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1 SGs (ISG(low)), low viral loads and abundant infiltrating activated CD8(+) T cells and macrophages.
5 n are important methods in the prediction of infiltrating and non-infiltrating lymph nodes, and the d
6 ained with this interface were examined with infiltrating and noninfiltrating tumors, and were compar
7 ls, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors a
8 s has begun to define the phenotypes of both infiltrating and resident immune cells, as well as paren
9 text of acute inflammation and discover both infiltrating and tissue-resident immune cells to be visi
10 atients and shows that circulating and tumor-infiltrating ARG1-expressing cells were mainly immature
11 nalysis reveals versatile functions of tumor-infiltrating B cells and their potential clinical implic
13 nses in human cancer and suggest that tumour-infiltrating B cells could be harnessed for the developm
16 y eliminated long-term repopulating LSCs and infiltrating blast cells, conferring a survival advantag
19 sident CD11b/CD45(int)Ly6C(-) microglia, and infiltrating CD11b(+)/CD45(high) monocytes/macrophages c
21 PD-1 and CTLA-4 were upregulated on tumor-infiltrating CD4(+) and CD8(+) T cells in irradiated and
24 depletion promoted GzmB expression by tumor-infiltrating CD4(+), and this was prevented by interleuk
25 ze was negatively associated with numbers of infiltrating CD4+ T cells, CD4+CD127+ T cells, and CD8+C
26 Carbon monoxide did not affect the number of infiltrating CD45(+) cells in the prostates of E. coli-
27 is often correlates with the number of tumor-infiltrating CD8 T cells, but many of these cells recogn
28 n intratumoral IL-2 and 2.1-fold increase in infiltrating CD8 T cells, resulting in significantly slo
29 significantly increased the number of tumor-infiltrating CD8(+) T and natural killer cells, slowed t
30 4-deficient tumors increased cytotoxic tumor-infiltrating CD8(+) T cells and elevated secretion of IF
32 s, a comparison of these cells with melanoma-infiltrating CD8(+) T cells revealed upregulated cytokin
39 roposed to explain how these multiple tumour-infiltrating cell types block the development of an effe
40 rine signals with other cancer cells and the infiltrating cell types that populate the microenvironme
41 an uveitis and healthy tissues suggests that infiltrating cells could be targeted by inhibitors of th
42 med an unbiased examination of diverse islet-infiltrating cells during autoimmune diabetes in the non
44 e-cell analysis of intrinsic renal cells and infiltrating cells from patients with LN is a new approa
46 ir associated receptor expression by retinal infiltrating cells in mouse and human tissues, and in at
47 T cell proliferation and polarization, renal infiltrating cells, and cytokines in wild-type and NGAL-
48 mitigation of the inflammatory status of the infiltrating cells, improved electrophysiologic visual f
52 the first time complete regression of a non-infiltrating ciliary body medulloepithelioma with seedin
53 ical type, Scarf-Bloom, Ki67, and p53 in the infiltrating component as well as in the in situ compone
55 t with a reduction in TAMs the percentage of infiltrating cytotoxic T cells is increased, indicating
56 organisms revealed that the numbers of tumor-infiltrating dendritic cells (TIDC) drastically decrease
57 ncluding tumor-associated macrophages, tumor-infiltrating dendritic cells and regulatory T cells.
58 ansfecting a substantial proportion of tumor-infiltrating dendritic cells, macrophages, and T cells i
60 3), the most common histologic subtypes were infiltrating ductal carcinoma (IDC, 84.9%) and luminal A
63 bearing mregDC1s, expands the pool of tumour-infiltrating effector T cells and reduces tumour burden.
64 , a DNA hypomethylating drug increases tumor-infiltrating effector T cells, increases a subset of M2
69 containing protein 3 (TIM-3) expressed by TG infiltrating gB-specific CD8(+) T cells from the HSV-1 0
70 sy-proven patient data identified as diffuse infiltrating glioma patients whose disease progressed/re
71 ignificant challenge in follow-up of diffuse infiltrating gliomas, particularly high grade, which lea
74 iagnosis was based on findings of eosinophil-infiltrating granulomatous vasculitis of the skin accomp
75 cell infiltration and the migratory path of infiltrating H3K27M DMG cells into other midline structu
77 Finally, a higher proportion of bone marrow-infiltrating ICOShigh/PD-1- Treg cells is a highly signi
83 imilar subtypes, characterized by changes to infiltrating immune and stromal expression signatures.
85 nalysis of genomic, transcriptomic and tumor-infiltrating immune cell profiles demonstrated alignment
86 gs promoted the assembly of ASC complexes in infiltrating immune cells (neutrophils and inflammatory
87 inflammatory mediators and increasing tumour-infiltrating immune cells - phenomena often described co
90 e (ie, patients with PD-L1-expressing tumour infiltrating immune cells covering >=1% of tumour area)
91 e tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticanc
95 examined steroid hormone receptors and tumor-infiltrating immune cells in metastatic lesions with or
100 s the proportions of stromal cells and tumor-infiltrating immune cells, as well as associations of th
101 an interferon signature in the skin without infiltrating immune cells, but with interferon-kappa pro
103 onally, by modulating the reuptake of tissue-infiltrating immune cells, lymphatics regulate immune re
104 s evaluated by immunohistochemistry in tumor infiltrating immune cells, while PD-L1 expression in the
112 (2019) demonstrate a novel role for tumor-infiltrating innate-like B1a B cells in promoting melano
113 as a reduction in the number of immune cells infiltrating into the brain, mitigation of the inflammat
118 e antigen-4 (CTLA-4), respectively, on tumor-infiltrating leukocytes eliciting immunosuppression.
119 onclusion: (18)F-FAC PET can visualize brain-infiltrating leukocytes in a mouse MS model and can moni
122 rmine whether (18)F-FAC accumulates in brain-infiltrating leukocytes, EAE mice were analyzed with (18
123 itated the targeted gene expression in tumor-infiltrating leukocytes, including antigen-presenting de
131 odel, the frequency of PD-1-expressing tumor-infiltrating LSD1-deficient CD8 T cells was greater than
132 ds in the prediction of infiltrating and non-infiltrating lymph nodes, and the determination of their
133 Finally, we evaluated the immune cell tumor-infiltrating lymphocyte (TIL) score for correlation with
136 esolution subgroup significantly depended on infiltrating lymphocyte counts, with patients who showed
138 tions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor
140 vestigation, we explored the effect of tumor-infiltrating lymphocyte subpopulations on lung cancer bi
142 nodal status (N0 vs rest), number of tumour-infiltrating lymphocytes (continuous variable), subtype
144 Here, we show that P2X7 activity in tumor-infiltrating lymphocytes (TIL) induces cellular senescen
145 of spatial relations between tumor and tumor-infiltrating lymphocytes (TIL) is increasingly important
146 DAC led to increased CD4(+) and CD8(+) tumor-infiltrating lymphocytes (TIL), PD1 expression, and tumo
147 mal toxicity in ex vivo-expanded human tumor-infiltrating lymphocytes (TIL), proliferating TILs, and
148 en-specific, activated effector CD8(+) tumor-infiltrating lymphocytes (TILs) after interaction with t
149 d the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immuno
150 latory microenvironment harboring more tumor infiltrating lymphocytes (TILs) and up-regulation of inf
152 ACT) using ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) can mediate complete reg
153 rvivors had a reduced frequency of CD8 tumor-infiltrating lymphocytes (TILs) concomitant with an incr
154 enhances the expansion and function of tumor-infiltrating lymphocytes (TILs) for treating cancer pati
155 cterisation and clinical relevance of tumour-infiltrating lymphocytes (TILs) in leiomyosarcoma (LMS),
156 ultifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associa
162 d a higher response of patient-matched tumor infiltrating lymphocytes against antigens diferentially
165 at MHC class II (MHCII) expression and tumor infiltrating lymphocytes are important prognostic factor
166 hat the presence and quantification of tumor-infiltrating lymphocytes are significantly associated wi
169 ccessible in Nr4a triple knockout CAR tumour-infiltrating lymphocytes compared to wild type were enri
172 n the presence of Wnt5A-depleted MDSC, tumor-infiltrating lymphocytes expressed decreased PD-1 and LA
173 FK_pY416 staining was also observed in tumor-infiltrating lymphocytes in a subset of TNBCs with high
174 y of this tool by using it to classify tumor-infiltrating lymphocytes in breast carcinoma and cutaneo
176 ssion is increased in keratinocytes and skin-infiltrating lymphocytes of psoriatic lesions in human s
177 lies on reinvigoration of pre-existing tumor-infiltrating lymphocytes or on recruitment of novel T ce
179 SWe recently developed a process using tumor-infiltrating lymphocytes to identify the specific immuno
180 omeostatic myeloid cells were outnumbered by infiltrating lymphocytes which modulated the local cell-
181 d enhancement of antitumor activity in tumor-infiltrating lymphocytes without disrupting immune homeo
182 of lymphokine-activated killer cells, tumour-infiltrating lymphocytes, and allogeneic haemopoietic st
183 at rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endothelial cells
184 rognostic significance of intratumoral tumor infiltrating lymphocytes, as well as subsets of CD3, CD8
185 gene, Ki-67 proliferation marker, and tumor-infiltrating lymphocytes, carry prognostic significance,
186 clinical-pathological data on stromal tumour-infiltrating lymphocytes, PAM50 subtypes, and expression
187 18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy
188 -L1 expression in both tumor cells and tumor-infiltrating lymphocytes, suggesting that immune checkpo
189 and immunohistochemical stainings for tumor-infiltrating lymphocytes, tissue-based hypoxia, and micr
191 wth was measured by serial ultrasound, tumor-infiltrating lymphoid and myeloid cells were characteriz
192 nd increases both TILs and a subset of tumor-infiltrating M2-polarized macrophages in the KPC model o
195 urther, during chronic neuroinflammation CNS-infiltrating macrophages and not peripheral myeloid cell
197 persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repai
201 Furthermore, comparison of diseased KCs and infiltrating macrophages revealed that these two macroph
203 rated neutrophils, and then overexpressed in infiltrating macrophages, AnxA1 activated FPR2/ALX recep
204 neutrophils and Ly6C(hi) and Ly6C(lo) muscle-infiltrating macrophages, with a distinct pro-resolving
210 euro-oncology MRI data can already delineate infiltrating margins of diffuse gliomas, differentiate p
212 are a large number of circulating and tumor-infiltrating MDSCs existing in gastric cancer (GC) patie
213 ddition, our investigation showed that tumor-infiltrating MDSCs from 6 GAC patients consisted of >35%
215 nt models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease s
216 onal abundance of tissue-resident microglia, infiltrating monocyte-derived macrophages, neutrophils,
217 hages, describe possible mechanisms by which infiltrating monocytes acquire unique macrophage fates,
218 file of blood-derived monocytes versus tumor-infiltrating monocytes and found increased expression of
219 sophil-derived interleukin-4 can act on lung-infiltrating monocytes causing aberrant expression of th
220 tanding the respective role of microglia and infiltrating monocytes in neuroinflammatory conditions h
223 nalysis shows the expression of GPR35 on the infiltrating monocytes/macrophages and neutrophils in th
224 the frequency of myeloid-derived cells, both infiltrating monocytes/macrophages and resident microgli
225 s, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and oth
226 Here, we report that STAT3 is activated in infiltrating monocytic cells near active MS lesions and
227 phenotypic profile resembling that of tumor infiltrating myeloid and lymphoid populations, but with
228 This study ultimately demonstrates that infiltrating myeloid cell TGF-beta1 is responsible for t
230 troke, we characterized the phenotypes of CP-infiltrating myeloid cells after transient middle cerebr
231 th resulted in significantly decreased brain-infiltrating myeloid cells as well as attenuated cachexi
232 polarization of central nervous system (CNS)-infiltrating myeloid cells into an antiinflammatory/repa
233 s cytometry revealed a wide heterogeneity of infiltrating myeloid cells with increased infiltration o
234 Understanding the migratory patterns of CP-infiltrating myeloid cells with intact and disrupted CX3
236 s well as the number and functions of tumour-infiltrating natural-killer and CD8(+) T lymphocytes.
238 is currently known about the origin of tumor-infiltrating nerves, how they may be recruited to tumors
240 We demonstrated in a recent study that tumor-infiltrating neutrophil density correlated with TC size.
241 rface CD62L and upregulation of Cxcr4, heart infiltrating neutrophils acquired a unique SiglecF(hi) s
243 g the expression of these receptors on tumor-infiltrating NK cells in human tumors, whereas tumor cel
247 significantly reduced numbers of bone marrow-infiltrating OX40+ cytotoxic T cells and helper T cells,
249 of studies did not evaluate the presence of infiltrating peripheral immune cells in the central nerv
250 , including their interaction with allograft-infiltrating recipient immune cells and potential therap
252 covered a significant heterogeneity of tumor-infiltrating slan(+) -cells, including a macrophage-like
254 owever, in advanced stages, cancer cells and infiltrating stromal components interfere with the immun
257 mation, which is reflected by high levels of infiltrating T cells and interferon-gamma (IFNgamma) sig
259 omise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear.
260 umors grow slower than in wild-type mice and infiltrating T cells are less exhausted and more active
261 s the expression of CTLA-4 molecule on tumor-infiltrating T cells by siRNA-loaded chitosan-lactate (C
266 ponses to HIPs were observed among the islet-infiltrating T cells of pancreatic organ donors and in t
268 onment, including increased numbers of tumor-infiltrating T cells, elevated IFN signaling, and immune
269 roenvironment, significantly increased tumor infiltrating T cells, lowered the hypoxia level, decreas
270 ed to the downregulation of CTLA-4 on tumor -infiltrating T cells, which was associated with tumor re
277 ilar means as those used to reactivate tumor-infiltrating T lymphocytes (TIL), for example, by cytoki
278 hared antigenic epitopes recognized by tumor-infiltrating T lymphocytes (TILs) from eight melanoma pa
280 Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened by elev
281 mune checkpoint molecules expressed on tumor-infiltrating T lymphocytes, such as cytotoxic T-lymphocy
283 ted the involvement of virus-specific, joint-infiltrating Th1 cells as one of the main pathogenic med
284 CXCL2 expression, prevents macrophages from infiltrating the bite site, protects susceptible IFNAR(-
286 we show that memory phenotype CD4(+) T cells infiltrating the central nervous system during experimen
289 subset bias was observed among GC Tfh cells infiltrating the pancreas of NOD mice, which was enhance
290 e 3D distribution and density of lymphocytes infiltrating the tissue, and by providing histograms of
291 main trajectory of human slan(+) -monocytes infiltrating the tonsil tissue is toward a macrophage-li
292 nal form of EB have significantly more cells infiltrating their wounds compared with patients with re
294 icroenvironment and the composition of tumor-infiltrating Treg and myeloid-derived suppressor cells.
297 Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metas
298 The pathology revealed diffusely and deeply infiltrating tumour cells extending through the dermis,
299 sion is altered at the surface of leukocytes infiltrating unhealed atherothrombotic lesions and that