ライフサイエンスコーパス: inefficient

1 engineering based on trial and error highly inefficient.

2 tunable parameters, and are computationally inefficient.

3 nsis MR-1 remains complicated, expensive and inefficient.

4 t has multiple bottleneck steps and hence is inefficient.

5 ze the largest connected component, are cost inefficient.

6 lity of RNN to compute long sequence data is inefficient.

7 cal features, is informationally "cheap" but inefficient.

8 mphoproliferative tumors (LTs) is costly and inefficient.

9 urrent technologies are energy intensive and inefficient.

10 ChE conjugate to free the active enzyme, are inefficient.

11 ividual pathway components are biochemically inefficient.

12 rase-bias while existing chemical routes are inefficient.

13 require the data normality assumption or are inefficient.

14 kes up a majority of the material, making it inefficient.

15 anism renders designing a selective catalyst inefficient.

16 containing mixed sequences remains slow and inefficient.

17 blems wherein this paradigm is fundamentally inefficient.

18 pathways within the vascular niche have been inefficient.

19 uminescence quenching is still comparatively inefficient.

20 but reactions of unactivated alkenes remain inefficient.

21 cross synapses, this seems both wasteful and inefficient.

22 AMD makes reading challenging and inefficient.

23 enous DNA can make transgene expression very inefficient.

24 re lean, obesity-resistant and metabolically inefficient.

25 cell nuclear transfer cloning, which can be inefficient.

26 uences, where RecA-mediated recombination is inefficient.

27 for propensity score matching (statistically inefficient), 18.2% for coarsened exact matching (high),

28 the use of selective irradiation schemes and inefficient 1D data acquisition methods.

29 S(4) was not well understood and required an inefficient 24 h growth to dissolve an iron sulfide impu

30 f delivered protein cargo with concomitantly inefficient access to the cytosol and other organelles,

31 ect is due to hyperactivation of cofilin and inefficient actin polymerization.

32 As in prior research, judgments of inefficient actions were biased toward efficiency expect

33 sed care; freeing patients and physicians of inefficient administrative and billing tasks and documen

34 signaling that deter egg predators are often inefficient against resistant conspecifics.

35 sunderstood and mischaracterized, leading to inefficient allocation of resources and, as a result, an

36 However, this process is inefficient and arbitrary.

37 cells is limited because vector delivery is inefficient and can perturb cell states.

38 n the lungs, H5N1 (2:6)-infected mice showed inefficient and delayed viral clearance compared with H1

39 f solar energy into chemical bonds are rare, inefficient and do not use significant portions of the v

40 It can however be inefficient and ineffective when dealing with datasets w

41 ion is that saying more than is necessary is inefficient and may be driven by age-related decline in

42 Furthermore, otherwise inefficient and non-stereoselective transformations with

43 Conventional "bulk" PCR often yields inefficient and nonuniform amplification of complex temp

44 These issues have led to inefficient and overlapping management, waste of adminis

45 with deaminase base editing technologies are inefficient and rely on downstream sequencing techniques

46 Intriguingly, most helicases are inefficient and require either oligomerization or assist

47 the water-driven cell-migration mechanism is inefficient and requires more energy.

48 of higher-dimensional grid responses, a cell-inefficient and rigid mechanism.

49 for Cornelia de Lange syndrome results in an inefficient and senescent placenta that impairs embryoni

50 with the robustness aspect of the otherwise inefficient and stochastic OSKM reprogramming.

51 However, endogenous neovascularization is inefficient and the regulatory pathways directing corona

52 and several newly proposed methods are often inefficient and time consuming and consequently, only ab

53 This process could be extensive, inefficient and time-consuming, especially for long term

54 alogues, the process can be relatively slow, inefficient, and frequently low-yielding.

55 nant interferon gamma (IFN-gamma) therapy is inefficient, and hematopoietic stem cell transplantation

56 em responses are frequently under-resourced, inefficient, and ineffective, leading to an imbalance be

57 ncorporated, the excision of UMP is slow and inefficient, and modifications to the 2'-carbon of the U

58 s for screening of electrogenic bacteria are inefficient, and often prevent rapid, high-throughput an

59 denaturation step as a significant cause for inefficient aptamer selection.

60 electrodes usually exhibit invasive or power-inefficient architectures, inability to form uniform and

61 s to below 10 mug/L, which was attributed to inefficient As(III) oxidation.

62 However, this is unnecessary and inefficient, as prior solutions can be used to inform fu

63 o the membrane or the ER lumen, resulting in inefficient assembly with partner TMDs.

64 macrophage activation, rendering these cells inefficient at controlling infection.

65 However, these approaches have proven inefficient at identifying pathogenic repeat expansions.

66 which highly elongated cardiomyocytes become inefficient at producing force.

67 technologies, while widespread, are usually inefficient at removing organic pollutants from sewage o

68 trast, E46K alphaS fibrils are intrinsically inefficient at seeding alphaS inclusion pathology.

69 cells specific for C-terminal epitopes were inefficient at taking up TG2-gluten complexes for presen

70 Our data show very inefficient attachment of VSV to the most resistant huma

71 main stable in HSV-1-infected mDCs due to an inefficient autophagic flux.

72 sue-specific stresses, such as DNA damage or inefficient autophagy.

73 at this is because the virus is surprisingly inefficient, barely replicating well enough to spread to

74 ameters from noninvasive genetic samples are inefficient because lower-quality samples cannot be used

75 wavelengths in free space, making them very inefficient because of fundamental limits on radiation f

76 nome-wide association analysis (GWAA) can be inefficient because single SNPs provide limited genetic

77 ously observed that mitoribosome assembly is inefficient because some mitoribosomal proteins are prod

78 and how stress can alter planning and foster inefficient behavior.

79 ctive due to short circulatory half-life and inefficient biodistribution.

80 fe-saving therapies require extensive use of inefficient bioprocessing equipment and specialized reag

81 r innovative development is still limited by inefficient bulky connections between functional modules

82 ch specific type of setup, which is not only inefficient but also requires substantial prior data to

83 HIF-1alpha-induced p53 is transcriptionally inefficient but is abundantly available for protein-prot

84 rately for each variable was computationally inefficient, but dividing sites at random into evenly si

85 of effective antifungal treatment caused by inefficient Candida diagnosis contributes to its notorio

86 e new insights into the mechanistic basis of inefficient cardiac reprogramming and can help to devise

87 ted with disruption of genome fragile sites, inefficient cell cycle progression, and increased DNA da

88 This is likely a consequence of inefficient chaperoning and accumulation of alpha7 subun

89 heterointerfaces in solar cells suffer from inefficient charge separation yet the origin of performa

90 s with altered distribution, morphology, and inefficient clearance by microglia.

91 ease, suggesting plumes are a consequence of inefficient clearance following synaptic release.

92 opathy, suggesting dysregulation of ERAD and inefficient clearance of proteins targeted for proteasom

93 or IL10 neutralization as monotherapies were inefficient, combination of these two led to improved su

94 Nucleation is inefficient compared with microtubule elongation.

95 zling since fixing nitrogen is energetically inefficient compared with using available ammonium.

96 such error-prone/efficient and hyperaccurate/inefficient conformations during the splicing cycle to r

97 -drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries.

98 o the severe interface recombination and the inefficient contacts.

99 rogeneous, dyssynchronous Ca(2+) release and inefficient contraction.

100 ed" and T cell exhaustion is associated with inefficient control of infections.

101 ansion of these MBCs is also associated with inefficient control of infections.

102 Inefficient cooking and heating with solid fuels in poor

103 Reducing human reliance on energy-inefficient cooling methods such as air conditioning wou

104 reprogramming process can be stochastic and inefficient, creating many partially reprogrammed interm

105 and influenza C virus (ICV) resulted in the inefficient cross-recognition of the heterotypic promote

106 Loss of miR-181a/b-1 resulted in inefficient de novo generation of Treg cells in the thym

107 ia reduced proline hydroxylation and, hence, inefficient degradation by the proteasome.

108 elivery vector and DNA cargo, and subsequent inefficient delivery to target cells.

109 Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by

110 ings in phage-based delivery systems such as inefficient delivery, narrow host range, and potential t

111 tor II in bone marrow progenitors results in inefficient development of ILC2s, but not ILC1s or ILC3s

112 liliters), architecturally complex and often inefficient devices, and labor-intensive operation.

113 DAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance.

114 sk due to the long incubation period of MAP, inefficient diagnostic tests, and delayed clinical signs

115 ed peak summer temperatures, suggesting that inefficient dispersal, rather than climate, may have lim

116 G3BP1 deficiency led to inefficient DNA binding by cGAS and inhibited cGAS-depen

117 , leading to impaired target recognition and inefficient DNA degradation by the Cas10-Csm complex.

118 This is in part due to inefficient doping and dopant ions disturbing the orderi

119 veness of HR repair genes to irradiation and inefficient double-strand break repair correlated with s

120 ons are colloidal instability, hemolysis and inefficient drug loading and release.

121 show insufficient drug-loading capacity and inefficient drug release, and require complex modificati

122 diverse genetic make-up, chemoresistance and inefficient drug transport across the blood brain barrie

123 ring a trait by random mutagenesis is highly inefficient due to gene redundancy.

124 s, metamaterials, or cermets are either cost-inefficient due to the complexity of the required nanofa

125 t potent form of vitamin E, were found to be inefficient due to the preference for the combination of

126 ing the WDD owing to delayed endocytosis and inefficient early trafficking of IL10/IL-10R complexes.

127 i) macrophages was also impaired, leading to inefficient efferocytosis, accumulation of apoptotic car

128 However, we observe inefficient electrical performance, which we hypothesize

129 understood, and energy loss may occur due to inefficient electron transfer (ET) processes.

130 Their sluggish reaction kinetics lead to inefficient energy conversion.

131 for protein synthesis, enhanced proteolysis, inefficient energy generation and reduced cell growth.

132 FIXa is a notoriously inefficient enzyme that needs FVIIIa to drive its hemost

133 udies showed that CLN6 deficiency results in inefficient ER export of lysosomal enzymes and diminishe

134 cells and demonstrated dyserythropoiesis and inefficient erythropoiesis in all patients.

135 ved erythroferrone and leads to expanded but inefficient erythropoiesis in murine bone marrow and an

136 Many large proteins suffer from slow or inefficient folding in vitro.

137 Since it is inefficient for all visual data to be analyzed at once,

138 Current control strategies are inefficient for CBB management.

139 cally time-consuming and costly, making them inefficient for early diagnosis of infections and inconv

140 However, this method is inefficient for genes with high copy number due to polyp

141 ese parameters are laborious, expensive, and inefficient for handling multiple samples from complex m

142 f domain predictions and are computationally inefficient for high-resolution Hi-C data.

143 Because immunoblotting was found to be inefficient for most of these small basic proteins, IgE-

144 However, this approach is challenging and inefficient for multigene expression due to increased la

145 functional, yet not necessarily specialized, inefficient form in genomes undergoing reduction.

146 ose or lactate, presumably to compensate the inefficient fuel utilization.

147 ing capacity (anemia) but may also relate to inefficient gas exchange by red blood cells (RBCs), a pr

148 osal microbiota and exhibit hyperplastic yet inefficient GC responses that favor the production of un

149 Meanwhile, an inefficient health system is a barrier to tackling these

150 maintain plasmids, unusual codon usage, and inefficient homologous recombination are among the obsta

151 liquid biopsies and alleviates the need for inefficient imaging and biopsy sampling from potential m

152 that factor X activity is associated with an inefficient immune response and contributes to the patho

153 We hypothesize that this reflects inefficient import of non-mitochondrial PE into the IM.

154 In contrast, T182I was inefficient in both liposome insertion and permeabilizat

155 However, the wild type Int proved inefficient in catalyzing such RMCE reactions.

156 nd phagocytose bacteria, both mechanisms are inefficient in clearance of the biofilm biomass.

157 Induction of memory T cell response is inefficient in colorectal cancer (CRC) liver metastasis

158 ed with highly asymmetric gene-flow that was inefficient in maintaining connectivity between populati

159 We show that SSA becomes inefficient in mammalian cells when the distance between

160 DNA donor to recode the sequence and can be inefficient in many cell types.

161 Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis.

162 efficiency paradox, high-powered species are inefficient in that they release copious waste, but the

163 is process is not always optimal and becomes inefficient in the course of multiple sclerosis.

164 A change in spin state is inefficient in the product region so that excited-state

165 energy) analyses showed they were relatively inefficient in their use of material and labor resources

166 how that existing SABRE approaches are quite inefficient in use of para-hydrogen order, and present i

167 ic small molecules capable of activating the inefficient in vitro deacetylase activity of SIRT6.

168 Hence, carbon fixation by RuBisCO is highly inefficient; indeed, in higher C3 plants, about 30% of t

169 nol in an energetically unfavorable and atom-inefficient industrial process.

170 DC-SIGN-related (DC-SIGNR), suggesting that inefficient infection of lectin-expressing leukocytes co

171 ot infect wild-type laboratory mice owing to inefficient interactions between the viral spike protein

172 with the missense substitutions ranged from inefficient internal scaffolding protein B binding to fa

173 ted by factors such as chemical instability, inefficient intracellular delivery, and the triggering o

174 cells harvested from naive mice resulted in inefficient invasion by the bacteria (<0.1% of the inocu

175 ation punctuated at specific sites by small, inefficient IZs.

176 Here, we show inefficient ligation of pol beta insertion products with

177 DNA substrates, APE1 completely bypasses the inefficient lyase activity of NTHL1.

178 e lack of the DNA repair nuclease MRE11A and inefficient lysosomal tethering of AMPK due to deficienc

179 Despite inefficient maternal-fetal transfer of Cd, maternal Cd a

180 rsible inhibition seem to be responsible for inefficient mDC activation by RSV.

181 The inefficient mDC stimulation and immunological immaturity

182 tral reconstruction is a logical, yet highly inefficient means to determine gas-phase mobility coeffi

183 acetyl-CoA carboxylase pathway, and promoted inefficient metabolism, as shown by the increase in prot

184 However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss res

185 Thus, the user defaults to using inefficient methods for transfer across the commercial i

186 However, their widespread use is limited by inefficient microfabrication technologies and their low

187 electivity (1 < kappaobs < kA/kB), caused by inefficient microscopic mixing of a reagent X with two c

188 iaturized assays is often challenging due to inefficient mixing, aggregation, and the advanced instru

189 s have been developed for mRNA delivery, the inefficient mRNA expression inside cells remains a major

190 er harmonic generation are normally based on inefficient, multi-stage optical parametric amplifiers o

191 in damage following injury or disease due to inefficient myelin debris clearance.

192 velopment of overt metastases, revealing the inefficient nature of the metastatic process.

193 ator shortage and oversupply select for more inefficient network structures.

194 ed MINPP1(-/-) induced stem cells exhibit an inefficient neuronal differentiation combined with an in

195 Low quasispecies diversity and inefficient neutralizing activity were also significantl

196 at powers type IV pilus extension but remain inefficient on the ATPase that promotes pilus retraction

197 R gram-negative therapeutic trials are often inefficient, only evaluating a single antibiotic or stra

198 R Gram-negative therapeutic trials are often inefficient, only evaluating a single antibiotic or stra

199 peat patterns from the long-reads are either inefficient or lack sensitivity.

200 ly existing methods are either computational inefficient or not able to control type I error and prov

201 nge of chemical processes that are otherwise inefficient or problematic.

202 a discharge ion source, which is relatively inefficient, or by switching the gas/vapor in the ion so

203 erminant of imprecise innervation leading to inefficient oropharyngeal function associated with 22q11

204 demonstrate that FMRP deficiency results in inefficient oxidative phosphorylation during the neurode

205 nd experimental measurement we find that the inefficient packing of the two-dimensional (2D) chains o

206 M is limited by severe systemic toxicity and inefficient penetration of brain tumor tissue even when

207 al protein formulations has been hampered by inefficient penetration of drugs through the intestinal

208 le the HIV reservoir in the brain because of inefficient penetration to the blood-brain barrier (BBB)

209 dentification of intact glycopeptides due to inefficient peptide backbone fragmentation when using co

210 l-sediment-water treatments) showed slow and inefficient performance when it came to unconventional o

211 Current methods of determining AMR rely on inefficient phenotypic approaches, and there remains inc

212 luminescent molecular bio-probes; yet, their inefficient photoluminescence (quantum yield ~1%) drives

213 Inefficient physiological transitions are known to cause

214 D-induced transposon up-regulation is due to inefficient piRNA biogenesis.

215 d stem cell transplantation and may underlie inefficient platelet production by megakaryocytes derive

216 US were also observed in tni, perhaps due to inefficient polyubiquitin hydrolysis and proteasome-medi

217 grader discovery and optimization remains an inefficient process due to a lack of understanding of th

218 Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of th

219 erials use for energy applications and their inefficient processing is the main motivation for explor

220 In uncommon hosts, inefficient processing of MBLs leads to accumulation of

221 In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "i

222 nat levels in NatB mutants are mainly due to inefficient protein maturation.

223 te which, increasing RNA destabilization and inefficient protein translation of the viral Mecp2 trans

224 d 9B), which may result in an imbalanced and inefficient provision of resources to the poor.

225 To circumvent the use of expensive and inefficient Pt catalysts, multicopper oxidases (MCOs) ha

226 A more elegant solution to inefficient quenching can be realized by designing a com

227 preference between a person's efficient and inefficient reaches when the person grasped and displace

228 or immediate early (MIE) enhancer results in inefficient reactivation compared to WT.

229 ss is associated with CP nucleation defects, inefficient recruitment of CP assembly factors to the TZ

230 recycled materials, and industrial waste are inefficient, relying upon harsh conditions, repetitive s

231 ting HFA accumulation in these plants is the inefficient removal of HFA from the site of synthesis on

232 ly, MRE11 must be tightly regulated to avoid inefficient repair or nonspecific resection.

233 cation infidelity and DNA damage followed by inefficient repair or replicative bypass.

234 ilding blocks into polymerizable monomers is inefficient, requiring multistep synthesis and chromatog

235 ls at the nanoscale to address extensive and inefficient resource use.

236 the mCherry-eGFP-LC3A/B autophagy sensor, an inefficient response to starvation as evidenced by the a

237 exhibited a general attentional deficit and inefficient right-medial PFC activation.

238 Heightened fear and inefficient safety learning are key features of fear and

239 ss multiple individuals has been hampered by inefficient sample processing and technical batch effect

240 Inefficient secretory trafficking of ATZ in the absence

241 psis pex6 and pex26 mutants by screening for inefficient seedling beta-oxidation phenotypes.

242 cruitment to DivIVA, we found that it led to inefficient segrosomes separation and increased the cell

243 ined environments evolves as a by-product of inefficient short-term natural selection: populations th

244 the long term, can evolve as a by-product of inefficient short-term selection, without selection for

245 nimal peak intensity threshold is biased and inefficient since lipid species and classes vary in thei

246 g myocytes and subsequent myotube formation, inefficient skeletal muscle regeneration upon injury, an

247 5-47 nt as the critical elongation enabling (inefficient) spliceosome assembly for EMD intron 5.

248 es assembled at the alternative exon lead to inefficient splicing and intron retention.

249 nd to have retained introns, suggesting that inefficient splicing as well as rapid cell divisions con

250 X1 Map-based cloning identified TNI as UBP14 Inefficient splicing of the mutant TNI transcript result

251 of the Arabidopsis NTC and its loss leads to inefficient splicing.

252 Inefficient starch solubilization and the inability to s

253 of material and sensitivity due to multiple inefficient steps, while simplifying the workflow to enh

254 re particularly challenging, often requiring inefficient stepwise protection-deprotection strategies

255 Thus, inefficient stimulation of mDC by RSV and immunological

256 tion and cyclization of SFTI-1, however, was inefficient, suggesting that specific seed conditions or

257 However, bulk g-C(3) N(4) suffers from inefficient sunlight absorption and low carrier mobility

258 ae proved challenging, presumably due to the inefficient supply of NADPH, the preferred cofactor of G

259 llular and molecular mechanisms underpinning inefficient surveillance of EBV-infected B cells is requ

260 induction of immunological memory cells and inefficient T effector cells.

261 tion in Bacteria has been limited because of inefficient targeting or repair; and its application to

262 ptome amplification, was not appended due to inefficient template switching.

263 lower EAE severity, reduced Th17 program and inefficient Th17 cell differentiation.

264 , infants looked longer when this action was inefficient than when it was efficient.

265 s been raised that deep RL may be too sample-inefficient - that is, it may simply be too slow - to pr

266 Its dismal prognosis stems from inefficient therapeutic modalities owing to the lack of

267 inetics resulting in off-target toxicity and inefficient therapies.

268 Here, Joule heating and inefficient thermal dissipation are shown to be major ob

269 We found inefficient thermogenic respiration due to futile proton

270 dited plants through tissue culture is often inefficient, time-consuming, works for only limited spec

271 ies used to treat effluents have shown to be inefficient to remove or just to reduce the concentratio

272 ased handling time made shallow flowers more inefficient to visit.

273 ium venules (HEV), thereby attributing their inefficient trafficking to alterations in the subsequent

274 iple vectors is a frequent event despite the inefficient transfection efficiency.

275 f HFAs in seeds, which probably results from inefficient transfer of HFAs from their site of synthesi

276 vaccines (RepRNA) are RNase-sensitivity and inefficient translation in dendritic cells (DCs).

277 We propose that inefficient translation initiation allows these stall-co

278 variants appears to be frequent, suggesting inefficient translation termination.

279 Inefficient translational processes for technology-orien

280 e allowed salivary gland invasion but led to inefficient transmission to the rodent host.

281 poor cellular targeting, rapid clearance and inefficient transport to the cytosol where STING is loca

282 e work for other agents, which may result in inefficient treatment.

283 on due to intrinsic tumor drug resistance or inefficient tumor penetration of the drugs.

284 The nation's existing health care system is inefficient, unaffordable, unsustainable, and inaccessib

285 e spatiotemporal control of deformations and inefficient underwater actuation of existing stimuli-res

286 th on the nonpreferred beta-(1,4) was due to inefficient uptake.

287 Both over- and under-allocation leads to an inefficient use of computational infrastructure.

288 e (ROP) in potable reuse treatment trains is inefficient, using only 10% of the H(2)O(2).

289 ese species either contract their muscles at inefficient velocities or maintain a two-geared muscle s

290 In addition, the data suggest that inefficient viral control may be explained by an increas

291 ften exhibit crouch gait, a debilitating and inefficient walking pattern marked by excessive knee fle

292 l quantum dots is generally considered to be inefficient, we find that the intermediate negatively ch

293 rely on energy-intensive processes that are inefficient when applied to recycling e-waste that conta

294 CNV breakpoint junction, but this method is inefficient when challenged by structural complexity suc

295 and transmissibility in pig, but were still inefficient when compared to pH1N1.

296 oupling between subunits, making them highly inefficient when isolated.

297 rtly compensated by manual work that becomes inefficient when the solution space is large due to comb

298 filling mechanism that outweighs the cost of inefficient wiring.

299 generators that are heavy, bulky, and become inefficient with low water supply.

300 for nuclear-retained Xist lncRNA and suggest inefficient Xist splicing is an additional fail-safe mec