ライフサイエンスコーパス: infective

1 obes have become attractive targets for anti-infectives.

2 ioactive compounds for novel B. abortus anti-infectives.

3 ization; (2) a review of all prescribed anti-infectives; (3) a shared review by the physician and the

4 The infective ability of the opportunistic pathogen Staphylo

5 immunity thereby negating their use as anti-infectives, abrogation of alkaline signalling has, there

6 lites with antipredator, anticancer and anti-infective activities) were identified, suggesting the po

7 as thiazolides (TZD) endowed with broad anti-infective activities.

8 s study provides an explanation for the anti-infective activity of peppertree remedies and yields ins

9 ffector gene avrPphB from its chromosome are infective against previously resistant plant hosts.

10 lection of a bifunctional peptide-based anti-infective agent and its delivery via biodegradable nanop

11 d mortality in Latin-America triggered by an infective agent.

12 nfections during pregnancy treated with anti-infective agents (n = 567,016) increased the risk of men

13 Therefore, the discovery of novel anti-infective agents accelerating healing of infected injure

14 ould be valuable for the development of anti-infective agents against this important pathogen.

15 d by suicide (64% had been treated with anti-infective agents and 13% had been hospitalized for infec

16 te self-harm (92% had been treated with anti-infective agents and 19% had been hospitalized for infec

17 iations between infections treated with anti-infective agents and infections requiring hospitalizatio

18 ts have been able to generate effective anti-infective agents based on the structural differences in

19 talizations with infections, prescribed anti-infective agents during childhood, parental mental disor

20 ndividuals with infections treated with anti-infective agents had an increased risk of deliberate sel

21 ndividuals with infections treated with anti-infective agents in temporal and dose-response associati

22 al and paternal infections treated with anti-infective agents or hospital contacts before, during, or

23 ber of maternal infections treated with anti-infective agents, particularly during and after pregnanc

24 e, hastening the need for selective new anti-infective agents.

25 lular target for the development of new anti-infective agents.

26 ront and overcome mammalian cell barriers to infective agents.

27 rthermia is an effective method to kill host-infective amastigotes, with morphological changes consis

28 ncolytic reovirus (r2Reovirus) with enhanced infective and cytotoxic properties in TNBC cells.

29 reoviruses by forward genetics with enhanced infective and cytotoxic properties in triple-negative br

30 te A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in

31 ally resistant to eCD4-Ig were markedly less infective and more sensitive to antibodies in the serum

32 e HTLV-1(p12KO) In rabbits, HTLV-1(p12KO) is infective and persists efficiently.

33 ere used for functional analysis of nematode infective and reproductive parameters.

34 s key questions that concern the use of anti-infectives and both microbe- and host-based immunomodula

35 itiated to investigate the potential of anti-infectives and immunomodulators in asthma.

36 ith applications for the development of anti-infectives and the prevention of biocontrol emasculation

37 We retrospectively measured anti-infective (antibiotic, antiviral, antifungal) use hospit

38 acids, and commonly used drugs, such as anti-infectives, antihypertensives, and cholesterol lowering

39 and Enterococcus faecalis (Ef) by using anti-infective, antivirulence, and antibiotic assays.

40 In an infective arthritis murine model induced by injection of

41 quantified human exposure to both bites and infective bites of a major malaria vector in Papua New G

42 ed polymer (LMIP) designed to act as an anti-infective by blocking the quorum sensing (QS) mechanism

43 at promoted macrophage inflammatory and anti-infective capacity.

44 Our findings suggest non-infective causes of diarrhoea in ICU predominate and pat

45 with 1 study each on antihypertensives, anti-infectives, central nervous system stimulants for attent

46 e highest expression was detected during the infective cercaria stage.

47 Additionally, anti-infective chemotherapies may be successfully achieved by

48 (CAPA) was recently reported as a potential infective complication affecting critically ill patients

49 tritional adjuncts in reducing postoperative infective complications in elective abdominal surgery.

50 -cytarabine plus rituximab and thiotepa, but infective complications were similar in the three groups

51 c hospital, we retrospectively assessed anti-infective cost using pharmacy purchasing data, patient-l

52 iety of America (IDSA) recommended that anti-infective costs be measured by patient-level administrat

53 y available and standardized measure of anti-infective costs over time.

54 orruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chroni

55 There were 2 early infective deaths and 3 further deaths from pulmonary inf

56 Although some individuals with high peak infective dose (ID(50) > 10,000) maintained neutralizing

57 ly pathogenic with an estimated median viral infective dose (ID(50)) ranging from 18 to 1015 genome c

58 different subtypes with a geometric mean 50% infective dose (ID50) between 100 and 800.

59 ere inoculated with 10(5) 50% tissue culture infective dose (TCID(50)) of D/bovine/France/5920/2014 (

60 as determined to be 0.004 50% tissue culture infective dose (TCID(50))/ml using inactivated virus and

61 g virus was revealed by a 50% tissue culture infective dose assay after the combined treatment under

62 se death in infected BALB/c mice, even at an infective dose of 10(7) CFU.mL(-1).

63 essation of viral shedding, the cell culture infective dose of shed virus in virus-positive stools, a

64 with as little as 10(2) EID(50)/mL (50% egg infective dose per microliter), with a virus specificity

65 ated median shedding index (50% cell culture infective dose/g), was observed to be greater with candi

66 nging from 10(7) to 10(9) 50% tissue culture infective doses (TCID50) consistently infected all the a

67 a recipient sites never exceeded the minimal infective doses for poultry; however, the continuous exp

68 ly 10(6) genome copies or 50% tissue culture infective doses/ml).

69 ia, especially in antiproliferative and anti-infective drug classes.

70 tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibito

71 years, the most successful strategy in anti-infective drug discovery for the treatment of such probl

72 te that the FDA-approved broad-spectrum anti-infective drug nitazoxanide (NTZ) blocks astrovirus repl

73 valuate a panel of antivirals and other anti-infective drugs, and we identify nelfinavir, rupintrivir

74 sms and are currently in development as anti-infective drugs.

75 her investigations in the quest for new anti-infective drugs.

76 ercentage of children ever receiving an anti-infective during admission likewise declined, from 65% t

77 mmation around day 21 after inoculation with infective eggs that is transcriptionally characterized b

78 Infection is initiated by ingestion of infective eggs, which hatch in the intestine.

79 (3.49/1000 patient-years), and 20 (0.7%) had infective endocarditis (3.65/1000 patient-years).

80 Drug use-associated infective endocarditis (DUA-IE) is increasing as a resul

81 curately capture data on drug use-associated infective endocarditis (DUA-IE).

82 Injection drug use-associated infective endocarditis (IDU-IE) is rising and valve surg

83 ong those with injection drug use-associated infective endocarditis (IDU-IE), against medical advice

84 atus, and dental procedures in patients with infective endocarditis (IE) according to whether the IE-

85 ta sources and national burden estimates for infective endocarditis (IE) and skin and soft-tissue inf

86 ity to echocardiography in the evaluation of infective endocarditis (IE) and surgical planning.

87 antibiotic prophylaxis for the prevention of infective endocarditis (IE) for only the highest-risk pa

88 Rising rates of hospitalization for infective endocarditis (IE) have been increasingly tied

89 comes in people who inject drugs (PWID) with infective endocarditis (IE) have often been retrospectiv

90 comes in people who inject drugs (PWID) with infective endocarditis (IE) have often been retrospectiv

91 l database of all residents hospitalized for infective endocarditis (IE) in an acute care hospital fr

92 03/31/2017 of all residents hospitalized for infective endocarditis (IE) in an acute care hospital.

93 population-based epidemiological changes in infective endocarditis (IE) in Europe.

94 ed as a useful diagnostic tool for suspected infective endocarditis (IE) in patients with prosthetic

95 of Diseases, 9thRevision diagnosis codes for infective endocarditis (IE) in the National Inpatient Sa

96 Infective endocarditis (IE) is a complex disease with ca

97 or and treating the portal of entry (POE) of infective endocarditis (IE) is important, but published

98 es of resected heart valves of patients with infective endocarditis (IE) is influenced by pre-operati

99 Infective endocarditis (IE) is the most feared complicat

100 Infective endocarditis (IE) often requires surgical inte

101 No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic va

102 Background Infective endocarditis (IE) remains a difficult to diagn

103 biotic prophylaxis (AP) for those at risk of infective endocarditis (IE) undergoing dental procedures

104 ET/CT) is commonly used for the diagnosis of infective endocarditis (IE), but its prognostic value re

105 e incidence of bacterial infections, such as infective endocarditis (IE), have been reported in conju

106 l cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with

107 In the management of infective endocarditis (IE), the presence of extracardia

108 significant increases in infections such as infective endocarditis (IE), which is tied to injection

109 Streptococci frequently cause infective endocarditis (IE), yet the prevalence of IE in

110 tal role in the evaluation and management of infective endocarditis (IE)-a condition with high morbid

111 t (OPAT) has proven efficacious for treating infective endocarditis (IE).

112 faecalis is the third most frequent cause of infective endocarditis (IE).

113 of hemorrhagic stroke (HS) in patients with infective endocarditis (IE).

114 cement (SAVR) are considered at high risk of infective endocarditis (IE).

115 tal plaque and important agents of bacterial infective endocarditis (IE).

116 chemic stroke (IS) during the acute phase of infective endocarditis (IE).

117 ncreased risk of deleterious sequelae due to infective endocarditis (IE).

118 tissues during cardiac surgery of left-sided infective endocarditis (LSIE) helps to guide antibiotic

119 surgery on outcomes of Staphylococcus aureus infective endocarditis (SAIE) remains controversial.

120 ac deaths 21.3%, reoperation on the MV 4.6%, infective endocarditis 1.1%, thromboembolism 10.3%, and

121 Infective endocarditis after TAVR most frequently occurs

122 es, types of microorganisms, and outcomes of infective endocarditis after TAVR.

123 acteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter ao

124 Infective endocarditis and in-hospital mortality after i

125 er aortic valve replacement for incidence of infective endocarditis and infective endocarditis for in

126 sent article reviews the challenges posed by infective endocarditis and outlines current and future s

127 the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in nati

128 The challenges posed by infective endocarditis are significant.

129 (95% CI, 10.4%-19.2%) of patients during the infective endocarditis episode.

130 for incidence of infective endocarditis and infective endocarditis for in-hospital mortality.

131 age approach, all patients hospitalized with infective endocarditis from 1990 to 2014 were identified

132 revealed higher microglial activation in the infective endocarditis group (n = 11/23, 48%), when comp

133 In the infective endocarditis group, MRI revealed at least one

134 In the infective endocarditis group, neuropathology revealed br

135 group were similar to those observed in the infective endocarditis group.

136 ophylaxis guidelines, the crude incidence of infective endocarditis has remained stable.

137 Prophylaxis and treatment guidelines for infective endocarditis have changed substantially over t

138 - and sex-adjusted incidence and outcomes of infective endocarditis hospitalizations.

139 stic pathogen, as well as a leading cause of infective endocarditis in humans.

140 fy trends in the incidence and etiologies of infective endocarditis in the United States.

141 important interaction in the pathogenesis of infective endocarditis is attachment of the organisms to

142 Infective endocarditis is defined by a focus of infectio

143 ival for people who inject drugs (PWID) with infective endocarditis is good, long-term survival is po

144 Infective endocarditis is life-threatening; identificati

145 Similar structures were observed on all infective endocarditis isolates examined, suggesting tha

146 Infective endocarditis may affect patients after transca

147 Infective endocarditis may require valve surgery, but su

148 n of empA also resulted in attenuation in an infective endocarditis model (P = 0.0088).

149 Neurologic lesions observed in the infective endocarditis model were compared with three ot

150 Moreover, with the use of the rabbit infective endocarditis model, we demonstrate that the di

151 ibute to USA300 JE2 pathogenesis using a rat infective endocarditis model.

152 A total of 250 cases of infective endocarditis occurred in 20006 patients after

153 Infective endocarditis occurs worldwide, and is defined

154 Patients with infective endocarditis on the left side of the heart are

155 to define the cerebral lesion spectrum in an infective endocarditis rat model.

156 This original model of infective endocarditis recapitulates the neurologic lesi

157 Despite improvements in management, infective endocarditis remains associated with high mort

158 reveal that the oral colonizer and cause of infective endocarditis Streptococcus oralis subsp. denti

159 as an index test, (b) data were provided as infective endocarditis valvular complications (classifie

160 The annualized incidence of infective endocarditis was 1.6% in the Melody group and

161 Infective endocarditis was classified into early (peri-p

162 urvival free of valve replacement because of infective endocarditis was comparable between both group

163 Health care-associated infective endocarditis was present in 52.8% (95% CI, 46.

164 State, the overall standardized incidence of infective endocarditis was stable from 1998 through 2013

165 ar survival, freedom of reinterventions, and infective endocarditis with or without the need of repla

166 eremia and associated sternal osteomyelitis, infective endocarditis) caused by Staphylococcus aureus.

167 with or without AIDS, the viral hepatitides, infective endocarditis, and skin and soft-tissue infecti

168 ion of interest was all hospitalizations for infective endocarditis, epidural abscess, septic arthrit

169 ted hospitalizations for serious infections (infective endocarditis, epidural abscess, septic arthrit

170 nagement-based approach for the treatment of infective endocarditis, leading to a strong reduction of

171 nism involved in neurologic complications of infective endocarditis.

172 ith C. burnetii can cause a life-threatening infective endocarditis.

173 Infective endocarditis.

174 re complications of Streptococcus agalactiae infective endocarditis.

175 coccus oralis is a leading cause of subacute infective endocarditis.

176 endocarditis and in-hospital mortality after infective endocarditis.

177 icantly associated with an increased risk of infective endocarditis.

178 ary tract infections (UTIs), bacteremia, and infective endocarditis.

179 with Streptococcus mutans and virulence for infective endocarditis.

180 alizations (65+/-17 years, 51% females) with infective endocarditis.

181 43% of hospitalizations for IDRIs involved infective endocarditis.

182 this bacterium may cause the serious illness infective endocarditis.

183 ntibiotic prophylaxis guidelines on incident infective endocarditis.

184 lorhexidine 0.05% or 0.1% for prophylaxis of infective endophthalmitis was undertaken.

185 ion in vivo in health and in vitro in milder infective events, but not in severe sepsis, supporting t

186 equal to 10 mum in aerodynamic diameter with infective exacerbations was also evident and supported b

187 ual pheromones elicit mating resulting in an infective filament able to infect corn plants.

188 ll cycle arrest to lead the formation of the infective filament.

189 sodA cultures were strongly depleted in this infective form and more susceptible to reactive oxygen s

190 asmodium berghei ANKA sporozoites, the liver-infective form of the parasite and the natural route of

191 ontaining the MASP SP in EVs secreted by the infective forms of the parasite.

192 chanisms required for the differentiation of infective forms.

193 as restored in Pla2g1b(-/-) mice by treating infective H. polygyrus L3 larvae with PLA2g1B, which red

194 stant infections, and several MNP-based anti-infectives have already entered phase 1, 2, and 3 clinic

195 ment C3, influences blood clearance and anti-infective immunity.

196 All parasites were infective in vivo However, infectivity of NF54 was drama

197 rgy & Clinical Immunology Task Force on Anti-infectives in Asthma was initiated to investigate the po

198 Anti-infectives, including antibiotics, are essentially diffe

199 t number of approaches to develop novel anti-infectives is currently pursued.

200 e transcriptome in addition to pre- and post-infective J2 gland cell transcriptome using Next Generat

201 to this end, we sequenced a whole animal pre-infective J2-stage transcriptome in addition to pre- and

202 d by entomopathogenic nematodes (EPNs) drive infective juvenile (IJ) emergence from consumed cadavers

203 roduction and colonization initiation in the infective juvenile (IJ) stage nematode that carries X. n

204 stages: juvenile, adult and pre-transmission infective juvenile (IJ).

205 nematodes and the bacteria, MBOA-Glc repels infective juvenile nematodes.

206 epoxidase gene was dispensable in a nematode-infective juvenile recovery assay, indicating the oxidiz

207 he highest larval mortality rate (80%) at 50 infective juveniles (IJs) cm(-2).

208 Free-living infective juveniles (IJs) of EPNs employ host-seeking be

209 egulation of neuropeptides in the dauer-like infective juveniles of diverse parasitic nematodes, sugg

210 iRNAs, mir-228 and mir-235, were enriched in infective L3 larvae, an arrested stage analogous to Caen

211 ment as developmentally arrested third-stage infective larvae (iL3s) that navigate toward host-emitte

212 ers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm inf

213 oats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days.

214 emination, we image Litomosoides sigmodontis infective larvae during their escape from the skin.

215 Infective larvae released from snails carry a handful of

216 ed pathologies depend on the location of the infective larvae when their migration, the asymptomatic

217 ooked molluscs or vegetables contaminated by infective larvae.

218 he homologues of which are intact in all ape-infective Laverania species.

219 odium falciparum is the most lethal of human-infective malaria parasites.

220 nd across PIR proteins from mouse- and human-infective malaria parasites.

221 on recommendations of nonpharmacologic anti-infective measures and infectious complications were ava

222 Although nonpharmacologic anti-infective measures are widely used in children treated f

223 y unappreciated mechanism of action for anti-infective medicinal plants.

224 sease and other inflammatory, granulomatous, infective, metabolic, and genetic causes that can mimic

225 els of H(2)O(2), generate a greater yield of infective metacyclic promastigotes, and have increased v

226 During differentiation to infective metacyclics, d-arabinopyranose (d-Arap) caps t

227 1.0-9.2]; P = .047), comedication with anti-infectives (mOR, 3.7 [95% CI, 1.0-12.6]; P = .045), and

228 el of the sporozoite rate (the proportion of infective mosquitoes) that emphasized changes in mosquit

229 uivalent to 200 viruses/mL) detection of the infective murine norovirus (MNV), a readily cultivable s

230 en delivered to the lungs of mice, this anti-infective nanomaterial exhibits improved safety profiles

231 r to improve antibacterial delivery, an anti-infective nanomaterial is developed that utilizes two st

232 Finally, non-infective nematodes that rely on universal morpho-physio

233 velopment of AEF in patients presenting with infective, neurological, gastrointestinal, or cardiac sy

234 Orders for anti-infective (odds ratio, 1.66; 95% CI, 1.19-2.32), hematol

235 to develop a biocompatible hydrogel as anti-infective ointment.

236 We showed that MHV and varphi6 remained infective on the time scale of days.

237 These appearances suggested chronic infective osteomyelitis of the xiphoid process of the st

238 calized, heat-based method to kill the human-infective parasite in vitro.

239 ched for its subcellular localization in the infective parasite stages (intracellular amastigotes and

240 e cytoplasm, as is typically observed in the infective parasite stages.

241 Trichomonas vaginalis, a human-infective parasite, causes the most prevalent nonviral s

242 - a differential timing only seen in mammal-infective parasites.

243 pathway-mediated assemblage and excretion of infective particles represent appealing targets to reduc

244 rigins and evolutionary history of all human-infective Plasmodium species, the time and circumstances

245 these patients to decide on appropriate anti-infective preventive measures.

246 In contrast, the infective process of P. aeruginosa in the chronic biofil

247 riggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic infla

248 finding that might be important for the anti-infective properties of B. subtilis and its relatives.

249 Infective PSTVd circles are replicated via an asymmetric

250 us adverse events occurred in four children: infective pulmonary exacerbation of cystic fibrosis (n=2

251 The most common adverse events were infective pulmonary exacerbations, cough, increased sput

252 d crescentic GN, acute tubular necrosis, and infective pyelonephritis or sepsis.

253 paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which comb

254 Infective rhinitis can be caused by viruses, and less co

255 iopsy (9%), HBsAg+ (6%), neoplastic (6%), or infective risk (5%).Most recipient and donor features we

256 the virulence of each of the 214 known human-infective RNA virus species.

257 bition may have an antiinflammatory and anti-infective role in CF.

258 We compared responses of infective second stage juveniles (J2s) to root volatiles

259 Anti-infective shortages are a pervasive problem in the Unite

260 mong critically ill patients, sepsis and non-infective SIRS are associated with substantial, differen

261 ifferentially affected during sepsis and non-infective SIRS.

262 ; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied.

263 tionship of these species to the other human-infective species has been contested.

264 vant for P. falciparum, the only known human-infective species of the Laverania sub-genus, all other

265 lack of genetic information for three human-infective species: P. malariae and two P. ovale species

266 Plasmodium falciparum antigen upregulated in infective sporozoites 3 (PfUIS3) as a vaccine candidate.

267 tility, and immune evasion properties of the infective sporozoites.

268 humans by immunization with sporozoites, the infective stage injected by bite of the mosquito vector,

269 in activation and flight towards a host when infective stage larvae (L3) were present (p < 0.001).

270 nce dispersal from the environmental pool of infective stages (i.e. the regional species pool).

271 limate warming increases the availability of infective stages of both helminth species and the propor

272 ins that are preferentially expressed in the infective stages of the human parasite Trypanosoma cruzi

273 ematode parasite (production of the cercaria infective stages) and the parasite's snail intermediate

274 cystic fibrosis (CF) patients during chronic infective states has not yet been evaluated.

275 Metabolite-driven diagnostic and anti-infective strategies for preventing salmonellosis could

276 at could guide the development of novel anti-infective strategies.

277 t-directed therapeutics are a promising anti-infective strategy against intracellular bacterial patho

278 psis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS)

279 me lytic factors (TLFs), against which human-infective T. brucei gambiense and T. brucei rhodesiense

280 ved from HIV-1 infected DCs were 4 fold more infective than either cell free HIV-1 or exosomes derive

281 oduction, confirming their potential as anti-infectives that do not function by traditional bacterioc

282 Antimicrobial peptides (AMPs) are anti-infectives that may represent a novel and untapped class

283 for measuring the amount of circulating anti-infective therapeutic antibodies.

284 ns is expected to help in the design of anti-infective therapeutic interventions.

285 lis fimbriae are attractive targets for anti-infective therapeutics to prevent or treat periodontal d

286 novel mucolytic, anti-inflammatory, and anti-infective therapies is likely to remain important, espec

287 oblem and highlights the need for novel anti-infective therapies.

288 Delayed administration of active anti-infective therapy is associated with increased rates of

289 peri-implantitis and received surgical anti-infective therapy were selected.

290 x-CcP overexpressers were significantly more infective to macrophages and cardiomyocytes, as well as

291 ly sexual parasites, called gametocytes, are infective to the mosquito vector.

292 stant to sequestered benzoxazinoids and more infective toward the western corn rootworm than nematode

293 parse regarding less severe infections, anti-infective treatment, and deliberate self-harm.

294 ip, that effectively decreased hospital anti-infective use and costs in its pilot year (2013).

295 Hospital-wide mean anti-infective use significantly decreased, from 891 (95% con

296 19 does not necessarily indicate shedding of infective virions.

297 by D. magna was observed through recovery of infective viruses from the daphnid tissue.

298 of children admitted ever receiving an anti-infective was also measured, as well as severity-adjuste

299 acy of a novel boric acid-based vaginal anti-infective with enhanced antibiofilm activity (TOL-463) i

300 concerned with the development of novel anti-infectives with dual antibacterial and antiretroviral ac