ライフサイエンスコーパス: infertile

1 ertility and mice lacking both receptors are infertile.

2 Mice deficient in this Fue homologue are infertile.

3 t (Lep(ob/ob)) mice are obese, diabetic, and infertile.

4 ne epithelium, and female UtEpialphaERKO are infertile.

5 orn and grow normally but are reproductively infertile.

6 t for members of the CatSper gene family are infertile.

7 anulosa cell tumors that renders the animals infertile.

8 but all PTM-ARKO males were azoospermic and infertile.

9 n-Crtc1(-/-) mice are hyperphagic, obese and infertile.

10 ant mice were phenotypically normal but were infertile.

11 ice in which Nell2 had been knocked out were infertile.

12 of mice expressing the hypomorphic allele is infertile.

13 ps per month, Bmp2d/d females are completely infertile.

14 sequently, the Ant4-deficient male mice were infertile.

15 ient in both AtATM and AtNBS1 are completely infertile.

16 wever, both males and females are completely infertile.

17 have normal fertility, Tpst2(-/-) males are infertile.

18 The female C/EBPbeta-null mice are infertile.

19 and follicle maturation, Plk1 cKO mice were infertile.

20 tic fringe null female mice were found to be infertile.

21 ts in meiotic chromosome segregation and are infertile.

22 action of adult "escapers" that are weak and infertile.

23 d phosphatase, in testis and sperm, are also infertile.

24 in, and all of these high-titer monkeys were infertile.

25 eriod were hyperphagic, obese, diabetic, and infertile.

26 s observed only when cases were concurrently infertile.

27 le and grossly normal, Zar1(-/-) females are infertile.

28 tility, yet CatSper2-/- males are completely infertile.

29 and immune deficient, and mutant males were infertile.

30 le and female Ercc1-deficient mice were both infertile.

31 Cpe(fat/fat) mice are obese, diabetic, and infertile.

32 6-deficient males surviving to maturity were infertile.

33 e and found that homozygous mutant males are infertile.

34 ficient mice, and some of the male mice were infertile.

35 show progressive motility and male mice were infertile.

36 esults in Man2a2 null males that are largely infertile.

37 gic, cold intolerant, insulin resistant, and infertile.

38 Resulting females were infertile.

39 ice lacking VDAC3 are healthy, but males are infertile.

40 HDLs, ovulate dysfunctional oocytes, and are infertile.

41 y the NHE3 knockout and alpha ERKO mice were infertile.

42 ritestin (ADAM 3) and found mutant males are infertile.

43 ry, have low levels of progesterone, and are infertile.

44 nd approximately 60% of Tnp1-null males were infertile.

45 ause mice lacking PR fail to ovulate and are infertile.

46 exception that males, but not females, were infertile.

47 protein results in mice that are healthy but infertile.

48 tdh knock-out mice are viable, but males are infertile.

49 ble to conceive after a year and are labeled infertile.

50 ts receptor fail to complete puberty and are infertile.

51 ons that inactivate kisspeptin signaling are infertile.

52 isk (ie, perceived no risk but were impaired/infertile; 16.3% of male and 5.3% of female survivors).

53 ring asexual development in both fertile and infertile adults, and was also enriched in a population

54 While female wild-type mice became infertile after 4 months of HCD feeding, infertility ons

55 and 319 (51%) were concerned about becoming infertile after treatment.

56 blishing a permanent reference of benign vs. infertile alleles.

57 the transgene in the gonads and the mice are infertile, allowing examination of the function of BRCA2

58 ations in both GSL1 and GSL5 rendered pollen infertile, although such a chromosome could be transmitt

59 a targeted deletion in the Tdrd12 locus are infertile and derepress retrotransposons.

60 Smad5 Smad8 conditional knockout mice become infertile and develop metastatic granulosa cell tumors.

61 Male Ts65Dn DS mice are infertile and display a profound low bone mass phenotype

62 cking the transcription factor C/EBPbeta are infertile and display markedly reduced estrogen (E)-indu

63 at male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack

64 Male and female mice are also infertile and exhibit a primary defect in gametogenesis.

65 ce deficient in the tyrosine kinase cSrc are infertile and exhibit improper cauda epididymis developm

66 In this strain, the male mice are infertile and exhibit severe deficiencies in spermatogen

67 Fancb mutant mice were infertile and exhibited primordial germ cell (PGC) defec

68 px4-null mice rescued by the sGPX4 gene were infertile and exhibited sperm malformation.

69 d obesity (DIO) wild-type (DIO-WT) mice were infertile and experienced increased circulating testoste

70 pR) (ob/ob and db/db mice, respectively) are infertile and fail to enter puberty.

71 These groups are designated as infertile and fertile in the text.

72 incomplete blockage of reproductive tract in infertile and fertile males, respectively.

73 hin populations of single spermatocytes from infertile and fertile men who reported for assisted repr

74 Gapds(-/-) males were infertile and had profound defects in sperm motility, ex

75 termined that Akita homozygous male mice are infertile and have reduced testis size and abnormal morp

76 Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with norma

77 with oocyte-specific depletion of Snf2h are infertile and oocytes lacking Snf2h fail to undergo meio

78 nitis biovar of Chlamydia trachomatis became infertile and sustained high rates of hydrosalpinx forma

79 Tbc1d20 (ZFN/ZFN) males are infertile and the analysis of the seminiferous tubules i

80 ing the sperm tail-specific CATSPERdelta are infertile and their spermatozoa lack both Ca(2+) current

81 mice overexpressing aromatase in testis were infertile and/or had larger than normal testicles.

82 ce homozygous null for alpha2(alpha2-/-) are infertile, and spermatogenesis is disrupted at mid- or l

83 Male SAFB1 null mice were infertile, apparently because of low circulating levels

84 Female SR-BI KO mice are infertile, apparently because of their abnormal choleste

85 Women become infertile approximately 10 years before menopause, and a

86 Female mice were infertile as a result of anovulation from hemorrhagic cy

87 inant source of cAMP in male germ cells, are infertile, as the sperm are immotile.

88 s of the N-end rule proteolytic pathway, are infertile associated with meiotic arrest at prophase I.

89 We crossed the self-infertile ATP synthase beta subunit knockout parasites w

90 Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correl

91 this protein are viable, but female mice are infertile because of complete failure of mature follicle

92 Male NKCC1-deficient mice are infertile because of defective spermatogenesis, as shown

93 bly, adult FOXA2-deleted mice are completely infertile because of defects in blastocyst implantation

94 Similar to Pgr null mice, Pgr null rats were infertile because of deficits in sexual behavior, ovulat

95 Male mice deficient in Spem1 were completely infertile because of deformed sperm characterized by a b

96 meric and heterozygous males were completely infertile because of disrupted spermiogenesis characteri

97 eletion ofMsxgenes (Msx1(d/d)/Msx2(d/d)) are infertile because of implantation failure associated wit

98 The AF2ERKI male homozygotes are infertile because of seminiferous tubular dysmorphogenes

99 cil-1 mutants are infertile because of sperm activation and motility defec

100 Moreover, Styx(-/-) males are infertile because of structural head abnormalities in re

101 normal number of oocytes but were completely infertile, because ovulated oocytes were arrested at the

102 c targeting of the Great gene in mice causes infertile bilateral intraabdominal cryptorchidism.

103 human BOULE transgene can advance meiosis in infertile boule mutant flies.

104 Here, we studied two infertile brothers exhibiting normal sperm morphology bu

105 Vglut2-ires-Cre;Esr1(lox/lox) mice were also infertile but displayed a wider range of deficits, inclu

106 Pmca4-/- male mice were infertile but had normal spermatogenesis and mating beha

107 The Pten/Kras mutant mice were infertile but lacked granulosa cell tumors.

108 Female mice were infertile, but male mice were not.

109 ral blood or bone marrow) become permanently infertile, but others retain or recover fertility.

110 Slo3(-/-) male mice are infertile, but Slo3(-/-) sperm exhibit some fertility wi

111 acked Gemc1, Mcidas or Ccno were found to be infertile, but the origin of this defect has remained un

112 who were previously thought to be hopelessly infertile, but who are now able to conceive their own bi

113 e initially fertile, Taf4b-null males become infertile by 3 mo of age and eventually exhibit seminife

114 gressive dominants render their subordinates infertile by inducing chronic physiological "stress." Ho

115 diment infilling, croplands will be rendered infertile by salt, and water scarcity will pit growing d

116 A total of 650 infertile cases and 698 fertile controls were compared.

117 ording ionic currents from spermatozoa of an infertile CatSper-deficient patient, we demonstrate that

118 e induces fertilizing capacity in sperm from infertile CatSper1 (Ca(2+) channel), Adcy10 (soluble ade

119 M2 (fertilin beta) or ADAM3 (cyritestin) are infertile; cauda epididymal sperm (mature sperm) from th

120 arf8 double-null mutant flowers arrested as infertile closed buds with short petals, short stamen fi

121 Species adapted to infertile conditions are systematically reduced at high

122 Likewise, obesity is associated with infertile conditions such as polycystic ovary syndrome.

123 nfertility who did not have tubal occlusion (infertile controls) and 584 primigravid women (pregnant

124 lving the women with tubal occlusion and the infertile controls, the odds ratio for tubal occlusion a

125 cimens from each of the male partners in 765 infertile couples and 696 fertile couples at nine sites.

126 However, many infertile couples continue to be labeled with the diagno

127 The female partners in the infertile couples had normal results on fertility evalua

128 ouse and human embryos, embryos from fertile/infertile couples, and following growth factor supplemen

129 utinely used to evaluate the male partner in infertile couples, sperm measurements that discriminate

130 Among infertile couples, treatment with induction of superovul

131 so observed between embryos from fertile and infertile couples, which were largely equalized in respo

132 ver, as do new methods to diagnose and treat infertile couples.

133 ole for varicocelectomy in the management of infertile couples.

134 singly becoming a concern for physicians and infertile couples.

135 bias resulting from exclusion of relatively infertile couples.

136 ovarian failure, a disease that burdens many infertile couples.

137 enable the production of healthy gametes for infertile couples.

138 om the retroposition from its parental gene, Infertile crescent (Ifc), and integrated into heterochro

139 nt sperm functions, Calpha(2) null males are infertile despite normal mating behavior.

140 have normal fertility, Tpst2(-/-) males are infertile despite normal spermatogenesis.

141 lt in progeny with the genetic makeup of the infertile donor male.

142 ntation of spermatogonial stem cells from an infertile donor to a permissive testicular environment c

143 ants consuming soy-based infant formulas are infertile due in part to uterine implantation defects.

144 nscription factor 1 (HSF1) in the testis are infertile due to a block in spermatogenesis.

145 oule, the Drosophila homologue of Dazl1, are infertile due to a G(2)/M meiotic block.

146 e for Dazl1, the mouse homologue of DAZ, are infertile due to a meiotic entry defect.

147 collected from mice lacking Spag6, which are infertile due to a motility defect.

148 dditionally, the homozygous male mutants are infertile due to azoospermia, a condition that was not a

149 cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of

150 ut (cKO; Ltf (iCre/+) Foxa2 (f/f) ) mice are infertile due to defective embryo implantation arising f

151 However, Stat3(d/d) female mice were infertile due to defective embryo implantation.

152 le, the homozygous males unexpectedly proved infertile due to defective spermatogenesis, which was ev

153 Female Wnt7a-Cre(+)PR(f/-) mice are infertile due to defects in embryo attachment, stromal c

154 Both Drosha and Dicer cKO males were infertile due to disrupted spermatogenesis characterized

155 Smad2/3 cKO mice were infertile due to endometrial hyperproliferation observed

156 Odf2(+/-) males were infertile due to haploinsufficiency caused by heterozygo

157 Adults are infertile due to lack of mature germ cells, and 50% deve

158 t promoter, and female mice lacking EGR1 are infertile due to LHbeta deficiency.

159 anicle was significantly reduced in size and infertile due to multiple defects in floral development.

160 Female PR knockout mice are infertile due to ovarian defects.

161 Female mice deficient in TNFIP6 are infertile due to the lack of a correctly formed cumulus

162 Both male and female homozygous KO mice were infertile, due to abnormal genital organs.

163 sequences lead to the production of flaccid, infertile eggs with a soluble, rather than insoluble, vi

164 ne as sV23 protein null mutants lay flaccid, infertile eggs.

165 rred in mountainous regions due to abandoned infertile farmland, secondary succession, and government

166 Farming infertile fish is the most effective genetic-containment

167 d from these conditions were all found to be infertile fish that possessed minimally-developed gonads

168 mmersion is an effective strategy to produce infertile fish without introducing transgenic modificati

169 matic cells, which resulted in generation of infertile fish.

170 rsion technology to produce large numbers of infertile fish.

171 flox);Esr2(cre/+);Runx2(flox/flox) mice were infertile; follicles developed to the preovulatory folli

172 te, randomized trial, 666 women who had been infertile for more than 1 year and were scheduled to und

173 ales progressively lost fertility and became infertile from 6 to 12 mo.

174 precision cytogenetics for annotation of the infertile genome, suggests that these mechanisms should

175 stological evaluation of the testes from the infertile group showed variable degrees of Leydig cell h

176 The median of the lower allele size in the infertile group was only 2.5 kb compared with 3.4 kb in

177 nomics program at The Jackson Laboratory are infertile, have low epididymal sperm concentrations, and

178 uction of diploid males that are inviable or infertile, imposing a high cost on matings between close

179 wn fertility history, 274 were classified as infertile, including 30 classified as sterile.

180 eduction in testicular Usp14 levels and were infertile, indicating that Usp14 is required for develop

181 unmodified centrioles, engaged or not, were "infertile," indicating that engagement specifically bloc

182 entially clinically important for asthmatic, infertile individuals and society because treatment of t

183 m of the present study was to investigate an infertile interspecific hybrid (recipient) as an appropr

184 leles whose interaction produces inviable or infertile interspecific hybrids but does not reduce fitn

185 Consistent with this notion, 12 PEGs in the infertile interspecific hybrids matched MEGs in fertile

186 ting (W), to determine if stem cells from an infertile male were capable of generating spermatogenesi

187 ion, the diagnosis should be suspected in an infertile male with oligospermia or azoospermia with low

188 ur ability both to diagnose and to treat the infertile male.

189 utionized the diagnosis and treatment of the infertile male.

190 Because of these severe abnormalities, these infertile males presented with diaphragmatic hernias, he

191 Exome sequencing of infertile males revealed three heterozygous SYCP2 frames

192 Cases were defined as infertile males whose partner had an infertility evaluat

193 Instead, brca2(Q658X) homozygotes develop as infertile males with meiotic arrest in spermatocytes.

194 There are infertile males, including human patients, who have a hi

195 f limited success in separating fertile from infertile males.

196 ects that reduce the wild population through infertile matings.

197 Next, we screened four large cohorts of infertile men and identified three additional individual

198 ements that discriminate between fertile and infertile men are not well defined.

199 were collected from 35 healthy donors and 35 infertile men at the Andrology laboratory from August 20

200 smission to the offspring of these otherwise infertile men conceived using an assisted reproductive t

201 berrations in testicular tissue samples from infertile men confirmed to have impaired spermatogenesis

202 ns relevant to immune infertility, sera from infertile men containing antisperm antibodies (ASA) were

203 A subset of infertile men exhibit reduced testosterone and enhanced

204 that of segregation of unbalanced gametes in infertile men harboring a BCA, and provides evidence of

205 In this review, we present evidence that infertile men have poor overall health and increased mor

206 <0.05) and mRNA (P<0.05) in spermatozoa from infertile men were significantly lower than those from f

207 of systemic disease and illness harbored by infertile men who otherwise appear healthy.

208 and lipid peroxidation (Bodipy probe) in 18 infertile men with grade II or III varicocele, and 20 fe

209 chemical and biophysical changes in HSF from infertile men with spinal cord injury compared to age-ma

210 Moreover, cross-sectional data revealed that infertile men with the highest serum Klotho levels had s

211 id peroxidation were significantly higher in infertile men with varicocele compared to fertile men.

212 xtensive overlap between the fertile and the infertile men within both the subfertile and the fertile

213 Infertile men's seminal fluid had significantly lower G-

214 ts helped to distinguish between fertile and infertile men, none was a powerful discriminator.

215 te that TAS1R3 and GNAT3 activators may help infertile men, particularly those that are affected by s

216 protamine-2 have been identified in sperm of infertile men, suggesting that our results may have clin

217 at intake and a lower sperm concentration in infertile men.

218 nd changes in chemokine-cytokine profiles in infertile men.

219 ment exists to improve semen quality in most infertile men.

220 rm production in a significant percentage of infertile men.

221 ements in discriminating between fertile and infertile men.

222 nts for the main sperm defect encountered in infertile men.

223 normal men, but was significantly reduced in infertile men.

224 to be significantly reduced in the semen of infertile men.

225 n cause of meiotic arrest and azoospermia in infertile men.

226 ve azoospermia is unknown in the majority of infertile men.

227 ervation of low CHD5 expression in testes of infertile men.

228 tic mutant Mei1 was isolated in a screen for infertile mice descended from chemically mutagenized emb

229 r pituitary of fertile mice lacking Ink4c or infertile mice doubly deficient for Ink4c and Ink4d prod

230 In contrast, sperm from infertile mice lacking the Ca(2+) efflux pump PMACA4 wer

231 Finally, the oviducts of infected infertile mice showed evidence of caspase-mediated cleav

232 Here, we examined two infertile mouse models, Steel/Steel(Dickie)(Sl/Sl(d)) an

233 que of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white s

234 changes in the reproductive cycle in obese, infertile ob/ob mice with no circulating leptin and infe

235 le ob/ob mice with no circulating leptin and infertile, obese, agouti (Ay/a) mice with high circulati

236 between species often leads to non-viable or infertile offspring, yet examples of evolutionarily succ

237 d9(-/-) and Izumo1(-/-) mice are healthy but infertile or severely subfertile due to defective sperm-

238 rcentage of insects that were dead/deformed, infertile, or fertile and subjected to chi-squared analy

239 Two percent of men are infertile owing to defects in sperm production.

240 yos, whereas UBR2(-/-) males were viable but infertile, owing to the postnatal degeneration of the te

241 mated with sham-infected male mice (0%) were infertile (P < 0.05).

242 s, is viable and could be an alternative for infertile patients suffering from Odf2-DDS.

243 e-transcription PCR on spermatozoal RNA from infertile patients with wide-ranging sperm concentration

244 les (22-54 years; 44 fertile controls and 27 infertile patients), along with total levels and localis

245 ave been isolated by positional cloning from infertile patients.

246 t time described in the same ejaculate of an infertile, phenotypically normal male patient.

247 onderance of patients with varicocele in the infertile population leads to the search for causality a

248 ogesterone receptor knockout (PRKO) mice are infertile primarily due to ovulatory failure and lack th

249 such that older multiply mated males become infertile principally via reduced sperm transfer and via

250 ertility by donor stem cells transplanted to infertile pups.

251 the transduced stem cells into the testes of infertile recipient mice, approximately 4.5% of progeny

252 of spermatogenesis upon transplantation into infertile recipient testes, were present almost exclusiv

253 recipient testes, and restored fertility to infertile recipients.

254 n the containers, which were embedded within infertile sand.

255 However, whereas db/db mice are infertile, short and diabetic, s/s mice are fertile, lon

256 In addition, these flies are infertile, show significantly reduced longevity, and are

257 attributed to either explosive radiation on infertile soils under fire-prone, summer-dry climates or

258 specially with respect to plant breeding for infertile soils.

259 g fertile areas whereas thin roots dominated infertile soils.

260 ockout parasites with a male-deficient, self-infertile strain of P. berghei, which restored fertility

261 drosalpinx were 2.11 times more likely to be infertile than those without hydrosalpinx (95% CI: 1.02-

262 cking FKBP4 have been previously reported as infertile through implantation failure.

263 Female mice are also rendered infertile through rAAV-dependent expression of an antibo

264 For example, Muslim couples who are infertile throughout the world are permitted to use assi

265 idence of aneuploidy in the spermatocytes of infertile top3 beta(-/-) males.

266 Although Prl receptor (PrlR)-null mice are infertile, we were able to maintain pregnancies in a few

267 nrolment or had been previously diagnosed as infertile were excluded.

268 D-type cyclin-dependent kinases (Cdks), are infertile, whereas female fecundity is unaffected.

269 -pathway mutations, Marf1 mutant females are infertile, whereas mutant males are fertile.

270 ) females, 20% of 129S6 NRC(+/-) females are infertile while 80% are hypofertile.

271 In one group animals were completely infertile, while in the other group animals were fertile

272 ransgenic males that either kills or renders infertile wild-type female recipients and an antidote ex

273 The mutant males became infertile with age, with all LC in older testis showing

274 bertal recipient macaques that were rendered infertile with alkylating chemotherapy.

275 Male Camk4-/- mice are infertile with impairment of spermiogenesis in late elon

276 with a high level of mutant germ cells were infertile with low sperm counts and a high frequency of

277 stantial concern at diagnosis about becoming infertile with treatment.

278 Vgat-ires-Cre;Esr1(lox/lox) mice were infertile, with abnormal estrous cycles, and exhibited a

279 S-AR(-/y) mice were infertile, with spermatogenic arrest predominately at th

280 Ten to 15% of couples are infertile, with the most common causes being linked to t

281 PAG1 antibodies derived from the serum of an infertile woman were reported to cause sperm agglutinati

282 d obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 w

283 Finally, parallels to the overall health of infertile women are presented.

284 Pregnancy rates among infertile women have been reported to increase after hys

285 er was similar to the US national mean among infertile women of a similar age undergoing in vitro fer

286 ce serum antibody titers were recorded among infertile women seen at St. Michael's Hospital in Bristo

287 in 27 hospitals in the Netherlands in which infertile women who were undergoing hysterosalpingograph

288 d the pregnancy rate in overweight and obese infertile women who were undergoing in vitro fertilizati

289 We randomly assigned infertile women with a body-mass index (the weight in ki

290 re female germ cells for future treatment of infertile women with a diminishing ovarian reserve and f

291 ts could provide a new treatment regimen for infertile women with low responses to the traditional go

292 We randomly assigned 626 infertile women with the polycystic ovary syndrome to re

293 rior to metformin in achieving live birth in infertile women with the polycystic ovary syndrome, alth

294 higher live-birth and ovulation rates among infertile women with the polycystic ovary syndrome.

295 orylation of STAT3 in eutopic endometrium of infertile women with this disorder leading to over-expre

296 on 3347 consecutive treatment cycles in 1494 infertile women, 441 of which resulted in pregnancy.

297 In obese infertile women, a lifestyle intervention preceding infe

298 ncidence of high-order multiple pregnancy in infertile women, though only to a limited extent and at

299 in which we analyzed 26 overweight or obese infertile women.

300 k of formation of the outer segment, whereas infertile wpk males developed spermatids with very short