ライフサイエンスコーパス: infectivity

1 d infectivity (negative imprinting of virion infectivity).

2 r hTfR1 comparably enhances JUNV virus entry/infectivity.

3 c activity of the protein as an inhibitor of infectivity.

4 rin cleavage site did not depend on NRP1 for infectivity.

5 tion of genes contributing to B. burgdorferi infectivity.

6 cations for maintaining virion stability and infectivity.

7 nt's secretions is not confirmative of viral infectivity.

8 3 intact, and produce virions of much higher infectivity.

9 tage, as this would reduce their duration of infectivity.

10 HA) by host proteases is essential for virus infectivity.

11 wne (TN) gO (GT4), despite similar cell-free infectivity.

12 ved in neurodevelopment, as critical for AdV infectivity.

13 ase processing efficiency that impacts viral infectivity.

14 alic acid expression and T3SA(+) binding and infectivity.

15 cosine destroys toxicity without diminishing infectivity.

16 ive pathogens and is essential for bacterial infectivity.

17 deletion of gL resulted in markedly reduced infectivity.

18 vitro, temperature sensitivity, or specific infectivity.

19 es of phage structural genes associated with infectivity.

20 as the rate at which infectious virions lose infectivity.

21 ts ligands (LIGHT, CD160, and BTLA) on HSV-1 infectivity.

22 e in T. gondii tachyzoites and for T. gondii infectivity.

23 V) also use bacterial components to modulate infectivity.

24 nuclear envelope of macrophages and reduced infectivity.

25 les to PFU indicated that Slfn11 impairs WNV infectivity.

26 n of the PR that determines viral fusion and infectivity.

27 changes, as well as attenuate S. pneumoniae infectivity.

28 otein results in a strong reduction in virus infectivity.

29 ns that package IFITMs and exhibit decreased infectivity.

30 ng a clear dissociation between PrP(res) and infectivity.

31 o-opting necessary for viral replication and infectivity.

32 rexpression significantly increases parasite infectivity.

33 al protein HTLV-1 bZIP factor (HBZ) promotes infectivity.

34 acilitates virus release, and enhances viral infectivity.

35 tations did not influence HBsAg secretion or infectivity.

36 ction and evaluation of DTA-expressing virus infectivity.

37 ns on HIV-1 Env stability, viral fusion, and infectivity.

38 had mostly negative impacts on viability and infectivity.

39 for light-mediated control of P. aeruginosa infectivity.

40 ole of the PR in regulating HIV-1 fusion and infectivity.

41 mbi choanomastigotes, resulting in a loss of infectivity.

42 O-antigen and with oligosaccharides reduces infectivity.

43 d maintenance of cellular ligand binding and infectivity.

44 for membrane fusion and essential for virus infectivity.

45 Nef- and CD3-dependent enhancement of viral infectivity.

46 interface reduces binding activity and viral infectivity.

47 ated with SERINC5's ability to inhibit HIV-1 infectivity.

48 ities showed no effect on the mucin-enhanced infectivity.

49 on overall fitness, morphology and in vitro infectivity.

50 ated, interferon-inducible) to enhance viral infectivity.

51 switch of the large envelope protein confers infectivity.

52 lux is required for higher recoveries of VZV infectivity.

53 antibodies do not necessarily neutralize AAV infectivity.

54 promastigote stationary phase phenotype and infectivity.

55 43 closely correlates with diminished virion infectivity.

56 expression of lipoproteins involved in host infectivity.

57 btypes have significantly strengthened their infectivity.

58 terol from HIV-1 particles inactivates their infectivity.

59 ch as plate counts, plaque assays, or animal infectivity.

60 lence, the additional gain from selection on infectivity accelerates disease eradication and reduces

61 l fibers-can be definitively correlated with infectivity, allowed a direct test of this assertion.

62 gonize SERINC-mediated diminishment of HIV-1 infectivity, also effectively counteract TIM-mediated in

63 trates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking

64 ences will allow us to further explore their infectivities and ecological strategies.

65 to the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help

66 /gO and gH/gL/UL128-131, and this can impact infectivity and cell tropism.

67 ion in airways and lungs has consequences on infectivity and clinical outcomes of COVID-19.

68 We develop assays to test the relative infectivity and competitive ability of the viral variant

69 h viral species and devise an assay of their infectivity and competitive ability.

70 l possible mechanisms influencing SARS-CoV-2 infectivity and COVID-19 clinical outcomes.

71 rs as a class of drugs that enhance reovirus infectivity and cytotoxicity of triple-negative breast c

72 ur data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral

73 ijacked CRL5 complex that contributes to HIV infectivity and demonstrate the operation of the E1-E2-E

74 viruses had defective Gag cleavage, reduced infectivity and diminished capacity to saturate TRIM5alp

75 ibiting severe defects in cell-free particle infectivity and Env-mediated fusogenicity.

76 glycosylation plays an important role in the infectivity and evasion of immune responses of many euka

77 that the CS and suberization impact nematode infectivity and feeding site size.

78 , S532A mutation significantly reduced HIV-1 infectivity and fusogenicity but not Env expression and

79 -Ig, with correspondingly dramatic losses in infectivity and greater sensitivity to a V3 antibody and

80 rectal chancres, to reduce their duration of infectivity and hence reduce onward transmission.

81 he hypothesis that they are a determinant of infectivity and host demise.

82 .IMPORTANCE The spike protein determines the infectivity and host range of coronaviruses.

83 on as evidenced by lower viral titres, lower infectivity and hypermutation.

84 ona pre-coating differentially affects viral infectivity and immune cell activation.

85 D46/NS2/N/DeltaM2-2-HindIII had excellent infectivity and immunogenicity and primed vaccine recipi

86 ulture may be used as a surrogate marker for infectivity and inform de-isolation protocols.

87 n early in the pandemic that confers greater infectivity and is now the globally dominant form.

88 UL74(gO) is an important determinant of HCMV infectivity and one of the most diverse loci in the vira

89 -HB-MOR7 strains showed significantly higher infectivity and penetration rates when compared to the o

90 ns of the exported DNA while maintaining its infectivity and production purity to produce sequences l

91 e for chemosensation in iL3 host seeking and infectivity and provide insight into the molecular mecha

92 l called SIRE (standing for "Susceptibility, Infectivity and Recoverability Estimation"), which allow

93 -19 to better understand risks for prolonged infectivity and reinfection.

94 Virus with this Env retained good infectivity and replicative capacity; however, analysis

95 M132V PV had reduced specific infectivity and RNA uncoating compared with those of wil

96 ion, that modulate viral cytopathic effects, infectivity and sensitivity to inhibition.

97 ane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediate

98 y host cell proteases is essential for virus infectivity and spread.

99 imary human airway tissues by increasing the infectivity and stability of virions.

100 and pathogen lipids influence mycobacterial infectivity and suggests the use of statins as tuberculo

101 The huge issue is the high infectivity and the absence of vaccine and customised dr

102 dy, we examined the role of 6S RNA in murine infectivity and tick persistence of the Lyme disease spi

103 mber (REi) as an estimate of individual case infectivity and to examine how transmission changes over

104 suggest a role for CLEC5A in human monocyte infectivity and to show that newborn monocytes are inter

105 the later stages of the outbreak had higher infectivity and transmissibility in chickens than the wi

106 ration of viral shedding is a determinant of infectivity and transmissibility, but few data exist abo

107 Here we investigate the infectivity and transmission of DWV in bumble bees using

108 destabilizing mutation also increased early infectivity and type I interferon (IFN) responses in mou

109 C5 and was associated with decreasing virion infectivity and viral replication in primary lymphocytes

110 sruption of Nef homodimers may control HIV-1 infectivity and viral spread by enhancing virion incorpo

111 rectal chancres, to reduce their duration of infectivity and, hence, reduce onward transmission.Men w

112 ce of FHL1 has a stimulatory effect on CHIKV infectivity and, subsequently, the infection spread.

113 concentration, relevant to clinical testing, infectivity and, therefore, oncolytic activity will not

114 l observations, in combination, suggest that infectivity (and, by inference, oncolytic activity) of r

115 tibody-binding assays, measurements of virus infectivity, and analyses of lipid membrane order, we fo

116 ol exhibit high viability, maintain in vitro infectivity, and are infectious to interferon-gamma (IFN

117 Our new findings on the phylogeny, infectivity, and immunoreactivity of HBoV1 capsid varian

118 y during infection, decreased viral specific infectivity, and increased the number and proportion of

119 arkable morphological abnormality, decreased infectivity, and no replicative ability, which correlate

120 vo and in vitro studies of cellular tropism, infectivity, and pathogenesis of influenza viruses durin

121 ion and negligible impacts on IAV infection, infectivity, and pathogenicity, NS1-ARF2(1-8) provides a

122 nal N-glycosylation can therefore make HSV-1 infectivity, and possibly masking of immunogenic peptide

123 lar cyclic lipopeptides had no effect on CoV infectivity, and the inhibitory effect of surfactin exte

124 enrolled in 2 studies to assess the safety, infectivity, and transmissibility of a new P. vivax isol

125 The mobility, infectivity, and ultimately pathogenesis of Plasmodium f

126 y host cell proteases is essential for viral infectivity, and understanding the mechanisms for HA pro

127 Gametocyte persistence and infectivity are lower when PQ is combined with AL compar

128 racteristics of vCJD brain PrP(D), including infectivity, are preserved in PrP(D) present in urine an

129 tive genetic interaction mapping using viral infectivity as a functional readout and constructed a vi

130 exosomes, is mainly responsible for exo-HAV infectivity as assessed by methylene blue inactivation o

131 human immunodeficiency virus type 1 (HIV-1) infectivity as Nef does.

132 of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides

133 A culture-based infectivity assay was used to evaluate viral inactivatio

134 own owing to the lack of a readily available infectivity assay.

135 We carried out virus infectivity assays on bat cell lines expressing induced

136 Large-scale virulence and infectivity assays using insect and mouse models indicat

137 tagenesis of OC43, BCoV, and PHEV S1(A), and infectivity assays with BCoV-S-pseudotyped vesicular sto

138 oach to study JCPyV infection in vitro Using infectivity assays, quantitative PCR, and immunofluoresc

139 is unraveling the mechanisms that drive high infectivity, broad tissue tropism, and severe pathology.

140 cess disrupts viral envelopes and diminishes infectivity but leaves cellular membranes intact.

141 rradiation of viral particles suppressed HBV infectivity but not the induction of cytokines in PHH, s

142 S glycoprotein decreased virus stability and infectivity, but greatly enhanced syncytium-forming abil

143 -2 using cell-based culture likely indicates infectivity, but there are limited data on the correlati

144 results indicate that SERINC5 inhibits HIV-1 infectivity by altering the conformation of gp120 on vir

145 plays an essential role in enhancing virion infectivity by antagonizing the host restriction molecul

146 Thus, D614G may increase infectivity by assembling more functional S protein into

147 ermore, the F287A substitution reduced viral infectivity by attenuating subgenomic RNA synthesis.

148 f the negative imprinting of virion particle infectivity by IFITMs and about its relationship with ta

149 to budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion.

150 istance to proteinase K (PrP(res)), residual infectivity by mouse bioassay and in vitro templating ac

151 utants lacking Bb6S RNA were compromised for infectivity by needle inoculation, but injected mice ser

152 ncurrent with inactivation; sigma3 preserves infectivity by preventing mu1 rearrangements.

153 enterocyte brush border supports intestinal infectivity by SARS-CoV-2.

154 that the PR is critical for HIV-1 fusion and infectivity by stabilizing Env trimers.

155 MA-CA protein into HIV-1 particles inhibited infectivity by ~95%, and the resulting viral particles e

156 The infectivity (cell-killing activity by infecting cells) o

157 for JCPyV persistence, but retained the CNS infectivity, cell tropism, and neuropathology of the par

158 t the D614G substitution enhances SARS-CoV-2 infectivity, competitive fitness, and transmission in pr

159 -Ob (Ob), originally mapped within the virus infectivity controller 1 (vic1) locus, is responsible fo

160 ice carry an additional genetic locus, virus infectivity controller 2 (vic2), that abrogates neonatal

161 Upon challenge, compared to infectivity controls, 3/3 chloroquine arm subjects displ

162 Upon challenge, compared to infectivity controls, 3/3 chloroquine arm subjects displ

163 washout, subjects, including treatment-naive infectivity controls, underwent homologous PfSPZ control

164 washout, subjects, including treatment-naive infectivity controls, underwent homologous, PfSPZ contro

165 anisms, including enhanced viral release and infectivity, decrease of cell reinfection, and protectio

166 w that the N57A mutation confers a postentry infectivity defect that significantly differs in magnitu

167 y has demonstrated genetic variation in host infectivity, despite strong evidence for considerable ph

168 related HIV-1 strains may impart significant infectivity differences, careful consideration should be

169 using current approaches for assessing HuNoV infectivity (e.g., surrogates, molecular methods).

170 at an "efflorescence/deliquescence divergent infectivity" (EDDI) model accurately predicts the RH-dep

171 Human immunodeficiency virus-1 viral infectivity factor (Vif) is an intrinsically disordered

172 ciency virus type 1 (HIV-1) encode the viral infectivity factor (Vif) protein to counteract APOBEC3 p

173 a viral accessory protein called the virion infectivity factor (Vif), which recruits A3 proteins to

174 Vif (viral infectivity factor) is a protein that is essential for t

175 incubated CoVs with LPS and PG and evaluated infectivity, finding no change following LPS treatment.

176 nsistent with arms-race dynamics while phage infectivity fluctuated through time, as expected when co

177 Results showed dose-dependent infectivity from 43% for 8 x 102 PfSPZ to 100% for 4.8 x

178 of the genes on lp36, we identified a novel infectivity gene of unknown function, bbk13, which encod

179 Strain-to-strain variation in host-specific infectivity has been documented, but the molecular basis

180 plasmid 36 (lp36) is critical for mammalian infectivity; however, the full complement of genes on lp

181 sed individual to survive the infection) and infectivity (i.e. the propensity of an infected individu

182 ith antibody escape phenotypes that maintain infectivity.IMPORTANCE Biologics based on recombinant AA

183 sults suggest that HBZ contributes to HTLV-1 infectivity.IMPORTANCE Human T-cell leukemia virus type

184 ts flavivirus replication by impairing viral infectivity.IMPORTANCE We provide evidence that the cell

185 ude that SAMHD1 is an essential modulator of infectivity in a sex-dependent manner in macrophages, co

186 tive inhibitors reduced SARS-CoV-2 entry and infectivity in cell culture.

187 ry samples, symptom onset to test (STT), and infectivity in cell culture.

188 We tested for CWD infectivity in cultured slices using sensitive seeding a

189 generating these deletion variants and their infectivity in different animal models would improve our

190 erstanding of what factors may determine HIV infectivity in humans.

191 of HIV-1-infected T-cell lines promote KSHV infectivity in immortalized and primary human oral epith

192 ed by HIV-infected T-cell lines promote KSHV infectivity in immortalized and primary oral epithelial

193 roaches, we have further characterized JCPyV infectivity in NHAs.

194 formation on virus replication, immunity and infectivity in specific sites of the body.

195 ease of aerosolization and high retention of infectivity in the aerosol form.

196 es insight into how viral particles maintain infectivity in the environment.

197 s essential for thermotolerance and parasite infectivity in the mammalian host.

198 Adding infectivity in the selection objective accelerated the d

199 ein, and blocking this binding reduces virus infectivity in vitro and also affects gK and UL20 subcel

200 tion of RV with SFB-containing feces reduced infectivity in vitro, suggesting direct neutralization o

201 To determine how SPP affects HSV-1 infectivity in vivo, the SPP gene was deleted using a ta

202 irect evidence for genetic variation in host infectivity, in addition to variation in resistance and

203 nce of gRNA in virions is required for viral infectivity, in its absence, Gag can assemble around cel

204 gizes with the EGFR cascade, but its role in infectivity, inclusions, and EMT induction is unknown.

205 Infectivity is a critical determinant in informing publi

206 piratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 20

207 that are important for virion production and infectivity is particularly dependent on the EBV SM prot

208 se mechanism by which SERINC5 inhibits HIV-1 infectivity is unclear, previous studies have suggested

209 but whether illness severity correlates with infectivity is unknown.

210 owever, rigorous determination of SARS-CoV-2 infectivity is very difficult owing to its continuous ev

211 human immunodeficiency virus type 1 (HIV-1) infectivity, is a single-stranded DNA (ssDNA) deoxycytid

212 target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelop

213 s the most thermolabile strain (6 to 7 log10 infectivity loss), followed by 22L (5 log10) while BSE w

214 e loss of PrP(res) and a radically different infectivity loss: RML was the most thermolabile strain (

215 For infectivity, many epidemics with few individuals give su

216 lly predominant SARS-CoV-2 strains increased infectivity, modestly enhanced responsiveness to the ACE

217 hat incorporate IFITMs and exhibit decreased infectivity (negative imprinting of virion infectivity).

218 partially contributes to the mucin-enhanced infectivity of A. baumannii in this model.

219 hes GAG expression reduced CHIKV binding and infectivity of all strains.

220 mucin has been commonly used to enhance the infectivity of bacterial pathogens, including Acinetobac

221 s and optimized a screening protocol for the infectivity of biological samples in this CWD slice cult

222 as ADgO(GT1a)] drastically reduced cell-free infectivity of both strains on fibroblasts and epithelia

223 We used humanized mouse models to assess the infectivity of both wild-type HTLV-1 (HTLV-1(WT)) and HT

224 n processing of viral glycans and reduce the infectivity of bovine viral diarrhea and dengue viruses

225 oV-2 receptor, could contribute to increased infectivity of COVID-19 in patients with diabetes, but A

226 The cellular protein SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is

227 a result of differences in the quantity and infectivity of extracellular released progeny.

228 The higher infectivity of Fe-SODB overexpressers compared with WT p

229 I696N and I696T abrogated infectivity of H77/JFH1 and broadly increased neutraliza

230 In contrast to exo-HAV, infectivity of HAV particles is pH-independent and requi

231 However, the specific infectivity of HCMV virions suffers in the absence of UL

232 NC5 is a host cell protein that inhibits the infectivity of HIV-1 by a novel and poorly understood me

233 Point mutations at each position reduced the infectivity of HIV-1 produced from transfected 293T cell

234 ation and reveal a new strategy to limit the infectivity of HIV.

235 re-exposure prophylaxis (PrEP) to reduce the infectivity of HIV.

236 ral infection (SEVI), that enhance the viral infectivity of human immunodeficiency virus.

237 yl-linked serine ubiquitination and promotes infectivity of Legionella pneumophila, a pathogenic bact

238 nked (PR) serine ubiquitination and promotes infectivity of Legionella pneumophila.

239 and respiratory symptoms were indicators of infectivity of Nipah virus.

240 The infectivity of oncolytic rNDV was found to be independen

241 ; thus, its ability to determine duration of infectivity of patients is limited.

242 Infectivity of patients with Ct > 24 and duration of sym

243 testing does not provide information on the infectivity of patients, seroprevalence studies may enab

244 We explored whether sex affects HIV-1 infectivity of primary human macrophages and CD4+ T cell

245 or CD43 in virus-producing cells reduces the infectivity of progeny virions and that HIV-1 infection

246 that has no effect on HCV RNA production or infectivity of progeny virus.

247 A comparison of the infectivity of PrP(Sc) attached to SMA lipid particles i

248 tionally, Mov10 overexpression decreases the infectivity of released virus, unlike control P-body pro

249 RINC family, especially SERINC5, inhibit the infectivity of retroviral virions.

250 Furthermore, infectivity of T3SA(+) was diminished to levels similar

251 Using purified virions, we assessed infectivity of the gH-null mutant in diverse mammalian c

252 ssed whether flow and peristalsis impact the infectivity of the human pathogen Shigella within a 3D c

253 on of its ATG initiation codon abolishes the infectivity of the molecular clone HTLV-1(p12KO) In rabb

254 ared with that of wild-type (WT) strain, the infectivity of the mutant was severely attenuated in a m

255 elative to that of the wild-type strain, the infectivity of the mutant was severely attenuated in a m

256 Primary endpoints were safety and infectivity of the new isolate.

257 TbIP(3)R), which is essential for growth and infectivity of the parasite Trypanosoma brucei However,

258 However, infectivity of the polyomavirus simian virus 40 (SV40) w

259 C HIV-1.IMPORTANCE We sought to enhance the infectivity of three SHIV stocks by optimization of a ke

260 PHgO(GT2a) increased cell-free infectivity of TR in both cell types, but spread in fibr

261 iral envelope glycoprotein distinctly affect infectivity of two different viruses.

262 ited the degradation of A3G, and reduced the infectivity of viral particles by increased packaging of

263 ticity, cell growth and differentiation, and infectivity of viruses and other pathogens.

264 cts are hypothesized to be important in the "infectivity" of amyloids and are linked to the developme

265 All mutants were compromised in infectivity on N. benthamiana and papaya.

266 mechanism of the virus, which regulates its infectivity, pathogenesis and host range.

267 ce of lipid A as a crucial determinant in Yp infectivity, pathogenesis, and host innate immune evasio

268 ins, salts, and sugars, which can affect the infectivity potential of the virus and inhibition of thi

269 ptibility (propensity to acquire infection), infectivity (propensity to transmit infection to others)

270 he most thermostable strain with low or null infectivity reduction showing a clear dissociation betwe

271 SERINC5 and subsequent enhancement of viral infectivity require Nef homodimers and support a mechani

272 Surface stability was assessed using infectivity, SARS-CoV-2 survived on stainless steel, pla

273 ces MLV replication but also increases HIV-1 infectivity similarly as Nef.

274 While specific aspects of the coronavirus infectivity, spread, and routes of transmission are stil

275 ite and D614G, have evolved to balance virus infectivity, stability, cytopathicity and antibody vulne

276 However, comparative ZIKV infectivity studies in New World primates are lacking.

277 disrupted ME-infected cells contained scant infectivity, suggesting that the efficient cell-to-cell

278 ion polymerase chain reaction (RT-qPCR)) and infectivity (TCID(50)).

279 a significantly higher transmission rate and infectivity than SARS-CoV-1 and has infected in a few mo

280 l to have rapid quantitative tests for viral infectivity that can be performed without strict biocont

281 iated exosomes contributes to enhancing KSHV infectivity through the epidermal growth factor receptor

282 cyte carriers from Burkina Faso, we assessed infectivity to mosquitoes by direct skin feeding and mem

283 Taking advantage of the infectivity to the standard strain C. parasitica EP155,

284 and these traits are associated with higher infectivity toward a defense sequestering herbivore.

285 bolic resistance and benzoxazinoid-dependent infectivity toward the western corn rootworm.

286 s been redefined based on infectiousness and infectivity, ushering in a new era of HIV prevention wit

287 banded cucumber beetle (D. balteata), while infectivity varied strongly for WCR larvae.

288 L128-131, is RL13 impaired, and produces low infectivity virions in fibroblasts, whereas TB40/e (TB)

289 Accordingly, XG4J viability and infectivity was also restored by the exogenous expressio

290 genetic variation in both susceptibility and infectivity was combined with quantitative genetics sele

291 In conclusion, host infectivity was found to be an important trait to target

292 This sex-dependent difference in macrophage infectivity was independent of the requirement for CD4/C

293 SARS-CoV-2 Vero cell infectivity was only observed for RT-PCR Ct < 24 and STT

294 No mortality or clinical signs and similar infectivity were observed in mallards inoculated with th

295 insic membrane protein that suppresses HIV-1 infectivity when incorporated into budding virions.

296 APX expression restored APX single-knockout infectivity, while expression of catalytically inactive

297 By assessing the infectivity with > 18 000 pairwise challenges, we docume

298 g cell type-dependent dysfunction (affecting infectivity with Vero cells much more than with the 293

299 s abolished or significantly decreased HIV-1 infectivity without affecting viral production.

300 LID/DeltaM2-2/1030s had excellent infectivity without evidence of genetic instability, ind