ライフサイエンスコーパス: ineffective

1 asses, including cannabinoids and SSRIs, are ineffective.

2 5K1; transfection of kinase-dead PPIP5K1 was ineffective.

3 produced symptom relief while low rates were ineffective.

4 r in which the standard therapies are mostly ineffective.

5 e established, immunotherapy appears largely ineffective.

6 s such as tamoxifen and aromatase inhibitors ineffective.

7 of pulmonary-administered ciprofloxacin was ineffective.

8 okaryotic ClpB and hyperactive variants were ineffective.

9 aining is not only laborious but can also be ineffective.

10 CR analysis of the eDNA samples proved to be ineffective.

11 s those targeting homogenous resistance were ineffective.

12 orter domains (SCR-3, SCR-2-3, SCR-3-4) were ineffective.

13 Drug therapy of FAT is often difficult and ineffective.

14 ghly infiltrative, rendering focal therapies ineffective.

15 so induce remissions if initial EBV-CTLs are ineffective.

16 Xanthomonas spp., making copper bactericides ineffective.

17 n whom previous CFTR modulator regimens were ineffective.

18 ins high globally and treatment can often be ineffective.

19 In contrast, treatment with DOAC was largely ineffective.

20 CB monotherapy in such malignancies has been ineffective.

21 PCPs accountable for readmissions may prove ineffective.

22 ol, or treatment measures remain limited and ineffective.

23 xic and isoform-specific inhibition is often ineffective.

24 mended to use either one if the other proves ineffective.

25 the T-cell activator phytohaemagglutinin is ineffective.

26 ending corticopontocerebellar pathway may be ineffective.

27 respond to this drug, in most patients it is ineffective.

28 binding of Pygo2 to H3K4me(2/3) was rendered ineffective.

29 dampening of BG505 trimers by ICs is rather ineffective.

30 r in which the standard therapies are mostly ineffective.

31 rodrug, chloramphenicol succinate (CLsu), is ineffective.

32 t analysis methods challenging and partially ineffective.

33 d itch disorders in which antihistamines are ineffective.

34 a administered 24 h before MSU challenge was ineffective.

35 ndered a number of commonly used antibiotics ineffective.

36 y, as current systemic therapies are largely ineffective.

37 impair tissue perfusion, and are frequently ineffective.

38 difficult and its treatment continues to be ineffective.

39 cromolar concentrations, whereas others were ineffective.

40 L, while blockade of Tim-3, TIGIT or LAG3 is ineffective.

41 tion as to why physical therapy may often be ineffective.

42 gs of other PP-InsP signaling molecules were ineffective.

43 h to emerging zoonotic infectious disease is ineffective.

44 ncluding soluble CD4 (sCD4) and CD4-Ig, were ineffective.

45 ids and immunosuppressive drugs were largely ineffective.

46 treatment of diet-induced obesity have been ineffective.

47 This renders the agent ineffective.

48 ic clips are unsuccessful or predicted to be ineffective.

49 arities each year, yet much of our giving is ineffective.

50 on and treatment strategies remain generally ineffective.

51 of glioblastoma multiforme (GBM) are largely ineffective.

52 %, n = 96), and pain treatments were largely ineffective (70%, n = 58).

53 ation of Drd2 expressing pyramidal cells was ineffective across anxiety-like and depression-like meas

54 1, is active against most single mutants but ineffective against all tested compound mutants.

55 gainst conventional CD4-based inhibitors are ineffective against CD4-VLPs.

56 e is a major reason why most antibiotics are ineffective against Gram-negative bacteria.

57 o trigger channel conductance and renders it ineffective against Gram-positive bacteria while neverth

58 However, FTIs proved ineffective against KRAS-driven tumors.

59 culture conditions, but this combination was ineffective against neuroblastoma xenografts.

60 he Ebolavirus genus, Ebola virus (EBOV), and ineffective against other ebolaviruses associated with E

61 he Ebolavirus genus, Ebola virus (EBOV), and ineffective against outbreak-causing Bundibugyo virus (B

62 Moreover, current seasonal vaccines are ineffective against pandemic influenza, and production o

63 rapy causes off-target toxicity and is often ineffective against solid tumors.

64 In addition, it appears to be ineffective against strains that lack anthrax toxin.

65 RS-67,333 was ineffective against stress-induced depressive-like behav

66 mental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV.

67 LCHP was ineffective against the phages in the presence of blood,

68 odides as radical precursors was found to be ineffective, an alternative route involving alkylsulfony

69 te onset, and antipsychotic treatment may be ineffective and associated with adverse effects.

70 ed, and the existing therapies are partially ineffective and cause serious adverse effects.

71 accumulate evidence that current actions are ineffective and consequently drive changes in behavioral

72 Seasonal vaccines are often ineffective and escape mutants have been reported to all

73 am + lambda-cyhalothrin AIs were universally ineffective and highly repellent; and finally, evolution

74 whom conventional antipsychotic treatment is ineffective and offer alternative treatments.

75 e disease for which the current treatment is ineffective and often toxic.

76 ertoires with specialized assays can be cost-ineffective and time-consuming.

77 Antiviral compounds may be ineffective and/or pose dose-limiting toxicity, and ther

78 ailable, neutralizing antibody therapies are ineffective, and current antivirals have limited long-te

79 surgical and pharmacological approaches are ineffective, and liver transplantation represents the on

80 e modulators have thus far proven clinically ineffective, and multi-modal therapies targeting mechani

81 not immediate pain (<=2 hours), tramadol was ineffective, and opioids increased the risk for gastroin

82 ctive isolation mechanisms are effective and ineffective, and the evolutionary consequences of partia

83 Because in many cases it was harmful and ineffective, and with the emergence of radiotherapy and

84 Ineffective antibiotic therapy increases mortality of ac

85 Widespread ineffective antibiotic use has led to increased isolatio

86 with treatment-resistant depression from an ineffective antidepressant to flexibly dosed esketamine

87 stituting cardiomyocytes is a simplistic and ineffective approach.

88 euptake inhibitor (SSRI) fluoxetine (Flx) is ineffective as a prophylactic, we hypothesized that othe

89 rently FDA-approved rexinoid, bexarotene, is ineffective as a single agent for treating epithelial ca

90 n mice with induced colitis, while they were ineffective as antiepileptics at the same doses in contr

91 LSD1 inhibition is ineffective as monotherapy but demonstrates synergy with

92 Dogma suggests that antibiotics ineffective as monotherapy can be effective in combinati

93 its patients with early disease, but becomes ineffective as PCa progresses to a castration-resistant

94 ng tumor cells from blood, these devices are ineffective at capturing CTC clusters, incapable of sepa

95 Natural preexisting immunity is ineffective at clearing an HCMV infection, and an incomp

96 lls of the innate immune system appear to be ineffective at clearing the material; however, human lig

97 and in which anti-inflammatory therapies are ineffective at controlling symptoms.

98 ys are often unsatisfactory because they are ineffective at delivering medication to high/deep sites

99 potential solution but has historically been ineffective at detecting treatment response.

100 tional ROS-inducing chemotherapies are often ineffective at eradicating residual disease, despite eff

101 h as ribavirin and 5-fluorouracil, have been ineffective at inhibiting CoVs.

102 Existing technologies are ineffective at maintaining the therapeutic efficacies of

103 ween SM and GM genes, any single feature was ineffective at predicting SM from GM genes.

104 Immunosuppression therapy is ineffective at preventing chronic rejection of lung allo

105 ons that inhibit NET release would likely be ineffective at preventing NET-based injury.

106 smission, these management strategies may be ineffective at stopping Bsal invasion in eastern newt po

107 nes and HIV-infected CD4(+) T cells but were ineffective at targeting FDC bearing HIV-ICs.

108 blastoma, (131)I-metaiodobenzylguanidine, is ineffective at targeting micrometastases because of the

109 for high-risk neuroblastoma, (131)I-MIBG, is ineffective at targeting micrometastases due to the low

110 1379), although the CIMIC programme was cost-ineffective at the lowest threshold with a probability o

111 g candidates that are potent inhibitors, but ineffective at treating the disease.

112 onventional chemotherapies remain limited by ineffective blood-brain barrier (BBB) penetrance.

113 effectiveness and prevent the extinction of ineffective Bradyrhizobium from natural populations.

114 Population-based screening has been ineffective, but new approaches for early diagnosis and

115 d in the control arm, treatment with ULT was ineffective, but this finding should not be used as an a

116 ines can prevent infection, but are rendered ineffective by antigenic drift.

117 As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be sh

118 antibiotics, which are increasingly rendered ineffective by rising bacterial multidrug resistance.

119 ber of participants treated with placebo and ineffective candidates.

120 Catalysts generated from BINOL and VAPOL are ineffective catalysts.

121 blish emergent susceptibilities to otherwise ineffective chemo- and immunotherapies through SASP-depe

122 Ineffective clearance of Bpm by antibiotics is believed

123 in the clinic or office before surgery, and ineffective communication during time outs suggest a nee

124 x separation methods but sterile females are ineffective control agents.

125 ed adaptation of the virus to the vector and ineffective control of the contacts between infected mos

126 eks after infection, which is in contrast to ineffective control of the pathogen after infection with

127 ponded to drowsiness by engaging in multiple ineffective countermeasures (e.g., listening to music) a

128 ic for effective antiviral siRNAs than their ineffective counterparts.

129 re, direct vaccination of neonates is likely ineffective due to the immaturity of their immune system

130 Copper (Cu) bactericides are often ineffective due to the presence of Cu-tolerant strains.

131 ede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Dia

132 induced lung injury, dynamic hyperinflation, ineffective efforts, and respiratory alkalosis.

133 iotic resistance increases the likelihood of ineffective empirical therapy.

134 ia intermedia is a disorder characterized by ineffective erythropoiesis (IE), anemia, splenomegaly, a

135 ed genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia and a

136 , which are coordinated by HRI to circumvent ineffective erythropoiesis (IE).

137 te loss of beta-globin synthesis, leading to ineffective erythropoiesis and RBCs with a short life sp

138 They belong to the wide group of ineffective erythropoiesis conditions that mainly result

139 xcess hepcidin suppression in the setting of ineffective erythropoiesis contributes to iron-loading a

140 ens anemia in iron-deficient mice because of ineffective erythropoiesis possibly due to erythropoieti

141 Cyclin ET74AT393A mice develop ineffective erythropoiesis that resembles early-stage hu

142 thways, eIF2alphaP and mTORC1, to circumvent ineffective erythropoiesis, highlighting heme and transl

143 uch infections induced dyserythropoiesis and ineffective erythropoiesis.

144 ease progression, resulting in apoptosis and ineffective erythropoiesis.

145 optotic destruction of erythroblasts causing ineffective erythropoiesis.

146 marrow, and serum LDH level, consistent with ineffective erythropoiesis.

147 therapies only palliate the symptoms but are ineffective, evidenced by a low survival rate of ~11%.

148 The mistakes have their origins in ineffective experimental designs, inappropriate analyses

149 EC arises from incomplete As(III) oxidation, ineffective Fe(II) oxidation and the formation of Fe(II-

150 , I demonstrate that hairpinned DNA ends are ineffective for activating the kinase toward many of its

151 ons based on attention bias modification are ineffective for anxiety.

152 es an N3-protonated form of caC but would be ineffective for C, mC, or hmC.

153 , existing copper chelators are too toxic or ineffective for cancer treatment.

154 or data post-processing, making them largely ineffective for complex in-situ sensing and monitoring.

155 n oncology, the PET radiotracer (18)F-FDG is ineffective for improving early detection of pancreatic

156 n oncology, the PET radiotracer (18)F-FDG is ineffective for improving early detection of pancreatic

157 cological treatments for these disorders are ineffective for many individuals, physical activity is b

158 and cognitive behavioural therapy (CBT), are ineffective for many patients.

159 th, and that antiangiogenic therapies may be ineffective for melanoma tumors because of their ability

160 c characterization of primary tumors and are ineffective for metastatic disease.

161 , we reveal that voltage clamp is completely ineffective for most excitatory synapses due to spine el

162 treated individuals, immune therapy is still ineffective for most patients with cancer(1,2).

163 hat improved tics for some patients but were ineffective for others.

164 BAC treatment was ineffective for reducing the pressure and energy require

165 o recover muscle quantity will likely remain ineffective for regaining strength and improving quality

166 di-t-butylphosphino-substituted species are ineffective for such substrates; presumably, the marked

167 ing relapse rates in MS, such treatments are ineffective for treating cognitive dysfunction.

168 nts, antiparasitic CD4+ T-cell responses are ineffective for unknown reasons.

169 ral strains, but this approach is relatively ineffective for Zika virus because all known sequences a

170 or which conventional approaches have proven ineffective-for example, a universal influenza vaccine.

171 ermore, deep brain stimulation at clinically ineffective frequencies did not alter the source power s

172 hat alleviate motor symptoms, two clinically ineffective frequencies were tested as control condition

173 2 predominant season when TIV was relatively ineffective.Funded by Seqirus.

174 broad cytokine-mediated pathology along with ineffective fungal clearance.

175 exhibited defective synchronized beating and ineffective generation of directional flow likely underl

176 control uses chemical agents that often are ineffective, harmful to non-target organisms, and enviro

177 t a group of clonal disorders that result in ineffective hematopoiesis and are associated with an inc

178 dysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias.

179 lure syndromes (IBMFSs) are characterized by ineffective hematopoiesis and increased risk for develop

180 plastic syndromes (MDS) are characterized by ineffective hematopoiesis and often include a dysregulat

181 nts developed in nonprimate species entirely ineffective if applied to primates (including humans).

182 Effective therapy exists but is ineffective if end-organ damage is severe.

183 This study shows that ineffective immune responses not only fail to clear a ma

184 storm, suggesting close connections between ineffective immune responses to SARS-CoV-2, severe pneum

185 treatment for anxiety disorders but remains ineffective in a large proportion of patients.

186 free IL18 levels, was found to be safe, yet ineffective in a phase II trial for type 2 diabetes.

187 Notably, (i) JWH133 was behaviorally ineffective in animals that had no prior experience with

188 optogenetic inhibition of TRN-PV neurons was ineffective in blocking spindles but increased both wake

189 s in non-DSS-treated mice while MSZ remained ineffective in both groups.

190 CMP-NulOs were ineffective in Camp-/- mice, revealing that cathelicidin

191 ty of LRAs identified to date are relatively ineffective in cells from infected individuals despite a

192 The inflammatory response is ineffective in clearing the infection, leading to diseas

193 This approach, however, may be ineffective in complex habitats where matching one patch

194 paired antigen-presenting functions and were ineffective in driving encephalitogenic T cell different

195 ich interfere with phospholipid binding, are ineffective in enhancing CME.

196 ipally modify the illuminant and are largely ineffective in enhancing discrimination or perception be

197 agonistic antibody to the 4-1BB receptor was ineffective in generating immune protection against tumo

198 explain why therapies that work in HFrEF are ineffective in HFpEF.

199 external electric field and generally become ineffective in high ionic concentration conditions.

200 ntrary to our hypothesis, pressurization was ineffective in increasing total PC contents of JPS.

201 inct responses in different cells and may be ineffective in killing particular clones.

202 proved LADC patient survival but are largely ineffective in LSCC.

203 ren, and the only currently approved drug is ineffective in malnourished children and immunocompromis

204 patients, but the only approved treatment is ineffective in malnourished children and immunocompromis

205 dicated as first-line treatment, but this is ineffective in many cases.

206 e receptor-binding domain and S2 portion are ineffective in neutralizing the PDF2180 chimera.

207 drugs currently available to treat mTLE are ineffective in one-third of patients and lack disease-mo

208 herapy-resistant ER + breast cancers, but is ineffective in others.

209 nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need

210 nfortunately, this approach has been largely ineffective in pancreatic cancer.

211 Cytotoxic chemotherapy is generally ineffective in patients with hepatocellular carcinoma.

212 ntiangiogenic therapy-previously found to be ineffective in patients with TNBC.

213 against the B cell trophic factor BAFF, was ineffective in phase III trials, and efgartigimod, which

214 e functional in model systems but relatively ineffective in primary cells.

215 t maleic-itaconic copolymer treated urea was ineffective in reducing ammonia volatilization loss and

216 EDTA injections or blank nanoparticles were ineffective in reversing MAC.

217 n through mass drug administration have been ineffective in some regions; one of their new recommende

218 e efficacy for peripheral arthritis, but was ineffective in studies of axial spondyloarthritis.

219 Similarly, SNC80 was ineffective in the cortical spreading depression model o

220 s, which are usually harmful or likely to be ineffective in the long term.

221 atory phase is partially MyD88 dependent and ineffective in the lungs but controls systemic infection

222 Standard anti-epileptic drug monotherapy was ineffective in the patient.

223 s, including the parent hydroxytyrosol, were ineffective in the tested concentration range (0.5-5 muM

224 s immunoglobulin which is both expensive and ineffective in the treatment of POEMS.

225 e deacetylase inhibitors (HDACi) are largely ineffective in the treatment of solid tumors.

226 may render the immunomodulatory therapeutic ineffective in these combinatorial treatments.

227 ,E,E isomer, while other studied anions were ineffective in this reaction.

228 er, pig CD47 has previously been shown to be ineffective in transducing signals through primate signa

229 mic and in reducing mortality, would also be ineffective in ultimately preventing ICUs from becoming

230 which is currently used for PAM therapy, was ineffective in vitro and vivo.

231 old-blooded vertebrates, but this process is ineffective in warm-blooded vertebrates.

232 cursor phosphtidylglycerol (PG), is entirely ineffective, indicating an obligate functional interacti

233 rg [HRS] cells) embedded within a robust but ineffective inflammatory milieu.

234 Our data underscore the role of a perturbed, ineffective inflammatory response as a major contributor

235 erived macrophages orchestrate a strong, but ineffective, inflammatory response against uropathogenic

236 f narco-trafficking are not a consequence of ineffective interdiction, but rather part and natural co

237 examples of epidemiologic studies promoting ineffective interventions and little evident attempt to

238 frequently under-resourced, inefficient, and ineffective, leading to an imbalance between disease bur

239 een prison and probation, imprisonment is an ineffective long-term intervention for violence preventi

240 onse can lead to refractory alveolar damage, ineffective lung repair mechanisms, and systemic inflamm

241 discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rathe

242 proven/viable approaches, obviate the use of ineffective measures, and avoid unwarranted intervention

243 Use of ineffective medications in infants with bronchiolitis at

244 arting from the highest potency binder is an ineffective method for discovering active compounds.

245 to quickly identify those therapies that are ineffective, modify or change therapy, and avoid disease

246 ithin the sectors of effective (fix(+) ) and ineffective (nifH mutant, fix(-) ) endosymbionts.

247 ules, earlier onset of nodule senescence, or ineffective nodules compared to the wild-type control.

248 ing gene, MtNPD1, resulted in development of ineffective nodules.

249 r a few days, resulting in abnormally small, ineffective nodules.

250 ed mothers and 77% of their infants received ineffective non-nucleoside reverse transcriptase inhibit

251 ed Fc gamma receptor (FcgammaR) rendered 2C7 ineffective, nonetheless; (2) 2C7 was nonfunctional in C

252 ial for modern vaccines which are relatively ineffective on their own.

253 match their backgrounds [5, 6], are rendered ineffective once prey are moving [7-10].

254 e not been adequately tested and some may be ineffective or harmful.

255 ific therapies are likely to be effective or ineffective or in whom the driving biology could motivat

256 Current treatments are ineffective or only partially effective and in some case

257 UTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new th

258 Symptomatic treatment was mostly ineffective or produced unacceptable side effects.

259 were then classified as effective, mediocre, ineffective, or irrelevant.

260 Ineffective oral wound healing is detrimental to patient

261 Ineffective pain control results in many postoperative c

262 th radiotherapy is to induce a shift from an ineffective, pre-existing immune response to a long-last

263 (+/-)-PPCC, PRE-084, and (+)-SKF10047) were ineffective preblocking agents, except FTC146 and F4 at

264 t predictor of disease progression, it is an ineffective predictor of response to disease-modifying t

265 The presently studied frailty indices are ineffective predictors of 30-day morbidity and mortality

266 -step and PCR-based, time-consuming and cost-ineffective procedures.

267 inhibitory function, a finding attributed to ineffective recognition of cytoplasmic viral capsids by

268 estabilizes the Poldelta complex, leading to ineffective recruitment of replication factor C to initi

269 tory process resulting in tissue damage with ineffective repair in response to toxic inhalants (espec

270 s with reduced ETO2, loss of ETO2 results in ineffective silencing of embryonic/fetal globin gene exp

271 tia/Alzheimer's disease can be expensive and ineffective sometimes, the prevention of MCI by identify

272 histaminergic itch pathway have been largely ineffective, suggesting the existence of nonhistaminergi

273 Interestingly, low levels of ineffective sulforaphane nitrile were detected and posit

274 ent host control predicts the extirpation of ineffective symbionts, but they are nonetheless widespre

275 rance of clonal neoantigens as the basis for ineffective T cell immunity to melanoma and support the

276 te how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7

277 rugs advance from Phase II to approval, with ineffective targets accounting for over 50% of these fai

278 esults suggest that oxidative DNA damage and ineffective the DSBs repair via the impaired NHEJ may co

279 ings under Pd and Ni catalysis were minor or ineffective, the AA ligated Cu-catalyzed C-N cross-coupl

280 reveals that modulational instabilities are ineffective, third-order resonances negligible and the l

281 d tumors, EPA as a monotherapy is clinically ineffective; thus, we sought to develop a novel targeted

282 Conversely, Ac2-26 peptide was ineffective to afford protection in Fpr2/3 KO mice durin

283 existing global normalization approaches are ineffective to correct for degradation bias.

284 ting P. aeruginosa infections is found to be ineffective to inhibit or eliminate this drug-resistant

285 crofilariae in the bloodstream, but is often ineffective to kill adult filarial (macrofilariae) in th

286 treatment that lead to high toxicity and/or ineffective transfection.

287 son with the wild type strain, likely due to ineffective translation of transcription factors.

288 response that can lead to drug toxicity and ineffective treatment, making CYP2D6 one of the most imp

289 identification of physiological instability, ineffective treatment, or iatrogenic harm.

290 rgeted host-directed immunotherapy to reduce ineffective treatment, to improve patient outcomes, and

291 tem cells (CSCs) are regulated, resulting in ineffective treatments for pancreatic cancer.

292 ver, inhaled or systemic corticosteroids are ineffective treatments in many patients with asthma and

293 This has led to ineffective treatments, significant morbidity, and high

294 st is high, weak inspiratory efforts promote ineffective triggering, periodic breathing, and diaphrag

295 his coordinated behavior in effective versus ineffective tumor control will advance immunotherapies.

296 ion of gC, pUL47, and pUL48 and, ultimately, ineffective virus production in cell culture.

297 iglycerides; worsening of schizophrenia/drug ineffective was less frequent in F17464.

298 ficant artifacts for sources associated with ineffective-wavepath cancellation.

299 It can however be inefficient and ineffective when dealing with datasets with significant

300 this material in a pH range that was proven ineffective with previously reported metal-organic frame