ライフサイエンスコーパス: infectious virus

1 gut, and contained replication-competent and infectious virus.

2 kes and nucleocapsid is necessary to produce infectious virus.

3 establish latency and reactivate to produce infectious virus.

4 ting in viral DNA replication and release of infectious virus.

5 ication, resulting in enhanced production of infectious virus.

6 of viral DNA that can be packaged to produce infectious virus.

7 biting a 4-log decrease in the production of infectious virus.

8 s, generating progeny cells that can release infectious virus.

9 ned in yeast into mammalian cells to produce infectious virus.

10 and targeted EDIII or quaternary epitopes on infectious virus.

11 piked with viral RNA, inactivated virus, and infectious virus.

12 ses, and cells from these clones can release infectious virus.

13 (VLPs) that accurately mimic the budding of infectious virus.

14 assembly, but principally the secretion, of infectious virus.

15 s-host interaction crucial for production of infectious virus.

16 VP40-driven virus-like particles (VLPs) and infectious virus.

17 has different antigenic properties than the infectious virus.

18 s postinfection (dpi), despite production of infectious virus.

19 d (ATM) protein produced wild-type levels of infectious virus.

20 dd4 facilitate efficient release of VLPs and infectious virus.

21 apsid, sometimes called a procapsid, and the infectious virus.

22 evel of KSHV reactivation and an increase in infectious virus.

23 lytic replication and the production of new infectious virus.

24 s required for KSHV to replicate and produce infectious virus.

25 ation pathway, resulting in the formation of infectious virus.

26 slational machinery to replicate and produce infectious virus.

27 ress immediate early lytic genes and produce infectious virus.

28 expanded and antigenically distinct from the infectious virus.

29 s also replicated and produced low levels of infectious virus.

30 ets directly bind DENV saturably and produce infectious virus.

31 (CEs), have been implicated in production of infectious virus.

32 sue sites and also neutralized reservoirs of infectious virus.

33 logy, irregular HIV-1 core formation and non-infectious virus.

34 replication, which assists in production of infectious virus.

35 itive individuals as a proxy for shedding of infectious virus.

36 A hyperphosphorylation and the production of infectious virus.

37 novel accessory factor in the production of infectious virus.

38 is not sufficient to result in production of infectious virus.

39 ed to increased viral load and production of infectious virus.

40 transcription cascade and the production of infectious virus.

41 /-) mice, consistent with similar control of infectious virus.

42 ZV), and the cell culture medium contains no infectious virus.

43 es, high viral genome copies, and release of infectious virus.

44 gRNA) into the viral nucleocapsid to produce infectious virus.

45 al loads that correlate with the presence of infectious virus.

46 nner in cell culture, producing little to no infectious virus.

47 t lead to major changes in the production of infectious virus.

48 ene expression that results in production of infectious virus.

49 chikungunya (CHIKV) virus-like particles and infectious virus.

50 expression of IAV proteins but also contain infectious virus.

51 ion, including reactivation to produce newly infectious virus.

52 s temporal replication without production of infectious virus.

53 uselloviruses, vp3, allows the production of infectious viruses.

54 rminating, but did not propagate or transmit infectious viruses.

55 tors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.

56 imilar trend as plaque assay measurements of infectious viruses.

57 Pases that convey resistance to a variety of infectious viruses.

58 RNA genome during virus assembly to generate infectious viruses.

59 or evidence of clones of cells that produced infectious viruses.

60 e required for the assembly and secretion of infectious viruses.

61 he AAA ATPase p97/VCP in a similar manner to infectious viruses.

62 It was based on the recovery of infectious virus 28 days or more post infection and has

63 y known to be critical for the production of infectious virus(3); our findings provide insights into

64 he 2014-2015 viruses by increased release of infectious virus, a more pronounced loss of ciliated cel

65 iral polyproteins is essential to generating infectious viruses, a process known as 'maturation' that

66 iral outgrowth assays for cells that release infectious virus after one round of T cell activation(1)

67 n the context of both the JFH-1 cell culture infectious virus and a corresponding subgenomic replicon

68 dritic cells (FDCs) serve as a reservoir for infectious virus and an obstacle to curative therapies.

69 This was also associated with a decrease in infectious virus and fewer RSV-positive cells in culture

70 y of UL12 is essential for the production of infectious virus and may be considered a target for deve

71 action that is crucial for the production of infectious virus and reveal that HPV infection remodels

72 itors were rapidly depleted of intracellular infectious virus and RNA-containing hepatitis C virus pa

73 ucture-led reverse genetic approach, in both infectious virus and sub-genomic replicon systems, we id

74 10 overexpression suppresses HCV RNA in both infectious virus and subgenomic replicon systems.

75 VZV is a highly infectious virus and the causative agent of chickenpox a

76 h is required for the secretion of cell-free infectious virus and thus has been identified as an anti

77 e colonies, quickly become infected, produce infectious virus and undergo lysis within 48 h after exp

78 Detection of infectious viruses and disease biomarkers is of utmost i

79 iruses (E-, X-, and P-MLVs) exist in mice as infectious viruses and endogenous retroviruses (ERVs) in

80 ilitate the development of sensors to detect infectious viruses and novel disinfection strategies to

81 unction as an adaptive immune system against infectious viruses and plasmids.

82 mune system that defends prokaryotes against infectious viruses and plasmids.

83 question has been how a cell can assemble an infectious virus, and dismantle a virus entering an unin

84 Pol eta resulted in decreased production of infectious virus, and further, Pol eta was found to bind

85 Analyses were conducted with replicons, infectious virus, and human hepatoma cells that express

86 cing levels of Rad18 decreased production of infectious virus, and infectious titers of BPLF1 knockou

87 scriptase-quantitative PCR, no production of infectious virus, and maintenance of the viral DNA genom

88 gree to which clonally expanded cells harbor infectious viruses, and thus the extent to which they co

89 protein interactions that govern budding of infectious virus are not known.

90 ous human immunodeficiency virus, but highly infectious viruses are able to establish infection regar

91 ocesses that govern epitope accessibility on infectious viruses are reversible.

92 source of replication-competent HIV-1 and of infectious virus, as compared to any other (CXCR5(-)PD-1

93 s in the increased production and release of infectious virus, as well as increased susceptibility to

94 dramatic reduction in the amount of progeny infectious viruses, as also described in the accompanyin

95 nvolved in both viral-genome replication and infectious-virus assembly.

96 t induce antibodies that bind to and capture infectious virus but do not inhibit virus infectivity wi

97 -induced antibody that binds to and captures infectious virus but does not inhibit its infectivity ma

98 ater was completely restricted for producing infectious virus but induced a significant increase in t

99 5RO(+) CD4(+) T cells were main producers of infectious virus but largely refractory to TCR-CD3 downm

100 in the process of assembly and production of infectious virus, but the molecular mechanism of RSV ass

101 w preneutralized HIV-1 can be transferred as infectious virus by DCs, we followed the processing of 2

102 these bunyavirid-like sequences belong to an infectious virus by passaging KIGV in mosquito cell cult

103 e infected intravenously with HAdV-C6, live, infectious virus can be isolated from the lung and the k

104 SV can directly reactivate in the CNS and/or infectious virus can be transported to the CNS following

105 This assay does not require the handling of infectious virus, can be adjusted to detect different an

106 re unable to replicate the viral genome, and infectious virus cannot propagate.

107 ductive tract infection with ZIKV results in infectious virus capable of being sexually transmitted i

108 extracellular virions, and the production of infectious virus capable of infecting naive fibroblasts.

109 144 vaccinees synergized for neutralization, infectious virus capture, and ADCC.

110 Infectious virus cores can move from one cell to another

111 Infectious virus cores can move from one cell to another

112 re is due to a drug effect of generating non-infectious virus could be a basis for future response gu

113 ble IE expression by immunofluorescence, and infectious virus could be produced upon differentiation

114 trigeminal ganglia, but a cellular source of infectious virus could not be identified in the brain st

115 These findings suggest that infectious virus detected in the brain stem is primarily

116 We show that infectious virus detection by direct homogenization of e

117 cinated animals possessed significantly less infectious virus during acute infection in the trigemina

118 y reduced in the CNS, resulting in increased infectious virus during persistence.

119 es virus (MeV) involves rapid elimination of infectious virus during the rash followed by slow elimin

120 research studies on the detection of similar infectious viruses, especially severe acute respiratory

121 an Escherichia coli host, and reconstituted infectious virus following transfection into mammalian c

122 lion, could be stress reactivated to produce infectious virus, following explant cocultivation and th

123 Postmortem examination identified infectious virus for up to 185 dpi and viral genomes for

124 hood method to estimate the fraction of true infectious viruses for a given host in viral tagging exp

125 ive Bayes for separating infectious from non-infectious viruses for nine bacterial host genera with a

126 NL10" and "HL18NL11." All efforts to isolate infectious virus from bats or to generate these viruses

127 nd significantly decreased the production of infectious virus from latently infected primary CD34(+)

128 hese same inhibitors block the production of infectious virus from lytically infected cells, each at

129 coinfected, which indicates that exposure to infectious virus from multiple sources is common during

130 employed to assess the early reactivation of infectious virus from reservoirs in HIV-1-infected indiv

131 unique tool to assess early reactivation of infectious virus from reservoirs in HIV-infected individ

132 We determined the frequency of isolation of infectious virus from semen and serum samples prospectiv

133 envelopment in the cytoplasm and release of infectious virus from the cell) are severely restricted

134 vage and leading to the efficient release of infectious virus from the cells.

135 is in adult C57BL/6 mice during clearance of infectious virus from the CNS, and the virus-specific im

136 ion following inoculation with no detectable infectious virus from the sensory neurons.

137 5) LD50 of MERS-CoV, we were able to recover infectious virus from these mice only infrequently, alth

138 e hepatitis C virus genotype 1a cell culture-infectious virus H77S.3.

139 but its biological role in the context of an infectious virus has not been fully characterized.

140 fect monocytes and reprogram them to deliver infectious virus, HCMV must overcome biological obstacle

141 To generate infectious viruses, HIV-1 must package viral RNA genome

142 ons with Ab to NGF resulted in production of infectious virus in about 25% of the latently infected c

143 ations caused defects in the accumulation of infectious virus in both the cellular and supernatant fr

144 ability to interfere with the replication of infectious virus in cell culture and their potential as

145 205432 retains similar potency against fully infectious virus in cultured human neuronal cells.

146 sal virus challenge can involve clearance of infectious virus in distal tissues.

147 tive, large-scale screening and titration of infectious virus in experimental and clinical samples, i

148 ower or in some cases undetectable levels of infectious virus in faeces and tissues.

149 This lethality results from a pool of infectious virus in glial cells and is regulated by the

150 h viral protein expression, but detection of infectious virus in medium samples from explanted cultur

151 Residual infectious virus in neutralized samples was assessed by

152 These criteria confirmed the presence of infectious virus in semen specimens from 8 of 97 patient

153 ty of Q80K variants to replicate and produce infectious virus in subtype 1a and 1b cell culture.

154 nts include weight loss and viral RNA and/or infectious virus in swabs and organs (e.g., lungs).

155 Thus, methods for rapid detection of this infectious virus in the environment are urgently needed

156 ous tissues, contributing to the presence of infectious virus in the periphery and to viral transmiss

157 ion technologies and novel sensors to detect infectious viruses in drinking water.

158 out this mutation, and the same was true for infectious virus, including in competition assays.

159 Antibody capacity to recognize infectious virus is a prerequisite of many antiviral fun

160 Within 7-8 days after infection infectious virus is cleared from neurons through the ant

161 n events occur in women when semen harboring infectious virus is deposited onto the mucosal barriers

162 urons, viral gene expression is minimal, and infectious virus is not released.

163 viral RNA is usually detectable longer than infectious virus is present.

164 a major site of the virus lytic cycle, where infectious virus is propagated and transmitted via saliv

165 These results suggest that infectious virus is transported from the ganglia to the

166 h is required for the secretion of cell-free infectious virus, is not required for cell-to-cell sprea

167 NP-Ct is also required for the production of infectious virus-like particles (VLPs), and that defecti

168 n silico-designed DIs as fully encapsidated, infectious virus-like particles termed defective interfe

169 Self-propagating, infectious, virus-like vesicles (VLVs) are generated whe

170 rtain immunocompromised individuals may shed infectious virus longer than previously recognized.

171 U/cell) have been reached, with loss of most infectious virus (<5 PFU/cell) by 20 to 24 h p.i.

172 stablishment of subgenomic replicons and the infectious virus model (HCVcc).

173 regulates its genome packaging and generate infectious viruses necessary for transmission to new hos

174 wed a significant reduction in the amount of infectious virus on day 2 but not on day 4 postinfection

175 We confirmed isolation of infectious virus on the basis of a tissue culture cytopa

176 scriptionally silent genomes able to produce infectious virus once reactivated.

177 ts, relevant gaps in the architecture of the infectious virus particle remain.

178 ifferent conformations in the context of the infectious virus particle.

179 To this end, individual, infectious virus particles bound by fluorescently labele

180 even mutations that prevented generation of infectious virus particles did not abolish acylation of

181 ture system (HCVcc), it is known that highly infectious virus particles have low to very low buoyant

182 hances intracellular HCV RNA and accumulates infectious virus particles in cells.

183 nomic HCV replicons as well as production of infectious virus particles in mammalian cell culture mod

184 transmission is dependent on the release of infectious virus particles into the virological synapse.

185 Some poxviruses embed infectious virus particles outside of factories in membr

186 ecular mechanisms related to the assembly of infectious virus particles that is supported by experime

187 produce, for the first time in any metazoan, infectious virus particles through self-assembly from tr

188 an horses" during viral infections, carrying infectious virus particles to immune privileged sites an

189 While HCV is mainly transmitted via mature infectious virus particles, it has also been suggested t

190 plets but appeared to decrease production of infectious virus particles, suggesting a block in virion

191 6 and BPV-1 L2 resulted in the production of infectious virus particles, with no differences in effic

192 events are mediated by exosomes rather than infectious virus particles.

193 xhibited postponed and reduced production of infectious virus particles.

194 viral and host factors to optimally produce infectious virus particles.

195 erroneously produced and are packaged into "infectious" virus particles.

196 owever, qRT-PCR does not confirm presence of infectious virus, presenting limitations in patient and

197 reactivation and the corresponding amount of infectious virus produced in the ganglia per reactivatio

198 CpG dinucleotides on HIV-1 RNA abundance and infectious virus production and also enhanced the produc

199 ion at residue 76 (Y76A), were essential for infectious virus production and filament formation while

200 A virus M2 protein that drastically reduces infectious virus production and filament formation with

201 ion of miR-H2 but showed wild-type levels of infectious virus production and no increase in ICP0 expr

202 p caused an approximately 1-log reduction in infectious virus production compared to that of the wild

203 its binding partner, ORF38, are required for infectious virus production due to their important role

204 These M1 suppressor mutations restored infectious virus production in the presence of M2Y76A an

205 y different from wild-type virus in terms of infectious virus production in the trigeminal ganglia du

206 sed a gain-of-function phenotype, increasing infectious virus production up to 1 log more than in the

207 Finally, the contribution of Rad18 levels to infectious virus production was examined with small inte

208 s glutamine led to a substantial decrease in infectious virus production, whereas starving infected c

209 ll plaque formation and drastic reduction in infectious virus production, while mutation of C82 and C

210 Ebola, exploit AAK1 and GAK during entry and infectious virus production.

211 us genetic information in the absence of any infectious virus production.

212 t the EBV SM protein, which is essential for infectious virus production.

213 acilitate cytoplasmic virion envelopment and infectious virus production.

214 required by the nonpermissive cell to ensure infectious virus production.

215 ir ability to inhibit virion envelopment and infectious virus production.

216 , which is essential for EBV replication and infectious virus production.

217 is a key step in the process of assembly and infectious virus production.

218 ry syncytial virus, Nipah virus) to suppress infectious virus production.

219 using small molecule inhibitors also reduces infectious virus production.

220 lation of cytoplasmic virion envelopment and infectious virus production.

221 site (Thr205) in M that is critical for RSV infectious virus production.

222 polyprotein synthesis, virion assembly, and infectious virus production.

223 hyperphosphorylation-dependent regulation of infectious virus production.

224 se involved in NS5A hyperphosphorylation and infectious virus production.

225 lation of cytoplasmic virion envelopment and infectious virus production.

226 acilitate formation of the VAC for efficient infectious virus production.

227 opology and efficient virion envelopment and infectious virus production.

228 eactivation, and POU2F1 knockdown diminished infectious virus production.

229 in and that treatment with XX-650-23 reduced infectious-virus production and limited lesion formation

230 ct on RNA expression, protein abundance, and infectious-virus production.

231 which consists of proteolytically processed, infectious virus progenies within autophagosome-derived

232 iral proteins except M but does not generate infectious virus progeny, resulting in a single-cycle in

233 Furthermore, it reduced infectious virus release by 80-90% without affecting vir

234 d KSHV spontaneous lytic gene expression and infectious virus release.

235 alphaviruses has strong negative effects on infectious virus release.

236 Attempts to isolate infectious virus rely on in vivo or basic cell culture a

237 rmitting accurate determination of levels of infectious virus remaining following treatment.

238 However, the efficiency of infectious virus replication was still dependent on the

239 s sufficient for viral protein synthesis and infectious virus replication, and the regulatory mechani

240 a molecular mechanistic understanding of how infectious viruses reproduce in their living host cells.

241 ontaining inducible replication-competent or infectious virus, respectively.

242 inate expression of disease-causing genes or infectious viruses, resulting in the preclinical and cli

243 s isolation study has been done to elucidate infectious virus secretion or serotype variability.

244 on of neutralization of more than 50% of the infectious virus seed dose on plaque-reduction neutraliz

245 least two virus variants in the RhCMV 180.92 infectious virus stock.

246 ed-flow kinetics, quench-flow reactions, and infectious virus studies were used to characterize 15 en

247 t only VPA induced significant production of infectious virus, suggesting that HDAC regulation after

248 39, U90, and U100, without the production of infectious virus, suggesting that the tested stimuli wer

249 y reduced viral spread and progeny titers of infectious virus, suggesting that these sncRNA promoted

250 fetal myeloid cells contained viral RNA and infectious virus, suggesting they may be infected and co

251 tem, illustrating the importance of using an infectious-virus system for analyzing viral glycoprotein

252 g genotype 2a JFH-1 subgenomic replicons and infectious virus systems.

253 C2A mRNA produced approximately 10-fold less infectious virus than the controls.

254 The highly expanded clone produced infectious virus that was detected as persistent plasma

255 The reverse genetics process produced infectious virus that was neutralized by specific antise

256 ie, show less severe symptoms, and shed less infectious virus themselves, when infected by vaccinated

257 tly activate into the lytic phase to produce infectious virus, thereby causing disease.

258 RT-PCR detects RNA, not infectious virus; thus, its ability to determine duratio

259 eading frame (ORF), had little effect on the infectious virus titer of PR8 or PR8 7:1 reassortants wi

260 h doses of favipiravir significantly reduced infectious virus titers in the lungs and markedly improv

261 Infectious virus titers were present in the blood and mo

262 roteins in A549 cells consistent with higher infectious virus titers.

263 fection and that cell-cell contact transmits infectious virus to and from T lymphocytes.IMPORTANCE Eq

264 by catalyzing the transition from the mature infectious virus to the A-particle uncoating intermediat

265 Dormant HIV genomes readily produce infectious virus upon cellular activation because host t

266 HIV genomes, which are capable of producing infectious virus upon T cell activation.

267 man SOCS3 enhances budding of Ebola VLPs and infectious virus via a mechanism linked to the host ubiq

268 Quantitation of infectious virus, via the fluorescent forming unit assay

269 l-dependent, antibody-independent control of infectious virus was associated with a similar recruitme

270 Infectious virus was detected in 15 of 26 (58%) specimen

271 No infectious virus was detected in cells inoculated with E

272 In wild-type mice, infectious virus was detected in the femur, tibia, patel

273 No infectious virus was detected with this non-quantitative

274 ly initiated infection; however, no released infectious virus was detected.

275 Ninety percent of infectious virus was inactivated every 6.8 minutes in si

276 In contrast, infectious virus was no longer detectable by days 30 to

277 le threshold value 23.7) than plasma (31.3); infectious virus was only recovered from CSF.

278 Infectious virus was readily isolated from samples deriv

279 R amplification were severely reduced and no infectious virus was recovered after RNA transfection in

280 In this study, infectious virus was recovered from both the trigeminal

281 l and intraperitoneal mouse models, and less infectious virus was recovered from organs.

282 After intranasal inoculation, infectious virus was recovered only from nasal epitheliu

283 of ZIKV in a novel linear vector from which infectious virus was recovered.

284 o-plasmid infectious clone system from which infectious virus was rescued that replicates in human an

285 Infectious virus was then reisolated in culture, fulfill

286 S5A- or protease-inhibitors can generate non-infectious virus, we incorporated this effect into a mat

287 nine bacterial host genera with at least 45 infectious viruses, we show that random forest together

288 The HTNV genomic RNA (vRNA) copy number and infectious virus were measured in lungs of untreated and

289 The virus genome and infectious virus were observed soon after immunization,

290 ency of reactivation and increased titers of infectious virus were recovered from the trigeminal gang

291 e NS6-7 junction, leads to the production of infectious virus when the MNV NS6 protease, but not the

292 es substantially decreases the production of infectious virus, which can be rescued through medium su

293 anced late gene expression and production of infectious virus, while ectopic Pin1 showed inhibitory e

294 SARS-CoV-2 is a highly infectious virus with no vaccine or antiviral therapy av

295 DV reverse-genetics system that can generate infectious viruses with replication kinetics similar to

296 on and also a later stage during assembly of infectious virus, with COPI knockdown reducing titers by

297 a later stage during assembly and egress of infectious virus, with COPI-knockdown reducing titers by

298 We demonstrate that ISG15 suppressed infectious virus yield in human cardiac myocytes and the

299 to the suppression of viral replication and infectious virus yield in the heart; in the absence of s

300 antly impaired viral replication and reduced infectious virus yields without substantially affecting