive signals.

23 tion but only as cells that respond to tooth-inductive signals.

24 are still competent to respond to pronephric-inductive signals.

25 and/or serving as one component of multiple inductive signals.

26 ete functional areas in response to specific inductive signals.

27 orrect patterning by later position-specific inductive signals.

28 developmental systems patterned by transient inductive signals.

29 forms dorsal mesoderm in response to ventral inductive signals.

30 ty of endodermal intermediates to respond to inductive signals.

31 ter CiFT2 even in the presence of the floral inductive signals.

32 t imprecision of spatial patterning by noisy inductive signals.

33 helial cell migratory responses to lymphatic-inductive signals.

34 e patterned by a handful of highly conserved inductive signals.

35 endoderm and was mediated by secreted cardio-inductive signals.

36 ation to the underlying cardiac mesoderm via inductive signals.

37 nchymal progenitor population in response to inductive signals.

38 types in response to just a few families of inductive signals.

39 mouse embryonic stem (ES) cells using known inductive signals.

40 s, that are dependent on the level of neural-inductive signaling.

41 ling compacted chromatin before the onset of inductive signalling.

42 ells in the Drosophila eye are determined by inductive signalling.

43 Inductive signals across germ layers are important for t

44 ct cell types is thought to be controlled by inductive signals acting at different concentration thre

45 ic metabolic regulation, contributing to the inductive signaling activity.

46 patterned by a LET-23/EGF receptor-mediated inductive signal and a LIN-12/Notch-mediated lateral sig

47 g the L3 stage by the EGFR-Ras-MAPK-mediated inductive signal and the LIN-12/Notch-mediated lateral s

48 Here, we have interrogated inductive signaling and find that active CaMKII colocali

49 liver progenitors have focused on individual inductive signals and cellular responses.

50 Thus, while somatic inductive signals and chromosome karyotype have overlapp

51 The balance between the inductive signals and endogenous anti-apoptotic mechanis

52 esence of nephrogenic factors can respond to inductive signals and form epithelial structures in vitr

53 These changes are elicited by inductive signals and genetic regulatory factors that ar

54 mbined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell diff

55 ction in Drosophila, various combinations of inductive signals and mesoderm-intrinsic transcription f

56 ink between the competence to receive floral inductive signals and restructuring of the SAM during fl

57 e response of ectodermal cells to endogenous inductive signals and that both of these activities are

58 vertebrates is dependent upon the balance of inductive signals and their specific antagonists.

59 nisms have revealed evolutionarily conserved inductive signals and transcription factor networks that

60 Inductive signals and transcription factors involved in

61 the next hour as it is patterned by maternal inductive signals and zygotic gene products.

62 nder favorable conditions, the EGF-mediated "inductive" signal and the LIN-12/Notch-mediated "lateral

63 sent in all VPCs but is not modulated by the inductive signal, and that transcription of lag-2 requir

64 Therefore, the loss of responsiveness to the inductive signal appears not to be associated with the l

65 Inductive signals are also required for Drosophila heart

66 genes such as LEAFY, indicating that floral inductive signals are integrated upstream of LEAFY Here

67 A series of inductive signals are necessary to subdivide the mesoder

68 The initial floral inductive signals are perceived in the leaves and transm

69 In mice, neural inductive signals are thought to reside in an area of vi

70 Together, this work identifies inductive signaling as an effective organizing strategy

71 The inductive signals at the neural plate border region are

72 osynthesis and transport of the lateral root-inductive signal auxin through local regulation of trypt

73 We propose that subsequent inductive signaling between amnioserosa and dorsal ectod

74 s such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmen

75 pression is dependent upon the nature of the inductive signal, but independent of the amplitude of ER

76 se at the neural plate border in response to inductive signals, but much remains to be learned about

77 t, like BMP4, FGF8 constitutes an epithelial inductive signal capable of inducing the expression of d

78 hick embryo is dependent on a medial-lateral inductive signaling cascade moving sequentially from the

79 le of Blimp1 in promoting the dermal papilla inductive signaling cascade that initiates HF growth.

80 from iNOS can be distinct and depend on the inductive signal cascades.

81 Inductive signals cause conversion of mesenchyme into ep

82 During this developmental transition, floral inductive signals cause the vegetative meristem to under

83 SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs.

84 by apoptosis and decreased responsiveness to inductive signals (competence).

85 ral neurogenesis is mediated in the leech by inductive signals conveyed retrogradely to each hemigang

86 of the dorsal neural tube to respond to this inductive signal declined after stage 10.

87 Hedgehog, a secreted protein, is an inductive signal delivered by retinal axons for the init

88 array of neurons is generated in response to inductive signals derived from localized organizing cent

89 Hedgehog genes have been implicated in inductive signaling during development in a variety of o

90 rate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been

91 system for studying the role of Msx genes in inductive signaling during organogenesis.

92 ergo an alkalinization in response to planar inductive signals during neural induction in explants.

93 in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud.

94 inherited determinants (preformation) or by inductive signals (epigenesis).

95 l in which differential reception of cardiac inductive signals establishes chamber proportion.

96 led quantitative picture of an ERK-dependent inductive signaling event in the early Drosophila embryo

97 porally and spatially integrated programs of inductive signaling events.

98 s indicate that Eya1 controls critical early inductive signalling events involved in ear and kidney f

99 es these cells to be competent to respond to inductive signals, expanding the equivalence group.

100 backgrounds as well as timed ablation of the inductive signal favor one geometric model and suffice t

101 LIN-3 is the inductive signal for hermaphrodite vulval differentiatio

102 dings argue that FGF-3 is not required as an inductive signal for invagination of the otic placode to

103 al activation of beta-catenin is the primary inductive signal for taste placode formation, followed b

104 n through its inhibition of p63 and a strong inductive signal for terminal differentiation through it

105 ct of an axon with a dendrite is a necessary inductive signal for the assembly of functional presynap

106 in (MAP) kinase pathway signaling acts as an inductive signal for the CD4 lineage.

107 epidermal growth factor receptor provides an inductive signal for the specification of a large subset

108 ulating hormone (TSH; ie, thyrotropin) as an inductive signal for tumor necrosis factor-alpha (TNF-al

109 te, a region that also serves as a source of inductive signals for mDN specification such as Sonic He

110 ovide metabolic sustenance, but also provide inductive signals for organ development.

111 Although inductive signals for otic placode formation have been c

112 pears to act as a permissive, rather than an inductive, signal for slow MyHC expression in myoblasts.

113 MAP Kinase signaling cascade transduces the inductive signal from 3D and specifies cell fate among t

114 ue of their lineage or their proximity to an inductive signal from another cell.

115 activation of the Ras pathway by an EGF-like inductive signal from the AC.

116 the otic placode is believed to depend on an inductive signal from the adjacent hindbrain.

117 an individual ommatidium is regulated by an inductive signal from the adjacent R7 cell.

118 val precursor cells (VPCs) to respond to the inductive signal from the anchor cell of the somatic gon

119 degrees ) fate in response to a Ras-mediated inductive signal from the gonad.

120 results show that evolutionary changes in an inductive signal from the lens are involved in cave fish

121 These findings show that GDF7 is an inductive signal from the roof plate required for the sp

122 n of Pax2 and Gdnf, which in turn elicits an inductive signal from the ureteric bud.

123 intained later in development as a result of inductive signaling from one embryonic cell type to anot

124 by acting within the mesoderm and partly by inductive signaling from the ectoderm.

125 les), indicating that they are the target of inductive signaling from the ureteric bud, and that rena

126 sis involves epithelial growth controlled by inductive signalling from specialised mesenchymal subset

127 Inductive signals from adjacent tissues initiate differe

128 Inductive signals from extrinsic elements such as growth

129 ential keratin expression does not depend on inductive signals from hematopoietic cells.

130 al segments in its lack of dependence on Hox-inductive signals from local tissues, including paraxial

131 h the patterning of the paraxial mesoderm by inductive signals from midline tissues [1, 2].

132 specific cells in early embryogenesis, or by inductive signals from neighboring cells to germ cell pr

133 ormation in multicellular organisms requires inductive signals from neighboring cells.

134 o form anterior neural tissue in response to inductive signals from normal dorsal mesoderm.

135 To test whether inductive signals from one tissue can compensate for los

136 However, Pax-3 inductive signals from posterior nonaxial mesoderm are W

137 his regionalization process is instructed by inductive signals from the adjacent mesenchyme.

138 m an ectodermal placode that is specified by inductive signals from the adjacent neurectoderm and und

139 rocess that requires at least two sequential inductive signals from the diencephalon.

140 rm at the neural plate border in response to inductive signals from the ectoderm.

141 controls ovo-B expression in the absence of inductive signals from the female soma.

142 ing that the leaf vascular system depends on inductive signals from the margin of the leaf.

143 rm must occur quite late, and as a result of inductive signals from the mesoderm.

144 m the WD or the ureter stalk by antagonizing inductive signals from the metanephric mesenchyme to the

145 Inductive signals from the neural tube, notochord, and o

146 ysis of somite development in the absence of inductive signals from the notochord and floor plate.

147 domains that have different responses to the inductive signals from the prechordal plate, Sonic Hedge

148 Nonautonomous inductive signals from the soma and autonomous signals d

149 Genetic analysis clearly indicates that inductive signals from the soma are not required for ovo

150 Data suggest that inductive signals from the tailbud are primarily respons

151 m the metanephric mesenchyme after receiving inductive signals from the ureteric bud and from the ren

152 is response of the metanephric mesenchyme to inductive signals from the ureteric bud.

153 iption factors expressed in the pouch and by inductive signals from the ventral diencephalon/infundib

154 ents show that vMP2 fate is specified by an "inductive" signal from outside the MP2 lineage.

155 f the developing vertebrate limb responds to inductive signals, giving rise to skeletal elements that

156 While the outcomes of many inductive signals have been described to require enzymat

157 N-12 stability or translation in response to inductive signalling helps impose a bias on lateral sign

158 ure of leaves to become permanent sources of inductive signal in addition to the lack of meristem com

159 cap assays and also respond to the embryonic inductive signal in Nieuwkoop recombinants.

160 tted along the retinal axons to serve as the inductive signal in the brain.

161 This could reflect the absence of an inductive signal in the environment of the dorsal telenc

162 sponse of single VPCs to controlled doses of inductive signal in wild-type and in mab-5 mutant animal

163 ble dominant-negative mutant disrupted early inductive signaling in affected tissues, indicating that

164 genitor cells (O-2As) to examine the role of inductive signals in astroglial lineage commitment.

165 nism to provide the competence to respond to inductive signals in different ways, ultimately generati

166 turn regulates the reciprocal expression of inductive signals in the mesenchyme which then act back

167 When exposed to inductive signals in vitro, only those progenitors that

168 ers Arabidopsis plants incompetent to floral inductive signals, including long-day (LD) photoperiod.

169 cell fates appears to depend on a cascade of inductive signals initiated by cells of the epidermal ec

170 nitor cells, and is activated in response to inductive signals involved in lineage specification.

171 Thus, inductive signals involved in normal pathways of neuroge

172 al steps in cerebellar development depend on inductive signaling involving FGF and Wnt proteins produ

173 ich mediates repression in all VPCs when the inductive signal is absent, and another promoter element

174 each side of a ganglion, indicating that the inductive signal is both highly localized and conveyed t

175 This inductive signal is overridden in the dorsal midline cel

176 ptional control of the lateral signal by the inductive signal is part of the mechanism by which these

177 Here, we provide evidence that the inductive signal is spatially graded and initially activ

178 ack reproductive structures, suggesting that inductive signaling is involved in planarian germ cell s

179 Inductive signaling is of pivotal importance for develop

180 Since inductive signalling is common in many organisms and its

181 Citrus, the response to environmental floral inductive signals is inhibited by the presence of develo

182 ng cells that determines how they respond to inductive signals is known as competence, and it differs

183 ll lack understanding of how the response to inductive signals is modulated to generate the proper tr

184 so that the competence to respond to floral inductive signals is reset in the new leaves.

185 efined in stereotypic domains in response to inductive signals is unknown.

186 Inductive signaling leads to the coactivation of regulat

187 precursor cells might bind and sequester the inductive signal LIN-3 EGF, thereby preventing diffusion

188 zebrafish indicate that the source of these inductive signals may be the extra-embryonic yolk syncyt

189 orms the mature bony labyrinth and regulates inductive signaling mechanisms in the otic mesenchyme.

190 but adopt different fates as a result of an inductive signal mediated by the Ras pathway and a later

191 ed competency of mesothelium and a localized inductive signal might play a role in restricting the in

192 e in developing tissues under instruction of inductive signal (morphogen) gradients, which specify di

193 he absence of ERK activation, revealing that inductive signaling must be sufficiently sustained to en

194 a morphologically normal node to provide the inductive signals necessary for their expression.

195 actors have been identified that provide the inductive signals necessary to transform the simple otic

196 However, it is not clear whether the inductive signal of Wnt arises intradermally or intraepi

197 hoots, and examined the competence to floral inductive signals of old and new leaves derived from the

198 bsence of a pathogen is a paradoxically weak inductive signal, often requiring concentrations of 0.5

199 to adopt vulval cell fates in response to an inductive signal, only three of these cells are induced

200 ism of control has evolved because different inductive signals operate in each population of muscle p

201 actors dictate lineage-specific responses to inductive signals or facilitate these responses in colla

202 on whether cell fates are specified through inductive signals or maternal determinants, respectively

203 septum transversum mesenchyme, and receives inductive signaling originating from both the septum tra

204 mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degre

205 caused by mutations in several genes of the inductive signaling pathway.

206 ressors, leaving unresolved the link between inductive signaling pathways and transcriptional activat

207 target and a mediator of key dermal papilla inductive signaling pathways including transforming grow

208 it also provides novel targets to study the inductive signaling pathways that direct somite patterni

209 However, we also show that female inductive signals positively regulate ovo-B transcriptio

210 iew, we describe how a limited repertoire of inductive signals-principally FGFs, Wnts and BMPs-set up

211 entral midline of the CNS is dependent on an inductive signaling process mediated by the secreted pro

212 cation program and for the expression of two inductive signals produced by micromeres.

213 First, the coupling between the long-range inductive signals produced by the proneural Hh signaling

214 eloping vertebrate nervous system depends on inductive signals provided by local cell groups that act

215 vertebrate central nervous system depends on inductive signals provided by local organizing cell grou

216 cellular types are generated in response to inductive signals provided by specialized cellular group

217 he generation of dorsal interneurons through inductive signals provided by the roof plate.

218 ng blocks are related to the distribution of inductive signals, provided by the highly conserved epid

219 at the Nematostella germline is specified by inductive signals rather than maternal factors, and supp

220 l ages retain the memory of an area-specific inductive signal received in vivo, even though they may

221 In addition to the inductive signals regulating cardiac specification, thes

222 s with the competence to respond to germline inductive signals remain unknown.

223 , but the molecular nature of the endogenous inductive signals remains unknown.

224 of the cardiac mesoderm, both by inhibiting inductive signals required for the development of noncar

225 Competence to respond to the inductive signal requires that the VPCs do not fuse to t

226 and morphogenesis gleaned through studies on inductive signals, responding stem cells, and the extrac

227 of metanephric mesenchyme is triggered by an inductive signal(s) from the epithelial ureteric bud.

228 The mode of action of these inductive signal(s) remains unresolved, since various or

229 te heart develops from mesoderm and requires inductive signals secreted from early endoderm.

230 y and interacts with the mobile tuberization inductive signal SP6A.

231 We show that LIN-3 is an inductive signal sufficient to promote the P12 fate, and

232 tiated or upregulated in VPCs in response to inductive signaling, suggesting that direct transcriptio

233 anted somites cannot be over-ridden by local inductive signals, suggesting that somitic tissue may be

234 n these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenes

235 sponse to activation of EGFR/Ras/MAPK by the inductive signal that initiates vulval development.

236 senchyme that forms the calvarial bones from inductive signaling that establishes discrete bone cente

237 Hox gene in the gut mesoderm influences the inductive signaling that leads to regionally specific di

238 amic interplay between these progenitors and inductive signals that act in concert to specify brown a

239 combination of external and internal floral inductive signals that are perceived across the whole pl

240 development cell commitment is regulated by inductive signals that are tightly controlled in time an

241 t restrain autophagy, the nature of positive inductive signals that can promote autophagy remain cryp

242 Our data suggest that the inductive signals that control Myf5 expression switch ra

243 ental markers, we tested for the presence of inductive signals that control the differentiation of an

244 morphogenesis is a complex event mediated by inductive signals that establish and maintain the distin

245 ermine whether paraxis might be a target for inductive signals that influence somite patterning, we e

246 space and time, and is under the control of inductive signals that initiate gastrulation movements.

247 FGF4 and BMP4 are inductive signals that participate in the communication

248 the utility of treating ES cells with local, inductive signals that regulate CNS neuronal development

249 about the appropriateness of targets and/or inductive signals that trigger the cascade of events lea

250 responsible for their different responses to inductive signals that use a common receptor.

251 In order to be receptive to the micromere inductive signal the macromeres first must transport bet

252 ulval patterning depends on both a localized inductive signal, the LIN-3 growth factor, and lateral s

253 During kidney development and in response to inductive signals, the metanephric mesenchyme aggregates

254 manner in which they may be established, the inductive signals they produce, and candidate signaling

255 N-3 EGF, thereby preventing diffusion of the inductive signal to distal vulval precursor cells.

256 and it has been suggested that Hh acts as an inductive signal to induce cells to enter a furrow fate

257 uggest that at least two signals, a positive inductive signal to specify the aboral ectoderm and a ne

258 r to play significant roles in conveying the inductive signal to the CNS.

259 ly during vertebrate organogenesis to permit inductive signaling to occur back and forth between tiss

260 has demonstrated that the notochord provides inductive signals to activate myoD and pax1 regulatory g

261 rm a versatile transport network and provide inductive signals to regulate tissue-specific functions.

262 Early in gut development, the endoderm sends inductive signals to the mesoderm.

263 itional identity of prechordal mesendodermal inductive signals to the overlying neuroectoderm.

264 rix of these cells and activation of a novel inductive signal transduction pathway.

265 1 function and suggests dlf1 mediates floral inductive signals transmitted from leaves to the shoot a

266 Here we show that Hedgehog, an initial inductive signal transported along retinal axons from th

267 ial ectoderm is competent to respond to this inductive signal, trunk ectoderm is not.

268 w specific defects in lateral inhibition and inductive signaling, two characteristic processes regula

269 gehog, and distinct anterior-posterior (A-P) inductive signals, two topographically related progenito

270 e posterior marginal zone, which secretes an inductive signal, undergo spatially directed cytokineses

271 is paper, we have analysed the nature of the inductive signal underlying the formation of the epibran

272 umber of second messenger pathways propagate inductive signals via protein-protein interactions that

273 To investigate inductive signaling, we have isolated clusters of epithe

274 ctivated B cells with or without plasma cell-inductive signals, we find that follicular B cells up-re

275 s and using specific inhibitors of different inductive signals, we show that the first inductive step

276 functional fibers is coordinated largely by inductive signals which act through discrete intracellul

277 at Jagged1-Notch signaling conveys a lateral inductive signal, which is indispensable for lens progen

278 ed at regulating the overall strength of the inductive signal, which may contribute to the quantitati

279 duced to differentiate and, depending on the inductive signal, will adopt either the osteogenic or ad

280 acts to pattern the response of ectoderm to inductive signals (Wnt-like).

281 le progress has been achieved in identifying inductive signals, yet how tissues control their respons